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Critical Care

Ausgabe 1/2023

Inhalt (495 Artikel)

Open Access Research

Clustering of critically ill patients using an individualized learning approach enables dose optimization of mobilization in the ICU

Kristina E. Fuest, Bernhard Ulm, Nils Daum, Maximilian Lindholz, Marco Lorenz, Kilian Blobner, Nadine Langer, Carol Hodgson, Margaret Herridge, Manfred Blobner, Stefan J. Schaller

Open Access Review

The rate and assessment of muscle wasting during critical illness: a systematic review and meta-analysis

Brigitta Fazzini, Tobias Märkl, Christos Costas, Manfred Blobner, Stefan J. Schaller, John Prowle, Zudin Puthucheary, Henning Wackerhage

Open Access COVID-19 Research

Epidemiology and outcomes of early-onset AKI in COVID-19-related ARDS in comparison with non-COVID-19-related ARDS: insights from two prospective global cohort studies

Bairbre A. McNicholas, Emanuele Rezoagli, Andrew J. Simpkin, Sankalp Khanna, Jacky Y. Suen, Pauline Yeung, Daniel Brodie, Gianluigi Li Bassi, Tai Pham, Giacomo Bellani, John F. Fraser, John Laffey

Open Access Research

The effect of blood pressure on mortality following out-of-hospital cardiac arrest: a retrospective cohort study of the United Kingdom Intensive Care National Audit and Research Centre database

Peter J. McGuigan, Elisa Giallongo, Bronagh Blackwood, James Doidge, David A. Harrison, Alistair D. Nichol, Kathryn M. Rowan, Manu Shankar-Hari, Markus B. Skrifvars, Karen Thomas, Danny F. McAuley

Open Access Correspondence

MIRACLE2 and SCAI grade identify patients for early wakening after out-of-hospital cardiac arrest: a post hoc analysis of the THAW trial

Rupert Simpson, Grigoris V. Karamasis, John Davies, Nilesh Pareek, Thomas R. Keeble, Maria Maccaroni, Max Damian, Noel Watson

Open Access Research

Post-cardiac surgery fungal mediastinitis: clinical features, pathogens and outcome

Geoffroy Hariri, Mathieu Genoud, Vincent Bruckert, Samuel Chosidow, Emmanuel Guérot, Antoine Kimmoun, Nicolas Nesseler, Emmanuel Besnier, Fabrice Daviaud, David Lagier, Julien Imbault, David Grimaldi, Adrien Bouglé, Nicolas Mongardon

Open Access Research

Association between early nutrition support and 28-day mortality in critically ill patients: the FRANS prospective nutrition cohort study

Emmanuel Pardo, Thomas Lescot, Jean-Charles Preiser, Pablo Massanet, Antoine Pons, Samir Jaber, Vincent Fraipont, Eric Levesque, Carole Ichai, Laurent Petit, Fabienne Tamion, Garry Taverny, Priscilla Boizeau, Corinne Alberti, Jean-Michel Constantin, Marie-Pierre Bonnet, Désiré Samba, Jean-Denis Moyer, Philippe Montravers, Nicolas Mongardon, Arnaud Meffert, Audrey De Jong, Fouad Belafia, Jérome Morel, Karim Asehnoune, Pierre-Joachim Mahé, Alain D’Hondt, Nicolas Paquot, Marc Leone, Michel Kaidomar, Ludovic Grech, Eliane Gouteix, Elise Barsam, Jacques Duranteau, Orianne Martinez

Open Access Research

Valproic acid as adjuvant treatment for convulsive status epilepticus: a randomised clinical trial

Tarek Sharshar, Raphaël Porcher, Pierre Asfar, Lamiae Grimaldi, Julien Jabot, Laurent Argaud, Christine Lebert, Pierre-Edouard Bollaert, Marie Line Harlay, Patrick Chillet, Eric Maury, Francois Santoli, Pascal Blanc, Romain Sonneville, Dinh Chuyen Vu, Benjamin Rohaut, Aurelien Mazeraud, Jean-Claude Alvarez, Vincent Navarro, Bernard Clair, Hervé Outin, Laurent Argaud, Eric Azabou, François Beloncle, Omar Ben-Hadj, Pascal Blanc, Pierre-Edouard Bollaert, Francis Bolgert, Lila Bouadma, Patrick Chillet, Bernard Clair, Philippe Corne, Raphaël Clere-Jehl, Martin Cour, Arielle Crespel, Véronique Déiler, Jean Dellamonica, Sophie Demeret, Marie-Line Harley, Matthieu Henry-Lagarrigue, Julien Jabot, Nicholas Heming, Romain Hernu, Achille Kouatchet, Christine Lebert, Nicolas Lerolle, Eric Maury, Sophie Letrou, Aurélien Mazeraud, Alain Mercat, Satar Mortaza, Bruno Mourvillier, Hervé Outin, Catherine Paugham-Burtz, Marc Pierrot, Marion Provent, Benjamin Rohaut, Sylvie De La Salle, François Santoli, Maleka Schenk, Shidasp Siami, Vincent Souday, Tarek Sharshar, Romain Sonneville, Jean-François Timsit, Marie Thuong, Nicolas Weiss

Open Access COVID-19 Research

Efficacy and safety of baricitinib in hospitalized adults with severe or critical COVID-19 (Bari-SolidAct): a randomised, double-blind, placebo-controlled phase 3 trial

Marius Trøseid, José R. Arribas, Lambert Assoumou, Aleksander Rygh Holten, Julien Poissy, Vida Terzić, Fulvia Mazzaferri, Jesús Rodríguez Baño, Joe Eustace, Maya Hites, Michael Joannidis, José-Artur Paiva, Jean Reuter, Isabel Püntmann, Thale D. J. H. Patrick-Brown, Elin Westerheim, Katerina Nezvalova-Henriksen, Lydie Beniguel, Tuva Børresdatter Dahl, Maude Bouscambert, Monika Halanova, Zoltán Péterfi, Sotirios Tsiodras, Michael Rezek, Matthias Briel, Serhat Ünal, Martin Schlegel, Florence Ader, Karine Lacombe, Cecilie Delphin Amdal, Serge Rodrigues, Kristian Tonby, Alexandre Gaudet, Lars Heggelund, Joy Mootien, Asgeir Johannessen, Jannicke Horjen Møller, Beatriz Diaz Pollan, Anders Aune Tveita, Anders Benjamin Kildal, Jean-Christophe Richard, Olav Dalgard, Victoria Charlotte Simensen, Aliou Baldé, Lucie de Gastines, Marta del Álamo, Burç Aydin, Fridtjof Lund-Johansen, Mary-Anne Trabaud, Alpha Diallo, Bente Halvorsen, John-Arne Røttingen, Evelina Tacconelli, Yazdan Yazdanpanah, Inge C. Olsen, Dominique Costagliola, Anne Ma Dyrhol-Riise, Birgitte Stiksrud, Synne Jenum, Magnhild Eide MacPherson, Nikolai Ravn Aarskog, Kjerstin Røstad, Linda Gail Skeie, Åsne Dahl, Jeanette Konstance Steen, Sarah Nur, Filip Segers, Katrine Andersen Korsan, Ashwini Sethupathy, Ann Jorunn Sandstå, Gunn-Janne Paulsen, Thor Ueland, Annika Michelsen, Pål Aukrust, Jan Erik Berdal, Ingunn Melkeraaen, Merete Moen Tollefsen, Jessica Andreassen, Jannicke Dokken, Karl Erik Müller, Bjørn Martin Woll, Hanne Opsand, Mette Bogen, Linn-Therese Rød, Trude Steinsvik, Bjørn Åsheim-Hansen, Randi Haukaas Bjerkreim, Åse Berg, Solfrid Moen, Stina Kvalheim, Kristian Strand, Berit Gravrok, Vegard Skogen, Elias Myrvoll Lorentzen, Simen Walberg Schive, Lasse Rossvoll, Hedda Hoel, Simon Engebråten, Mia Schie Martinsson, Monica Thallinger, Elise Ådnanes, Raisa Hannula, Nina Bremnes, Kristin Liyanarachi, Birgitta Ehrnström, Martin Kvalshaug, Kari Berge, Marte Bygdås, Linda Gustafsson, Saad AballiB, Marianne Strand, Britt Andersen, Pål Aukrust, Andreas Barratt-Due, Katerina Nezvalova Henriksen, Trine Kåsine, Anne Ma Dyrhol-Riise, Jan Erik Berdal, Raphaël Favory, Saad Nseir, Sebastien Preau, Mercé Jourdain, Geoffrey Ledoux, Arthur Durand, Marion Houard, Anne-Sophie Moreau, Anahita Rouzé, Romain Tortuyaux, Guillaume Degouy, Clémentin Levy, Vincent Liu, Nicolas Dognon, Laure Mariller, Claire Delcourte, Zineb Reguig, Amélie Cerf, Marie Cuvelliez, Eric Kipnis, Marielle Boyer-Beysserre, Anne Bignon, Laurie Parmentier, Damia Meddour, Sarah Frade, Jean-François Timsit, Nathan Peiffer-Smadja, Paul-Henri Wicky, Etienne De Montmollin, Lila Bouadma, Julien Dessajan, Romain Sonneville, Juliette Patrier, Simona Presente, Zmihi Sylia, Christophe Rioux, Michaël Thy, Lio Collias, Yasmine Bouaraba, Nikita Dobremel, Anne-Florence Dureau, Pierre Oudeville, Valentin Pointurier, Yannick Rabouel, Laure Stiel, Camille Alzina, Camille Ramstein, Hafid Ait-Oufella, Fatima Hamoudi, Thomas Urbina, Yoann Zerbib, Julien Maizel, Celine Wilpotte, Lionel Piroth, Mathieu Blot, Thibault Sixt, Florian Moretto, Carole Charles, Sandrine Gohier, Damien Roux, Camille Le Breton, Coralie Gernez, Ingrid Thiry, Loredana Baboi, Denis Malvy, Alexandre Boyer, Pauline Perreau, Maddalena Armellini, Giulia De Luca, Ospedale S. M. Massimo Di Pietro, Benedetta Romanin, Michela Brogi, Francesco Castelli, Silvia Amadasi, Francesco Barchiesi, Benedetta Canovari, Nicola Coppola, Mariantonietta Pisaturo, Antonio Russo, Laura Occhiello, Francesco Cataldo, Marta Mora Rillo, Javier Queiruga, Enrique Seco, Stefan Stewart, Alberto M. Borobia, Paloma Moraga, Rocío Prieto, Irene García, Carlota Rivera, José Luis Narro, Natalia Chacón, Sandra de la Rosa, María Macías, Lydia Barrera, Almudena Serna, Virginia Palomo, Maria Isabel García Sánchez, David Gutiérrez, Ana Silva Campos, Miguel Ángel Gómez Garfia, Elvira Bonilla Toyos, Judith Sanabria Cabrera, María Isabel Lucena, Eva Larranaga Lapique, Pierre Englert, Zineb Khalil, Frédérique Jacobs, Justine Malaise, Odette Mukangenzi, Cinderella Smissaert, Marc Hildebrand, Delphine Martiny, Audrey Vervacke, Axelle Scarnière, Nicolas Yin, Charlotte Michel, Lucie Seyler, Sabine Allard, Johan Van Laethem, Gil Verschelden, Annelies Meeuwissen, Alex De Waele, Virgini Van Buggenhout, Dora Monteyne, Nils Noppe, Leila Belkhir, Jean Cyr Yombi, Julien De Greef, Jean Baptiste Mesland, Léopold De Ghellinck, Valérie Kin, Céline D’Aoust, Anne Bouvier, Anne- Charlotte Dekeister, Estelle Hawia, Adeline Gaillet, Hélène Deshorme, Severine Halleux, Vanessa Galand, Roberto Roncon-Albuquerque, Luís Linhares Santos, César Burgi Vieira, Rosana Magalhaes, Sónia Ferreira, Mariana Bernardo, Arthur Jackson, Corinna Sadlier, Sarah O’Connell, Matthew Blair, Edmund Manning, Fiona Cusack, Niamh Kelly, Hannah Stephenson, Ruben Keane, Aisling Murphy, Michele Cunnane, Fionnuala Keane, Mary-Claire O’Regan, Eoghan de Barra, Aimee McGreal Bellone, Siobhan O’Regan, Patrick Carey, Jeffrey Harte, Peter Coakley, Aoife Heeney, Dorothy Ryan, Gerard Curley, Samuel McConkey, Imran Sulaiman, Richard Costello, Cora McNally, Claire Foley, Sophie Trainor, Benson Jacob, Suchitra Vengathodi, Brian Kent, Colm Bergin, Liam Townsend, Colm Kerr, Nalini Panti, Alberto Garcia Sanz, Binny Benny, Edel O. Dea, Niamh Galvin, Claire Burke, Aisling Galvin, Sara Aisiyabi, Deepanjali Lobo, John Laffey, Bairbre McNicolas, David Cosgrave, J. R. Sheehan, Ciprian Nita, Ciara Hanley, Claire Kelly, Maeve Kernan, Jonathan Murray, Thérèse Staub, Thomas Henin, Gaelle Damilot, Tania Bintener, Joelle Colling, Christian Ferretti, Christophe Werer, Pascal Stammet, Pierre Braquet, Vic Arendt, Esther Calvo, Christian Michaux, Chouaib Mediouni, Ali Znati, Gloria Montanes, Laetitia Garcia, Claudius Thomé, Robert Breitkopf, Andreas Peer, Georg Lehner, Romuald Bellman, Adelheid Ditlbacher, Armin Finkenstedt, Klemens Zotter, Christian Preuss Hernandez, Sasa Rajsic, Barbara Lanthaler, Richard Greil, Kiss Tamás, Szilvia Kovácsné-Levang, David Sipos, Agnes Kappéter, Bernadett Halda-Kiss, Edit Madarassi-Papp, Edit Hajdu, Balázs Bende, Thomas Konstantinos, Charalambos Moschopoulos, Eleni Labrou, Maria Tsakona, Ioannis Grigoropoulos, Anastasia Kotanidou, Paraskevi Fragkou, Maria Theodorakopoulou, Eugenia Pantazi, Edison Jahai, Maria Moukouli, Dimitrios Siafakas, Bernd Mühlbauer, Rolf Dembinski, Kathrin Stich, Gerhard Schneider, Andrej Nagy, Karolína Grodová, Michaela Kubelová, Lenka Součková, Helena Kartáková Švábová, Regina Demlová, Simona Sonderlichová, Serhat Unal, A. C. Inkaya, Stephanie de Bono, Cynthia E. Kartman, David H. Adams, Brenda Crowe, Yazdan Yazdanapanah, Serhat Unal, Gerhard Schneider, Bernd Mühlbauer, Tone Ødegård, Gine Bakkehøi, Brigitte Autran, Magnar Bjørås, Xavier de- Lambellerie, Fulvia Mezzarri, Jeremie Guedj, Helene Esperou, Julia Lumbroso, Tobias Welte, Alexandra Calmy, Søren Pischke, Shaun Treweek, Els Goetghebeur, Adelaide Doussau, Laurence Weiss, Frank Hulstaert, Radu Botgros, Marta del Alamo, Florence Chung, Julia Lumbroso, Markus Zeitlinger, Begonya N. Escalera, Chantal Csajka, Clare Williams, Alain Amstutz, Corina Silvia Rüegg, Charles Burdet, Clement Massonnaud, Drifa Belhadi, France Mentré, Massinissa Aroun, France Mentré, Stephan Ehrmann, Helene Espoerou, Charles Burdet, Ragnhild Sørum Falk, Kristin Bjordal, Gina Bakkehøi, Tone Ødegård, Andreas Barratt-Due

Open Access Correspondence

Skin pigmentation bias in regional brain oximetry measurements?

V. Quaresima, F. Scholkmann, M. Ferrari

Open Access Research

The rapid detection of respiratory pathogens in critically ill children

John A. Clark, Andrew Conway Morris, Martin D. Curran, Deborah White, Esther Daubney, Iain R. L. Kean, Vilas Navapurkar, Josefin Bartholdson Scott, Mailis Maes, Rachel Bousfield, M. Estée Török, David Inwald, Zhenguang Zhang, Shruti Agrawal, Constantinos Kanaris, Fahad Khokhar, Theodore Gouliouris, Stephen Baker, Nazima Pathan

Open Access Research

Efficacy and safety of corticosteroids in cardiac arrest: a systematic review, meta-analysis and trial sequential analysis of randomized control trials

Jeremy Penn, Will Douglas, Jeffrey Curran, Dipayan Chaudhuri, Joanna C. Dionne, Shannon M. Fernando, David Granton, Rebecca Mathew, Bram Rochwerg

Open Access Perspective

“THE MANTLE” bundle for minimizing cerebral hypoxia in severe traumatic brain injury

Daniel Agustin Godoy, Francisco Murillo-Cabezas, Jose Ignacio Suarez, Rafael Badenes, Paolo Pelosi, Chiara Robba

Open Access Research

Temporal trends in mortality and provision of intensive care in younger women and men with acute myocardial infarction or stroke

Ketina Arslani, Janna Tontsch, Atanas Todorov, Bianca Gysi, Mark Kaufmann, Fabian Kaufmann, Alexa Hollinger, Karin Wildi, Hamid Merdji, Julie Helms, Martin Siegemund, Catherine Gebhard, Caroline E. Gebhard

Open Access Perspective

The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update?

