nach oben

Head and Neck Pathology

Erschienen in:

01.12.2024 | Meeting Report

Spindle Cell Tumors of the Sinonasal Tract: A Diagnostic Update with Focus on Ancillary Workup

verfasst von: Shahd S. Almohsen, Elizabeth G. Demicco

Erschienen in: Head and Neck Pathology | Ausgabe 1/2024

Einloggen, um Zugang zu erhalten

Abstract

Spindle cell neoplasms arising in the head and neck may be challenging to recognize due to their relative rarity. While underlying molecular alterations are increasingly elucidated, testing for these features may not be readily available. In most cases, combinations of key morphologic features and diagnostic immunohistochemical markers can be used to replace molecular diagnostics. Conversely, some molecular alterations and expression of their surrogate biomarkers are not specific for any one entity, and it is important to recognize these to avoid diagnostic pitfalls. In this review, we discuss both old and new spindle cell tumors of the sinonasal tract, with an emphasis on histologic features and clinically relevant immunohistochemical markers serving as surrogate markers for underlying genomic alterations.

WHO Classification of Tumours Editorial Board (2022) WHO classification of tumours. Lyon (France): International Agency for Research on Cancer; 2022. 5th edn [Available from: https://tumourclassification.iarc.who.int/chapters/52

Thompson LD, Miettinen M, Wenig BM (2003) Sinonasal-type hemangiopericytoma: a clinicopathologic and immunophenotypic analysis of 104 cases showing perivascular myoid differentiation. Am J Surg Pathol 27(6):737–749. https://doi.org/10.1097/00000478-200306000-00004CrossRefPubMed

Sangoi AR, Bishop JA (2020) Variability of CD34 expression in sinonasal glomangiopericytoma: a potential diagnostic pitfall. Head Neck Pathol 14(2):459–64. https://doi.org/10.1007/s12105-019-01063-9CrossRefPubMed

Haller F, Bieg M, Moskalev EA, Barthelmeß S, Geddert H, Boltze C, Diessl N, Braumandl K, Brors B, Iro H, Hartmann A, Wiemann S, Agaimy A (2015) Recurrent mutations within the amino-terminal region of β-catenin are probable key molecular driver events in sinonasal hemangiopericytoma. Am J Pathol 185(2):563–571. https://doi.org/10.1016/j.ajpath.2014.10.019CrossRefPubMed

Suzuki Y, Ichihara S, Kawasaki T, Yanai H, Kitagawa S, Shimoyama Y, Nakamura S, Nakaguro M (2018) β-catenin (CTNNB1) mutation and LEF1 expression in sinonasal glomangiopericytoma (sinonasal-type hemangiopericytoma). Virchows Archiv 473(2):235–239. https://doi.org/10.1007/s00428-018-2370-9CrossRefPubMed

Jo VY, Fletcher CDM (2017) Nuclear β-catenin expression is frequent in sinonasal hemangiopericytoma and its mimics. Head Neck Pathol 11(2):119–23. https://doi.org/10.1007/s12105-016-0737-2CrossRefPubMed

Kakkar A, Rajeshwari M, Sakthivel P, Sharma MC, Sharma SC (2018) Biphenotypic sinonasal sarcoma: a series of six cases with evaluation of role of β-catenin immunohistochemistry in differential diagnosis. Ann Diagn Pathol 33:6–10. https://doi.org/10.1016/j.anndiagpath.2017.11.005CrossRefPubMed

Abraham SC, Montgomery EA, Giardiello FM, Wu TT (2001) Frequent beta-catenin mutations in juvenile nasopharyngeal angiofibromas. Am J Pathol 158(3):1073–1078. https://doi.org/10.1016/s0002-9440(10)64054-0CrossRefPubMedPubMedCentral

Chen S, Gallant S, Cunningham MJ, Robson CD, Church AJ, Perez-Atayde AR et al (2023) CTNNB1 and APC mutations in sinonasal myxoma: expanding the spectrum of tumors driven by WNT/β-catenin pathway. Am J Surg Pathol. https://doi.org/10.1097/pas.0000000000002112CrossRefPubMedPubMedCentral

10.

