nach oben

Inflammation

Erschienen in:

08.11.2022 | Original Article

Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study

verfasst von: Yue Shen, Li Teng, Yuhan Qu, Yuehui Huang, Yi Peng, Min Tang, Qiang Fu

Erschienen in: Inflammation | Ausgabe 2/2023

Einloggen, um Zugang zu erhalten

Abstract

Osteoarthritis (OA), a common degenerative joint disease, is characterized by the progressive degradation of articular cartilage and inflammation. Hederagenin (HE) is a pentacyclic triterpenoid saponin extracted from many herb plants. It has anti-inflammatory, anti-lipid peroxidative, anti-cancer, and neuroprotective activities. However, its effect on OA has not been investigated. Our study found that HE may be a potential anti-OA drug. In vitro, HE could suppress extracellular matrix (ECM) degradation via up-regulating aggrecan and Collagen II levels as well as downregulating MMPs and ADAMTS5 levels. It could also reduce proinflammatory and inflammatory cytokines or enzymes production, including TNF-α, IL-6, iNOS, COX-2, NO, and PGE₂. Besides, HE markedly reduced IL-1β-induced C28/I2 cell apoptosis and ROS accumulation. Mechanistically, HE exerted chondroprotective and anti-inflammatory effects by partly inhibiting JAK2/STAT3/MAPK signalling pathway and the crosstalk of the two pathways. Also, HE exhibited anti-apoptotic and anti-oxidative effect via targeting Keap1-Nrf2/HO-1/ROS/Bax/Bcl-2 axis. In vivo, HE significantly reduced monosodium iodoacetate (MIA) induced cartilage destruction of rats with a lower OARSI score and inflammatory cytokine levels, further demonstrating its protective effects in OA progression. These results suggest that HE is a potential compound for the development of drugs to treat OA.

Graphical Abstract

Nur mit Berechtigung zugänglich

Ding, S.L., Z.Y. Pang, X.M. Chen, Z. Li, X.X. Liu, Q.L. Zhai, J.M. Huang, and Z.Y. Ruan. 2020. Urolithin a attenuates IL-1β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signalling pathways in rat articular chondrocytes. Journal of Inflammation-London 17 (13): 3. https://doi.org/10.1186/s12950-020-00242-8.CrossRef

Wang, H., Z. Jiang, Z. Pang, G. Qi, B. Hua, Z. Yan, and H. Yuan. 2021. Engeletin protects against TNF-α-induced apoptosis and reactive oxygen species generation in chondrocytes and alleviates osteoarthritis in vivo. Journal of Inflammation Research 14: 745–760. https://doi.org/10.2147/JIR.S297166.CrossRefPubMedPubMedCentral

Chen, H.W., A.H. Lin, H.C. Chu, C.C. Li, C.W. Tsai, C.Y. Chao, C.J. Wang, C.K. Lii, and K.L. Liu. 2011. Inhibition of TNF-α-induced inflammation by andrographolide via down-regulation of the PI3K/Akt signalling pathway. Jounal Nature Product 74 (11): 2408–2413. https://doi.org/10.1021/np200631v.CrossRef

Fei, J., B. Liang, C. Jiang, H. Ni, and L. Wang. 2019. Luteolin inhibits IL-1β-induced inflammation in rat chondrocytes and attenuates osteoarthritis progression in a rat model. Biomedicine & Pharmacotherapy 109: 1586–1592. https://doi.org/10.1016/j.biopha.2018.09.161.CrossRef

Chen, X., Z. Li, H. Hong, N. Wang, J. Chen, S. Lu, H. Zhang, X. Zhang, and C. Bei. 2021. Xanthohumol suppresses inflammation in chondrocytes and ameliorates osteoarthritis in mice. Biomedicine & Pharmacotherapy 137: 111238. https://doi.org/10.1016/j.biopha.2021.111238.CrossRef

Kloppenburg, M., and F. Berenbaum. 2020. Osteoarthritis year in review 2019: Epidemiology and therapy. Osteoarthritis Cartilage 28 (3): 242–248. https://doi.org/10.1016/j.joca.2020.01.002.CrossRefPubMed

Leopoldino, A.O., G.C. MacHado, P.H. Ferreira, M.B. Pinheiro, R. Day, A.J. McLachlan, D.J. Hunter, and M.L. Ferreira. 2019. Paracetamol versus placebo for knee and hip osteoarthritis. Cochrane Database of Systematic Reviews 2 (2): CD013273. https://doi.org/10.1002/14651858.CD013273.

