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Erschienen in:

03.08.2023 | Review

Brain MRI findings in neurologically symptomatic COVID-19 patients: a systematic review and meta-analysis

verfasst von: Amir Masoud Afsahi, Alexander M. Norbash, Shahla F. Syed, Maya Sedaghat, Ghazaleh Afsahi, Ramin Shahidi, Zohreh Tajabadi, Mahsa Bagherzadeh-Fard, Shaghayegh Karami, Pourya Yarahmadi, Shabnam Shirdel, Ali Asgarzadeh, Mansoureh Baradaran, Fattaneh Khalaj, Hamidreza Sadeghsalehi, Maryam Fotouhi, Mohammad Amin Habibi, Hyungseok Jang, Abass Alavi, Sam Sedaghat

Erschienen in: Journal of Neurology | Ausgabe 11/2023

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Abstract

Background

Coronavirus disease 2019 (COVID-19) has been associated with nervous system involvement, with more than one-third of COVID-19 patients experiencing neurological manifestations. Utilizing a systematic review, this study aims to summarize brain MRI findings in COVID-19 patients presenting with neurological symptoms.

Methods

Systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) checklist. The electronic databases of PubMed/MEDLINE, Embase, Scopus, and Web of Science were systematically searched for literature addressing brain MRI findings in COVID-19 patients with neurological symptoms.

Results

25 publications containing a total number of 3118 COVID-19 patients with neurological symptoms who underwent MRI were included. The most common MRI findings and the respective pooled incidences in decreasing order were acute/subacute infarct (22%), olfactory bulb abnormalities (22%), white matter abnormalities (20%), cerebral microbleeds (17%), grey matter abnormalities (12%), leptomeningeal enhancement (10%), ADEM (Acute Disseminated Encephalomyelitis) or ADEM-like lesions (10%), non-traumatic ICH (10%), cranial neuropathy (8%), cortical gray matter signal changes compatible with encephalitis (8%), basal ganglia abnormalities (5%), PRES (Posterior Reversible Encephalopathy Syndrome) (3%), hypoxic-ischemic lesions (4%), venous thrombosis (2%), and cytotoxic lesions of the corpus callosum (2%).

Conclusion

The present study revealed that a considerable proportion of patients with COVID-19 might harbor neurological abnormalities detectable by MRI. Among various findings, the most common MRI alterations are acute/subacute infarction, olfactory bulb abnormalities, white matter abnormalities, and cerebral microbleeds.

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Titel: Brain MRI findings in neurologically symptomatic COVID-19 patients: a systematic review and meta-analysis
verfasst von: Amir Masoud Afsahi
Alexander M. Norbash
Shahla F. Syed
Maya Sedaghat
Ghazaleh Afsahi
Ramin Shahidi
Zohreh Tajabadi
Mahsa Bagherzadeh-Fard
Shaghayegh Karami
Pourya Yarahmadi
Shabnam Shirdel
Ali Asgarzadeh
Mansoureh Baradaran
Fattaneh Khalaj
Hamidreza Sadeghsalehi
Maryam Fotouhi
Mohammad Amin Habibi
Hyungseok Jang
Abass Alavi
Sam Sedaghat
Publikationsdatum: 03.08.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Neurology / Ausgabe 11/2023
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-023-11914-9

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