Rui Moreno, Andrew Rhodes, Lise Piquilloud, Glenn Hernandez, Jukka Takala, Hayley B. Gershengorn, Miguel Tavares, Craig M. Coopersmith, Sheila N. Myatra, Mervyn Singer, Ederlon Rezende, Hallie C. Prescott, Márcio Soares, Jean-François Timsit, Dylan W. de Lange, Christian Jung, Jan J. De Waele, Greg S. Martin, Charlotte Summers, Elie Azoulay, Tomoko Fujii, Anthony S. McLean, Jean-Louis Vincent

Open Access Research

Association of ultra-early diffusion-weighted magnetic resonance imaging with neurological outcomes after out-of-hospital cardiac arrest

Changshin Kang, Jin Hong Min, Jung Soo Park, Yeonho You, Wonjoon Jeong, Hong Joon Ahn, Yong Nam In, In Ho Lee, Hye Seon Jeong, Byung Kook Lee, Jinwoo Jeong

Open Access Correspondence

In-hospital cardiac arrest: evidence and specificities of perioperative cardiac arrest

Quentin de Roux, Athanasios Chalkias, Theodoros Xanthos, Nicolas Mongardon

Open Access Research

Using automatic speckle tracking imaging to measure diaphragm excursion and predict the outcome of mechanical ventilation weaning

Daozheng Huang, Feier Song, Bangjun Luo, Shouhong Wang, Tiehe Qin, Zhuandi Lin, Tieying Hou, Huan Ma

Open Access Research

Severity scores for status epilepticus in the ICU: systemic illness also matters

Fang Yuan, Charlotte Damien, Nicolas Gaspard

Open Access Research

Perioperative changes in fluid distribution and haemodynamics in acute high-risk abdominal surgery

Mirjana Cihoric, Henrik Kehlet, Jakob Højlund, Morten Laksáfoss Lauritsen, Katrine Kanstrup, Nicolai Bang Foss

Open Access Brief Report

Electric impedance tomography-guided PEEP titration reduces mechanical power in ARDS: a randomized crossover pilot trial

Jose Victor Jimenez, Elizabeth Munroe, Andrew J. Weirauch, Kelly Fiorino, Christopher A. Culter, Kristine Nelson, Wassim W. Labaki, Philip J. Choi, Ivan Co, Theodore J. Standiford, Hallie C. Prescott, Robert C. Hyzy

Open Access Research

Variation in electroencephalography and neuroimaging for children receiving extracorporeal membrane oxygenation

Joseph G. Kohne, Graeme MacLaren, Renée A. Shellhaas, Giulia Benedetti, Ryan P. Barbaro

Open Access Correspondence

Chest physiotherapy guided by electrical impedance tomography in high-dependency unit patients with pulmonary diseases: an introduction of methodology and feasibility

Qing Li, Yi Li, Guangyu Niu, Mingna Li, Jia Deng, Knut Möller, Inéz Frerichs, Jianing Xi, Hongying Jiang, Zhanqi Zhao

Open Access Research

Association of red blood cells and plasma transfusion versus red blood cell transfusion only with survival for treatment of major traumatic hemorrhage in prehospital setting in England: a multicenter study

Harriet Tucker, Karim Brohi, Joachim Tan, Christopher Aylwin, Roger Bloomer, Rebecca Cardigan, Ross Davenport, Edward D. Davies, Phillip Godfrey, Rachel Hawes, Richard Lyon, Josephine McCullagh, Simon Stanworth, Julian Thompson, James Uprichard, Simon Walsh, Anne Weaver, Laura Green

Open Access Research

Effect of apneic oxygenation with intubation to reduce severe desaturation and adverse tracheal intubation-associated events in critically ill children

Natalie Napolitano, Lee Polikoff, Lauren Edwards, Keiko M. Tarquinio, Sholeen Nett, Conrad Krawiec, Aileen Kirby, Nina Salfity, David Tellez, Gordon Krahn, Ryan Breuer, Simon J. Parsons, Christopher Page-Goertz, Justine Shults, Vinay Nadkarni, Akira Nishisaki

Open Access Correspondence

The cephalic vein catheterization: maybe yes, but when there is no alternative

Ryszard Gawda, Tomasz Czarnik

Open Access Perspective

An updated “norepinephrine equivalent” score in intensive care as a marker of shock severity

Yuki Kotani, Annamaria Di Gioia, Giovanni Landoni, Alessandro Belletti, Ashish K. Khanna

Open Access Research

The safety and efficacy of mesenchymal stromal cells in ARDS: a meta-analysis of randomized controlled trials

Fengyun Wang, Yiming Li, Bingqing Wang, Jianguo Li, Zhiyong Peng

Open Access Research

Prognostic models for outcome prediction following in-hospital cardiac arrest using pre-arrest factors: a systematic review, meta-analysis and critical appraisal

Casey Grandbois van Ravenhorst, Marc Schluep, Henrik Endeman, Robert-Jan Stolker, Sanne Elisabeth Hoeks

Open Access COVID-19 Research

Clinician perceptions of the impact of ICU family visiting restrictions during the COVID-19 pandemic: an international investigation

Joanne McPeake, Nancy Kentish-Barnes, Emilie Banse, Lynne Anderson, Cecilia Cuzco, Elie Azoulay, Tara Quasim, Pedro Castro, Kathryn Puxty

Open Access COVID-19 Research

COVID-19 bacteremic co-infection is a major risk factor for mortality, ICU admission, and mechanical ventilation

Michael John Patton, Carlos J. Orihuela, Kevin S. Harrod, Mohammad A. N. Bhuiyan, Paari Dominic, Christopher G. Kevil, Daniel Fort, Vincent X. Liu, Maha Farhat, Jonathan L. Koff, Charitharth V. Lal, Anuj Gaggar, Robert P. Richter, Nathaniel Erdmann, Matthew Might, Amit Gaggar

Open Access Brief Report

Temperature control in adults after cardiac arrest: a survey of current clinical practice in Germany

Kevin Roedl, Sebastian Wolfrum, Guido Michels, Martin Pin, Gerold Söffker, Uwe Janssens, Stefan Kluge

Open Access Research

Cytokine hemoadsorption with CytoSorb® in post-cardiac arrest syndrome, a pilot randomized controlled trial

Céline Monard, Nathan Bianchi, Elettra Poli, Marco Altarelli, Anne Debonneville, Mauro Oddo, Lucas Liaudet, Antoine Schneider

Open Access Research

Pattern of disease and determinants of mortality among ICU patients on mechanical ventilator in Sub-Saharan Africa: a multilevel analysis

Semagn Mekonnen Abate, Bivash Basu, Bedru Jemal, Siraj Ahmed, Bahru Mantefardo, Tagesse Taye

Open Access COVID-19 Correspondence

P-SILI in critically ill COVID-19 patients: Macklin effect and the choice of noninvasive ventilatory support type

Alessandro Belletti, Luigi Vetrugno, Cristian Deana, Diego Palumbo, Salvatore M. Maggiore, Giovanni Landoni

Open Access Correspondence

The difference in the association between included ECPR patients and neurological outcomes

Toru Hifumi, Akihiko Inoue, Norio Otani

Open Access Correspondence

Trough concentration may not be a good target for polymyxin B therapeutic drug monitoring

Yuhua Zhao, Huadong Chen, Zhenwei Yu

Open Access Research

Impact of continuous hypertonic (NaCl 20%) saline solution on renal outcomes after traumatic brain injury (TBI): a post hoc analysis of the COBI trial

Olivier Huet, Xavier Chapalain, Véronique Vermeersch, Jean-Denis Moyer, Sigismond Lasocki, Benjamin Cohen, Claire Dahyot-Fizelier, Kevin Chalard, P. Seguin, Y. Hourmant, Karim Asehnoune, Antoine Roquilly

Open Access Review

Toward nutrition improving outcome of critically ill patients: How to interpret recent feeding RCTs?

Jan Gunst, Michael P. Casaer, Jean-Charles Preiser, Jean Reignier, Greet Van den Berghe

Open Access Correspondence

A pleural drainage tube misplaced into the right atrium

Yiping Feng, Shouyin Jiang, Shanxiang Xu, Xiao Lu

Open Access COVID-19 Research

COVID-19 does not influence functional status after ARDS therapy

Alice Bernard, Lina Maria Serna-Higuita, Peter Martus, Valbona Mirakaj, Michael Koeppen, Alexander Zarbock, Gernot Marx, Christian Putensen, Peter Rosenberger, Helene Anna Haeberle

Open Access Research

The low-dose colchicine in patients after non-CABG cardiac surgery: a randomized controlled trial

Tuo Pan, Chen-Yu Jiang, He Zhang, Xi-Kun Han, Hai-Tao Zhang, Xin-Yi Jiang, Wei Chen, Kuo Wang, Fu-Dong Fan, Jun Pan, Qing Zhou, Chuang-Shi Wang, Li Zhang, Dong-Jin Wang

Open Access Review

Rationale for sequential extracorporeal therapy (SET) in sepsis

Claudio Ronco, Lakhmir Chawla, Faeq Husain-Syed, John A. Kellum

Open Access Research

Levosimendan in patients undergoing extracorporeal membrane oxygenation after cardiac surgery: an emulated target trial using observational data

Julien Massol, Noémie Simon-Tillaux, Joanna Tohme, Geoffroy Hariri, Pauline Dureau, Baptiste Duceau, Lisa Belin, David Hajage, Yann De Rycke, Ahmed Charfeddine, Guillaume Lebreton, Alain Combes, Adrien Bouglé

Open Access Correspondence

Study claiming target in sepsis with erythromycin has no effect upon mortality and secondary outcomes includes patients with CRRT and RRT

Patrick M. Honore, Sydney Blackman, Emily Perriens, Ibrahim Bousbiat

Open Access COVID-19 Research

Intravenous methylprednisolone pulse therapy and the risk of in-hospital mortality among acute COVID-19 patients: Nationwide clinical cohort study

Takuhiro Moromizato, Ryoto Sakaniwa, Yasuharu Tokuda, Kiyosu Taniguchi, Kenji Shibuya

Open Access Research

Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study

Lucy A. Coupland, David J. Rabbolini, Jonathan G. Schoenecker, Philip J. Crispin, Jennene J. Miller, Tony Ghent, Robert L. Medcalf, Anders E. Aneman

Open Access Research

Extracorporeal treatment for ethylene glycol poisoning: systematic review and recommendations from the EXTRIP workgroup

Marc Ghannoum, Sophie Gosselin, Robert S. Hoffman, Valery Lavergne, Bruno Mégarbane, Hossein Hassanian-Moghaddam, Maria Rif, Siba Kallab, Steven Bird, David M. Wood, Darren M. Roberts, Badria Alhatali, Kurt Anseeuw, Ingrid Berling, Josée Bouchard, Timothy E. Bunchman, Diane P. Calello, Paul K. Chin, Kent Doi, Tais Galvao, David S. Goldfarb, Lotte C. G. Hoegberg, Sofia Kebede, Jan T. Kielstein, Andrew Lewington, Yi Li, Etienne M. Macedo, Rob MacLaren, James B. Mowry, Thomas D. Nolin, Marlies Ostermann, Ai Peng, Jean-Philippe Roy, Greene Shepherd, Anitha Vijayan, Steven J. Walsh, Anselm Wong, Christopher Yates

Open Access Comment

Time-controlled adaptive ventilation in patients with ARDS—lack of protocol adherence: a systematic review

Stephan Katzenschlager, Christoph M. Simon, Patrick Rehn, Maurizio Grilli, Mascha O. Fiedler, Michael Müller, Markus A. Weigand, Benjamin Neetz

Open Access Correspondence

Response to: The difference in the association between included ECPR patients and neurological outcomes

Makoto Watanabe, Tasuku Matsuyama, Tetsuhisa Kitamura

Open Access Research

Lung morphology impacts the association between ventilatory variables and mortality in patients with acute respiratory distress syndrome

Hui Chen, Qin Sun, Yali Chao, Yue Liu, Qian Yu, Jianfeng Xie, Chun Pan, Ling Liu, Yi Yang, Haibo Qiu

Open Access Research

Inhaled amikacin for pneumonia treatment and dissemination prevention: an experimental model of severe monolateral Pseudomonas aeruginosa pneumonia

Ana Motos, Hua Yang, Gianluigi Li Bassi, Minlan Yang, Andrea Meli, Denise Battaglini, Roberto Cabrera, Joaquim Bobi, Francesco Pagliara, Gerard Frigola, Marta Camprubí-Rimblas, Laia Fernández-Barat, Montserrat Rigol, Antoni Ferrer-Segarra, Kasra Kiarostami, Daniel Martinez, David P. Nicolau, Antonio Artigas, Paolo Pelosi, Jordi Vila, Antoni Torres

Open Access Research

Prevalence of long-term decision regret and associated risk factors in a large cohort of ICU surrogate decision makers

Sarah K. Andersen, Rachel A. Butler, Chung-Chou H. Chang, Robert Arnold, Derek C. Angus, Douglas B. White

Open Access Correspondence

Norepinephrine formulation for equivalent vasopressive score

Nicolas Mongardon, Quentin de Roux, Marc Leone, Philippe Guerci

Open Access Brief Report

Complement activation in severely ill patients with sepsis: no relationship with inflammation and disease severity

Aline H. de Nooijer, Antigone Kotsaki, Eleftheria Kranidioti, Matthijs Kox, Peter Pickkers, Erik J. M. Toonen, Evangelos J. Giamarellos-Bourboulis, Mihai G. Netea

Open Access Correspondence

Response to the Letter by Spurling and Colleagues

Craig I. Coleman, Olivia S. Costa, Stuart J. Connolly, Mukul Sharma, Jan Beyer-Westendorf, Mary J. Christoph-Schubel, Belinda Lovelace

Open Access Research

Fluid balance control in critically ill patients: results from POINCARE-2 stepped wedge cluster-randomized trial

Pierre-Edouard Bollaert, Alexandra Monnier, Francis Schneider, Laurent Argaud, Julio Badie, Claire Charpentier, Ferhat Meziani, Michel Bemer, Jean-Pierre Quenot, Marie Buzzi, Hervé Outin, Cédric Bruel, Laurent Ziegler, Sébastien Gibot, Jean-Marc Virion, Camille Alleyrat, Guillaume Louis, Nelly Agrinier

Open Access Research

Oxygenation thresholds for invasive ventilation in hypoxemic respiratory failure: a target trial emulation in two cohorts

Christopher J. Yarnell, Federico Angriman, Bruno L. Ferreyro, Kuan Liu, Harm Jan De Grooth, Lisa Burry, Laveena Munshi, Sangeeta Mehta, Leo Celi, Paul Elbers, Patrick Thoral, Laurent Brochard, Hannah Wunsch, Robert A. Fowler, Lillian Sung, George Tomlinson

Open Access Correspondence

Moving beyond the lines: lung ultrasound pixel-wise computer-assisted analysis for critically ill patients

Orphée Faucoz, Denis Standarovski, Amazigh Aguersif, Sihem Bouharaoua, Benjamine Sarton, Stein Silva

Open Access COVID-19 Research

Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19

Marius Trøseid, Jan Cato Holter, Kristian Holm, Beate Vestad, Taisiia Sazonova, Beathe K. Granerud, Anne Ma Dyrhol-Riise, Aleksander R. Holten, Kristian Tonby, Anders Benjamin Kildal, Lars Heggelund, Anders Tveita, Simen Bøe, Karl Erik Müller, Synne Jenum, Johannes R. Hov, Thor Ueland

Open Access Correspondence

No evidence for relevant impact of renal replacement therapy on clinical effect of erythromycin in critically ill patients with sepsis

Tom D. Y. Reijnders, Hessel Peters-Sengers, Tom van der Poll

Open Access Comment

Antifungal management in ICU: careful follow-up of voriconazole prescription needed!

