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Inflammation
Erschienen in: Inflammation 4/2023

18.04.2023 | REVIEW

Transient Receptor Potential Canonical 6 (TRPC6) Channel in the Pathogenesis of Diseases: A Jack of Many Trades

verfasst von: Uzma Saqib, Sreepadaarchana Munjuluri, Sutripta Sarkar, Subir Biswas, Oyshi Mukherjee, Hargopal Satsangi, Mirza S. Baig, Alexander G. Obukhov, Krishnan Hajela

Erschienen in: Inflammation | Ausgabe 4/2023

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Abstract

The mammalian Transient Receptor Potential Canonical (TRPC) subfamily comprises seven transmembrane proteins (TRPC1–7) forming cation channels in the plasma membrane of mammalian cells. TRPC channels mediate Ca2+ and Na+ influx into the cells. Amongst TRPCs, TRPC6 deficiency or increased activity due to gain-of-function mutations has been associated with a multitude of diseases, such as kidney disease, pulmonary disease, and neurological disease. Indeed, the TRPC6 protein is expressed in various organs and is involved in diverse signalling pathways. The last decade saw a surge in the investigative studies concerning the physiological roles of TRPC6 and describing the development of new pharmacological tools modulating TRPC6 activity. The current review summarizes the progress achieved in those investigations.
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Metadaten
Titel
Transient Receptor Potential Canonical 6 (TRPC6) Channel in the Pathogenesis of Diseases: A Jack of Many Trades
verfasst von
Uzma Saqib
Sreepadaarchana Munjuluri
Sutripta Sarkar
Subir Biswas
Oyshi Mukherjee
Hargopal Satsangi
Mirza S. Baig
Alexander G. Obukhov
Krishnan Hajela
Publikationsdatum
18.04.2023
Verlag
Springer US
Erschienen in
Inflammation / Ausgabe 4/2023
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-023-01808-3

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