Dong, F.Y., G.H. Cui, Y.H. Zhang, R.N. Zhu, X.J. Wu, T.T. Sun, and W. Wang. 2010. Clematomandshurica saponin E, a new triterpenoid saponin from Clematis mandshurica. Journal of Asian Natural Products Research 12 (12): 1061–1068. https://doi.org/10.1080/10286020.2010.533661.CrossRefPubMed

Li, L., W.H. Lin, P. Yan, R.T. Zhan, and H.F. Pan. 2013. Content measurement of hederagen and oleanolic acid in RADIX ET RHIZOMA CLEMATIDIS from different areas. Journal of Anhui Agricultural Sciences 41 (7): 2910–2911 (In Chinese).

10.

Zeng, J., T. Huang, M. Xue, J. Chen, L. Feng, R. Du, and Y. Feng. 2018. Current knowledge and development of hederagenin as a promising medicinal agent: A comprehensive review. RSC Advances 8 (43): 24188–24202. https://doi.org/10.1039/c8ra03666g.CrossRefPubMedPubMedCentral

11.

Ma, W., Q. Huang, G. Xiong, L. Deng, and Y. He. 2020. The protective effect of Hederagenin on pulmonary fibrosis by regulating the Ras/JNK/NFAT4 axis in rats. Bioscience, Biotechnology, and Biochemistry 84 (6): 1131–1138. https://doi.org/10.1080/09168451.2020.1721263.CrossRefPubMed

12.

Yang, Z., H. Wang, C. Zhang, and L.-E. Yang. 2020. Hederagenin modulates M1 microglial inflammatory responses and neurite outgrowth. Nature Product Communications 15 (8): 1–10. https://doi.org/10.1177/1934578X20946252.CrossRef

13.

Wang, K., X. Liu, Q. Liu, and I. ht. Ho, X. Wei, T. Yin, Y. Zhan, W.J. Zhang, W.B. Zhang, B. Chen, J. Gu, Y. Tan, L. Zhang, M.T. Chan, W.K. Wu, B. Du, and J. Xiao. 2020. Hederagenin potentiated cisplatin- and paclitaxel-mediated cytotoxicity by impairing autophagy in lung cancer cells. Cell Death & Disease 11 (8): 611. https://doi.org/10.1038/s41419-020-02880-5.CrossRef

14.

Kim, G.J., D.H. Song, H.S. Yoo, K.H. Chung, K.J. Lee, and J.H. An. 2017. Hederagenin supplementation alleviates the pro-inflammatory and apoptotic response to alcohol in rats. Nutrients 9 (1): 41. https://doi.org/10.3390/nu9010041.CrossRefPubMedPubMedCentral

15.

Yu, H., L. Song, X. Cao, W. Li, Y. Zhao, J. Chen, J. Li, Y. Chen, W. Yu, and Y. Xu. 2020. Hederagenin attenuates cerebral ischaemia/reperfusion injury by regulating MLK3 signalling. Frontiers in Pharmacology 11: 1173. https://doi.org/10.3389/fphar.2020.01173.CrossRefPubMedPubMedCentral

16.

Tian, K., Y. Su, J. Ding, D. Wang, Y. Zhan, Y. Li, J. Liang, X. Lin, F. Song, Z. Wang, J. Xu, Q. Liu, and J. Zhao. 2020. Hederagenin protects mice against ovariectomy-induced bone loss by inhibiting RANKL-induced osteoclastogenesis and bone resorption. Life Science 244: 117336. https://doi.org/10.1016/j.lfs.2020.117336.CrossRef

17.

Kim, E.H., S. Baek, D. Shin, J. Lee, and J.L. Roh. 2017. Hederagenin induces apoptosis in cisplatin-resistant head and neck cancer cells by inhibiting the Nrf2-ARE antioxidant pathway. Oxidative Medicine and Cellular Longevity. 2017: 5498908. https://doi.org/10.1155/2017/5498908.CrossRefPubMedPubMedCentral

18.

Ali, A., Y. Park, J. Lee, H.J. An, J.S. Jin, J.H. Lee, J. Chang, D.K. Kim, B. Goo, Y.C. Park, K.H. Leem, S. Seong, and W. Kim. 2021. In vitro study of licorice on IL-1β-induced chondrocytes and in silico approach for osteoarthritis. Pharmaceuticals 14: 1337. https://doi.org/10.3390/ph14121337.CrossRefPubMedPubMedCentral

19.

Li, Z., D. Meng, G. Li, J. Xu, K. Tian, and Y. Li. 2015. Celecoxib combined with diacerein effectively alleviates osteoarthritis in rats via regulating JNK and p38MAPK signaling pathways. Inflammation 38 (4): 1563–1572. https://doi.org/10.1007/s10753-015-0131-3.CrossRefPubMed

20.

Zhang, M., H. Wang, M. Wang, Y. Liu, Y. Liao, Y. Liu, Y. Zhang, T. Ma, and J. Chen. 2020. Reduced expression of α2 integrin is involved in T-2 toxin-induced matrix degradation in C28/I2 cells and cartilages from rats administrated with T-2 toxin. Toxicon 188: 127–133. https://doi.org/10.1016/j.toxicon.2020.10.016.CrossRefPubMed

21.

Jain, A., R. Singh, S. Singh, and S. Singh. 2015. Diacerein protects against iodoacetate-induced osteoarthritis in the femorotibial joints of rats. The Journal of Biomedical Research 29 (5): 405–413. https://doi.org/10.7555/JBR.29.20130092.CrossRefPubMed

22.

Pradit, W., S. Chomdej, K. Nganvongpanit, and S. Ongchai. 2015. Chondroprotective potential of Phyllanthus amarus Schum. Thonn. in experimentally induced cartilage degradation in the explants culture model. In Vitro Cellular and Developmental Biology - Anima 51 (4), 336–344. https://doi.org/10.1007/s11626-014-9846-y.

23.

Shin, H., H. Park, N. Shin, J. Shin, D. Gwon, H. Kwon, Y. Yin, J. Hwang, J. Hong, J. Heo, C. Kim, Y. Joo, Y. Kim, J. Kim, J. Beom, and D. Kim. 2020. p66shc siRNA nanoparticles ameliorate chondrocytic mitochondrial dysfunction in osteoarthritis. International Journal of Nanomedicine 15: 2379–2390. https://doi.org/10.2147/IJN.S234198.CrossRefPubMedPubMedCentral

24.

Pritzker, K.P.H., S. Gay, S.A. Jimenez, K. Ostergaard, J.P. Pelletier, K. Revell, and D. Salter. 2006. Osteoarthritis cartilage histopathology: Grading and staging. Osteoarthritis and Cartilage 14: 13–29. https://doi.org/10.1016/j.joca.2005.07.014.CrossRefPubMed

25.

Groc, L., L. Bezin, H. Jiang, T.S. Jackson, R.A. Levine, and J.D. Dingell. 2001. Bax, Bcl-2, and cyclin expression and apoptosis in rat substantia nigra during development. Neuroscience Letters. 306 (3): 198–202. https://doi.org/10.1016/s0304-3940(01)01897-3.CrossRefPubMed

26.

Wang, B.W., Y. Jiang, Z.L. Yao, P.S. Chen, B. Yu, and S.N. Wang. 2019. Aucubin protects chondrocytes against IL-1β-induced apoptosis in vitro and inhibits osteoarthritis in mice model. Drug Design, Development and Therapy 13: 3529–3538. https://doi.org/10.2147/DDDT.S210220.CrossRefPubMedPubMedCentral

27.

Hwang, H.S., and H.A. Kim. 2015. Chondrocyte apoptosis in the pathogenesis of osteoarthritis. International Journal of Molecular Sciences 16 (11): 26035–26054. https://doi.org/10.3390/ijms161125943.CrossRefPubMedPubMedCentral

28.

El-Ghafar, O.A.M.A., G.K. Helal, and A.M. Abo-Youssef. 2020. Apixaban exhibits anti-arthritic effects by inhibiting activated factor X-mediated JAK2/STAT3 and MAPK phosphorylation pathways. Inflammopharmacology 28 (5): 1253–1267. https://doi.org/10.1007/s10787-020-00693-8.CrossRefPubMed

29.

Qiao, Z., J. Tang, W. Wu, J. Tang, and M. Liu. 2019. Acteoside inhibits inflammatory response via JAK/STAT signaling pathway in osteoarthritic rats. BMC Complementary and Alternative Medicine 19 (1): 264. https://doi.org/10.1186/s12906-019-2673-7.CrossRefPubMedPubMedCentral

30.

Wang, B., Z. Shao, M. Gu, L. Ni, Y. Shi, Y. Yan, A. Wu, H. Jin, J. Chen, X. Pan, and D. Xu. 2020. Hydrogen sulfide protects against IL-1β-induced inflammation and mitochondrial dysfunction-related apoptosis in chondrocytes and ameliorates osteoarthritis. Journal of Cellular Physiology 236: 4369–4386. https://doi.org/10.1002/jcp.30154.CrossRefPubMed

31.

Pan, X., T. Chen, Z. Zhang, X. Chen, C. Chen, L. Chen, X. Wang, and X. Ying. 2019. Activation of Nrf2/HO-1 signal with Myricetin for attenuating ECM degradation in human chondrocytes and ameliorating the murine osteoarthritis. International Immunopharmacology 75: 105742. https://doi.org/10.1016/j.intimp.2019.105742.CrossRefPubMed

32.

Khan, N.M., I. Ahmad, and T.M. Haqqi. 2018. Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis. Free Radical Biology and Medicine 116: 159–171. https://doi.org/10.1016/j.freeradbiomed.2018.01.013.CrossRefPubMed

33.

Sun, K., J. Luo, X. Jing, J. Guo, X. Yao, X. Hao, Y. Ye, S. Liang, J. Lin, G. Wang, and F. Guo. 2019. Astaxanthin protects against osteoarthritis via Nrf2: A guardian of cartilage homeostasis. Aging (Albany NY). 2019, 11(22), 10513–10531. https://doi.org/10.18632/aging.102474.

34.

Yan, Z., W. Qi, J. Zhan, Z. Lin, J. Lin, X. Xue, X. Pan, and Y. Zhou. 2020. Activating Nrf2 signalling alleviates osteoarthritis development by inhibiting inflammasome activation. Journal of Cellular and Molecular Medicine 24 (22): 13046–13057. https://doi.org/10.1111/jcmm.15905.CrossRefPubMedPubMedCentral

35.

Ju, L.PHu., P. Chen, X. Xue, Z. Li, F. He, Z. Qiu, J. Cheng, and F. Huang. 2020. Huoxuezhitong capsule ameliorates MIA-induced osteoarthritis of rats through suppressing PI3K/Akt/NF-κB pathway. Biomedicine & Pharmacotherapy 129: 110471. https://doi.org/10.1016/j.biopha.2020.110471.CrossRef

36.

Liu, M., S. Zhong, R. Kong, H. Shao, C. Wang, H. Piao, W. Lv, X. Chu, and Y. Zhao. 2017. Paeonol alleviates interleukin-1β-induced inflammatory responses in chondrocytes during osteoarthritis. Biomedicine & Pharmacotherapy 95: 914–921. https://doi.org/10.1016/j.biopha.2017.09.011.CrossRef

37.

Vincent, T.L. 2019. IL-1 in osteoarthritis: Time for a critical review of the literature. F1000Research 8: 934. https://doi.org/10.12688/f1000research.

38.

Sokolove, J., and C.M. Lepus. 2013. Role of inflammation in the pathogenesis of osteoarthritis: Latest findings and interpretations. Therapeutic Advances in Musculoskeletal Disease 5 (2): 77–94. https://doi.org/10.1177/1759720X12467868.CrossRefPubMedPubMedCentral

39.

Shi, Y., X. Hu, J. Cheng, X. Zhang, F. Zhao, W. Shi, B. Ren, H. Yu, P. Yang, Z. Li, Q. Liu, Z. Liu, X. Duan, X. Fu, J. Zhang, J. Wang, and Y. Ao. 2019. A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development. Nature Communications 10 (1): 1914. https://doi.org/10.1038/s41467-019-09839-x.CrossRefPubMedPubMedCentral

40.

Lee, S.A., B.R. Park, S.M. Moon, J.H. Hong, D.K. Kim, and C.S. Kim. 2020. Chondroprotective effect of cynaroside in IL-1β-induced primary rat chondrocytes and organ explants via NF-κB and MAPK signaling inhibition. Oxidative Medicine and Cellular Longevity 2020: 9358080. https://doi.org/10.1155/2020/9358080.CrossRefPubMedPubMedCentral

41.

Burrage, P.S., K.S. Mix, and C.E. Brinckerhoff. 2006. Matrix metalloproteinases: Role in arthritis. Frontiers in Bioscience-Landmark 11: 529–543. https://doi.org/10.2741/1817.CrossRef

42.

Majumdar, M.K., R. Askew, S. Schelling, N. Stedman, T. Blanchet, B. Hopkins, E.A. Morris, and S.S. Glasson. 2007. Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis. Arthritis & Rheumatology 56 (11): 3670–3674. https://doi.org/10.1002/art.23027.CrossRef

43.

Jenei-Lanzl, Z., A. Meurer, and F. Zaucke. 2019. Interleukin-1β signaling in osteoarthritis - Chondrocytes in focus. Cellular Signalling. 53: 212–223. https://doi.org/10.1016/j.cellsig.2018.10.005.CrossRefPubMed

44.

Lim, H., D.S. Min, Y. Kang, H.W. Kim, K.H. Son, and H.P. Kim. 2015. Inhibition of matrix metalloproteinase-13 expression in IL-1β-treated articular chondrocytes by a steroidal saponin, spicatoside A, and its cellular mechanisms of action. Archives of Pharmacal Research 38 (6): 1108–1116. https://doi.org/10.1007/s12272-015-0581-z.CrossRefPubMed

45.

Dong, H.W., K. Wang, X.X. Chang, F.F. Jin, Q. Wang, X.F. Jiang, J.R. Liu, Y.H. Wu, and C. Yang. 2019. Beta-ionone-inhibited proliferation of breast cancer cells by inhibited COX-2 activity. Archives of Toxicology 93 (10): 2993–3003. https://doi.org/10.1007/s00204-019-02550-2.CrossRefPubMed

46.

Nieminen, R., S. Leinonen, A. Lahti, K. Vuolteenaho, U. Jalonen, H. Kankaanranta, M.B. Goldring, and E. Moilanen. 2005. Inhibitors of mitogen-activated protein kinases downregulate COX-2 expression in human chondrocytes. Mediators of Inflammation 2005 (5): 249–255. https://doi.org/10.1155/MI.2005.249.CrossRefPubMedPubMedCentral

47.

Lahti, A., H. Kankaanranta, and E. Moilanen. 2002. P38 mitogen-activated protein kinase inhibitor SB203580 has a bi-directional effect on iNOS expression and NO production. European Journal of Pharmacology 454: 115–123. https://doi.org/10.1016/s0014-2999(02)02490-1.CrossRefPubMed

48.

Huang, T.C., W.T. Chang, Y.C. Hu, B.S. Hsieh, H.L. Cheng, J.H. Yen, P.R. Chiu, and K.L. Chang. 2018. Zinc protects articular chondrocytes through changes in Nrf2-mediated antioxidants, cytokines and matrix metalloproteinases. Nutrients 10 (4): 471. https://doi.org/10.3390/nu10040471.CrossRefPubMedPubMedCentral

49.

Liu, P., A. Okun, J. Ren, R.C. Guo, M.H. Ossipov, J. Xie, T. King, and F. Porreca. 2011. Ongoing pain in the MIA model of osteoarthritis. Neuroscience Letters 493 (3): 72–75. https://doi.org/10.1016/j.neulet.2011.01.027.CrossRefPubMedPubMedCentral

50.

Musumeci, G., P. Castrogiovanni, F.M. Trovato, A.M. Weinberg, M.K. Al-Wasiyah, M.H. Alqahtani, and A. Mobasheri. 2015. Biomarkers of chondrocyte apoptosis and autophagy in osteoarthritis. International Journal of Molecular Sciences 16 (9): 20560–20575. https://doi.org/10.3390/ijms160920560.CrossRefPubMedPubMedCentral

51.

Altay, M.A., C. Ertürk, A. Bilge, M. Yaptı, A. Levent, and N. Aksoy. 2015. Evaluation of prolidase activity and oxidative status in patients with knee osteoarthritis: Relationships with radiographic severity and clinical parameters. Rheumatology International 35 (10): 1725–1731. https://doi.org/10.1007/s00296-015-3290-5.CrossRefPubMed

52.