Florian Reizine, Jean-Pierre Gangneux

Open Access Research

Severe community-acquired Streptococcus pneumoniae bacterial meningitis: clinical and prognostic picture from the intensive care unit

María Martín-Cerezuela, Maialen Aseginolaza-Lizarazu, Patricia Boronat-García, María José Asensio-Martín, Gisela Alamán-Laguarda, Francisco Álvarez-Lerma, David Roa-Alonso, Lorenzo Socias, Paula Vera-Artázcoz, Paula Ramírez-Galleymore, Bárbara Balandin-Moreno, Loreto Vidaur-Tello, Silvia Sánchez-Morcillo, Juan Carlos Ballesteros-Herráez, Sergio Ossa-Echeverri, David Andaluz-Ojeda, Miguel Ángel Blasco-Navalpotro, Ana Abella-Álvarez, Leonor Nogales-Martín, Emili Díaz-Santos, Oriol Plans-Galván, Isabel Conejo-Márquez

Open Access Perspective

A randomized, double-blind trial comparing the effect of two blood pressure targets on global brain metabolism after out-of-hospital cardiac arrest

Simon Mølstrøm, Troels Halfeld Nielsen, Carl-Henrik Nordstrøm, Axel Forsse, Søren Møller, Søren Venø, Dmitry Mamaev, Tomas Tencer, Ásta Theódórsdóttir, Thomas Krøigård, Jacob Møller, Christian Hassager, Jesper Kjærgaard, Henrik Schmidt, Palle Toft

Open Access Research

Plasma neurofilament light is a predictor of neurological outcome 12 h after cardiac arrest

Helena Levin, Anna Lybeck, Attila Frigyesi, Isabelle Arctaedius, Bergthóra Thorgeirsdóttir, Martin Annborn, Marion Moseby-Knappe, Niklas Nielsen, Tobias Cronberg, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Hans Friberg, Niklas Mattsson-Carlgren

Open Access Perspective

Can artificial intelligence help for scientific writing?

Michele Salvagno, Fabio Silvio Taccone, Alberto Giovanni Gerli

Open Access Brief Report

Incidence of near-death experiences in patients surviving a prolonged critical illness and their long-term impact: a prospective observational study

Anne-Françoise Rousseau, Laurence Dams, Quentin Massart, Laila Choquer, Héléna Cassol, Steven Laureys, Benoit Misset, Nadia Dardenne, Olivia Gosseries, Charlotte Martial

Open Access Review

Targeting circulating high mobility group box-1 and histones by extracorporeal blood purification as an immunomodulation strategy against critical illnesses

Yupei Li, Yu Chen, Tinghang Yang, Kaixi Chang, Ningyue Deng, Weifeng Zhao, Baihai Su

Open Access Review

The effects of flow settings during high-flow nasal cannula support for adult subjects: a systematic review

Jie Li, Fai A. Albuainain, Wei Tan, J. Brady Scott, Oriol Roca, Tommaso Mauri

Open Access Research

Serum-integrated omics reveal the host response landscape for severe pediatric community-acquired pneumonia

Yi Wang, Xiaolan Huang, Fang Li, Xinbei Jia, Nan Jia, Jin Fu, Shuang Liu, Jin Zhang, Haiyan Ge, Siyuan Huang, Yi Hui, Chunrong Sun, Fei Xiao, Xiaodai Cui, Laurence Don Wai Luu, Dong Qu, Jieqiong Li, Jun Tai

Open Access Guidelines

The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition

Rolf Rossaint, Arash Afshari, Bertil Bouillon, Vladimir Cerny, Diana Cimpoesu, Nicola Curry, Jacques Duranteau, Daniela Filipescu, Oliver Grottke, Lars Grønlykke, Anatole Harrois, Beverley J. Hunt, Alexander Kaserer, Radko Komadina, Mikkel Herold Madsen, Marc Maegele, Lidia Mora, Louis Riddez, Carolina S. Romero, Charles-Marc Samama, Jean-Louis Vincent, Sebastian Wiberg, Donat R. Spahn

Open Access Review

Improving vasopressor use in cardiac arrest

Gavin D. Perkins, Keith Couper

Open Access Research

Target attainment and population pharmacokinetics of flucloxacillin in critically ill patients: a multicenter study

Sjoerd D. Meenks, Nieko Punt, Jos L. M. L. le Noble, Norbert A. Foudraine, Kees Neef, Paddy K. C. Janssen

Open Access Research

Association of early mobility with the incidence of deep-vein thrombosis and mortality among critically ill patients: a post hoc analysis of PREVENT trial

Hasan M. Al-Dorzi, Samah AlQahtani, Abdulaziz Al-Dawood, Fahad M. Al-Hameed, Karen E. A. Burns, Sangeeta Mehta, Jesna Jose, Sami J. Alsolamy, Sheryl Ann I. Abdukahil, Lara Y. Afesh, Mohammed S. Alshahrani, Yasser Mandourah, Ghaleb A. Almekhlafi, Mohammed Almaani, Ali Al Bshabshe, Simon Finfer, Zia Arshad, Imran Khalid, Yatin Mehta, Atul Gaur, Hassan Hawa, Hergen Buscher, Hani Lababidi, Abdulsalam Al Aithan, Yaseen M. Arabi

Open Access Research

National incidence and mortality of hospitalized sepsis in China

Li Weng, Yang Xu, Peng Yin, Yi Wang, Yan Chen, Wei Liu, Shan Li, Jin-min Peng, Run Dong, Xiao-yun Hu, Wei Jiang, Chun-yao Wang, Pei Gao, Mai-geng Zhou, Bin Du

Open Access Research

Shock index as predictor of massive transfusion and mortality in patients with trauma: a systematic review and meta-analysis

Andrea Carsetti, Riccardo Antolini, Erika Casarotta, Elisa Damiani, Francesco Gasparri, Benedetto Marini, Erica Adrario, Abele Donati

Open Access Research

Hyperoxemia after reperfusion in cardiac arrest patients: a potential dose–response association with 30-day survival

Akil Awad, Per Nordberg, Martin Jonsson, Robin Hofmann, Mattias Ringh, Jacob Hollenberg, Jens Olson, Eva Joelsson-Alm

Open Access Perspective

How I prescribe prolonged intermittent renal replacement therapy

Edward G. Clark, Anitha Vijayan

Open Access Review

The Role of Transcriptomics in Redefining Critical Illness

Tiana M. Pelaia, Maryam Shojaei, Anthony S. McLean

Open Access Review

Metagenomic Sequencing in the ICU for Precision Diagnosis of Critical Infectious Illnesses

Lucile P. A. Neyton, Charles R. Langelier, Carolyn S. Calfee

Open Access Review

Interrogating the sepsis host immune response using cytomics

Robert B. Lindell, Nuala J. Meyer

Open Access Review

A structured diagnostic algorithm for patients with ARDS

Lieuwe Durk Jacobus Bos, Harm Jan de Grooth, Pieter Roel Tuinman

Open Access Review

Setting and Monitoring of Mechanical Ventilation During Venovenous ECMO

Benjamin Assouline, Alain Combes, Matthieu Schmidt

Open Access Review

Quality improvement in the determination of death by neurologic criteria around the world

Ariane Lewis, Matthew P. Kirschen, Rafael Badenes

Open Access Review

Host Response Biomarkers for Sepsis in the Emergency Room

Oren Turgman, Michiel Schinkel, Willem Joost Wiersinga

Open Access Review

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Christopher Lai, Xavier Monnet, Jean-Louis Teboul

Open Access Correction

Correction to: Can artificial intelligence help for scientific writing?

Michele Salvagno, Fabio Silvio Taccone, Alberto Giovanni Gerli

Open Access Comment

“Reply on: statistics on steroids—how recognizing competing risks gets us closer to the truth about COVID-19-associated VAP”

Fabiana Madotto, Amedeo Guzzardella, Vittorio Scaravilli, Giacomo Grasselli

Open Access Correspondence

The clinical frailty scale, but not the FRAIL checklist is associated with mortality in old critically ill patients with COVID-19

Bernhard Wernly, Hans Flaatten, Susannah Leaver, Bertrand Guidet, Christian Jung, Jesper Fjølner, Michael Beil, Sandra Oeyen, Wojtek Szczeklik, Muhammed Elhadi, Sigal Sviri, Dylan deLange, Rui Moreno, Antonio Artigas, David Dudzinski, Nicolas Serck, Helene Korvenius Nedergaard, Iman Shaat, Aliae Mohamed Hussein, Mostafa Zanaty, Ebtisam Hassanin, Aliae Mohamed Hussein, Nouralsabah Mohamed, Marwa Omar, Ghada Atef Ali Abd El-wahed, Shimaa Touny, Avinash Aujayeb, Saad Nseir, Thomas Urbina, Pierre Garcon, Jean-Philippe Rigaud, Thierry Vanderlinden, Xavier Valette, Buno Megarbane, Elodie Baron, Olivier Nigeon, Gaetan Plantefeve, Camille Foucault, Mehran Monchi, Kristina Fuest, Raphael Bruno, Malte Kelm, Hans-Joachim Kabitz, Stefan Schaller, Abdurraouf Abusalama, Hussein Embarek, Mohamed Anaiba, Ahmed Taher, Akram Alkaseek, Mirjam Evers, Willem Dieperink, Alexander Daniel Cornet, Filipa Brochado, Sonia Lopez-Cuenca, Mohammad Aldiabat, Mohammed Al-Sadawi

Open Access Perspective

Embracing complexity in sepsis

Alex R. Schuurman, Peter M. A. Sloot, W. Joost Wiersinga, Tom van der Poll

Open Access Research

Limitation of life-sustaining therapies in critically ill patients with COVID-19: a descriptive epidemiological investigation from the COVID-ICU study

Mikhael Giabicani, Christophe Le Terrier, Antoine Poncet, Bertrand Guidet, Jean-Philippe Rigaud, Jean-Pierre Quenot, Marie-France Mamzer, Jérôme Pugin, Emmanuel Weiss, Simon Bourcier, Alain Mercat, Pierre Asfar, François Beloncle, Julien Demiselle, Tài Pham, Arthur Pavot, Xavier Monnet, Christian Richard, Alexandre Demoule, Martin Dres, Julien Mayaux, Alexandra Beurton, Cédric Daubin, Richard Descamps, Aurélie Joret, Damien Du Cheyron, Frédéric Pene, Jean-Daniel Chiche, Mathieu Jozwiak, Paul Jaubert, Guillaume Voiriot, Muriel Fartoukh, Marion Teulier, Clarisse Blayau, Erwen L’Her, Cécile Aubron, Laetitia Bodenes, Nicolas Ferriere, Johann Auchabie, Anthony Le Meur, Sylvain Pignal, Thierry Mazzoni, Jean-Pierre Quenot, Pascal Andreu, Jean-Baptiste Roudau, Marie Labruyère, Saad Nseir, Sébastien Preau, Julien Poissy, Daniel Mathieu, Sarah Benhamida, Rémi Paulet, Nicolas Roucaud, Martial Thyrault, Florence Daviet, Sami Hraiech, Gabriel Parzy, Aude Sylvestre, Sébastien Jochmans, Anne-Laure Bouilland, Mehran Monchi, Marc Danguy des Déserts, Quentin Mathais, Gwendoline Rager, Pierre Pasquier, Jean Reignier, Amélie Seguin, Charlotte Garret, Emmanuel Canet, Jean Dellamonica, Clément Saccheri, Romain Lombardi, Yanis Kouchit, Sophie Jacquier, Armelle Mathonnet, Mai-Ahn Nay, Isabelle Runge, Frédéric Martino, Laure Flurin, Amélie Rolle, Michel Carles, Rémi Coudroy, Arnaud W. 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Delaborde, Aïssa Kherchache, Amina Chaalal, Jean-Damien Ricard, Marc Amouretti, Santiago Freita-Ramos, Damien Roux, Jean-Michel Constantin, Mona Assefi, Marine Lecore, Agathe Selves, Florian Prevost, Christian Lamer, Ruiying Shi, Lyes Knani, Sébastien Pili Floury, Lucie Vettoretti, Michael Levy, Lucile Marsac, Stéphane Dauger, Sophie Guilmin-Crépon, Hadrien Winiszewski, Gael Piton, Thibaud Soumagne, Gilles Capellier, Jean-Baptiste Putegnat, Frédérique Bayle, Maya Perrou, Ghyslaine Thao, Guillaume Géri, Cyril Charron, Xavier Repessé, Antoine Vieillard-Baron, Mathieu Guilbart, Pierre-Alexandre Roger, Sébastien Hinard, Pierre-Yves Macq, Kevin Chaulier, Sylvie Goutte, Patrick Chillet, Anaïs Pitta, Barbara Darjent, Amandine Bruneau, Sigismond Lasocki, Maxime Leger, Soizic Gergaud, Pierre Lemarie, Nicolas Terzi, Carole Schwebel, Anaïs Dartevel, Louis-Marie Galerneau, Jean-Luc Diehl, Caroline Hauw-Berlemont, Nicolas Péron, Emmanuel Guérot, Abolfazl Mohebbi Amoli, Michel Benhamou, Jean-Pierre Deyme, Olivier Andremont, Diane Lena, Julien Cady, Arnaud Causeret, Arnaud De La Chapelle, Christophe Cracco, Stéphane Rouleau, David Schnell, Camille Foucault, Cécile Lory, Thibault Chapelle, Vincent Bruckert, Julie Garcia, Abdlazize Sahraoui, Nathalie Abbosh, Caroline Bornstain, Pierre Pernet, Florent Poirson, Ahmed Pasem, Philippe Karoubi, Virginie Poupinel, Caroline Gauthier, François Bouniol, Philippe Feuchere, Florent Bavozet, Anne Heron, Serge Carreira, Malo Emery, Anne Sophie Le Floch, Luana Giovannangeli, Nicolas Herzog, Christophe Giacardi, Thibaut Baudic, Chloé Thill, Said Lebbah, Jessica Palmyre, Florence Tubach, David Hajage, Nicolas Bonnet, Nathan Ebstein, Stéphane Gaudry, Yves Cohen, Julie Noublanche, Olivier Lesieur, Arnaud Sément, Isabel Roca-Cerezo, Michel Pascal, Nesrine Sma, Gwenhaël Colin, Jean-Claude Lacherade, Gauthier Bionz, Natacha Maquigneau, Pierre Bouzat, Michel Durand, Marie-Christine Hérault, Jean-Francois Payen

Open Access Research

Right ventricle-specific therapies in acute respiratory distress syndrome: a scoping review

Simran Ganeriwal, Gabriele Alves dos Anjos, Mary Schleicher, Maxwell A. Hockstein, Adriano R. Tonelli, Abhijit Duggal, Matthew T. Siuba

Open Access Research

The physiologic response to epinephrine and pediatric cardiopulmonary resuscitation outcomes

Ryan W. Morgan, Robert A. Berg, Ron W. Reeder, Todd C. Carpenter, Deborah Franzon, Aisha H. Frazier, Kathryn Graham, Kathleen L. Meert, Vinay M. Nadkarni, Maryam Y. Naim, Bradley Tilford, Heather A. Wolfe, Andrew R. Yates, Robert M. Sutton, Tageldin Ahmed, Michael J. Bell, Robert Bishop, Matthew Bochkoris, Candice Burns, Joseph A. Carcillo, J. Michael Dean, J. Wesley Diddle, Myke Federman, Richard Fernandez, Ericka L. Fink, Stuart H. Friess, Mark Hall, David A. Hehir , Christopher M. Horvat, Leanna L. Huard, Tensing Maa, Arushi Manga, Patrick S. McQuillen, Peter M. Mourani, Daniel Notterman, Murray M. Pollack, Anil Sapru, Carleen Schneiter, Matthew P. Sharron, Neeraj Srivastava, Sarah Tabbutt, Shirley Viteri, David Wessel, Andrew R. Yates, Athena F. Zuppa

Open Access Research

Angiotensin 1–7 in an experimental septic shock model

Bruno Garcia, Fuhong Su, Francesca Manicone, Laurence Dewachter, Raphaël Favory, Amina Khaldi, Alexander Moiroux-Sahroui, Anthony Moreau, Antoine Herpain, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone, Filippo Annoni

Open Access Correspondence

Only the new beginning of VAP quality control

Xin Ding, Xudong Ma, Xiang Zhou

Open Access Research

Outcomes in critically Ill HIV-infected patients between 1997 and 2020: analysis of the OUTCOMEREA multicenter cohort

Antoine Gaillet, Elie Azoulay, Etienne de Montmollin, Maité Garrouste-Orgeas, Yves Cohen, Claire Dupuis, Carole Schwebel, Jean Reignier, Shidasp Siami, Laurent Argaud, Christophe Adrie, Bruno Mourvillier, Stéphane Ruckly, Jean-Marie Forel, Jean-Francois Timsit

Open Access Research

The outcome of IV vitamin C therapy in patients with sepsis or septic shock: a meta-analysis of randomized controlled trials

Baofang Liang, Jianwei Su, Hanquan Shao, Huiying Chen, Baocheng Xie

Open Access Research

Early adjunctive methylene blue in patients with septic shock: a randomized controlled trial

Miguel Ibarra-Estrada, Eduardo Kattan, Pavel Aguilera-González, Laura Sandoval-Plascencia, Uriel Rico-Jauregui, Carlos A. Gómez-Partida, Iris X. Ortiz-Macías, José A. López-Pulgarín, Quetzalcóatl Chávez-Peña, Julio C. Mijangos-Méndez, Guadalupe Aguirre-Avalos, Glenn Hernández

Open Access Research

Polymorphism in interferon alpha/beta receptor contributes to glucocorticoid response and outcome of ARDS and COVID-19

Juho Jalkanen, Sofia Khan, Kati Elima, Teppo Huttunen, Ning Wang, Maija Hollmén, Laura L. Elo, Sirpa Jalkanen

Open Access Research

Novel serum biomarkers for predicting neurological outcomes in postcardiac arrest patients treated with targeted temperature management

