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01.04.2024 | Review

Use of platelet- and leukocyte-rich fibrin (L-PRF) as a healing agent in the postoperative period of third molar removal surgeries: a systematic review

verfasst von: Eduardo Dias Ribeiro, Ilan Hudson Gomes de Santana, Mayara Rebeca Martins Viana, Julliana Cariry Palhano Freire, Osny Ferreira-Júnior, Eduardo Sant’Ana

Erschienen in: Clinical Oral Investigations | Ausgabe 4/2024

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Abstract

Objective

The aim of this study was to analyze the effectiveness of L-PRF as a healing agent in the postoperative period of third molar extraction surgeries, as well as to investigate secondary effects, such as the reduction of pain, edema and other discomforts after the surgical intervention.

Materials and methods

The methodology adopted consisted of carrying out a systematic review of the literature, following the model outlined by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The inclusion criteria were previously established according to a systematic review protocol approved by the Prospective Register of Systematic Reviews (PROSPERO) under number CRD42023484679. In order to carry out a comprehensive search, a search in five databases was carried out, PubMed, Web of Science, Scopus, Cochrane Library and Embase.

Results

The search resulted in the selection of randomized controlled trials that conformed to the established criteria. Two authors independently screened the records and extracted the data. The assessment of bias was conducted according to the guidelines recommended by the Cochrane Collaboration, using version 2 of the Cochrane tool for assessing the risk of bias in randomized trials (RoB 2).

Conclusion

This study demonstrated that L-PRF stands out by providing direct benefits to healing, vascularization and tissue regeneration. Clinical relevance: L-PRF plays an important role in reducing postoperative pain, edema, the incidence of alveolar osteitis and infections after third molar removal surgery, compared to patients who did not undergo the use of L-PRF.

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Titel: Use of platelet- and leukocyte-rich fibrin (L-PRF) as a healing agent in the postoperative period of third molar removal surgeries: a systematic review
verfasst von: Eduardo Dias Ribeiro
Ilan Hudson Gomes de Santana
Mayara Rebeca Martins Viana
Julliana Cariry Palhano Freire
Osny Ferreira-Júnior
Eduardo Sant’Ana
Publikationsdatum: 01.04.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 4/2024
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-024-05641-2

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Use of platelet- and leukocyte-rich fibrin (L-PRF) as a healing agent in the postoperative period of third molar removal surgeries: a systematic review