Arra, M., G. Swarnkar, K. Ke, J.E. Otero, J. Ying, X. Duan, T. Maruyama, M.F. Rai, R.J. O’Keefe, G. Mbalaviele, J. Shen, and Y. Abu-Amer. 2020. LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis. Nature Communications 11: 3427. https://doi.org/10.1038/s41467-020-17242-0.CrossRefPubMedPubMedCentral

53.

Kotlo, K.U., F. Yehiely, E. Efimova, H. Harasty, B. Hesabi, K. Shchors, P. Einat, A. Rozen, E. Berent, and L.P. Deiss. 2003. Nrf2 is an inhibitor of the Fas pathway as identified by Achilles’ Heel Method, a new function-based approach to gene identification in human cells. Oncogene 22 (6): 797–806. https://doi.org/10.1038/sj.onc.1206077.CrossRefPubMed

54.

Peng, Y.J.J.WLu., C.H. Lee, H.S. Lee, Y.H. Chu, Y.J. Ho, F.C. Liu, C.J. Huang, C.C. Wu, and C.C. Wang. 2021. Cardamonin attenuates inflammation and oxidative stress in interleukin-1β-stimulated osteoarthritis chondrocyte through the Nrf2 pathway. Antioxidants 10 (6): 862. https://doi.org/10.3390/antiox10060862.CrossRefPubMedPubMedCentral

55.

Wruck, C.J., A. Fragoulis, A. Gurzynski, L.O. Brandenburg, Y.W. Kan, K. Chan, J. Hassenpflug, S. Freitag-Wolf, D. Varoga, S. Lippross, and T. Pufe. 2011. Role of oxidative stress in rheumatoid arthritis: Insights from the Nrf2-knockout mice. Annals of the Rheumatic Diseases 70 (5): 844–850. https://doi.org/10.1136/ard.2010.132720.CrossRefPubMed

56.

Bolduc, J.A., J.A. Collins, and R.F. Loeser. 2018. Reactive oxygen species, aging and articular cartilage homeostasis. Free Radical Biology and Medicine 132: 73–82. https://doi.org/10.1016/j.freeradbiomed.2018.08.038.CrossRefPubMed

57.

Lippross, S., R. Beckmann, N. Streubesand, F. Ayub, M. Tohidnezhad, G. Campbell, Y.W. Kan, F. Horst, T.T. Sönmez, D. Varoga, P. Lichte, H. Jahr, T. Pufe, and C.J. Wruck. 2014. Nrf2 deficiency impairs fracture healing in mice. Calcified Tissue International 95 (4): 349–361. https://doi.org/10.1007/s00223-014-9900-5.CrossRefPubMed

58.

Zhu, J., Y. Tang, Q. Wu, Y.C. Ji, Z.F. Feng, and F.W. Kang. 2019. HIF-1α facilitates osteocyte-mediated osteoclastogenesis by activating JAK2/STAT3 pathway in vitro. Journal of Cellular Physiology 234 (11): 21182–21192. https://doi.org/10.1002/jcp.28721.CrossRefPubMed

59.

Legendre, F., J. Dudhia, J.P. Pujol, and P. Bogdanowicz. 2003. JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II Collagen, Aggrecan core, and link protein transcription in articular chondrocytes. Journal of Biological Chemistry 278 (5): 2903–2912. https://doi.org/10.1074/jbc.M110773200.CrossRefPubMed

60.

Chen, L.L., H.J. Zhang, J. Chao, and J.F. Liu. 2017. Essential oil of Artemisia argyi suppresses inflammatory responses by inhibiting JAK/STATs activation. Journal of Ethnopharmacology 204: 107–117. https://doi.org/10.1016/j.jep.2017.04.017.CrossRefPubMed

61.

Zhang, L.B., Z.T. Man, W. Li, W. Zhang, X.Q. Wang, and S. Sun. 2017. Calcitonin protects chondrocytes from lipopolysaccharide-induced apoptosis and inflammatory response through MAPK/Wnt/NF-κB pathways. Molecular Immunology 87: 249–257. https://doi.org/10.1016/j.molimm.2017.05.002.CrossRefPubMed

62.

Zhang, Y., T. Pizzute, and M. Pei. 2014. A review of crosstalk between MAPK and Wnt signals and its impact on cartilage regeneration. Cell and Tissue Research 358 (3): 633–649. https://doi.org/10.1007/s00441-014-2010-x.CrossRefPubMedPubMedCentral

63.

