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Pediatric Surgery International

Erschienen in:

20.04.2022 | Original Article

Environmental exposure in the etiology of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis

verfasst von: Ozlem Boybeyi-Turer, Hasan Tolga Celik, Umut Ece Arslan, Tutku Soyer, Feridun Cahit Tanyel, Sibel Kiran

Erschienen in: Pediatric Surgery International | Ausgabe 7/2022

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Abstract

Purpose

To investigate the occupational and environmental factors in the etiology of infantile hypertrophic pyloric stenosis (IHPS).

Methods

Protocol was drafted according to the PRISMA guidelines and registered on PROSPERO (CRD42020152460). A search for a combination of terms related to IHPS, fetus and neonates, and environmental exposure was performed for studies published between 2000 and 2020 in the EMBASE, Pubmed, and MEDLINE databases.

Results

Overall, 2203 abstracts were identified and 829 were screened. The full text of the selected articles (N = 98) was assessed for eligibility. Fifteen studies were included in quantitative synthesis. IHPS risk was significantly lower in black and Hispanic mothers than in white mothers [OR 0.47 (95% CI 0.44–0.51, p < 0.001), OR 0.85 (95% CI 0.77–0.94, p = 0.002), respectively]. Lower maternal education level and maternal smoking were risk factor for IHPS. We further observed a non-significant association between maternal folic acid usage and IHPS risk. Data were insufficient to evaluate occupational exposure.

Conclusion

This review provides an understanding of the role of environmental exposures in IHPS etiology. Lower maternal educational level, maternal smoking, and white ethnicity are associated with a significantly increased risk of IHPS, while folic acid use seems non-significantly associated with IHPS risk.

Level of evidence

III.

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Titel: Environmental exposure in the etiology of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis
verfasst von: Ozlem Boybeyi-Turer
Hasan Tolga Celik
Umut Ece Arslan
Tutku Soyer
Feridun Cahit Tanyel
Sibel Kiran
Publikationsdatum: 20.04.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Surgery International / Ausgabe 7/2022
Print ISSN: 0179-0358
Elektronische ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-022-05128-9

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Environmental exposure in the etiology of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis