Ausgabe 4/2024
Inhalt (10 Artikel)
Utility and impact of quantitative pharmacology on dose selection and clinical development of immuno-oncology therapy
Yan Ji, Sherwin K. B. Sy
CUDC-907 exhibits potent antitumor effects against ovarian cancer through multiple in vivo and in vitro mechanisms
Yuanpei Wang, Jing Wen, Xiangyi Sun, Yi Sun, Yuchen Liu, Xiaoran Cheng, Weijia Wu, Qianwen Liu, Fang Ren
Relative bioavailability of fedratinib through various alternative oral administration methods in healthy adults
Yizhe Chen, David Wyatt, Massimo Attanasio, Mark Thomas, Michael Thomas, Bing He, Rina Nishii, Liangang Liu, Vivian Shan, Yongjun Xue, Leonidas N. Carayannopoulos, Ken Ogasawara, Gopal Krishna
Quantitative assessment of skin disorders induced by panitumumab: a prospective observational study
Hiroaki Takahashi, Yoko Saito, Kanon Sugawara, Masaki Sato, Tomohiko Tairabune, Haruki Ujiie, Junichi Asaka, Kenzo Kudo
Pharmacokinetics and immunogenicity of eftozanermin alfa in subjects with previously-treated solid tumors or hematologic malignancies: results from a phase 1 first-in-human study
Carla Biesdorf, Xiaowen Guan, Satya R. Siddani, David Hoffman, Nils Boehm, Bruno C. Medeiros, Toshihiko Doi, Maja de Jonge, Drew Rasco, Rajeev M. Menon, Akshanth R. Polepally
Safety and pharmacokinetics of imaradenant (AZD4635) in Japanese patients with advanced solid malignancies: a phase I, open-label study
Nobuaki Matsubara, Shota Kusuhara, Noboru Yamamoto, Kazuki Sudo, Masahiko Yanagita, Kosho Murayama, Hisashi Kawasumi, Deanna L. Russell, Da Yin, Toshio Shimizu
Real-world data on the management of pazopanib-induced liver toxicity in routine care of renal cell cancer and soft tissue sarcoma patients
K. Westerdijk, S. D. Krens, N. Steeghs, W. T. A. van der Graaf, E. T. T. L. Tjwa, H. Westdorp, I. M. E. Desar, N. P. van Erp
Translational PK-PD/TD modeling of antitumor effects and peripheral neuropathy in gemcitabine and nab-paclitaxel chemotherapy from xenograft mice to patients for optimal dose and schedule
Shinji Kobuchi, Atsuko Morita, Shizuka Jonan, Kikuko Amagase, Yukako Ito
Andrographolide inhibits Burkitt’s lymphoma by binding JUN and CASP3 proteins
Junquan Zeng, Yongliang Zheng, Si Dong, Ting Ding, Shouhua Zhang, Kuangfan Li, Haiyun Liu, Quangang Fang, Sheng Yuan, Yujing Wei, Jing Li, Tingting Liu
Prospective validation of an equation based on plasma cystatin C for monitoring the glomerular filtration rate in children treated with cisplatin or ifosfamide for cancer
Marie Lambert, Mathieu Alonso, Caroline Munzer, Marie-Christine Zimoch, Laurence Malard, Marion Gambart, Marie-Pierre Castex, Carla Martins, Marlène Pasquet, Etienne Chatelut