The ratio of serum C-reactive protein level on postoperative day 3 to day 2 is a good marker to predict postoperative complications after laparoscopic radical gastrectomy for gastric cancer
verfasst von:
Bin Luo, Qianchao Liao, Jiabin Zheng, Weixian Hu, Xueqing Yao, Yong Li, Junjiang Wang
Study reported that C-reactive protein (CRP) would peak at 48 h after the initiation of an acute inflammatory response. We proposed that the ratio of CRP level on postoperative day 3 to day 2 (POD3/2 CRP) can be used to early predict major postoperative complications (PCs) for patients who underwent laparoscopic radical gastrectomy.
Methods
Patients were randomized into training cohort and validation cohort at a ratio of 7:3. PCs greater than grade II or more, according to Clavien-Dindo classification, were defined as major PCs. Three predictive models for major PCs based on CRP level were constructed, including POD3/2 CRP, the CRP level on POD3 (POD3 CRP), and the ratio of CRP level on POD3 to POD1 (POD3/1 CRP). The performances of three prediction models were assessed by AUC. Univariate and multivariate logistic regression analyses were performed to identify risk factors of major PCs.
Results
344 patients were included. Major PCs were observed in 57 patients (16.6%). In the training cohort, POD3/2 CRP provided the best diagnostic accuracy with an AUC of 0.929 at an optimal cut-off value of 1.08, and the sensitivity and specificity were 0.902 and 0.880, respectively. In the validation cohort, the corresponding AUC was 0.917. BMI ≥ 25 kg/m2 and POD3/2 CRP > 1 were identified as risk factors for major PCs.
Conclusion
POD3/2 CRP is a reliable marker to predict major PCs after laparoscopic radical gastrectomy. If CRP is higher on POD3 than on POD2, major PCs are highly likely.
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Introduction
Gastric cancer (GC) is the fifth most common malignant tumor worldwide [1]. Even though significant improvements have achieved in surgical techniques and perioperative management, the morbidity rate after laparoscopic gastrectomy is still high [2‐6]. Major postoperative complications (PCs) prolonged the hospitalization and increased mortality rate. It is reported that major PCs were also a risk factor of poor prognosis [7‐10]. However, major PCs are often diagnosed after the patient develops severe clinical symptoms, which makes patient requires major clinical interventions such as intensive care and reoperation. Therefore, it is of great importance to diagnose major PCs at early time.
C-reactive protein (CRP) is an important systemic inflammatory marker. Elevated CRP level was ahead of the onset of descriptive clinical manifestation and positive imaging findings. There are several studies utilizing serum CRP level at a certain day to early predict major PCs for patients who underwent gastrectomy. However, the reported cut-off value varied greatly [11‐15]. Study reported that CRP would peak at 48 h after the initiation of an acute inflammatory response [16]. So, we proposed that the ratio of CRP level on POD3 to day 2 (POD3/2 CRP) can be used to early predict major PCs for patients who underwent laparoscopic radical gastrectomy.
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In this study, we aimed to investigate whether POD3/2 CRP can be used as an early predictor for major PCs, and to compare the diagnostic accuracy of POD3/2 CRP for major PCs with other reported predictive models.
Materials and methods
Patients and data
Patients who underwent laparoscopic radical gastrectomy for gastric cancer from January 2017 to December 2020 were included in this study. Patients with missing value for CRP levels on POD1 to POD3 were excluded from this study. Patients who suffered from infectious diseases with elevated CRP levels before surgery were also excluded. Patients’ data were retrieved from a prospectively maintained database which was updated by surgeon monthly, including age, gender, body mass index (BMI), preoperative serum albumin level, American Society of Anesthesiologists (ASA) score, neoadjuvant chemotherapy, TNM stage according to the 8th edition of AJCC/UICC classification for gastric cancer, type of resection, combined resection, operation time, blood loss, PCs, and postoperative hospitalization.