Lu, W., Z. Ding, F. Liu, W. Shan, C. Cheng, J. Xu, W. He, W. Huang, J. Ma, and Z. Yin. 2019. Dopamine delays articular cartilage degradation in osteoarthritis by negative regulation of the NF-κB and JAK2/STAT3 signaling pathways. Biomedicine & Pharmacotherapy 119: 109419. https://doi.org/10.1016/j.biopha.2019.109419.CrossRef

64.

Zou, L.X., L. Yu, X.M. Zhao, J. Liu, H.G. Lu, G.W. Liu, and W.C. Guo. 2020. MiR-375 mediates chondrocyte metabolism and oxidative stress in osteoarthritis mouse models through the JAK2/STAT3 signaling pathway. Cells, Tissues, Organs 208 (1–2): 13–24. https://doi.org/10.1159/000504959.CrossRef

65.

Winston, L.A., and T. Hunter. 1995. JAK2, Ras, and Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth hormone. Journal of Biological Chemistry 270 (52): 30837–30840. https://doi.org/10.1074/jbc.270.52.30837.CrossRefPubMed

66.

Abe, J.I., and B.C. Berk. 1999. Fyn and JAK2 mediate Ras activation by reactive oxygen species. Journal of Biological Chemistry 274 (30): 21003–21010. https://doi.org/10.1074/jbc.274.30.21003.CrossRefPubMed

67.

Stivala, S., T. Codilupi, S. Brkic, A. Baerenwaldt, N. Ghosh, H. Hao-Shen, S. Dirnhofer, M.S. Dettmer, C. Simillion, B.A. Kaufmann, S. Chiu, M. Keller, M. Kleppe, M. Hilpert, A.S. Buser, J.R. Passweg, T. Radimerski, R.C. Skoda, RL. Levine, and S.C. Meyer. Targeting compensatory MEK/ERK activation increases JAK inhibitor efficacy in myeloproliferative neoplasms. Journal of Clinical Investigation 129 (4): 1596–1611. https://doi.org/10.1172/JCI98785.

68.

Gao, S., J. Hu, X. Wu, and Z. Liang. 2018. PMA treated THP-1-derived-IL-6 promotes EMT of SW48 through STAT3/ERK-dependent activation of Wnt/β-catenin signaling pathway. B Biomedicine & Pharmacotherapy 108: 618–624. https://doi.org/10.1016/j.biopha.2018.09.067.CrossRef

69.

Ni, Y., H. Zhang, J. Zhang, Z. Li, and Z. Li. 2020. Inhibition of JAK2 by AG490 promotes TNF-α-induced apoptosis by inhibiting autophagy in MC3T3-E1 cells. Die Pharmazie 75 (6): 255–260. https://doi.org/10.1691/ph.2020.0375.CrossRefPubMed

Titel: Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study
verfasst von: Yue Shen
Li Teng
Yuhan Qu
Yuehui Huang
Yi Peng
Min Tang
Qiang Fu
Publikationsdatum: 08.11.2022
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 2/2023
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-022-01763-5

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study

Abstract

Graphical Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

15% bedauern gewählte Blasenkrebs-Therapie

Costims – das nächste heiße Ding in der Krebstherapie?

Update Innere Medizin

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Graphical Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2023

FoxO1 Controls Redox Regulation and Cellular Physiology of BV-2 Microglial Cells

Interleukin-35 Promote Osteogenesis and Inhibit Adipogenesis: Role of Wnt/β-Catenin and PPARγ Signaling Pathways

Correction to: Circ_0060077 Knockdown Alleviates High‑Glucose‑Induced Cell Apoptosis, Oxidative Stress, Inflammation and Fibrosis in HK‑2 Cells via miR‑145‑5p/VASN Pathway

Silencing lncRNA CDKN2B-AS1 Alleviates Childhood Asthma Progression Through Inhibiting ZFP36 Promoter Methylation and Promoting NR4A1 Expression

ALCAM Deficiency Alleviates LPS-Induced Acute Lung Injury by Inhibiting Inflammatory Response

A NF-κB-Based High-Throughput Screening for Immune Adjuvants and Inhibitors

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

15% bedauern gewählte Blasenkrebs-Therapie

Costims – das nächste heiße Ding in der Krebstherapie?

Update Innere Medizin