Hwan Song, Hyo Jin Bang, Yeonho You, Jung Soo Park, Changshin Kang, Hyo Joon Kim, Kyu Nam Park, Sang Hoon Oh, Chun Song Youn

Open Access Research

Focused liquid ultrasonography in dropsy protocol for quantitative assessment of subcutaneous edema

Weiqing Zhang, Yanting Gu, Yujin Zhao, Jun Lian, Qian Zeng, Xiaoting Wang, Jun Wu, Qiuying Gu

Open Access Research

Neurological and respiratory effects of lung protective ventilation in acute brain injury patients without lung injury: brain vent, a single centre randomized interventional study

Erta Beqiri, Peter Smielewski, Claude Guérin, Marek Czosnyka, Chiara Robba, Lars Bjertnæs, Shirin K. Frisvold

Open Access Research

Reversible skin microvascular hyporeactivity in patients with immune-mediated thrombocytopenic thrombotic purpura

Jérémie Joffre, Lisa Raia, Tomas Urbina, Vincent Bonny, Paul Gabarre, Louai Missri, Jean-Luc Baudel, Paul Coppo, Bertrand Guidet, Eric Maury, Hafid Ait-Oufella

Open Access Research

CytoSorb hemoperfusion markedly attenuates circulating cytokine concentrations during systemic inflammation in humans in vivo

Aron Jansen, Nicole J. B. Waalders, Dirk P. T. van Lier, Matthijs Kox, Peter Pickkers

Open Access Brief Report

Positive end-expiratory pressure induced changes in airway driving pressure in mechanically ventilated COVID-19 Acute Respiratory Distress Syndrome patients

Mônica Rodrigues da Cruz, Luciana Moisés Camilo, Tiago Batista da Costa Xavier, Gabriel Casulari da Motta Ribeiro, Denise Machado Medeiros, Luís Felipe da Fonseca Reis, Bruno Leonardo da Silva Guimarães, André Miguel Japiassú, Alysson Roncally Silva Carvalho

Open Access Correspondence

Large language models and the perils of their hallucinations

Razvan Azamfirei, Sapna R. Kudchadkar, James Fackler

Open Access Correspondence

Letter to the Editor: Innovative future concepts of extracorporeal strategies in sepsis and septic shock

Klaus Stahl, Christian Bode, Sascha David

Open Access Research

Comparison of clinical outcomes between aggressive and non-aggressive intravenous hydration for acute pancreatitis: a systematic review and meta-analysis

Xiu-Wei Li, Chien-Ho Wang, Jhih-Wei Dai, Shu-Han Tsao, Po-Hsi Wang, Cheng-Chen Tai, Rong-Nan Chien, Shih-Chieh Shao, Edward Chia-Cheng Lai

Open Access Review

How I personalize fluid therapy in septic shock?

Xavier Monnet, Christopher Lai, Jean-Louis Teboul

Open Access Comment

Interleukin-6 inhibitors in non-COVID-19 ARDS: analyzing the past to step into the post-COVID-19 era

Lucia Gandini, Gabriele Fior, Andreas Schibler, Nchafatso G. Obonyo, Gianluigi Li Bassi, Jacky Y. Suen, John F. Fraser

Open Access Correspondence

Response to: norepinephrine formulation for equivalent vasopressive score

Yuki Kotani, Giovanni Landoni, Alessandro Belletti, Ashish K. Khanna

Open Access Research

Effect of total cholesterol and statin therapy on mortality in ARDS patients: a secondary analysis of the SAILS and HARP-2 trials

Shaun M. Pienkos, Andrew R. Moore, Jiazhen Guan, Joseph E. Levitt, Michael A. Matthay, Rebecca M. Baron, John Conlon, Daniel F. McAuley, Cecilia M. O’Kane, Angela J. Rogers

Open Access Research

Altered intestinal microbiome and metabolome correspond to the clinical outcome of sepsis

Silei Sun, Daosheng Wang, Danfeng Dong, Lili Xu, Mengqi Xie, Yihui Wang, Tongtian Ni, Weisong Jiang, Xiaojuan Zhu, Ning Ning, Qian Sun, Shuyuan Zhao, Mengjiao Li, Peili Chen, Meiling Yu, Jian Li, Erzhen Chen, Bing Zhao, Yibing Peng, Enqiang Mao

Open Access Research

Impact on the ability of healthcare professionals to correctly identify patient-ventilator asynchronies of the simultaneous visualization of estimated muscle pressure curves on the ventilator display: a randomized study (Pmus study)

Daniel Oliveira Silva, Patrícia Nery de Souza, Mayson Laercio de Araujo Sousa, Caio Cesar Araujo Morais, Juliana Carvalho Ferreira, Marcelo Alcantara Holanda, Wellington Pereira Yamaguti, Laerte Pastore Junior, Eduardo Leite Vieira Costa

Open Access Comment

Reexamining cholinesterase inhibitors for the prevention and treatment of delirium in high-risk populations

Ori J. Lieberman, Vanja C. Douglas, Sara C. LaHue

Open Access Research

Cerebro-spinal fluid glucose and lactate concentrations changes in response to therapies in patIents with primary brain injury: the START-TRIP study

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Open Access Correspondence

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Open Access Brief Report

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Open Access Perspective

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Open Access Brief Report

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Open Access Research

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Open Access Correspondence

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Open Access Research

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Open Access Perspective

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Open Access Research

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Open Access Retraction Note

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Open Access Comment

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Open Access Correspondence

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Open Access Research

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Open Access Comment

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Open Access Research

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Open Access Research

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Open Access Comment

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Open Access Research

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Open Access Research

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Open Access Perspective

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Open Access Research

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Open Access Correspondence

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Patrick M. Honore, Sydney Blackman, Emily Perriens, Ibrahim Bousbiat, Min-Min Wang

Open Access Correspondence

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Open Access Research

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Filippo Annoni, Fuhong Su, Lorenzo Peluso, Ilaria Lisi, Enrico Caruso, Francesca Pischiutta, Elisa Gouvea Bogossian, Bruno Garcia, Hassane Njimi, Jean-Louis Vincent, Nicolas Gaspard, Lorenzo Ferlini, Jacques Creteur, Elisa R. Zanier, Fabio Silvio Taccone

Open Access Research

The impact of unexpected intensive care unit admission after cancer surgery on long-term symptom burden among older adults: a population-based longitudinal analysis

Bourke W. Tillmann, Julie Hallet, Rinku Sutradhar, Matthew P. Guttman, Natalie Coburn, Tyler R. Chesney, Jesse Zuckerman, Alyson Mahar, Wing C. Chan, Barbara Haas, Amy Hsu, Douglas Manuel, Frances Wright, Dov Gandell, Ines Menjak, Lesley Gotlib-Conn, Grace Paladino, Pietro Galuzzo

Open Access Research

Early non-invasive ventilation and high-flow nasal oxygen therapy for preventing endotracheal intubation in hypoxemic blunt chest trauma patients: the OptiTHO randomized trial

Cédric Carrié, Benjamin Rieu, Antoine Benard, Kilian Trin, Laurent Petit, Alexandre Massri, Igor Jurcison, Guillaume Rousseau, David Tran Van, Marie Reynaud Salard, Jeremy Bourenne, Albrice Levrat, Laurent Muller, Damien Marie, Claire Dahyot-Fizelier, Julien Pottecher, Jean-Stéphane David, Thomas Godet, Matthieu Biais

Open Access Research

Optimization of polymyxin B regimens for the treatment of carbapenem-resistant organism nosocomial pneumonia: a real-world prospective study

Tiantian Tang, Ying Li, Ping Xu, Yanjun Zhong, Min Yang, Wanjun Ma, Daxiong Xiang, Bikui Zhang, Yangang Zhou

Open Access Brief Report

Skin biopsy in adult patients with meningococcal purpura fulminans: a multicenter retrospective cohort study

Damien Contou, Gaëtan Béduneau, Charlotte Rabault, Romain Sonneville, Antoine Marchalot, Rémi Coudroy, Damien Roux, Martin Cour, Julien Massol, Sébastien Préau, Nicolas de Prost, Frédéric Pène, Gwenhaël Colin, François Barbier, Kamel Toufik, Quentin Quelven, Guillaume Schnell, Stephan Ehrmann, Hélène Messet, Antoine Kimmoun, Pascal Beuret, Cédric Bruel, Delphine Colling, Alexandre Conia, Luis Ensenyat Martin, Danielle Reuter, Vincent Das, Marion Challier, Mathieu Jozwiak, Arnaud Galbois, Mégan Fraisse, Samir Jaber, Sébastien Jochmans, Pierre Kalfon, Marie Conrad, Alexandre Lautrette, Cédric Darreau, Nicolas Lerolle, Hugues Georges, Bruno Mégarbane, Claire Pichereau, Tomas Urbina, Eric Maury, Nicolas de Prost, Jean-Pierre Quenot, Bertrand Sauneuf, Matthieu Schmidt, Xavier Valette, Lara Zafrani, Daniel Da Silva, Guillaume Rigault, Paul-Louis Woerther

Open Access Research

Pharmacophenotype identification of intensive care unit medications using unsupervised cluster analysis of the ICURx common data model

Andrea Sikora, Alireza Rafiei, Milad Ghiasi Rad, Kelli Keats, Susan E. Smith, John W. Devlin, David J. Murphy, Brian Murray, Rishikesan Kamaleswaran

Open Access Correspondence

Elastance-derived transpulmonary pressure may overestimate the risk of overdistension in severely obese patients

Samuel Tuffet, Elsa Moncomble, Mohamed Ahmed Boujelben, Anne-Fleur Haudebourg, Armand Mekontso-Dessap, Guillaume Carteaux

Open Access Publisher Correction

Publisher Correction: The effect of blood pressure on mortality following out‑of‑hospital cardiac arrest: a retrospective cohort study of the United Kingdom Intensive Care National Audit and Research Centre database

Peter J. McGuigan, Elisa Giallongo, Bronagh Blackwood, James Doidge, David A. Harrison, Alistair D. Nichol, Kathryn M. Rowan, Manu Shankar‑Hari, Markus B. Skrifvars, Karen Thomas, Danny F. McAuley

Open Access Research

Heterogeneity in the definition of delirium in ICUs and association with the intervention effect in randomized controlled trials: a meta-epidemiological study

Lucie Collet, Aymeric Lanore, Camille Alaterre, Jean-Michel Constantin, Guillaume L. Martin, Agnès Caille, Arthur James, Agnès Dechartres

Open Access Correspondence

Clinical Frailty Scale and the FRAIL checklist: Can they complement each other?

Emmanuel Hei-Lok Cheung, Jonathan Chun-Hei Cheung, Yu-Yeung Yip

Open Access Perspective

Effectiveness of diaphragmatic ultrasound as a predictor of successful weaning from mechanical ventilation: a systematic review and meta-analysis

Henry M. Parada-Gereda, Adriana L. Tibaduiza, Alejandro Rico-Mendoza, Daniel Molano-Franco, Victor H. Nieto, Wanderley A. Arias-Ortiz, Purificación Perez-Terán, Joan R. Masclans

Open Access Research

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Open Access Brief Report

Impact of cardiac output and alveolar ventilation in estimating ventilation/perfusion mismatch in ARDS using electrical impedance tomography

Samuel Tuffet, Tommaso Maraffi, Matthieu Lacheny, François Perier, Anne-Fleur Haudebourg, Mohamed Ahmed Boujelben, Glasiele Alcala, Armand Mekontso-Dessap, Guillaume Carteaux

Open Access Correction

Correction: Obesity and critical care nutrition: current practice gaps and directions for future research

Roland N. Dickerson, Laura Andromalos, J. Christian Brown, Maria Isabel T. D. Correia, Wanda Pritts, Emma J. Ridley, Katie N. Robinson, Martin D. Rosenthal, Arthur R. H. van Zanten

Open Access Brief Report

Effects of airway pressure release ventilation on lung physiology assessed by electrical impedance tomography in patients with early moderate-to-severe ARDS

Ruiting Li, Yongran Wu, Hongling Zhang, Azhen Wang, Xin Zhao, Shiying Yuan, Le Yang, Xiaojing Zou, You Shang, Zhanqi Zhao

Open Access Research

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Open Access Correspondence

Artificial intelligence hallucinations

Michele Salvagno, Fabio Silvio Taccone, Alberto Giovanni Gerli

Open Access Correspondence

Use of the OpinionFamily program to improve satisfaction among families of intensive care unit patients

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Open Access Correspondence

Lactic alkalosis in intensive care: a red flag?

Auguste Dargent, Florent Wallet, Arnaud Friggeri, Julien Bohe, Charles-Hervé Vacheron

Open Access Correspondence

Near-death experience and quality of life: additional research

Bruce Greyson

Open Access Perspective

ICU without borders

Marlies Ostermann, Jean-Louis Vincent

Open Access Correspondence

Confounding factors in article stating that Ubiquitin C terminal hydrolase predicts poor neurological outcome after cardiac arrest

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Open Access Research

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Open Access Research

Sodium glucose co-transporter-2 inhibitors in intensive care unit patients with type 2 diabetes: a pilot case control study

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Open Access Review

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Open Access Correspondence

Reply to “Propofol and survival: an updated meta‑analysis of randomized clinical trials”

Manuel Alberto Guerrero Gutierrez, José A. Meade-Aguilar, Diego Escarraman Martinez

Open Access Research

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Alexis L. Benscoter, Jeffrey A. Alten, Mihir R. Atreya, David S. Cooper, Jonathan W. Byrnes, David P. Nelson, Nicholas J. Ollberding, Hector R. Wong

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Open Access Research

Fibroblast growth factor 21 attenuates ventilator-induced lung injury by inhibiting the NLRP3/caspase-1/GSDMD pyroptotic pathway

Peng Ding, Rui Yang, Cheng Li, Hai-Long Fu, Guang-Li Ren, Pei Wang, Dong-Yu Zheng, Wei Chen, Li-Ye Yang, Yan-Fei Mao, Hong-Bin Yuan, Yong-Hua Li

Open Access Correspondence

Pupillary dysfunction during hypothermic circulatory arrest: insights from automated pupillometry

Lorenzo Peluso, Federica Baccanelli, Valentina Grazioli, Paolo Panisi, Fabio Silvio Taccone, Giovanni Albano

Open Access Comment

Comment to: Propofol and survival: an updated meta-analysis of randomized clinical trials

David Benavides-Zora, Jose Hugo Arias-Botero

Open Access Research

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Open Access Review

Diagnostic accuracy of point-of-care ultrasound for shock: a systematic review and meta-analysis

Takuo Yoshida, Takuya Yoshida, Hisashi Noma, Takeshi Nomura, Akihiro Suzuki, Takahiro Mihara

Open Access Research

A deep learning model enables accurate prediction and quantification of pulmonary edema from chest X-rays

Dominik Schulz, Sebastian Rasch, Markus Heilmaier, Rami Abbassi, Alexander Poszler, Jörg Ulrich, Manuel Steinhardt, Georgios A. Kaissis, Roland M. Schmid, Rickmer Braren, Tobias Lahmer

Open Access Correction

Correction : Epidemiology and outcomes of early-onset AKI in COVID-19-related ARDS in comparison with non-COVID-19-related ARDS: insights from two prospective global cohort studies

Bairbre A. McNicholas, Emanuele Rezoagli, Andrew J. Simpkin, Sankalp Khanna, Jacky Y. Suen, Pauline Yeung, Daniel Brodie, Gianluigi Li Bassi, Tai Pham, Giacomo Bellani, John F. Fraser, John Laffey, Tala Al-Dabbous, Huda Alfoudri, Mohammed Shamsah, Qamrah Alhadad, Matly Hanan, Subbarao Elapavaluru, Ashley Berg, Christina Horn, Ahmed Reda Mohamed Elsayed Abdelhalim, Amro Essam Amer, Cinderella Omar Rageh Elnaggar, Ahmed Ayman Hassan, Ali Abdelaziz, Mohamed Abdelhalim, Yehia Samir Shaaban Aly Orabi, Zinah A. Alaraji, Mo’nes R. Muhaisen, Lana Almasri, Dana Mustafa, Shaher Hamdan, Yousef Al-Saba’a, Zaina Dalloul, Mohammed Alkahlout, Hamza Jaber, Osama Aldabbourosama, Aliae A. R. Mohamed Hussein, Zarief Kamel Emad, Sarah Khaled, Nouralsabah Mohamed, Ebtisam Hassanin, Abdelhafeez Hamdi, Abdelrahman Ragab, Mohammed G. Azizeldin, Yunis Mayasi, Stephan Schroll, Dan Meyer, Jorge Velazco, Ludmyla Ploskanych, Wanda Fikes, Rohini Bagewadi, Marvin Dao, Haley White, Alondra Berrios Laviena, Ashley Ehlers, Maysoon Shalabi-McGuire, Trent Witt, Lorenzo Grazioli, Luca Lorini, E. 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Authors’ reply to Hansel’s letter to the editor

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Comment to: “Propofol and survival: an updated meta-analysis of randomized clinical trials”: authors’ reply

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“Under pressure”: should we use diaphragm excursion to predict weaning success in patients receiving pressure support ventilation?