Classification and diagnosis of postoperative complications
In this study, pneumonia, pleural effusion, anastomotic leakage, bleeding, duodenal stump leakage, abdominal abscess, ileus, chylous leakage, and surgical site infection were analyzed. The Clavien-Dindo classification was adopted for the classification of postoperative complications. Major PCs were defined as PCs of grade II or more. Patients with PCs of grade I, or who had no PCs, were classified into the minor/no PCs group. Pneumonia, pleural effusion, ileus, and abdominal abscess were confirmed by the computer tomography (CT) scan. Anastomotic leakage and duodenal stump leakage were diagnosed by CT and abnormal drainage.
Surgical procedure and postoperative management
Most patients received D2 lymph node dissection. Additional mediastinal lymph nodes resection was performed for patients with Siewert type II adenocarcinoma of esophagogastric junction. Billroth II anastomosis was adopted for distal gastrectomy. Roux-en-Y anastomosis was carried out during total gastrectomy. As for proximal gastrectomy, double-tract anastomosis was the most common. The procedure of anastomosis was performed through laparoscopic approach or open approach. Patients who underwent distal gastrectomy were managed according to the enhanced recovery after surgery (ERAS) principle [17]. For patients who received total gastrectomy or proximal gastrectomy, oral diet was permitted only if esophageal dynamic radio-graphy demonstrated no evidence of anastomotic leakage on POD4 (Table 1).
Table 1
Detailed perioperative management procedure for patients who underwent laparoscopic radical gastrectomy
Distal gastrectomy
Total gastrectomy
Proximal gastrectomy
Gastrectomy-specific ERAS care
Preoperative nutrition for malnourished patients
○
○
○
Preoperative oral pharmaconutrion
Laparoscopic access
○
○
○
Transversus abdominis plane block
○
○
○
Nasogastric/nasojejunal decompression
○
Avoiding the use of abdominal drains
Early postoperative diet and artificial nutrition
○
Audit
○
○
○
General ERAS care
Dedicated preoperative counselling
○
○
○
Abstinence of smoking and alcohol consumption
○
○
○
Do not use mechanical bowel preparation
○
○
○
Preoperative fasting and preoperative treatment with carbohydrates
○
○
○
Optimal anaesthetic management
○
○
○
Preanaesthetic medication
Antithrombotic prophylaxis
○
○
○
Antimicrobial prophylaxis and skin preparation
○
○
○
Epidural analgesia
Intravenous analgesia through PCA
○
○
○
Multimodal intervention for PONV
○
○
○
Avoiding intraoperative hypothermia
○
○
○
Postoperative glycemic control
○
○
○
Near-zero fluid balance
○
○
○
Removing urinary drainage on POD1–2
○
○
○
Stimulation of bowel movement
○
○
○
Early and scheduled mobilization
○
○
○
ERAS enhanced recovery after surgery; PCA patient-controlled analgesia; PONV postoperative nausea and vomiting; POD postoperative day
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Statistical analysis
Patients were randomized into a training cohort and a validation cohort at a ratio of 7:3.
The Wilcoxon rank-sum test was used for non-normally distributed data. The χ2 test was performed to compare the enumeration data. The diagnostic accuracy of predictive models for major PCs was assessed by the area under the receiver operator curve (AUC). The optimal cut-off values were calculated by maximizing Youden’s index (sensitivity + specificity − 1). Univariate and multivariate logistic regressions were utilized to identify risk factors for postoperative complications. A two-side p value < 0.05 was considered significant. Statistical analysis was performed on SPSS (version 22.0 for Windows; SPSS Inc., Chicago, IL) and R software (version 4.0.3; http://www.r-project.org).
Results
Clinicopathologic characteristics
A total of 344 patients were enrolled in this study. Three hundred forty-four patients were randomized into a training cohort and a validation cohort at a ratio of 7:3.