Odintsov I, Dong F, Guenette JP, Fritchie KJ, Jo VY, Fletcher CDM et al (2023) Infantile sinonasal myxoma is clinically and genetically distinct from other myxomas of the craniofacial bones and from desmoid fibromatosis. Am J Surg Pathol. https://doi.org/10.1097/pas.0000000000002119CrossRefPubMed

11.

Velez Torres JM, Mata DA, Briski LM, Green DC, Cloutier JM, Kerr DA et al (2023) Sinonasal myxoma: a distinct entity or a myxoid variant of desmoid fibromatosis? Mod Pathol 36(7):100189. https://doi.org/10.1016/j.modpat.2023.100189CrossRefPubMed

12.

Thompson LDR, Lau SK (2018) Sinonasal tract solitary fibrous tumor: a clinicopathologic study of six cases with a comprehensive review of the literature. Head Neck Pathol 12(4):471–480. https://doi.org/10.1007/s12105-017-0878-yCrossRefPubMed

13.

Smith SC, Gooding WE, Elkins M, Patel RM, Harms PW, McDaniel AS et al (2017) Solitary fibrous tumors of the head and neck: a multi-institutional clinicopathologic study. Am J Surg Pathol 41(12):1642–1656. https://doi.org/10.1097/pas.0000000000000940CrossRefPubMedPubMedCentral

14.

Suster DI, Mackinnon AC, Mejbel HA, Gross JM, Suster S (2023) Epithelioid and clear cell solitary fibrous tumors: clinicopathologic, immunohistochemical, and molecular genetic study of 13 cases. Am J Surg Pathol 47(2):259–269. https://doi.org/10.1097/pas.0000000000001983CrossRefPubMed

15.

Guillou L, Gebhard S, Coindre JM (2000) Orbital and extraorbital giant cell angiofibroma: a giant cell-rich variant of solitary fibrous tumor? Clinicopathologic and immunohistochemical analysis of a series in favor of a unifying concept. Am J Surg Pathol 24(7):971–979. https://doi.org/10.1097/00000478-200007000-00008CrossRefPubMed

16.

Mosquera JM, Fletcher CD (2009) Expanding the spectrum of malignant progression in solitary fibrous tumors: a study of 8 cases with a discrete anaplastic component–is this dedifferentiated SFT? Am J Surg Pathol 33(9):1314–1321. https://doi.org/10.1097/pas.0b013e3181a6cd33CrossRefPubMed

17.

Collini P, Negri T, Barisella M, Palassini E, Tarantino E, Pastorino U et al (2012) High-grade sarcomatous overgrowth in solitary fibrous tumors: a clinicopathologic study of 10 cases. Am J Surg Pathol 36(8):1202–1215. https://doi.org/10.1097/PAS.0b013e31825748f0CrossRefPubMed

18.

Lu C, Alex D, Benayed R, Rosenblum M, Hameed M (2018) Solitary fibrous tumor with neuroendocrine and squamous dedifferentiation: a potential diagnostic pitfall. Hum Pathol 77:175–180. https://doi.org/10.1016/j.humpath.2017.12.024CrossRefPubMedPubMedCentral

19.

Doyle LA, Vivero M, Fletcher CD, Mertens F, Hornick JL (2014) Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics. Mod Pathol 27(3):390–395. https://doi.org/10.1038/modpathol.2013.164CrossRefPubMed

20.

Dermawan JK, Rubin BP, Kilpatrick SE, Gjorgova Gjeorgjievski S, Fritchie KJ, Goldblum JR et al (2021) CD34-negative solitary fibrous tumor: a clinicopathologic study of 25 cases and comparison with their CD34-positive counterparts. Am J Surg Pathol 45(12):1616–1625. https://doi.org/10.1097/pas.0000000000001717CrossRefPubMed

21.

