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Journal of Neurology

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29.06.2023 | Original Communication

Study of the relationship between onset lateralization and hemispheric white matter asymmetry in Parkinson's disease

verfasst von: Yuxia Zhu, Sichen Li, Xiaohui Da, Hongyu Lai, Changhong Tan, Xi Liu, Fen Deng, Lifen Chen

Erschienen in: Journal of Neurology | Ausgabe 10/2023

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Abstract

Background

Parkinson's disease (PD) is characterized by a lateralized onset, but its cause and mechanism are still unclear.

Methods

Obtaining diffusion tensor imaging (DTI) data from the Parkinson’s Progression Markers Initiative (PPMI). Tract-based spatial statistics analysis and region-of-interest-based analysis were performed to evaluate the white matter (WM) asymmetry using original DTI parameters, Z Score normalized parameters, or the asymmetry index (AI). Hierarchical cluster analysis and least absolute shrinkage and selection operator regression were performed to construct predictive models for predicting the PD onset side. DTI data from The Second Affiliated Hospital of Chongqing Medical University were obtained for external validation of the prediction model.

Results

118 PD patients and 69 healthy controls (HC) from PPMI were included. Right-onset PD patients presented more asymmetric areas than left-onset PD patients. The inferior cerebellar peduncle (ICP), superior cerebellar peduncle (SCP), external capsule (EC), cingulate gyrus (CG), superior fronto-occipital fasciculus (SFO), uncinate fasciculus (UNC), and tapetum (TAP) showed significant asymmetry in left-onset and right-onset PD patients. An onset-side-specific pattern of WM alterations exists in PD patients, and a prediction model was constructed. The predicting models based on AI and ΔZ Score presented favorable efficacy in predicting PD onset side by external validation in 26 PD patients and 16 HCs from our hospital.

Conclusions

Right-onset PD patients may have more severe WM damage than left-onset PD patients. WM asymmetry in ICP, SCP, EC, CG, SFO, UNC, and TAP may predict PD onset side. Imbalances in the WM network may underlie the mechanism of lateralized onset in PD.

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Titel: Study of the relationship between onset lateralization and hemispheric white matter asymmetry in Parkinson's disease
verfasst von: Yuxia Zhu
Sichen Li
Xiaohui Da
Hongyu Lai
Changhong Tan
Xi Liu
Fen Deng
Lifen Chen
Publikationsdatum: 29.06.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Neurology / Ausgabe 10/2023
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-023-11849-1

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