As shown in Table 2, the training cohort was comprised of 164 males and 76 females with a median age of 64 (54.25–70) years. The median BMI was 22.15 (19.71–24.01) kg/m2, and the average preoperative serum albumin level was 37.71 ± 4.20 g/L (reference range: 40–55 g/L). The proportions of patients of stages I, II, and III were 32.9%, 24.2%, and 42.9%, respectively. 10.8% patients received neoadjuvant chemotherapy, and 2.9% patients underwent combined resection, including cholecystectomy, partial transverse colectomy, and splenectomy. 50.4% patients underwent laparoscopic total gastrectomy.
Table 2
Patients’ characteristics and differences between major complications group and minor/no complications group in training cohort
Characteristics
Total
Major complicationsa
Minor/no complicationsa
pvalue
N= 240 (%)
n= 41 (%)
n= 199 (%)
Age
< 65 years
126 (52.5)
21 (51.2)
105 (52.8)
0.857
≥ 65 years
114 (47.5)
20 (48.8)
94 (47.2)
Gender
Male
164 (68.3)
30 (73.2)
134 (67.3)
0.296
Female
76 (31.7)
11 (26.8)
65 (32.7)
BMI (kg/m2)
22.15 (19.71–24.01)
23.20 (21.78–26.15)
21.78 (19.38–23.70)
0.002b
Preoperative serum albumin level (g/L)
37.71 ± 4.20
38.51 ± 3.32
37.55 ± 4.35
0.719
ASA score
I
26 (10.8)
4 (9.8)
22 (11.1)
0.949
II
207 (86.3)
36 (87.8)
171 (85.9)
III
7 (2.9)
1 (2.4)
6 (3.0)
Neoadjuvant chemotherapy
Yes
26 (10.8)
4 (9.8)
22 (11.1)
1.000
No
214 (89.2)
37 (90.2)
177 (88.9)
TNM stage
I
79 (32.9)
16 (39.0)
63 (31.7)
0.143
II
58 (24.2)
5 (12.2)
53 (26.6)
III
103 (42.9)
20 (48.8)
83 (41.7)
Type of resection
Distal gastrectomy
104 (43.3)
12 (29.3)
92 (46.2)
0.017
Total gastrectomy
121 (50.4)
23 (56.1)
98 (49.3)
Proximal gastrectomy
15 (6.3)
6 (14.6)
9 (4.5)
Combined resection
Yes
7 (2.9)
1 (2.4)
6 (3.0)
1.000
No
233 (97.1)
40 (97.6)
193 (97.0)
Operation time (min)
312.5 (255–312.5)
360 (295–442.5)
300 (250–340)
< 0.001b
Blood loss (ml)
50 (30–100)
100 (50–200)
50 (30–100)
0.010b
Postoperative hospitalization (day)
8 (6–10)
8 (6–9)
19 (11–37.5)
< 0.001b
BMI body mass index; ASA American Society of Anesthesiologists
aThe major complication group was defined as patients with postoperative complications (PCs) of grade II or more according to the Clavien-Dindo classification. Patients with PCs of grade I, or who had no PCs, were classified into the minor/no PCs group
bMann-Whitney test
The validation cohort consisted 67 males and 76 females with a median age of 61.5 (51.25–67) years. The median BMI was 21.62 (19.91–24.17) kg/m2, and the average preoperative serum albumin level was 38.25 ± 3.86 g/L. The proportions of patients of stages I, II, and III were 37.5%, 28.8%, and 33.7%, respectively. 11.5% patients received neoadjuvant chemotherapy. The rate of combined resection was 1.0%. About 50% patients underwent laparoscopic total gastrectomy (Table 3).