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Open Access Perspective

A long-lasting porcine model of ARDS caused by pneumonia and ventilator-induced lung injury

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Open Access Research

Prone position versus usual care in hypoxemic COVID-19 patients in medical wards: a randomised controlled trial

Mai-Anh Nay, Raphaël Hindre, Christophe Perrin, Jérémy Clément, Laurent Plantier, Aymeric Sève, Sylvie Druelle, Marine Morrier, Jean-Baptiste Lainé, Léa Colombain, Grégory Corvaisier, Nicolas Bizien, Xavier Pouget-Abadie, Adrien Bigot, Simon Jamard, Elsa Nyamankolly, Benjamin Planquette, Guillaume Fossat, Thierry Boulain

Open Access Research

International survey of antibiotic dosing and monitoring in adult intensive care units

Paul G. Williams, Alexis Tabah, Menino Osbert Cotta, Indy Sandaradura, Salmaan Kanji, Marc H. Scheetz, Sahand Imani, Muhammed Elhadi, Sònia Luque-Pardos, Natalie Schellack, Cristina Sanches, Jean-Francois Timsit, Jiao Xie, Andras Farkas, Kathryn Wilks, Jason A. Roberts, Alexander Brinkmann, Mahesh Ramanan, Despoina Koulenti, Mohan Gurjar, Helmi Sulaiman, Gentle Shrestha, Andrea Cortegiani, Monica Crespo, Lowell Ling, Khalid Abidi, Peter Schellongowski

Open Access Correspondence

Volume of oxygen administered during mechanical ventilation predicts mortality in ICU patients

C. C. A. Grim, L. I. van der Wal, J. A. Bouwens, D. J. van Westerloo, E. de Jonge, H. J. F. Helmerhorst

Open Access Research

Extracorporeal hemoadsorption in critically ill COVID-19 patients on VV ECMO: the CytoSorb therapy in COVID-19 (CTC) registry

J. W. Awori Hayanga, Tae Song, Lucian Durham, Lawrence Garrison, Deane Smith, Zsolt Molnar, Joerg Scheier, Efthymios N. Deliargyris, Nader Moazami

Open Access Research

Modifications of lung microbiota structure in traumatic brain injury ventilated patients according to time and enteral feeding formulas: a prospective randomized study

A. Cotoia, R. Paradiso, G. Ferrara, G. Borriello, F. Santoro, I. Spina, L. Mirabella, K. Mariano, G. Fusco, G. Cinnella, P. Singer

Open Access Research

Targeted therapy using polymyxin B hemadsorption in patients with sepsis: a post-hoc analysis of the JSEPTIC-DIC study and the EUPHRATES trial

Itsuki Osawa, Tadahiro Goto, Daisuke Kudo, Mineji Hayakawa, Kazuma Yamakawa, Shigeki Kushimoto, Debra M. Foster, John A. Kellum, Kent Doi

Open Access Correspondence

The absolute value of recruitment-to-inflation ratio does not correlate with the recruited volume

Zhanqi Zhao, Mei-Yun Chang, Chan-Ching Chu, Hou-Tai Chang, Knut Möller, Inéz Frerichs, Yeong-Long Hsu

Open Access Review

Respiratory challenges and ventilatory management in different types of acute brain-injured patients

S. Frisvold, S. Coppola, S. Ehrmann, D. Chiumello, Claude Guérin

Open Access Brief Report

Incidence and clinical features of HHV-7 detection in lower respiratory tract in patients with severe pneumonia: a multicenter, retrospective study

Jun Xu, Lin Zhong, Huanzhang Shao, Qianqian Wang, Muhua Dai, Peng Shen, Yonghui Xiong, Weijun Zhang, Xutao Deng, Mingqiang Wang, Yue Zhu, Xindie Reng, Yongpo Jiang, Mengyuan Chen, Chengcong Zhu, Xueling Fang, Guojun He, Yijiao Han, Xiaohan Huang, Xuwei He, Yinghe Xu, Hongliu Cai, Lingtong Huang

Open Access Perspective

Cerebral apolipoprotein E and amyloid precursor-like protein 1 as risk factors for chronic neurodegeneration after non-traumatic acute brain injury (ABI)

Carlos A. Santacruz, Jean-Louis Vincent, Virginie Imbault, Michael Bruneau, Jacques Creteur, Serge Brimioulle, Raussens Vincent, David Communi, Fabio S. Taccone

Open Access Research

Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1

Mihir R. Atreya, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Matthew N. Alder, Patrick Lahni, Scarlett Ripberger, Adesuwa Ekunwe, Kyle R. Campbell, Keith R. Walley, Stephen W. Standage

Open Access Research

The association of hypoglycemia with outcome of critically ill children in relation to nutritional and blood glucose control strategies

Jan Gunst, Astrid De Bruyn, An Jacobs, Lies Langouche, Inge Derese, Karolijn Dulfer, Fabian Güiza, Gonzalo Garcia Guerra, Pieter J. Wouters, Koen F. Joosten, Sascha C. Verbruggen, Ilse Vanhorebeek, Greet Van den Berghe

Open Access Research

Prevalence, reasons, and timing of decisions to withhold/withdraw life-sustaining therapy for out-of-hospital cardiac arrest patients with extracorporeal cardiopulmonary resuscitation

Hiromichi Naito, Masaaki Sakuraya, Takashi Hongo, Hiroaki Takada, Tetsuya Yumoto, Takashi Yorifuji, Toru Hifumi, Akihiko Inoue, Tetsuya Sakamoto, Yasuhiro Kuroda, Atsunori Nakao

Open Access Obituary

A tribute to Paolo Pelosi

Chiara Robba, Denise Battaglini, Lorenzo Ball

Open Access Review

Human-centered visualization technologies for patient monitoring are the future: a narrative review

Greta Gasciauskaite, Justyna Lunkiewicz, Tadzio R. Roche, Donat R. Spahn, Christoph B. Nöthiger, David W. Tscholl

Open Access Correspondence

Authors’ reply to the comment from Benavides-Zora et al.

Yuki Kotani, Alessandro Pruna, Todd C. Lee, Dominik Roth, Giovanni Landoni

Open Access Research

Telemedical support for prehospital emergency medical service in severe emergencies: an open-label randomised non-inferiority clinical trial

Ana Kowark, Marc Felzen, Sebastian Ziemann, Stephanie Wied, Michael Czaplik, Stefan K. Beckers, Jörg C. Brokmann, Ralf-Dieter Hilgers, Rolf Rossaint, J. Bartman, L. Becker, L. Bozlu, M. Coburn, G. Fazlipour, C. Fitzner, L. Grüßer, G.-A. Gunesch, P. Hess, M. Holten, E. Junge, Dennis Juppen, S. Kaffanke, T. Koch, P. Kranke, J. Liebens, M. Müller, Stephan Ortmanns, Martin Reugels, Ute Roschanski, Jane Schroeder, Pia Stadler, Carla Tutlies, Julia Van Waesberghe

Open Access Research

Clinical benefit of AI-assisted lung ultrasound in a resource-limited intensive care unit

Phung Tran Huy Nhat, Nguyen Van Hao, Phan Vinh Tho, Hamideh Kerdegari, Luigi Pisani, Le Ngoc Minh Thu, Le Thanh Phuong, Ha Thi Hai Duong, Duong Bich Thuy, Angela McBride, Miguel Xochicale, Marcus J. Schultz, Reza Razavi, Andrew P. King, Louise Thwaites, Nguyen Van Vinh Chau, Sophie Yacoub, Dang Phuong Thao, Dang Trung Kien, Doan Bui Xuan Thy, Dong Huu Khanh Trinh, Du Hong Duc, Ronald Geskus, Ho Bich Hai, Ho Quang Chanh, Ho Van Hien, Huynh Trung Trieu, Evelyne Kestelyn, Lam Minh Yen, Le Dinh Van Khoa, Le Thanh Phuong, Le Thuy Thuy Khanh, Luu Hoai Bao Tran, Luu Phuoc An, Angela Mcbride, Nguyen Lam Vuong, Nguyen Quang Huy, Nguyen Than Ha Quyen, Nguyen Thanh Ngoc, Nguyen Thi Giang, Nguyen Thi Diem Trinh, Nguyen Thi Le Thanh, Nguyen Thi Phuong Dung, Nguyen Thi Phuong Thao, Ninh Thi Thanh Van, Pham Tieu Kieu, Phan Nguyen Quoc Khanh, Phung Khanh Lam, Phung Tran Huy Nhat, Guy Thwaites, Louise Thwaites, Tran Minh Duc, Trinh Manh Hung, Hugo Turner, Jennifer Ilo Van Nuil, Vo Tan Hoang, Vu Ngo Thanh Huyen, Sophie Yacoub, Cao Thi Tam, Duong Bich Thuy, Ha Thi Hai Duong, Ho Dang Trung Nghia, Le Buu Chau, Le Mau Toan, Le Ngoc Minh Thu, Le Thi Mai Thao, Luong Thi Hue Tai, Nguyen Hoan Phu, Nguyen Quoc Viet, Nguyen Thanh Dung, Nguyen Thanh Nguyen, Nguyen Thanh Phong, Nguyen Thi Kim Anh, Nguyen Van Hao, Nguyen Van Thanh Duoc, Pham Kieu Nguyet Oanh, Phan Thi Hong Van, Phan Tu Qui, Phan Vinh Tho, Truong Thi Phuong Thao, Natasha Ali, David Clifton, Mike English, Jannis Hagenah, Ping Lu, Jacob McKnight, Chris Paton, Tingting Zhu, Pantelis Georgiou, Bernard Hernandez Perez, Kerri Hill-Cawthorne, Alison Holmes, Stefan Karolcik, Damien Ming, Nicolas Moser, Jesus Rodriguez Manzano, Liane Canas, Alberto Gomez, Hamideh Kerdegari, Andrew King, Marc Modat, Reza Razavi, Miguel Xochicale, Walter Karlen, Linda Denehy, Thomas Rollinson, Luigi Pisani, Marcus Schultz, Alberto Gomez

Open Access Review

Acute-on-chronic liver failure: far to go—a review

Jinjin Luo, Jiaqi Li, Peng Li, Xi Liang, Hozeifa Mohamed Hassan, Richard Moreau, Jun Li

Open Access Research

Prognostic and predictive value of endothelial dysfunction biomarkers in sepsis-associated acute kidney injury: risk-stratified analysis from a prospective observational cohort of pediatric septic shock

Mihir R. Atreya, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Matthew N. Alder, Stuart L. Goldstein, Natalja L. Stanski

Open Access Review

Personalized nutrition therapy in critical care: 10 expert recommendations

Paul E. Wischmeyer, Danielle E. Bear, Mette M. Berger, Elisabeth De Waele, Jan Gunst, Stephen A. McClave, Carla M. Prado, Zudin Puthucheary, Emma J. Ridley, Greet Van den Berghe, Arthur R. H. van Zanten

Open Access Research

A new reservoir-based CPAP with low oxygen consumption: the Bag-CPAP

Eloïse de Beaufort, Guillaume Carteaux, François Morin, Arnaud Lesimple, Anne-Fleur Haudebourg, Emeline Fresnel, Damien Duval, Alexandre Broc, Alain Mercat, Laurent Brochard, Dominique Savary, François Beloncle, Armand Mekontso Dessap, Jean-Christophe Richard

Open Access Research

A targeted metabolomics approach for sepsis-induced ARDS and its subphenotypes

Youjin Chang, Hyun Ju Yoo, Su Jung Kim, Kwangha Lee, Chae-Man Lim, Sang-Bum Hong, Younsuck Koh, Jin Won Huh

Open Access Review

Extended prone positioning for intubated ARDS: a review

Thaïs Walter, Jean-Damien Ricard

Open Access Review

Definitions of massive transfusion in adults with critical bleeding: a systematic review

Victor S. Lin, Emily Sun, Serine Yau, Chathuri Abeyakoon, Georgia Seamer, Simran Bhopal, Harriet Tucker, Carolyn Doree, Susan J. Brunskill, Zoe K. McQuilten, Simon J. Stanworth, Erica M. Wood, Laura Green

Open Access Research

Moderate exercise-induced dynamics on key sepsis-associated signaling pathways in the liver

Hari Prasad Osuru, Keita Ikeda, Navya Atluri, Robert H. Thiele

Open Access Research

Computational physiological models for individualised mechanical ventilation: a systematic literature review focussing on quality, availability, and clinical readiness

R. S. P. Warnaar, M. P. Mulder, L. Fresiello, A. D. Cornet, L. M. A. Heunks, D. W. Donker, E. Oppersma

Open Access Research

Plasma protein biomarkers reflective of the host response in patients developing Intensive Care Unit-acquired pneumonia

Tjitske S. R. van Engelen, Tom D. Y. Reijnders, Fleur P. Paling, Marc J. M. Bonten, Leen Timbermont, Surbhi Malhotra-Kumar, Jan A. J. W. Kluytmans, Hessel Peters-Sengers, Tom van der Poll, Martin Wolkewitz, Omar Ali, Alexey Ruzin, Leen Timbermont, Christine Lammens, Sebastiaan Hullegie, Darren Troeman, Denise van Hout, Daniël Prins, Rubana Kalyani, Mark Eickhoff, Kathryn Shoemaker, Tuba Vilken, Jelle Vlaeminck, Jasmine Coppens, Thomas van der Schalk, Basil Britto Xavier, Evelina Odisseeva, Rossitza Vatcheva, Michal Drab, Jaromir Vajter, Kadri Tamme, Muriel Fartoukh, Alain LePape, Mickael Landais, Gaetan Plantefève, Evelina Tacconelli, Achim Kaasch, Róbert Jurkinya, Iványi Zsolt, Miranda van Rijen, Olaf Cremer, Biljana Carevic, Jasna Jevdjić, Dolores Escudero, Miguel Sanchez Garcia, Cristina Prat-Aymerich, Borja Suberviola-Cañas, Angel Arenzana-Seisdedos, Hürrem Bodur, Cenk Kirakli, Ilkay Bozkurt, Sandra Long

Open Access Correspondence

Artificial intelligence is the new chief editor of Critical Care (maybe?)

Michele Salvagno, Fabio Silvio Taccone

Open Access Research

Development and validation of the creatinine clearance predictor machine learning models in critically ill adults

Chao-Yuan Huang, Fabian Güiza, Pieter Wouters, Liese Mebis, Giorgia Carra, Jan Gunst, Philippe Meersseman, Michael Casaer, Greet Van den Berghe, Greet De Vlieger, Geert Meyfroidt

Open Access Research

A novel method for assessment of airway opening pressure without the need for low-flow insufflation

Anne-Fleur Haudebourg, Elsa Moncomble, Arnaud Lesimple, Flora Delamaire, Bruno Louis, Armand Mekontso Dessap, Alain Mercat, Jean-Christophe Richard, François Beloncle, Guillaume Carteaux

Open Access Research

Efficacy and safety of adjunctive corticosteroids in the treatment of severe community-acquired pneumonia: a systematic review and meta-analysis of randomized controlled trials

Jheng-Yan Wu, Ya-Wen Tsai, Wan-Hsuan Hsu, Ting-Hui Liu, Po-Yu Huang, Min-Hsiang Chuang, Mei-Yuan Liu, Chih-Cheng Lai

Open Access Review

Continuous renal replacement therapy with the adsorptive oXiris filter may be associated with the lower 28-day mortality in sepsis: a systematic review and meta-analysis

Guizhong Wang, Yuxuan He, Qingling Guo, Ying Zhao, Jie He, Yue Chen, Weijia Chen, Yi Zhou, Zichong Peng, Ke Deng, Jianbin Guan, Wenting Xie, Ping Chang, Zhanguo Liu

Open Access Brief Report

Evaluation of Proenkephalin A 119–159 for liberation from renal replacement therapy: an external, multicenter pilot study in critically ill patients with acute kidney injury

Thilo von Groote, Felix Albert, Melanie Meersch, Raphael Koch, Joachim Gerss, Birte Arlt, Mahan Sadjadi, Christian Porschen, Peter Pickkers, Alexander Zarbock

Open Access Research

A user evaluation of speech/phrase recognition software in critically ill patients: a DECIDE-AI feasibility study

M. Musalia, S. Laha, J. Cazalilla-Chica, J. Allan, L. Roach, J. Twamley, S. Nanda, M. Verlander, A. Williams, I. Kempe, I. I. Patel, F. Campbell-West, B. Blackwood, D. F. McAuley

Open Access Research

Association between intrarenal venous flow from Doppler ultrasonography and acute kidney injury in patients with sepsis in critical care: a prospective, exploratory observational study

Kenichiro Fujii, Izumi Nakayama, Junichi Izawa, Noriko Iida, Yoshihiro Seo, Masayoshi Yamamoto, Norimichi Uenishi, Teruhiko Terasawa, Mitsunaga Iwata

Open Access Editorial

Harmful effects of propofol? The Editor’s standpoint

Jean-Louis Vincent

Open Access Correspondence

Magic mirror on the wall, which is the best meta-analysis one of all?

