Introduction
Objectives
Methods
Inclusion and exclusion criteria
Search strategy
Selection of publications and data management
Studies, subgroups, and strata
Assessment of the risk of bias of the included studies
Statistical analysis
Results
Description of included studies
Author, study, year, references | Strata | n case/control | Country | Cancer | Funding | Rand | Status | Timeline |
---|---|---|---|---|---|---|---|---|
Augustin (2005) | 1 | 329/357 | DE, CH | Skin | Foundational | No | Observational | Retrolective |
Dold (1991) | 1 | 114/113 | DE | Lung | Public/Institutional | Yes | Interventional | Prospective |
Fellmer (1966) | 2 | 81/800 | DE | Gynecological | Foundational | No | Interventional | Prospective |
Fritz (2018) | 2 | 164/18364 | DE | Breast | Foundational | No | Observational | Retrospective |
Grossarth-Maticek CORPUS (2008) | 3 | 198/198 | DE | Gynecological | Foundational and public | No | * | Prospective |
Grossarth-Maticek CORPUSRAND (2008) | 3 | 56/56 | DE | Gynecological | Foundational and public | Yes | * | Prospective |
Grossarth-Maticek OVAR (2007a) | 3 | 137/137 | DE | Gynecological | Foundational and public | No | * | Prospective |
Grossarth-Maticek OVARRAND (2007a) | 3 | 41/41 | DE | Gynecological | Foundational and public | Yes | * | Prospective |
Grossarth-Maticek CervixMetRand (2007b) | 1 | 19/19 | DE | Gynecological | Foundational and public | Yes | * | Prospective |
Grossarth-Maticek CERVIX (2007b) | 3 | 168/168 | DE | Gynecological | Foundational and public | No | * | Prospective |
Grossarth-Maticek Melanoma (2007c) | 1 | 32/32 | DE | Skin | Not reported | No | * | Prospective |
Grossarth-Maticek MelanomaRand (2007c) | 1 | 22/22 | DE | Skin | Not reported | Yes | * | Prospective |
Grossarth-Maticek Mamma (2006a) | 1 | 84/84 | DE | Breast | Foundational and public | No | * | Prospective |
Grossarth-Maticek MammaRand (2006a) | 1 | 38/38 | DE | Breast | Foundational and public | Yes | * | Prospective |
Grossarth-Maticek MammaRec (2006b) | 1 | 42/42 | DE | Breast | Foundational and public | No | * | Prospective |
Grossarth-Maticek MammaLym (2006b) | 1 | 55/55 | DE | Breast | Foundational and public | No | * | Prospective |
Grossarth-Maticek MammaMet (2006b) | 1 | 83/83 | DE | Breast | Foundational and public | No | * | Prospective |
Grossarth-Maticek MammaLymRand (2006b) | 1 | 17/17 | DE | Breast | Foundational and public | Yes | * | Prospective |
Grossarth-Maticek (2004) | 1 | 49/49 | DE | Multiple | Foundational and public | Yes | * | Prospective |
Grossarth-Maticek Full population strict (2001) | 1 | 396/396 | DE | Multiple | Foundational and public | No | * | Prospective |
Grossarth-Maticek Rand balanced (2001) | 1 | 49/49 | DE | Multiple | Foundational and public | Yes | * | Prospective |
Grossarth-Maticek Subgroups cancer type (2001) | 5 | 276/276 | DE | Multiple | Foundational and public | No | * | Prospective |
Günczler Mamma (1969) | 2 | 257/153 | AT | Breast | Not reported | No | Interventional | Retrospect. control group |
Günczler Colon (1969) | 1 | 47/91 | AT | Gastrointestinal | Not reported | No | Interventional | Prospective |
Günczler (1968) | 4 | 67/101 | AT | Gastrointestinal | Not reported | No | Interventional | Prospective |
Hassauer (1979) | 4 | 25/22 | DE | Gynecological | Not reported | No | Interventional | Retrospect. control group |
Hoffmann (1982) | 6 | 254/241 | DE, CH | Breast | Not reported | No | Interventional | Retrospect. control group |
Hoffmann(1979) | 2 | 188/122 | DE, CH | Multiple | Not reported | No | Interventional | Retrospect. control group |
Kleeberg (2004) | 3 | 102/102 | ** | Skin | Public and corporate | Yes | Interventional | Prospective |
Leroi (1977) | 2 | 319/228 | CH | Breast | Not reported | No | Observational | Retrospective |
Leroi (1975) | 1 | 81/30 | DE, CH | Breast | Not reported | No | Interventional | No Information |
1 | 9/10 | IT | Osteosarcoma | None | Yes | Interventional | Prospective | |
Matthes (2010) | 5 | 201/195 | DE, CH | Gastrointestinal | Foundational | No | Observational | Retrolective |
Salzer (1991) | 4 | 86/97 | DE, AT | Lung | Not reported | Yes | Interventional | Prospective |
Salzer (1985) | 6 | 37/40 | AT | Lung | Corporate | No | Observational | Retrospective |
Salzer (1983) | 2 | 62/75 | AT | Gastrointestinal | Not reported | Yes | Interventional | Prospective |
Schmidt (2007) | 1 | 710/732 | DE | Breast | Not reported | No | Observational | Retrolective |