Table 3
Patients’ characteristics and differences between major complications group and minor/no complications group in validation cohort
Characteristics
Total
Major complicationsa
Minor/no complicationsa
pvalue
N= 104 (%)
n= 16 (%)
n= 88 (%)
Age
< 65 years
63 (60.6)
8 (50.0)
55 (62.5)
0.347
≥ 65 years
41 (39.4)
8 (50.0)
33 (37.5)
Gender
Male
67 (64.4)
12 (75.0)
55 (62.5)
0.406
Female
37 (35.6)
4 (25.0)
33 (37.5)
BMI (kg/m2)
21.62 (19.91–24.17)
22.12 (20.54–25.05)
21.48 (19.64–23.62)
0.136b
Preoperative serum albumin level (g/L)
38.25 ± 3.86
37.76 ± 3.61
38.34 ± 3.91
0.585
ASA score
I
11 (10.6)
1 (6.3)
10 (11.4)
0.394
II
89 (85.6)
15 (93.7)
74 (84.1)
III
4 (3.8)
0 (0.0)
4 (4.5)
Neoadjuvant chemotherapy
Yes
12 (11.5)
2 (12.5)
10 (11.4)
1.000
No
92 (88.5)
14 (87.5)
78 (88.6)
TNM stage
I
39 (37.5)
3 (18.8)
36 (40.9)
0.213
II
30 (28.8)
6 (37.5)
24 (27.3)
III
35 (33.7)
7 (43.7)
28 (31.8)
Type of resection
Distal gastrectomy
45 (43.3)
4 (25.0)
41 (46.6)
0.090
Total gastrectomy
52 (50.0)
9 (56.3)
43 (48.9)
Proximal gastrectomy
7 (6.7)
3 (18.7)
4 (4.5)
Combined resection
Yes
1 (1.0)
0 (0.0)
1 (1.1)
1.000
No
103 (99.0)
16 (100.0)
87 (98.9)
Operation time (min)
300 (270–345)
345 (277.5–405)
300 (266.25–335)
0.030b
Blood loss (ml)
50 (50–100)
50 (50–150)
50 (50–100)
0.184b
Postoperative hospitalization (day)
8 (6–10)
29.5 (11.5–38.5)
7 (6–9)
< 0.001b
BMI body mass index; ASA American Society of Anesthesiologists
aThe major complication group was defined as patients with postoperative complications (PCs) of grade II or more according to the Clavien-Dindo classification. Patients with PCs of grade I, or who had no PCs, were classified into the minor/no PCs group
bMann-Whitney test
Relationship between major PCs and clinical characteristics
As shown in Table 4, major PCs were observed in 57 patients (16.6%), including anastomotic leakage in 24 (7.0%), pneumonia and pleural effusion in 10 (2.9%), ileus in 7 (2.0%), and bleeding in 4 (1.2%).
Table 4
Information about major complications
Type of postoperative complications
No. (%)
Clavien-Dindo classification
II
III
IV
V
Anastomotic leakage
24 (7.0)
4
12
6
2
Pneumonia and pleural effusion
10 (2.9)
6
4
Ileus
7 (2.0)
5
2
Bleeding
4 (1.2)
1
2
1
Duodenal stump leakage
2 (0.6)
1
1
Abdominal abscess
4 (1.2)
1
3
Chylous fistula
1 (0.3)
1
Surgical site infection
1 (0.3)
1
Other
4 (1.2)
1
2
1
Total
57 (16.6)
21
26
8
2
In the training cohort, 41 patients developed major PCs and 199 patients had minor or no PCs. Patients in the major PCs group had higher BMI (23.20 kg/m2 vs. 21.78 kg/m2, p = 0.002), higher rate of total gastrectomy and proximal gastrectomy (70.7% vs. 53.8%, p = 0.017), longer operation time [360 (295–442.5) min vs. 300 (250–340) min, p < 0.001], and greater blood loss [100 (50–200) ml vs. 50 (30–100) ml, p = 0.010], than minor/no PCs group. There were no significant differences in age, gender, preoperative serum albumin level, ASA score, neoadjuvant chemotherapy, and TNM stage. Furthermore, the postoperative hospitalization of major PCs groups was significantly prolonged than minor/no PCs group [19 (11–37.5) days vs. 8 (6–9) days, p < 0.001] (Table 2).