Fabio Silvio Taccone

Open Access Comment

Comment on Propofol and survival: an updated meta-analysis of randomized clinical trials

Adam Glass, Philip McCall, Ben Shelley

Open Access Research

Effects of a swallowing and oral-care program on resuming oral feeding and reducing pneumonia in patients following endotracheal extubation: a randomized, open-label, controlled trial

Shu-Fen Siao, Shih-Chi Ku, Wen-Hsuan Tseng, Yu-Chung Wei, Yu-Chun Chang, Tzu-Yu Hsiao, Tyng-Guey Wang, Cheryl Chia-Hui Chen

Open Access Correspondence

Suspected bias in selection criteria of target subpopulation and its validation

Masatoshi Uchida, Kentaro Hayashi

Open Access Review

Incidence and outcomes of critical illness in Indigenous peoples: a systematic review and meta-analysis

Samantha L. Bowker, Kienan Williams, Auriele Volk, Leonard Auger, Alika Lafontaine, Paige Dumont, Aireen Wingert, Amanda Davis, Liza Bialy, Erica Wright, Richard T. Oster, Sean M. Bagshaw

Open Access Research

Effects of intraoperative inspired oxygen fraction (FiO2 0.3 vs 0.8) on patients undergoing off-pump coronary artery bypass grafting: the CARROT multicenter, cluster-randomized trial

Karam Nam, Jae-Sik Nam, Hye-Bin Kim, Jaeyeon Chung, In Eob Hwang, Jae-Woo Ju, Jinyoung Bae, Seohee Lee, Youn Joung Cho, Jae-Kwang Shim, Young-Lan Kwak, Ji-Hyun Chin, In-Cheol Choi, Eun-Ho Lee, Yunseok Jeon

Open Access Research

Neighborhood socioeconomic deprivation, healthcare access, and 30-day mortality and readmission after sepsis or critical illness: findings from a nationwide study

Jay B. Lusk, Beau Blass, Hannah Mahoney, Molly N. Hoffman, Amy G. Clark, Jonathan Bae, Deepshikha C. Ashana, Christopher E. Cox, Bradley G. Hammill

Open Access Comment

Comment: Is off-label medication use in the ICU a problem?

Menino O. Cotta, Jason A. Roberts, Michael C. Reade

Open Access Review

Management of severe acute respiratory distress syndrome: a primer

John C. Grotberg, Daniel Reynolds, Bryan D. Kraft

Open Access Correspondence

Real life use of vasopressin in patients with cardiogenic shock: a retrospective cohort analysis

Maxime Nguyen, Vivien Berthoud, Alexis Rizk, Bélaïd Bouhemad, Pierre-Grégoire Guinot

Open Access Research

Defining critical illness using immunological endotypes in patients with and without sepsis: a cohort study

Jeremy A. Balch, Uan-I Chen, Oliver Liesenfeld, Petr Starostik, Tyler J. Loftus, Philip A. Efron, Scott C. Brakenridge, Timothy E. Sweeney, Lyle L. Moldawer

Open Access Research

Results from 237 extracorporeal membrane oxygenation runs with drowned patients: a nationwide retrospective study

Thomas Jasny, Jan Kloka, Oliver Old, Florian Piekarski, Gösta Lotz, Kai Zacharowski, Benjamin Friedrichson

Open Access Research

The Vasopressin Loading for Refractory septic shock (VALOR) study: a prospective observational study

Kensuke Nakamura, Hidehiko Nakano, Daisuke Ikechi, Masaki Mochizuki, Yuji Takahashi, Yasuaki Koyama, Hideki Hashimoto, Toshikazu Abe, Mineji Hayakawa, Kazuma Yamakawa

Open Access Research

Using metabolomics to predict severe traumatic brain injury outcome (GOSE) at 3 and 12 months

Mohammad M. Banoei, Chel Hee Lee, James Hutchison, William Panenka, Cheryl Wellington, David S. Wishart, Brent W. Winston, Ari Joffe, Karen Barlow, Keith Yeates, Michael Esser, Brent Winston, Cheryl Wellington, Ivan Torres, Keith Walley, Noah Silverberg, Priscilla Carrion, Quynh Doan, Sophie Stukas, Susan Vercauteren, Will Panenka, Angela Aquino, Audas Lorelei, David Clarke, Kelly Martin, Adrienne Davis, Angela Colantonio, Anne Wheeler, Anne-Marie Guerguerian, Andrew Baker, Elaine Gilfoyle, Jamie Hutchison, Lili-Naz Hazrati, Robin Green, Shannon Scratch, Elisa Wilson, Arash Khosroawshahi, Catherine Farrell, Jacques Lacroix

Open Access Correspondence

Successful treatment of endotracheal intubation-related lip pressure injury using a self-developed fixation device

Qibing Zhang, Xiaodong Zhang, Chunrong Han, Jiqin You, Yunxia Zhao, Rong Xu, Shiyan Zhao, Yan Geng

Open Access Research

How clinicians discuss patients’ donor registrations of consent and presumed consent in donor conversations in an opt-out system: a qualitative embedded multiple-case study

Sanne P. C. van Oosterhout, Anneke G. van der Niet, W. Farid Abdo, Marianne Boenink, Thomas G. V. Cherpanath, Jelle L. Epker, Angela M. Kotsopoulos, Walther N. K. A. van Mook, Hans P. C. Sonneveld, Meint Volbeda, Gert Olthuis, Jelle L. P. van Gurp

Open Access Research

Identification of indications for albumin administration in septic patients with liver cirrhosis

Wenhan Hu, Hui Chen, Chencheng Ma, Qin Sun, Meicheng Yang, Haofei Wang, Qingyun Peng, Jinlong Wang, Chen Zhang, Wei Huang, Jianfeng Xie, Yingzi Huang

Open Access Guideline

Guideline on multimodal rehabilitation for patients with post-intensive care syndrome

Caroline Renner, Marie-Madlen Jeitziner, Monika Albert, Sabine Brinkmann, Karin Diserens, Imanuel Dzialowski, Maria-Dorothea Heidler, Martina Lück, Ricki Nusser-Müller-Busch, Peter S. Sandor, Andreas Schäfer, Bettina Scheffler, Claus Wallesch, Gudrun Zimmermann, Peter Nydahl

Open Access Research

Prevalent diabetes and long-term cardiovascular outcomes in adult sepsis survivors: a population-based cohort study

Federico Angriman, Patrick R. Lawler, Baiju R. Shah, Claudio M. Martin, Damon C. Scales

Open Access Research

Sample size estimation in clinical trials using ventilator-free days as the primary outcome: a systematic review

Laurent Renard Triché, Emmanuel Futier, Manuela De Carvalho, Nathalie Piñol-Domenech, Laëtitia Bodet-Contentin, Matthieu Jabaudon, Bruno Pereira

Open Access Comment

Paediatric out-of-hospital cardiac arrest: Time to update registries?

Stephan Katzenschlager, Inga K. Kelpanides, Eirik Skogvoll, Guro Grindheim, Jan Wnent, Erik Popp, Markus A. Weigand, Jo Kramer-Johansen, Ingvild B. M. Tjelmeland, Jan-Thorsten Gräsner

Open Access Research

Dynamic lung aeration and strain with positive end-expiratory pressure individualized to maximal compliance versus ARDSNet low-stretch strategy: a study in a surfactant depletion model of lung injury

Congli Zeng, Min Zhu, Gabriel Motta-Ribeiro, David Lagier, Takuga Hinoshita, Mingyang Zang, Kira Grogg, Tilo Winkler, Marcos F. Vidal Melo

Open Access Research

Sex-related differences in adult patients with status epilepticus: a seven-year two-center observation

Sira M. Baumann, Pia De Stefano, Paulina S. C. Kliem, Pascale Grzonka, Caroline E. Gebhard, Oana E. Sarbu, Gian Marco De Marchis, Sabina Hunziker, Stephan Rüegg, Andreas Kleinschmidt, Jérôme Pugin, Hervé Quintard, Stephan Marsch, Margitta Seeck, Raoul Sutter

Open Access Correspondence

Is it reasonable to predict weaning by measuring diaphragm activity under ultrasound especially its reduction of excursion?

Linli Wang, Yaxiaerjiang Muhetaer, Ling Zhu, Qian Wang, Wei Wu

Open Access Correspondence

Validation study of ultrasonography versus computed tomography for measuring muscle mass loss in critically ill patients: CT mUS study

Leandro Moreira Peres, Fabio Luis-Silva, Mayra Gonçalves Menegueti, Wilson José Lovato, Douglas Alexandre do Espirito Santo, Mariana Derminio Donadel, Lucas Sato, Carolina Hunger Malek-Zadeh, Anibal Basile-Filho, Olindo Assis Martins-Filho, Maria Auxiliadora-Martins

Open Access Matters Arising

Cerebral autoregulation: every step counts

Timothée Ayasse, Jacques Duranteau, Anatole Harrois, Jonas Pochard

Open Access Research

Extracranial anticoagulant related bleedings admitted to intensive care units: a French multicenter retrospective study

Thomas Botrel, Sibylle Cunat, Julie Helms, Jérémie Lemarié, Jeanne Gaillon, Sébastien Préau, Raphael Favory, Arnaud W. Thille, Florence Boissier, Eric Maury, Jérémie Joffre, Hafid Ait-Oufella

Open Access Research

Different neuroprognostication thresholds of neuron-specific enolase in shockable and non-shockable out-of-hospital cardiac arrest: a prospective multicenter observational study in Korea (the KORHN-PRO registry)

Youn-Jung Kim, Yong Hwan Kim, Chun Song Youn, In Soo Cho, Su Jin Kim, Jung Hee Wee, Yoo Seok Park, Joo Suk Oh, Byung Kook Lee, Won Young Kim

Open Access Correspondence

Bias and potential premature conclusions regarding the clinical benefits of oXiris in septic adult patients

Jia-Jin Chen, Pei-Chun Lai, Yen-Ta Huang, Chao-Han Lai

Open Access Research

Physiological effects of awake prone position in acute hypoxemic respiratory failure

Domenico Luca Grieco, Luca Delle Cese, Luca S. Menga, Tommaso Rosà, Teresa Michi, Gianmarco Lombardi, Melania Cesarano, Valentina Giammatteo, Giuseppe Bello, Simone Carelli, Salvatore L. Cutuli, Claudio Sandroni, Gennaro De Pascale, Antonio Pesenti, Salvatore M. Maggiore, Massimo Antonelli

Open Access Research

Differential effect on mortality of the timing of initiation of renal replacement therapy according to the criteria used to diagnose acute kidney injury: an IDEAL-ICU substudy

Saber Davide Barbar, Abderrahmane Bourredjem, Rémi Trusson, Auguste Dargent, Christine Binquet, Jean-Pierre Quenot, Raphaël Clere-Jehl, Romain Hernu, Florent Montini, Rémi Bruyère, Christine Lebert, Julien Bohé, Julio Badie, Jean-Pierre Eraldi, Jean-Philippe Rigaud, Bruno Levy, Shidasp Siami, Guillaume Louis, Lila Bouadma, Jean-Michel Constantin, Emmanuelle Mercier, Kada Klouche, Damien Du Cheyron, Gaël Piton, Djillali Annane, Samir Jaber, Therry van der Linden, Gilles Blasco, Jean-Paul Mira, Carole Schwebel, Loïc Chimot, Philippe Guiot, Mai-Anh Nay, Ferhat Meziani, Julie Helms, Claire Roger, Benjamin Louart

Open Access Research

Performance of urinary C–C motif chemokine ligand 14 for the prediction of persistent acute kidney injury: a systematic review and meta-analysis

Yih‑Ting Chen, Heng-Chih Pan, Cheng-Kai Hsu, Chiao-Yin Sun, Chun-Yu Chen, Yi-Hung Chen, Heng-Jung Hsu, I-Wen Wu, Vin-Cent Wu, Eric Hoste

Open Access Correspondence

Hemodynamic impact of chest compression location during cardiopulmonary resuscitation guided by transesophageal echocardiography

Felipe Teran, Clark G. Owyang, Manuel Martin-Flores, Derek Lao, Andrea King, Joanna Palasz, Joaquin D. Araos

Open Access Research

Performance of the ROX index in predicting high flow nasal cannula failure in COVID-19 patients: a systematic review and meta-analysis

Chun En Yau, Dawn Yi Xin Lee, Adithi Vasudevan, Ken Junyang Goh, Evelyn Wong, Andrew Fu Wah Ho, Daniel Yan Zheng Lim

Open Access Research

The interaction of thrombocytopenia, hemorrhage, and platelet transfusion in venoarterial extracorporeal membrane oxygenation: a multicenter observational study

Senta Jorinde Raasveld, Claudia van den Oord, Jimmy Schenk, Walter M. van den Bergh, Annemieke Oude Lansink - Hartgring, Franciska van der Velde, Jacinta J. Maas, Pablo van de Berg, Roberto Lorusso, Thijs S. R. Delnoij, Dinis Dos Reis Miranda, Erik Scholten, Fabio Silvio Taccone, Dieter F. Dauwe, Erwin De Troy, Greet Hermans, Federico Pappalardo, Evgeny Fominskiy, Višnja Ivancan, Robert Bojčić, Jesse de Metz, Bas van den Bogaard, Dirk W. Donker, Christiaan L. Meuwese, Martin De Bakker, Benjamin Reddi, José P. S. Henriques, Lars Mikael Broman, Dave A. Dongelmans, Alexander P. J. Vlaar

Open Access Comment

Evidence for a personalized early start of norepinephrine in septic shock

Xavier Monnet, Christopher Lai, Gustavo Ospina-Tascon, Daniel De Backer

Open Access Research

Pneumocystis jirovecii pneumonia in intensive care units: a multicenter study by ESGCIP and EFISG

Daniele Roberto Giacobbe, Silvia Dettori, Vincenzo Di Pilato, Erika Asperges, Lorenzo Ball, Enora Berti, Ola Blennow, Bianca Bruzzone, Laure Calvet, Federico Capra Marzani, Antonio Casabella, Sofia Choudaly, Anais Dartevel, Gennaro De Pascale, Gabriele Di Meco, Melissa Fallon, Louis-Marie Galerneau, Miguel Gallego, Mauro Giacomini, Adolfo González Sáez, Luise Hänsel, Giancarlo Icardi, Philipp Koehler, Katrien Lagrou, Tobias Lahmer, P. Lewis White, Laura Magnasco, Anna Marchese, Cristina Marelli, Mercedes Marín-Arriaza, Ignacio Martin-Loeches, Armand Mekontso-Dessap, Malgorzata Mikulska, Alessandra Mularoni, Anna Nordlander, Julien Poissy, Giovanna Russelli, Alessio Signori, Carlo Tascini, Louis-Maxime Vaconsin, Joel Vargas, Antonio Vena, Joost Wauters, Paolo Pelosi, Jean-Francois Timsit, Matteo Bassetti, Matteo Cerchiaro, Mario Zaccarelli, Chiara Robba, Denise Battaglini, Iole Brunetti, Filippo Del Puente, Sara Mora, Sofía de la Villa, Maricela Valerio, Patricia Muñoz, Gianmarco Lombardi, Melania Cesarano, Veronica Gennenzi, Philippe Meersseman, Greet Hermans, Alexander Wilmer, Keyvan Razazi, Guillaume Carteaux, Nicolas de Prost, Oliver A. Cornely, Danila Seidel, Ana Alastruey-Izquierdo, Jorge Garcia Borrega, Christine Bonnal, Etienne de Montmollin, Julien Dessajan, Mariaelena Ceresini, Francesco Mojoli, Ambra Vola, Cécile Garnaud, Emili Díaz, Oriol Gasch, Elena Prina, Sebastian Rasch, Miriam Dibos, Stefanie Haschka

Open Access Correspondence

Comment on: Results from 237 extracorporeal membrane oxygenation runs with drowned patients

Romain Jouffroy, Benoît Vivien

Open Access Correspondence

Authors’ reply to the comment from Uchida et al.

Itsuki Osawa, Kent Doi

Open Access Research

Neuropsychological outcome after cardiac arrest: results from a sub-study of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial

Erik Blennow Nordström, Susanna Vestberg, Lars Evald, Marco Mion, Magnus Segerström, Susann Ullén, John Bro-Jeppesen, Hans Friberg, Katarina Heimburg, Anders M. Grejs, Thomas R. Keeble, Hans Kirkegaard, Hanna Ljung, Sofia Rose, Matthew P. Wise, Christian Rylander, Johan Undén, Niklas Nielsen, Tobias Cronberg, Gisela Lilja

Open Access Research

Haloperidol for the treatment of delirium in critically ill patients: an updated systematic review with meta-analysis and trial sequential analysis

Nina Christine Andersen-Ranberg, Marija Barbateskovic, Anders Perner, Marie Oxenbøll Collet, Lone Musaeus Poulsen, Mathieu van der Jagt, Lisa Smit, Jørn Wetterslev, Ole Mathiesen, Mathias Maagaard

Open Access Correspondence

Uncovering the power of synergy: a hybrid human–machine model for maximizing AI properties and human expertise

Elena Bignami, Jonathan Montomoli, Valentina Bellini, Marco Cascella

Open Access Research

FX06 to rescue SARS-CoV-2-induced acute respiratory distress syndrome: a randomized clinical trial

Emmanuelle Guérin, Lisa Belin, Guillaume Franchineau, Loïc Le Guennec, David Hajage, Mamadou Hassimiou Diallo, Thomas Frapard, Lucie Le Fèvre, Charles-Edouard Luyt, Alain Combes, Stéphane Germain, Jan Hayon, Pierre Asfar, Nicolas Bréchot

Open Access Correspondence

Use of dexmedetomidine in critical-ill patients: is it time to look to the actual evidence?