Dagrada GP, Spagnuolo RD, Mauro V, Tamborini E, Cesana L, Gronchi A et al (2015) Solitary fibrous tumors: loss of chimeric protein expression and genomic instability mark dedifferentiation. Mod Pathol 28(8):1074–1083. https://doi.org/10.1038/modpathol.2015.70CrossRefPubMed

22.

Doyle LA, Tao D, Mariño-Enríquez A (2014) STAT6 is amplified in a subset of dedifferentiated liposarcoma. Mod Pathol 27(9):1231–1237. https://doi.org/10.1038/modpathol.2013.247CrossRefPubMed

23.

Xu B, Chang K, Folpe AL, Kao YC, Wey SL, Huang HY et al (2020) Head and neck mesenchymal neoplasms with GLI1 gene alterations: a pathologic entity with distinct histologic features and potential for distant metastasis. Am J Surg Pathol 44(6):729–737. https://doi.org/10.1097/pas.0000000000001439CrossRefPubMedPubMedCentral

24.

Agaram NP, Zhang L, Sung YS, Singer S, Stevens T, Prieto-Granada CN et al (2019) GLI1-amplifications expand the spectrum of soft tissue neoplasms defined by GLI1 gene fusions. Mod Pathol 32(11):1617–1626. https://doi.org/10.1038/s41379-019-0293-xCrossRefPubMedPubMedCentral

25.

Stevens TM, Rooper LM, Bacchi CE, Fernandes IL, Antonescu CR, Gagan J et al (2022) Teratocarcinosarcoma-Like and adamantinoma-like head and neck neoplasms harboring NAB2::STAT6: unusual variants of solitary fibrous tumor or novel tumor entities? Head Neck Pathol 16(3):746–754. https://doi.org/10.1007/s12105-022-01444-7CrossRefPubMedPubMedCentral

26.

Terry J, Saito T, Subramanian S, Ruttan C, Antonescu CR, Goldblum JR et al (2007) TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies. Am J Surg Pathol 31(2):240–246. https://doi.org/10.1097/01.pas.0000213330.71745.39CrossRefPubMed

27.

Pan H, Byers J, Yin H, Rytting H, Logan S, He M et al (2023) The utility of TLE1 and BCOR as immunohistochemical markers for angiomatoid fibrous histiocytoma. Int J Clin Exp Pathol 16(2):32–39PubMedPubMedCentral

28.

Rekhi B, Kosemehmetoglu K, Ergen FB, Vengurlekar V, Rumde R, Shetty O et al (2023) Spectrum of histopathological, immunohistochemical, molecular and radiological features in 12 Cases of BCOR::CCNB3-positive sarcomas with literature review. Int J Surg Pathol 31(7):1244–1264. https://doi.org/10.1177/10668969221143467CrossRefPubMed

29.

Baranov E, McBride MJ, Bellizzi AM, Ligon AH, Fletcher CDM, Kadoch C et al (2020) A novel SS18-SSX fusion-specific antibody for the diagnosis of synovial sarcoma. Am J Surg Pathol 44(7):922–933. https://doi.org/10.1097/pas.0000000000001447CrossRefPubMedPubMedCentral

30.

Zaborowski M, Vargas AC, Pulvers J, Clarkson A, de Guzman D, Sioson L et al (2020) When used together SS18-SSX fusion-specific and SSX C-terminus immunohistochemistry are highly specific and sensitive for the diagnosis of synovial sarcoma and can replace FISH or molecular testing in most cases. Histopathology 77(4):588–600. https://doi.org/10.1111/his.14190CrossRefPubMed

31.

Agaimy A, Baněčková M, De Almeida J, Dickson BC, Dimmler A, Hartmann W et al (2023) Recurrent EWSR1::COLCA2 fusions define a novel sarcoma with spindle/round cell morphology and strong predilection for the sinonasal tract. Am J Surg Pathol 47(3):361–369. https://doi.org/10.1097/pas.0000000000002000CrossRefPubMed

32.