In the validation cohort, 16 patients developed major PCs and 88 patients had minor or no PCs. Significant differences in BMI, operation time, and postoperative hospitalization were observed between the two groups. However, there were no significant differences in resection range and blood loss between the two groups.
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The variation tendency of serum CRP level
As shown in Fig. 1, for patients with minor or no PCs, the serum CRP level peaked on POD2, and reduced to normal range, gradually. However, the serum CRP level for patients developed major PCs continued to increase on POD2 and maintained at a high level, even though effective antibiotics had been used.
Fig. 1
The variation tendency of serum CRP level in major complications group and minor/no complications group
×
Diagnostic accuracy of different predictive models for major PCs
Based on above analysis, we proposed that POD3/2 CRP can be used to early predict major PCs.
As shown in Fig. 2, in the training cohort, the AUC of POD3/2 CRP was 0.929, with an optimal cut-off value of 1.08, and the sensitivity and specificity were 0.902 and 0.880, respectively. The AUC of POD3 CRP was 0.886, with an optimal cut-off value of 128.1 mg/L. The corresponding sensitivity and specificity were 0.854 and 0.764, respectively. Another predictive model based on serum CRP level, POD3/1 CRP, was reported to be a good predictor for major PCs [18]. We utilized this model in the training cohort. The AUC of POD3/1 CRP was 0.786, with an optimal cut-off value of 1.890, and the sensitivity and specificity were 0.912 and 0.558, respectively (Table 5).
Fig. 2
ROC curves for the diagnostic accuracy of prediction models based on CRP in training cohort
Table 5
Risk factors for major complications based on univariate and multivariate logistical regression analyses
Characteristics
Univariate logistical analysis
Multivariate logistical analysis
OR
95% CI
pvalue
OR
95% CI
pvalue
Age
< 65 years
Reference
≥ 65 years
1.216
0.688–2.149
0.500
Gender
Female
Reference
Reference
Male
1.452
0.767–2.748
0.252
0.989
0.423–2.314
0.980
BMI
< 25 kg/m2
Reference
Reference
≥ 25 kg/m2
2.872
1.478–5.580
0.002
2.936
1.088–7.928
0.034
Preoperative serum albumin level
≥ 40 g/L
Reference
< 40 g/L
0.867
0.469–1.602
0.648
ASA score
0.681
I
Reference
II
1.332
0.495–3.584
0.570
III
0.640
0.067–6.142
0.699
Neoadjuvant chemotherapy
No
Reference
Yes
0.891
0.373–2.358
0.891
T stage
T1–2
Reference
T3–4
1.003
0.562–1.790
0.992
N stage
N0
Reference
N1–3
1.259
0.706–2.244
0.435
Type of resection
0.002
0.148
Distal gastrectomy
Reference
Reference
Proximal gastrectomy
5.755
2.126–15.575
0.001
4.933
0.931–26.124
0.061
Total gastrectomy
1.887
0.990–3.596
0.054
1.309
0.430–3.982
0.636
Combined resection
No
Reference
Yes
0.714
0.086–5.920
0.755
Operation time
≤ 300 min
Reference
Reference
> 300 min
3.009
1.614–5.608
0.001
2.108
0.706–6.293
0.181
Blood loss
< 100 ml
Reference
Reference
≥ 100 ml
1.751
0.988–3.105
0.055
0.958
0.374–2.452
0.928
POD3/2 CRP
≤ 1.0
Reference
> 1.0
37.422
15.971–87.687
< 0.001
42.548
16.967–106.700
< 0.001
OR odds ratio; CI confidence interval; BMI body mass index; ASA American Society of Anesthesiologists; POD3/2 CRP the ratio of CRP level on postoperative day 3 to day 2
×
In the validation cohort, the AUC of POD3/2 CRP was 0.917, the corresponding false positive rate and false negative rate were 14.8% and 18.8%, respectively. In detail, among the validation cohort of 104 patients, there were 26 patients whose POD3/2 CRP value was higher than the cut-off value. Of those, 13 patients developed major PCs, and 7 patients received over-diagnosis. The AUCs of POD3 CRP and POD3/1 CRP were 0.872 and 0.796, respectively (Fig. 3). In addition, we utilized reported cut-off values in the validation cohort and compared them with POD3/2 CRP approach, and we found that POD3/2 CRP provided the best Youden’s index (Table 6) [11‐15, 18].