Schuppli (1990) | 1 | 84/114 | CH | Skin | Not reported | No | Interventional | Prospective |
Tröger (2013) | 5 | 110/110 | RS | Gastrointestinal | Foundational | Yes | Interventional | Prospective |
Excluded studies
Risk of bias
Author | Year | Random sequence generation | Effect of assignment to intervention | Effect of adhering to intervention | Missing outcome data | Measurement of the outcome | Selection of the reported result | Overall risk of bis |
---|---|---|---|---|---|---|---|---|
Dold | 1991 | Low | High | High | Low | Some | High | High |
Grossarth-Maticek CORPUSRAND | 2008 | High | Some | High | Low | Some | High | High |
Grossarth-Maticek OVARRAND | 2007c | Some | Some | High | Low | Some | High | High |
Grossarth-Maticek CervixMetRand | 2007b | Some | Some | High | Low | Some | High | High |
Grossarth-Maticek MelanomRand | 2007a | Some | High | High | Low | Some | High | High |
Grossarth-Maticek MammaRAND | 2006b | Some | High | High | Low | Some | High | high |
Grossarth-Maticek MammaLymRand | 2006a | Some | High | High | Low | Some | High | High |
Grossarth-Maticek | 2004 | Some | High | High | Some | Some | High | High |
Grossarth-Maticek | 2001 | Some | High | High | Some | Some | High | High |
Kleeberg | 2004 | Low | Some | Low | Low | Low | Some | Some |
Longhi | 2020 | Low | High | High | Low | Some | Some | High |
Salzer | 1991 | Low | High | High | Low | Some | Some | High |
Salzer | 1983 | Low | High | High | High | some | High | High |
Tröger | 2013 | Low | Low | Some | Low | Some | Some | Some |
Author | Year | Risk of confounding | Selection of participants | Classification of intervention | Deviations from intended intervention | Missing outcome data | Measurement of the outcome | Selection of reported results | Overall risk of bias |
---|---|---|---|---|---|---|---|---|---|
Augustin | 2005 | Moderate | Serious | Moderate | NI | Moderate | Moderate | moderate | serious |
Fellmer | 1966 | Moderate | Moderate | Moderate | moderate | Serious | Moderate | serious | serious |
Fritz | 2018 | Moderate | Moderate | Moderate | NI | Low | Moderate | Serious | Serious |
Grossarth-Maticek CORPUS | 2008 | Serious | Moderate | Serious | serious | Moderate | Moderate | Serious | Serious |
Grossarth-Maticek OVAR | 2007c | Serious | Moderate | Serious | serious | Moderate | Moderate | Serious | Serious |
Grossarth-Maticek CERVIX | 2007b | Serious | Moderate | Serious | serious | Moderate | Moderate | Serious | Serious |
Grossarth-Maticek Melanoma | 2007a | Moderate | Low | Serious | serious | Serious | Moderate | Serious | Serious |
Grossarth-Maticek Mamma | 2006b | Moderate | Low | Serious | critical | Serious | Moderate | Serious | Critical |
Grossarth-Maticek MammaRec | 2006a | Moderate | Serious | Serious | serious | Moderate | Moderate | Serious | Serious |
Grossarth-Maticek MammaLym | 2006a | Moderate | Moderate | Serious | serious | Moderate | Moderate | Serious | Serious |
Grossarth-Maticek MammaMet | 2006a | Moderate | Moderate | Serious | serious | Moderate | Moderate | Serious | Serious |
Grossarth-Maticek Full population strict | 2001 | Serious | Moderate | Serious | NI | Serious | Moderate | Serious | Serious |
Grossarth-Maticek Subgroups cancer type | 2001 | Serious | Moderate | Serious | NI | Serious | Moderate | Serious | Serious |
Günczler Mamma | 1969 | Serious | Serious | Low | serious | Moderate | Moderate | Moderate | Serious |
Günczler Colon | 1969 | NI | NI | NI | NI | NI | NI | NI | NI |
Günczler | 1968 | Serious | Low | Moderate | serious | Serious | Moderate | Low | Serious |
Hassauer | 1979 | Serious | Moderate | Moderate | serious | Serious | Moderate | Serious | Serious |
Hoffmann | 1982 | Serious | Serious | Moderate | serious | Low | Moderate | Low | Serious |
Hoffmann | 1979 | Serious | Serious | Moderate | serious | NI | Moderate | Moderate | Serious |
Leroi | 1977 | Serious | Serious | Moderate | NI | Serious | Moderate | Serious | Critical |
Leroi* | 1975 | NI | NI | NI | NI | NI | NI | NI | NI |
Matthes | 2010 | Low | Moderate | Low | NI | Moderate | Moderate | Serious | Serious |
Salzer | 1985 | Moderate | Low | Moderate | NI | NI | Moderate | Moderate | Moderate |
Schmidt | 2007 | Low | Moderate | Moderate | NI | Moderate | Moderate | Moderate | Moderate |
Schuppli | 1990 | Serious | Moderate | Low | NI | NI | Moderate | Moderate | Serious |