Lanic MD, Guérin R, Wassef M, Durdilly P, Rainville V, Sater V et al (2023) Detection of salivary gland and sinonasal fusions by a next-generation sequencing based, ligation-dependent, multiplex RT-PCR assay. Histopathology. https://doi.org/10.1111/his.14971CrossRefPubMed

33.

Koshyk O, Dehner CA, van den Hout M, Vanden Bempt I, Sciot R, Huang HY et al (2023) EWSR1::POU2AF3(COLCA2) sarcoma: an aggressive, polyphenotypic sarcoma with a head and neck predilection. Mod Pathol. https://doi.org/10.1016/j.modpat.2023.100337CrossRefPubMed

34.

Hiemenz MC, Kaur J, Kuang Z, Huang RSP, Harries L, Metzger D et al (2023) POU2AF3-rearranged sarcomas: a novel tumor defined by fusions of EWSR1 or FUS to a gene formerly designated COLCA2. Genes Chromosomes Cancer 62(8):460–470. https://doi.org/10.1002/gcc.23136CrossRefPubMed

35.

Lewis JT, Oliveira AM, Nascimento AG, Schembri-Wismayer D, Moore EA, Olsen KD et al (2012) Low-grade sinonasal sarcoma with neural and myogenic features: a clinicopathologic analysis of 28 cases. Am J Surg Pathol 36(4):517–525. https://doi.org/10.1097/PAS.0b013e3182426886CrossRefPubMed

36.

Gross J, Fritchie K (2020) Soft tissue special issue: biphenotypic sinonasal sarcoma—a review with emphasis on differential diagnosis. Head Neck Pathol 14(1):33–42. https://doi.org/10.1007/s12105-019-01092-4CrossRefPubMedPubMedCentral

37.

Carter CS, East EG, McHugh JB (2018) Biphenotypic Sinonasal sarcoma: a review and update. Arch Pathol Lab Med 142(10):1196–1201. https://doi.org/10.5858/arpa.2018-0207-RACrossRefPubMed

38.

Le Loarer F, Laffont S, Lesluyes T, Tirode F, Antonescu C, Baglin AC et al (2019) Clinicopathologic and molecular features of a series of 41 biphenotypic sinonasal sarcomas expanding their molecular spectrum. Am J Surg Pathol 43(6):747–754. https://doi.org/10.1097/pas.0000000000001238CrossRefPubMedPubMedCentral

39.

Jo VY, Mariño-Enríquez A, Fletcher CDM, Hornick JL (2018) Expression of PAX3 distinguishes biphenotypic sinonasal sarcoma from histologic mimics. Am J Surg Pathol 42(10):1275–1285. https://doi.org/10.1097/pas.0000000000001092CrossRefPubMed

40.

Meyer A, Klubíčková N, Mosaieby E, Grossmann P, Kalmykova A, Koshyk O et al (2023) Biphenotypic sinonasal sarcoma with PAX3::MAML3 fusion transforming into high-grade rhabdomyosarcoma: report of an emerging rare phenomenon. Virchows Arch 482(4):777–82. https://doi.org/10.1007/s00428-023-03501-0CrossRefPubMedPubMedCentral

41.

Georgantzoglou N, Green D, Stephen SA, Kerr DA, Linos K (2022) Biphenotypic sinonasal sarcoma with PAX7 expression. Int J Surg Pathol 30(6):642–5. https://doi.org/10.1177/10668969221080082CrossRefPubMed

42.

Huang SC, Ghossein RA, Bishop JA, Zhang L, Chen TC, Huang HY et al (2016) Novel PAX3-NCOA1 fusions in biphenotypic sinonasal sarcoma with focal rhabdomyoblastic differentiation. Am J Surg Pathol 40(1):51–59. https://doi.org/10.1097/pas.0000000000000492CrossRefPubMedPubMedCentral

43.