Fig. 3
ROC curves for the diagnostic accuracy of prediction models based on CRP in validation cohort
Table 6
Receiver operating characteristic analysis for the diagnosis of major PCs in validation cohort
Characteristics
Sensitivity
Specificity
Youden’s index
Ratio
POD3/2 = 1.08
0.812
0.852
0.664
POD3/1 = 2.13 [18]
0.938
0.523
0.461
Value
167 mg/L on POD5 [13]
0.455
1.000
0.455
168 mg/L on POD4 [14]
0.385
0.963
0.348
177 mg/L on POD3 [11]
0.563
0.909
0.472
114 mg/L on POD3 [12]
0.981
0.602
0.583
177 mg/L on POD2 [15]
0.438
0.830
0.268
×
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Risk factors analysis for major PCs
In the univariate logistic analysis, BMI ≥ 25 kg/m2 (OR = 2.872, 95% CI 1.478–5.580, p = 0.002), proximal gastrectomy (OR = 5.755, 95% CI 2.126–15.575, p = 0.001), operation time longer than 300 min (OR = 3.009, 95% CI 1.614–5.608, p = 0.001), and POD3/2 CRP > 1 (OR = 37.422, 95% CI 15.971–87.687, p < 0.001) were identified as risk factors for major PCs. Further analyzed by multivariate logistic analysis, BMI ≥ 25 kg/m2 and POD3/2 CRP > 1 were identified as risk factors for major PCs (Table 4).
Discussion
In this study, we found that the serum CRP level peaked on POD2 in patients with minor or no PCs, and proposed that this feature could be used to early predict major PCs. Then, we compared the diagnostic accuracy of POD3/2 CRP with other reported predictive models, such as POD3 CRP and POD3/1 CRP, and found that POD3/2 CRP can provide the best performance in early predict major PCs with an optimal cut-off value of 1.08 (AUC = 0.929, sensitivity = 0.902, specificity = 0.880).
CRP was an acute-phase protein first reported in 1930 [19]. CRP was synthesized by hepatocytes quickly upon the inflammatory stimulation, and would peaked at 48 h after the initiation of an acute inflammatory response [16, 19]. This feature was consistent with our result that the mean CRP level in patients with no/minor PCs peaked at POD2 and reduced to baseline gradually. Another study, comparing the differences in CRP level for patients who underwent emergency or elective colorectal surgery, also reported this feature [20]. Other studies investigating the value of CRP level in early predicting major PCs did not detect CRP level on POD2 routinely. We recommended that serum CRP level should be tested routinely on POD 1, 2, and 3, and then examined according to patients’ status. In addition, the variation tendency of serum CRP level is a reliable marker to indicate the presence of major PCs.
There were several studies using the cut-off value of CRP at a certain day to early predict the onset of PC [11‐15]. As a systematic inflammatory factor, serum CRP level varied individually according to age, sex, nutrient status, and operation [21‐24]. Therefore, the diagnostic accuracy of postoperative serum CRP level on a certain day was not very precise. The reported cut-off value of CRP level varied greatly. Shishido et al. found that CRP level on POD3 had the highest diagnostic accuracy for PCs with a cut-off value of 177 mg/L [11]. The optimal cut-off value of CRP level on POD3 reported by Okubo et al. was 114 mg/L [12]. Utilizing the variation tendency of CRP for early prediction of major PCs can avoid above limitation caused by individual heterogeneity. Tanaka et al. used POD3/1 CRP to predict the onset of PCs [18]. In their study, they reported a cut-off CRP ratio of 2.13 with 55% sensitivity and 82% specificity for major PCs. In our study, we also constructed the POD3/1 CRP model. We found that POD3/1 CRP had slight superiority in sensitivity (0.912 vs. 0.902), but significant shortage in specificity (0.558 vs. 0.880), compared with POD3/2 CRP. This means patients would receive extra examinations if treatment strategy was made based on POD3/1 CRP model.