Orlando R. Pérez-Nieto, Rafael A. Reyes-Monge, Ignacio Rodríguez-Guevara, Eder I. Zamarrón-López, José A. Meade-Aguilar

Open Access Comment

Artificial intelligence: a new editor limiting self-citation malpractice

Filippo Sanfilippo, A. Messina, F. Corradi, C. Robba

Open Access Correspondence

Authors’ reply to the comment from Glass et al.

Yuki Kotani, Alessandro Pruna, Alessandro Belletti, Todd C. Lee, Giovanni Landoni

Open Access Correspondence

Effects of corticosteroids on severe community-acquired pneumonia: a closer look at the evidence

Cho-Han Chiang, Xin Ya See, Tsu Hsien Wang, Yu-Cheng Chang, Jui-En Lo, Wei-Tao Liu, Cheryn Yu Wei Choo, Cho-Hsien Chiang, Yuan Ping Hsia, Cho-Hung Chiang

Open Access Research

Transcutaneous electrical diaphragmatic stimulation in mechanically ventilated patients: a randomised study

Clément Medrinal, Margaux Machefert, Bouchra Lamia, Tristan Bonnevie, Francis-Edouard Gravier, Roger Hilfiker, Guillaume Prieur, Yann Combret

Open Access Research

Brain tissue oxygen monitoring in traumatic brain injury: part I—To what extent does PbtO2 reflect global cerebral physiology?

Teodor Svedung Wettervik, Erta Beqiri, Stefan Yu Bögli, Michal Placek, Mathew R. Guilfoyle, Adel Helmy, Andrea Lavinio, Ronan O’Leary, Peter J. Hutchinson, Peter Smielewski

Open Access Research

Long-term immunosuppressive treatment is not associated with worse outcome in patients hospitalized in the intensive care unit for septic shock: the PACIFIC study

Julien Vaidie, Edwige Peju, Louise-Marie Jandeaux, Mathieu Lesouhaitier, Jean-Claude Lacherade, Antoine Guillon, Xavier Wittebole, Pierre Asfar, Bruno Evrard, Thomas Daix, Philippe Vignon, Bruno François

Open Access Review

Acute kidney injury in neurocritical care

Faeq Husain-Syed, Tomonori Takeuchi, Javier A. Neyra, Gonzalo Ramírez-Guerrero, Mitchell H. Rosner, Claudio Ronco, Ashita J. Tolwani

Open Access Comment

Final approval for corticosteroids in severe CAP? For sure, in septic shock

Ignacio Martin-Loeches, Blin Nagavci, Antoni Torres

Open Access Research

Advanced respiratory mechanics assessment in mechanically ventilated obese and non-obese patients with or without acute respiratory distress syndrome

François M. Beloncle, Jean-Christophe Richard, Hamid Merdji, Christophe Desprez, Bertrand Pavlovsky, Elise Yvin, Lise Piquilloud, Pierre-Yves Olivier, Dara Chean, Antoine Studer, Antonin Courtais, Maëva Campfort, Hassene Rahmani, Arnaud Lesimple, Ferhat Meziani, Alain Mercat

Open Access Research

Impact of Covid-19 on risk of severe maternal morbidity

Nathalie Auger, U. Vivian Ukah, Shu Qin Wei, Jessica Healy-Profitós, Ernest Lo, Natalie Dayan

Open Access Matters Arising

Drug diluent and efficacy of methylene blue in septic shock: authors’ reply

Miguel Ibarra-Estrada, Eduardo Kattan, Guadalupe Aguirre-Avalos, Glenn Hernández

Open Access Research

Prospective, multicenter validation of the deep learning-based cardiac arrest risk management system for predicting in-hospital cardiac arrest or unplanned intensive care unit transfer in patients admitted to general wards

Kyung-Jae Cho, Jung Soo Kim, Dong Hyun Lee, Sang‑Min Lee, Myung Jin Song, Sung Yoon Lim, Young-Jae Cho, You Hwan Jo, Yunseob Shin, Yeon Joo Lee

Open Access Research

Hyperferritinemic sepsis, macrophage activation syndrome, and mortality in a pediatric research network: a causal inference analysis

Zhenziang Fan, Kate F. Kernan, Yidi Qin, Scott Canna, Robert A. Berg, David Wessel, Murray M. Pollack, Kathleen Meert, Mark Hall, Christopher Newth, John C. Lin, Allan Doctor, Tom Shanley, Tim Cornell, Rick E. Harrison, Athena F. Zuppa, Katherine Sward, J. Michael Dean, H. J. Park, Joseph A. Carcillo

Open Access Research

Out-of-hospital cardiac arrest in children: an epidemiological study based on the German Resuscitation Registry identifying modifiable factors for return of spontaneous circulation

Stephan Katzenschlager, Inga K. Kelpanides, Patrick Ristau, Matthias Huck, Stephan Seewald, Sebastian Brenner, Florian Hoffmann, Jan Wnent, Jo Kramer-Johansen, Ingvild B. M. Tjelmeland, Markus A. Weigand, Jan-Thorsten Gräsner, Erik Popp

Open Access Correspondence

Does AI's touch diminish the artistry of scientific writing or elevate it?

Mugdha Gandhi, Madhura Gandhi

Open Access Research

Outcome assessment for out-of-hospital cardiac arrest patients in Singapore and Japan with initial shockable rhythm

Yohei Okada, Nur Shahidah, Yih Yng Ng, Michael Y. C. Chia, Han Nee Gan, Benjamin S. H. Leong, Desmond R. Mao, Wei Ming Ng, Taro Irisawa, Tomoki Yamada, Tetsuro Nishimura, Takeyuki Kiguchi, Masafumi Kishimoto, Tasuku Matsuyama, Norihiro Nishioka, Kosuke Kiyohara, Tetsuhisa Kitamura, Taku Iwami, Marcus Eng Hock Ong

Open Access Matters Arising

Is handheld video microscopy really the future of microcirculation monitoring?

Matthias Jacquet-Lagrèze, Mathieu Magnin, Bernard Allaouchiche, Stanislas Abrard

Open Access Correspondence

Hyperchloremia, a necessary evil in neurocritical care

Gonzalo Ramírez-Guerrero, Matteo Marcello, Thiago Reis

Open Access Review

Prevention of cardiac surgery-associated acute kidney injury: a systematic review and meta-analysis of non-pharmacological interventions

Geoffroy Hariri, Lucie Collet, Lucie Duarte, Guillaume L. Martin, Matthieu Resche-Rigon, Guillaume Lebreton, Adrien Bouglé, Agnès Dechartres

Open Access Perspective

Recommendations on palliative care aspects in intensive care medicine

Guido Michels, Manuela Schallenburger, Martin Neukirchen, Stefan John, Uwe Janssens, Philip Raake, Katharina Andrea Schütt, Johann Bauersachs, Thomas Barchfeld, Bernd Schucher, Sandra Delis, Rüdiger Karpf-Wissel, Matthias Kochanek, Simone von Bonin, Christiane M. Erley, Susanne D. Kuhlmann, Wolfgang Müllges, Georg Gahn, Hans Jürgen Heppner, Christoph H. R. Wiese, Stefan Kluge, Hans-Jörg Busch, Claudia Bausewein, Martin Pin

Open Access Matters Arising

Blood purification in critically ill patients: not enough, but still helpful

Federico Pappalardo, Astrid Cardinale, Nicoletta D’Ettore, Giulia Maj

Open Access Matters Arising

Effect of corticosteroids on mortality in patients with community-acquired pneumonia

Shangzhong Chen, Caibao Hu

Open Access Research

Non-ventilator-associated ICU-acquired pneumonia (NV-ICU-AP) in patients with acute exacerbation of COPD: From the French OUTCOMEREA cohort

Louis-Marie Galerneau, Sébastien Bailly, Nicolas Terzi, Stéphane Ruckly, Maité Garrouste-Orgeas, Johanna Oziel, Vivien Hong Tuan Ha, Marc Gainnier, Shidasp Siami, Claire Dupuis, Jean-Marie Forel, Anaïs Dartevel, Julien Dessajan, Christophe Adrie, Dany Goldgran-Toledano, Virginie Laurent, Laurent Argaud, Jean Reignier, Jean-Louis Pepin, Michael Darmon, Jean-François Timsit, Jean-François Timsit, Elie Azoulay, Maïté Garrouste-Orgeas, Jean-Ralph Zahar, Bruno Mourvillier, Michael Darmon, Corinne Alberti, Stephane Ruckly, Sébastien Bailly, Aurélien Vannieuwenhuyze, Christophe Adrie, Carole Agasse, Bernard Allaouchiche, Olivier Andremont, Pascal Andreu, Laurent Argaud, Claire Ara-Somohano, Elie Azoulay, Francois Barbier, Jean-Pierre Bedos, Thomas Baudry, Julien Bohé, Lila Bouadma, Jeremy Bourenne, Noel Brule, Frank Chemouni, Julien Carvelli Elisabeth Coupez, Michael Darmon, Claire Dupuis, Etienne de Montmollin, Loa Dopeux, Anne-Sylvie Dumenil, Claire Dupuis, Jean-Marc Forel, Marc Gainnier, Charlotte Garret, Dany Goldgran-Tonedano, Steven Grangé, Antoine Gros, Hédia Hammed, Akim Haouache, Tarik Hissem, Vivien Hong Tuan Ha, Sébastien Jochmans, Jean-Baptiste Joffredo, Hatem Kallel, Guillaume Lacave, Virgine Laurent, Alexandre Lautrette, Clément Le bihan, Virgine Lemiale, David Luis, Guillaume Marcotte, Jordane Lebut, Bruno Mourvillier, Benoît Misset, Bruno Mourvillier, Mathild Neuville, Laurent Nicolet, Johanna Oziel, Laurent Papazian, Juliette Patrier, Benjamin Planquette, Aguila Radjou, Marie Simon, Romain Sonneville, Jean Reignier, Bertrand Souweine, Carole Schwebel, Shidasp Siami, Romain Sonneville, Nicolas Terzi, Gilles Troché, Fabrice Thiollieres, Guillaume Thierry, Guillaume Van Der Meersch, Marion Venot, Florent Wallet, Sondes Yaacoubi, Olivier Zambon, Jonathan Zarka, Mireille Adda, Vanessa Vindrieux, Marion Provent, Sylvie de la Salle, Pauline Enguerrand, Vincent Gobert, Stéphane Guessens, Helene Merle, Nadira Kaddour, Boris Berthe, Samir Bekkhouche, Kaouttar Mellouk, Mélaine Lebrazic, Carole Ouisse, Diane Maugars, Christelle Aparicio, Igor Theodose, Manal Nouacer, Veronique Deiler, Fariza Lamara, Myriam Moussa, Atika Mouaci, Nassima Viguier

Open Access Comment

Beta-blockers in refractory hypoxemia on venovenous extracorporeal membrane oxygenation: a double-edged sword

Dawid L. Staudacher, Tobias Wengenmayer, Matthieu Schmidt

Open Access Research

Variables influencing the prediction of fluid responsiveness: a systematic review and meta-analysis

Jorge Iván Alvarado Sánchez, Juan Daniel Caicedo Ruiz, Juan José Diaztagle Fernández, Luís Eduardo Cruz Martínez, Fredy Leonardo Carreño Hernández, Carlos Andrés Santacruz Herrera, Gustavo Adolfo Ospina-Tascón

Open Access Research

Spinal cord perfusion pressure correlates with breathing function in patients with acute, cervical traumatic spinal cord injuries: an observational study

Ravindran Visagan, Ellaine Boseta, Argyro Zoumprouli, Marios C. Papadopoulos, Samira Saadoun

Open Access Research

Heterogeneity in defining multiple trauma: a systematic review of randomized controlled trials

Thomas Jeanmougin, Elaine Cole, Baptiste Duceau, Mathieu Raux, Arthur James

Open Access Matters Arising

Disrupting the “Animal Farm” of scientific research and publishing: AI as an impartial sidekick

Michele Salvagno, Fabio Silvio Taccone

Open Access Research

Single-plane versus real-time biplane approaches for ultrasound-guided central venous catheterization in critical care patients: a randomized controlled trial

Ying-Ying Li, Yi-Hao Liu, Lin Yan, Jing Xiao, Xin-Yang Li, Jun Ma, Li-Gang Jia, Rui Chen, Chao Zhang, Zhen Yang, Ming-Bo Zhang, Yu-Kun Luo

Open Access Correspondence

Lower oxygen saturation with higher rates of norepinephrine in bone fractures of polytrauma patients: a pilot study

Laura Koch, Marcel Orth, Tobias Fink, Andreas Meiser, Thomas Volk, Michael D. Menger, Matthias W. Laschke, Torsten Pastor, Matthias Knobe, Tim Pohlemann, Bergita Ganse

Open Access Brief Report

Sonometric assessment of cough predicts extubation failure: SonoWean—a proof-of-concept study

Vincent Bonny, Jeremie Joffre, Paul Gabarre, Tomas Urbina, Louai Missri, Mathilde Ladoire, Maxime Gasperment, Jean-Luc Baudel, Bertrand Guidet, Guillaume Dumas, Eric Maury, Laurent Brochard, Hafid Ait-Oufella

Open Access Research

Incidence, microbiological and immunological characteristics of ventilator-associated pneumonia assessed by bronchoalveolar lavage and endotracheal aspirate in a prospective cohort of COVID-19 patients: CoV-AP study

Davide Mangioni, Mauro Panigada, Emanuele Palomba, Chiara Bobbio, Liliane Chatenoud, Laura Alagna, Jacopo Fumagalli, Andrea Gori, Anna Grancini, Amedeo Guzzardella, Andrea Lombardi, Caterina Matinato, Andrea Meli, Antonio Muscatello, Laura Porretti, Mara Tomasello, Elena Trombetta, Luca Valenti, Alessandra Bandera, Giacomo Grasselli

Open Access Research

Brain tissue oxygen monitoring in traumatic brain injury—part II: isolated and combined insults in relation to outcome

Teodor Svedung Wettervik, Erta Beqiri, Anders Hånell, Stefan Yu Bögli, Michal Placek, Mathew R. Guilfoyle, Adel Helmy, Andrea Lavinio, Ronan O’Leary, Peter J. Hutchinson, Peter Smielewski

Open Access Research

Mega-dose sodium ascorbate: a pilot, single-dose, physiological effect, double-blind, randomized, controlled trial

Fumitaka Yanase, Sofia Spano, Akinori Maeda, Anis Chaba, Thummaporn Naorungroj, Connie Pei Chen Ow, Yugeesh R. Lankadeva, Clive N. May, Ashenafi H. Betrie, Darius J. R. Lane, Glenn M. Eastwood, Mark P. Plummer, Rinaldo Bellomo

Open Access Research

Immunosuppressive effects of circulating bile acids in human endotoxemia and septic shock: patients with liver failure are at risk

Julia Leonhardt, Mirrin J. Dorresteijn, Sophie Neugebauer, Diana Mihaylov, Julia Kunze, Ignacio Rubio, Frank-Stephan Hohberger, Silke Leonhardt, Michael Kiehntopf, Klaus Stahl, Christian Bode, Sascha David, Frank A. D. T. G. Wagener, Peter Pickkers, Michael Bauer

Open Access Research

Prophylactic platelet transfusion response in critically ill patients: a prospective multicentre observational study

Florian Reizine, Sarah Le Marec, Anthony Le Meur, Maëlys Consigny, Florian Berteau, Laetitia Bodenes, Marie Geslain, Zoe McQuilten, Catherine Le Niger, Julien Huntzinger, Philippe Seguin, Jean-Baptiste Thibert, David Simon, Jean Reignier, Pierre-Yves Egreteau, Jean-Marc Tadié, Olivier Huet, Pierre Asfar, Stephan Ehrmann, Cécile Aubron

Open Access Research

Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction

Gabriel Jakobsson, Praveen Papareddy, Henrik Andersson, Megan Mulholland, Ravi Bhongir, Irena Ljungcrantz, Daniel Engelbertsen, Harry Björkbacka, Jan Nilsson, Adrian Manea, Heiko Herwald, Marisol Ruiz-Meana, Antonio Rodríguez-Sinovas, Michelle Chew, Alexandru Schiopu

Open Access Correspondence

Proportions and trends of critical care trials in leading general medical journals, 1970–2022

Nin-Chieh Hsu, Charles Liao, Chia-Hao Hsu

Open Access Research

Risk of malignant disease in 1-year sepsis survivors, a registry-based nationwide follow-up study

Johanna Hästbacka, Anna But, Gunnar Strandberg, Miklós Lipcsey

Open Access Correspondence

Can normal breath sounds in mechanically ventilated patients be termed vesicular?

Sai Saran, Saumitra Misra, Avinash Agrawal, Suhail Sarwar Siddiqui

Open Access Research

Time definition of reintubation most relevant to patient outcomes in critically ill patients: a multicenter cohort study

Aiko Tanaka, Yoshimitsu Shimomura, Akinori Uchiyama, Natsuko Tokuhira, Tetsuhisa Kitamura, Hirofumi Iwata, Haruka Hashimoto, Suguru Ishigaki, Yusuke Enokidani, Tomonori Yamashita, Yukiko Koyama, Naoya Iguchi, Takeshi Yoshida, Yuji Fujino

Open Access Brief Report

Improvement of central vein ultrasound-guided puncture success using a homemade needle guide—a simulation study

Antoine Villa, Vladimir Hermand, Vincent Bonny, Gabriel Preda, Tomas Urbina, Maxime Gasperment, Paul Gabarre, Louai Missri, Jean-Luc Baudel, Daniel Zafimahazo, Jérémie Joffre, Hafid Ait-Oufella, Eric Maury

Open Access Editorial

Training in critical care cardiology: making the case for a standardized core curriculum

Leonhard Binzenhöfer, Holger Thiele, Enzo Lüsebrink

Open Access Research

Enteral citrulline supplementation versus placebo on SOFA score on day 7 in mechanically ventilated critically ill patients: the IMMUNOCITRE randomized clinical trial

Jean-Marc Tadié, Clara Locher, Adel Maamar, Jean Reignier, Pierre Asfar, Morgane Commereuc, Mathieu Lesouhaitier, Murielle Gregoire, Estelle Le Pabic, Claude Bendavid, Caroline Moreau, Jean-Luc Diehl, Alain Gey, Eric Tartour, Yves Le Tulzo, Ronan Thibault, Nicolas Terzi, Arnaud Gacouin, Mikael Roussel, Christophe Delclaux, Karin Tarte, Luc Cynober

Open Access Perspective

Critical appraisal beyond clinical guidelines for intraabdominal candidiasis

Emilio Maseda, Ignacio Martín-Loeches, Rafael Zaragoza, Javier Pemán, Jesús Fortún, Santiago Grau, Gerardo Aguilar, Marina Varela, Marcio Borges, María-José Giménez, Alejandro Rodríguez

Open Access Correspondence

Pharyngeal electrical stimulation for postextubation dysphagia in acute stroke: a randomized controlled pilot trial

Sonja Suntrup-Krueger, Bendix Labeit, Thomas Marian, Jens Schröder, Inga Claus, Sigrid Ahring, Tobias Warnecke, Rainer Dziewas, Paul Muhle

Open Access Correspondence

Shedding light on carboxyhaemoglobin in extracorporeal membrane oxygenation

Kenneth R. Hoffman, Arne Diehl, Eldho Paul, Warwick Butt, Aidan J. C. Burrell

Open Access Research

Lung abscess following ventilator-associated pneumonia during COVID-19: a retrospective multicenter cohort study

S. Hraiech, K. Ladjal, C. Guervilly, H. Hyvernat, L. Papazian, J. M. Forel, A. Lopez, N. Peres, J. Dellamonica, M. Leone, I. Gragueb-Chatti

Open Access Review

The spectrum of sepsis-associated encephalopathy: a clinical perspective

Romain Sonneville, Sarah Benghanem, Lina Jeantin, Etienne de Montmollin, Marc Doman, Augustin Gaudemer, Michael Thy, Jean-François Timsit

Open Access Research

Restrictive versus high-dose oxygenation strategy in post-arrest management following adult non-traumatic cardiac arrest: a meta-analysis

S. Macherey-Meyer, S. Heyne, M. M. Meertens, S. Braumann, C. Hueser, V. Mauri, S. Baldus, S. Lee, C. Adler

Open Access Research

Identification of post-cardiac arrest blood pressure thresholds associated with outcomes in children: an ICU-Resuscitation study

Monique M. Gardner, David A. Hehir, Ron W. Reeder, Tageldin Ahmed, Michael J. Bell, Robert A. Berg, Robert Bishop, Matthew Bochkoris, Candice Burns, Joseph A. Carcillo, Todd C. Carpenter, J. Michael Dean, J. Wesley Diddle, Myke Federman, Richard Fernandez, Ericka L. Fink, Deborah Franzon, Aisha H. Frazier, Stuart H. Friess, Kathryn Graham, Mark Hall, Monica L. Harding, Christopher M. Horvat, Leanna L. Huard, Tensing Maa, Arushi Manga, Patrick S. McQuillen, Kathleen L. Meert, Ryan W. Morgan, Peter M. Mourani, Vinay M. Nadkarni, Maryam Y. Naim, Daniel Notterman, Murray M. Pollack, Anil Sapru, Carleen Schneiter, Matthew P. Sharron, Neeraj Srivastava, Bradley Tilford, Shirley Viteri, David Wessel, Heather A. Wolfe, Andrew R. Yates, Athena F. Zuppa, Robert M. Sutton, Alexis A. Topjian

Open Access Research

Low levels of small HDL particles predict but do not influence risk of sepsis

Fergus Hamilton, Kasper Mønsted Pedersen, Peter Ghazal, Børge Grønne Nordestgaard, George Davey Smith

Open Access Research

Improvement of composite kidney outcomes by AKI care bundles: a systematic review and meta-analysis

Chun Yin See, Heng-Chih Pan, Jui-Yi Chen, Chun-Yi Wu, Hung-Wei Liao, Yen-Ta Huang, Jung-Hua Liu, Vin-Cent Wu, Marlies Ostermann

Open Access Research

Procalcitonin-guided antibiotic therapy may shorten length of treatment and may improve survival—a systematic review and meta-analysis

Márton Papp, Nikolett Kiss, Máté Baka, Domonkos Trásy, László Zubek, Péter Fehérvári, Andrea Harnos, Caner Turan, Péter Hegyi, Zsolt Molnár

Open Access Matters Arising

Multimodal neuromonitoring in traumatic brain injury patients: the search for the Holy Graal

Fabio Silvio Taccone, Elda Diletta Sterchele, Michael Piagnerelli

Open Access Comment

What applications for plasma endocan measurement in intensive care? A clarification

Victoria Dubar, Camille Chenevier-Gobeaux, Julien Poissy, Alexandre Gaudet

Open Access Brief Report

Physiological effects of lung-protective ventilation in patients with lung fibrosis and usual interstitial pneumonia pattern versus primary ARDS: a matched-control study

Roberto Tonelli, Salvatore Grasso, Andrea Cortegiani, Lorenzo Ball, Ivana Castaniere, Luca Tabbì, Riccardo Fantini, Dario Andrisani, Filippo Gozzi, Antonio Moretti, Giulia Bruzzi, Linda Manicardi, Stefania Cerri, Anna Valeria Samarelli, Giulia Raineri, Francesco Murgolo, Andrea Carzoli, Rossella Di Mussi, Stefano Busani, Raffaella Rizzoni, Giacomo Grasselli, Enrico Clini, Alessandro Marchioni

Open Access Research

The impact of higher protein dosing on outcomes in critically ill patients with acute kidney injury: a post hoc analysis of the EFFORT protein trial

Christian Stoppe, Jayshil J. Patel, Alex Zarbock, Zheng-Yii Lee, Todd W. Rice, Bruno Mafrici, Rebecca Wehner, Man Hung Manuel Chan, Peter Chi Keung Lai, Kristen MacEachern, Pavlos Myrianthefs, Evdoxia Tsigou, Luis Ortiz-Reyes, Xuran Jiang, Andrew G. Day, M. Shahnaz Hasan, Patrick Meybohm, Lu Ke, Daren K. Heyland

Open Access Perspective

The role of endotoxin in septic shock

John A. Kellum, Claudio Ronco

Open Access Research

Lower versus higher oxygen targets for out-of-hospital cardiac arrest: a systematic review and meta-analysis

Xin Cheng, Yu Zhang, Haidong Deng, Yuning Feng, Weelic Chong, Yang Hai, Pengfei Hao, Jialing He, Tiangui Li, Liyuan Peng, Peng Wang, Yangchun Xiao, Fang Fang

Open Access Research

Creating the ICU of the future: patient-centred design to optimise recovery

Oystein Tronstad, Dylan Flaws, Sue Patterson, Robert Holdsworth, John F. Fraser

Open Access Research

Prevalence and predictors of shared decision-making in goals-of-care clinician-family meetings for critically ill neurologic patients: a multi-center mixed-methods study

Victoria Fleming, Abhinav Prasad, Connie Ge, Sybil Crawford, Shazeb Meraj, Catherine L. Hough, Bernard Lo, Shannon S. Carson, Jay Steingrub, Douglas B. White, Susanne Muehlschlegel

Open Access Matters Arising

Association between early enteral nutrition and mortality in critically ill patients

Shangzhong Chen, Caibao Hu

Open Access Research

Quantitative analysis of early apparent diffusion coefficient values from MRIs for predicting neurological prognosis in survivors of out-of-hospital cardiac arrest: an observational study

Jung A. Yoon, Changshin Kang, Jung Soo Park, Yeonho You, Jin Hong Min, Yong Nam In, Wonjoon Jeong, Hong Joon Ahn, In Ho Lee, Hye Seon Jeong, Byung Kook Lee, Jae Kwang Lee

Open Access Perspective

How I manage differential gas exchange in peripheral venoarterial extracorporeal membrane oxygenation

Richa Asija, Justin A. Fried, Eric C. Siddall, Dana A. Mullin, Cara L. Agerstrand, Daniel Brodie, Joshua R. Sonett, Philippe H. Lemaitre, Darryl Abrams

Open Access Matters Arising

ECMO in resuscitated drowning patients: a propensity score matched sub-analysis—a response to Jouffroy et al.

Thomas Jasny, Jan Kloka, Oliver Old, Florian Piekarski, Gösta Lotz, Kai Zacharowski, Benjamin Friedrichson

Open Access Research

Serial assessments of cardiac output and mixed venous oxygen saturation in comatose patients after out-of-hospital cardiac arrest

Johannes Grand, Christian Hassager, Henrik Schmidt, Simon Mølstrøm, Benjamin Nyholm, Henrik Frederiksen Høigaard, Jordi S. Dahl, Martin Meyer, Rasmus P. Beske, Laust Obling, Jesper Kjaergaard, Jacob E. Møller

Open Access Correction

Correction to: Efficacy and safety of adjunctive corticosteroids in the treatment of severe community‑acquired pneumonia: a systematic review and meta‑analysis of randomized controlled trials

Jheng‑Yan Wu, Ya‑Wen Tsai, Wan‑Hsuan Hsu, Ting‑Hui Liu, Po‑Yu Huang, Min‑Hsiang Chuang, Mei‑Yuan Liu, Chih‑Cheng Lai

Open Access Research

Characteristics of pulmonary artery catheter use in multicenter ICUs in Japan and the association with mortality: a multicenter cohort study using the Japanese Intensive care PAtient Database

Kentaro Fukano, Yusuke Iizuka, Seiya Nishiyama, Koichi Yoshinaga, Shigehiko Uchino, Yusuke Sasabuchi, Masamitsu Sanui

Open Access Research

Efficacy of haloperidol to decrease the burden of delirium in adult critically ill patients: the EuRIDICE randomized clinical trial

Lisa Smit, Arjen J. C. Slooter, John W. Devlin, Zoran Trogrlic, Nicole G. M. Hunfeld, Robert Jan Osse, Huibert H. Ponssen, Arjen J. B. W. Brouwers, Jeannette F. Schoonderbeek, Koen S. Simons, Mark van den Boogaard, Judith A. Lens, Dirk P. Boer, Diederik A. M. P. J. Gommers, Wim J. R. Rietdijk, Mathieu van der Jagt

Open Access Research

Utilization of spontaneous breathing trial, objective cough test, and diaphragmatic ultrasound results to predict extubation success: COBRE-US trial

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Open Access Perspective

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Open Access Perspective

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Open Access Research

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Open Access Research

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Open Access Correction

Correction: Plasma protein biomarkers reflective of the host response in patients developing Intensive Care Unit-acquired pneumonia

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Open Access Matters Arising

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Open Access Research

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Open Access Research

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Open Access Research

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Open Access Research

Inflammation and altered metabolism impede efficacy of functional electrical stimulation in critically ill patients

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Open Access Research

Effect on capillary refill time of volume expansion and increase of the norepinephrine dose in patients with septic shock

Nicolas Fage, Francesca Moretto, Daniela Rosalba, Rui Shi, Christopher Lai, Jean-Louis Teboul, Xavier Monnet

Open Access Research

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Open Access Perspective

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Open Access Research

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Open Access Review

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Open Access Perspective

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Open Access Research

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Most patients with an increased risk for sepsis-related morbidity or death do not recognize sepsis as a medical emergency: results of a survey study using case vignettes

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Relationship between the shape of intracranial pressure pulse waveform and computed tomography characteristics in patients after traumatic brain injury

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Open Access Review

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Open Access Matters Arising

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Open Access Brief Report

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Open Access Correspondence

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Open Access Brief Report

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Open Access Research

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Open Access Review

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Open Access Research

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Open Access Research

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Open Access Matters Arising

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Björn Koos, Matthias Unterberg, Tim Rahmel, Michael Adamzik, Stefan F. Ehrentraut

Open Access Research

Positive single-center randomized trials and subsequent multicenter randomized trials in critically ill patients: a systematic review

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Open Access Research

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Open Access Research

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Open Access Review

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Open Access Publisher Correction

Publisher Correction to: Critical Illness Weakness, Polyneuropathy and Myopathy: Diagnosis, treatment, and long‑term outcomes

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Open Access Research

Combination of serum and peritoneal 1.3-beta-d-glucan can rule out intra-abdominal candidiasis in surgical critically ill patients: a multicenter prospective study

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Open Access Matters Arising

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Yang Zhao, Qian Wang, Bin Zang

Open Access Research

Dysnatremia at ICU admission and functional outcome of cardiac arrest: insights from four randomised controlled trials

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Open Access Review

Prognostic value of capillary refill time in adult patients: a systematic review with meta-analysis

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Open Access Brief Report

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Open Access Review

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Open Access Research

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Open Access Research

Critical illness among patients experiencing homelessness: a retrospective cohort study

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Open Access Review

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Open Access Brief Report

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Yohei Okada, Nur Shahidah, Yih Yng Ng, Michael Y. C. Chia, Han Nee Gan, Benjamin S. H. Leong, Desmond R. Mao, Wei Ming Ng, Nausheen Edwin, Takeyuki Kiguchi, Norihiro Nishioka, Tetsuhisa Kitamura, Taku Iwami, Marcus Eng Hock Ong

Open Access Matters Arising

Potential confounders in linking elevated S100A8/A9 to left ventricular dysfunction in septic shock patients

Patrick M. Honore, Emily Perriens, Sydney Blackman

Open Access Research

Proenkephalin as a biomarker correlates with acute kidney injury: a systematic review with meta-analysis and trial sequential analysis

Li-Chun Lin, Min-Hsiang Chuan, Jung-Hua Liu, Hung-Wei Liao, Leong L. Ng, Martin Magnusson, Amra Jujic, Heng-Chih Pan, Vin-Cent Wu, Lui G. Forni

Open Access Editorial

Reflections from the bedside: a nursing perspective on three decades of intensive care

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Open Access Review

Do critical illness survivors with multimorbidity need a different model of care?

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Open Access Research

Whole blood transcriptomics identifies subclasses of pediatric septic shock

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Open Access Research

Interventions to promote cost-effectiveness in adult intensive care units: consensus statement and considerations for best practice from a multidisciplinary and multinational eDelphi study

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Open Access Matters Arising

Continuous monitoring of the lower limit of reactivity in traumatic brain injury patients: understanding what is feasible

Erta Beqiri, Joseph Donnelly, Marcel Aries, Ari Ercole, Peter Smielewski

Open Access Publisher Correction

Publisher Correction: Early corticosteroids are associated with lower mortality in critically ill patients with COVID‑19: a cohort study

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Open Access Research

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Effects of a multilevel intervention of resistance training with or without beta-hydroxy-beta-methylbutyrate in medical ICU patients during entire hospitalisation: a four-arm multicentre randomised controlled trial

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Association between selective digestive decontamination and decreased rate of acquired candidemia in mechanically ventilated ICU patients: a multicenter nationwide study

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Open Access Research

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Wer sich an einem Essensrest verschluckt und um Luft ringt, benötigt vor allem rasche Hilfe. Dass Umstehende nur in jedem zweiten Erstickungsnotfall bereit waren, diese zu leisten, ist das ernüchternde Ergebnis einer Beobachtungsstudie aus Japan. Doch es gibt auch eine gute Nachricht.

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