Erschienen in:
20.05.2023 | COMMENTARY
Towards an integrated and life-course approach to the epidemiology of dementia
verfasst von:
Yuan Ma
Erschienen in:
European Journal of Epidemiology
|
Ausgabe 7/2023
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Excerpt
Dementia is the most common neurodegenerative disease in older people and is often accompanied by significant disability and dependency [
1]. Cardiometabolic risk factors play an important role in the multifaceted etiology of Alzheimer’s disease and related dementias [
2,
3]. While hypertension, obesity, and diabetes in mid-life have been linked to an increased risk of dementia, [
4,
5] the relationship between cardiometabolic risk factors in late-life and dementia risk remains controversial in epidemiological studies. For instance, low blood pressure and body weight in late life have been associated with an increased risk of dementia [
6,
7]. This has hindered our understanding of the role of cardiometabolic diseases in the etiology of dementia. Longitudinal studies examining the relationship between cardiometabolic factors and dementia over an extended follow-up period would offer valuable insights into the etiological and methodological factors contributing to these controversial findings. …