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Some studies tried to use the CRP level on POD5 to increase the specificity and negative predictive value [13, 25]. However, with the increasing popularity of ERAS, more and more patients underwent laparoscopic distal gastrectomy discharged on POD4. This method is not suitable for hospitals which have rich experience in ERAS because of short postoperative hospitalization.
The multivariate analysis suggested that BMI ≥ 25 kg/m2 significantly increased the risk of major PCs (OR 2.936, 95% CI 1.088–7.928, p = 0.034). Because extended lymph node dissection may be hampered by excess bodyweight [26‐28], this finding was consistent with other studies [29, 30]. Interestingly, our research revealed that proximal gastrectomy with double-tract anastomosis (PG-DTR) may increase the risk of major PCs (OR 4.933, 95% CI 0.931–26.124, p = 0.061). Compared with Roux-en-Y reconstruction for total gastrectomy, one more anastomosis, gastrojejunostomy, is performed. This procedure prolongs the operation time and double anastomotic stoma means double risk of leakage. However, PG-DTR was considered superior to total gastrectomy with Roux-en-Y reconstruction in terms of nutrition [31]. Hence, PG-DTR procedure may be performed by experienced surgeon in not fat patients.
The limitations of this study included its retrospective and single-institution design. Prospective studies should be performed to investigate whether early diagnostic or therapeutic approaches based on POD3/2 CRP could actually lead to earlier detection of infectious complications and improve outcomes.
Conclusion
POD3/2 CRP is a reliable marker to predict major PCs after laparoscopic radical gastrectomy. If CRP is higher on POD3 than on POD2, major PCs are highly likely.
BMI ≥ 25 kg/m2 and POD3/2 CRP >1 were identified as significant independent risk factors for major PCs.
Acknowledgements
We acknowledged Miss Zhan for contribution to figure editing.
Declarations
Ethics approval and consent to participate
Due to the retrospective nature of the study, informed consent was waived, but this research was approved by the Research Ethics Committee of Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences.
Competing interests
The authors declare no competing interests.
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The ratio of serum C-reactive protein level on postoperative day 3 to day 2 is a good marker to predict postoperative complications after laparoscopic radical gastrectomy for gastric cancer
verfasst von
Bin Luo Qianchao Liao Jiabin Zheng Weixian Hu Xueqing Yao Yong Li Junjiang Wang
In der Notaufnahme wird die Chance, Opfer von häuslicher Gewalt zu identifizieren, von Orthopäden und Orthopädinnen offenbar zu wenig genutzt. Darauf deuten die Ergebnisse einer Fragebogenstudie an der Sahlgrenska-Universität in Schweden hin.
Darüber reden und aus Fehlern lernen, sollte das Motto in der Medizin lauten. Und zwar nicht nur im Sinne der Patientensicherheit. Eine negative Fehlerkultur kann auch die Behandelnden ernsthaft krank machen, warnt Prof. Dr. Reinhard Strametz. Ein Plädoyer und ein Leitfaden für den offenen Umgang mit kritischen Ereignissen in Medizin und Pflege.
Ein Frauenanteil von mindestens einem Drittel im ärztlichen Op.-Team war in einer großen retrospektiven Studie aus Kanada mit einer signifikanten Reduktion der postoperativen Morbidität assoziiert.
Bei schwerer Aortenstenose und obstruktiver KHK empfehlen die Leitlinien derzeit eine chirurgische Kombi-Behandlung aus Klappenersatz plus Bypass-OP. Diese Empfehlung wird allerdings jetzt durch eine aktuelle Studie infrage gestellt – mit überraschender Deutlichkeit.
Update Chirurgie
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Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.
Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?
Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.