Wong WJ, Lauria A, Hornick JL, Xiao S, Fletcher JA, Marino-Enriquez A (2016) Alternate PAX3-FOXO1 oncogenic fusion in biphenotypic sinonasal sarcoma. Genes Chromosomes Cancer 55(1):25–9. https://doi.org/10.1002/gcc.22295CrossRefPubMed

44.

Nichols MM, Alruwaii F, Chaaban M, Cheng YW, Griffith CC (2023) Biphenotypic sinonasal sarcoma with a novel PAX3::FOXO6 Fusion: a case report and review of the literature. Head Neck Pathol 17(1):259–264. https://doi.org/10.1007/s12105-022-01479-wCrossRefPubMed

45.

Viramontes A, Mueller N, Gocke CD, Deklotz TR, Ozdemirli M (2023) Novel PAX3::INO80D fusion in biphenotypic sinonasal sarcoma in an adult. JAMA Otolaryngol Head Neck Surg. https://doi.org/10.1001/jamaoto.2023.1708CrossRefPubMed

46.

Bhele S, Chrisinger JSA, Farrell NF, Van Tine BA, Raptis CA, Chernock RD (2023) Biphenotypic sinonasal sarcoma with a novel PAX7::PPARGC1 fusion: expanding the spectrum of gene fusions beyond the PAX3 gene. Head Neck Pathol. https://doi.org/10.1007/s12105-023-01566-6CrossRefPubMed

47.

Mechtersheimer G, Andrulis M, Delank KW, Volckmar AL, Zhang L, von Winterfeld M et al (2021) RREB1-MKL2 fusion in a spindle cell sinonasal sarcoma: biphenotypic sinonasal sarcoma or ectomesenchymal chondromyxoid tumor in an unusual site? Genes Chromosomes Cancer 60(8):565–570. https://doi.org/10.1002/gcc.22948CrossRefPubMedPubMedCentral

48.

Siegfried A, Romary C, Escudié F, Nicaise Y, Grand D, Rochaix P et al (2018) RREB1-MKL2 fusion in biphenotypic “oropharyngeal” sarcoma: new entity or part of the spectrum of biphenotypic sinonasal sarcomas? Genes Chromosomes Cancer 57(4):203–210. https://doi.org/10.1002/gcc.22521CrossRefPubMed

49.

Agaimy A, Din NU, Dermawan JK, Haller F, Melzer K, Denz A et al (2023) RREB1::MRTFB fusion-positive extra-glossal mesenchymal neoplasms: a series of five cases expanding their anatomic distribution and highlighting significant morphological and phenotypic diversity. Genes Chromosomes Cancer 62(1):5–16. https://doi.org/10.1002/gcc.23082CrossRefPubMed

50.

Hasnie S, Glenn C, Peterson JEG, El Rassi ET, McKinney KA (2022) High-grade biphenotypic sinonasal sarcoma: a case report. J Neurol Surg Rep 83(3):e105–e109. https://doi.org/10.1055/s-0042-1755599CrossRefPubMedPubMedCentral

51.

Bell D, Phan J, DeMonte F, Hanna EY (2022) High-grade transformation of low-grade biphenotypic sinonasal sarcoma: radiological, morphophenotypic variation and confirmatory molecular analysis. Ann Diagn Pathol 57:151889. https://doi.org/10.1016/j.anndiagpath.2021.151889CrossRefPubMed

52.

Dehner CA, Broski SM, Meis JM, Murugan P, Chrisinger JSA, Sosa C et al (2023) Fusion-driven spindle cell rhabdomyosarcomas of bone and soft tissue: a clinicopathologic and molecular genetic study of 25 cases. Mod Pathol 36(10):100271. https://doi.org/10.1016/j.modpat.2023.100271CrossRefPubMed

53.

WHO Classification of Tumours Editorial Board (2020) Soft tissue and bone tumours, 5th edn. International Agency for Research on Cance, Lyon (France)

54.

Agaram NP, LaQuaglia MP, Alaggio R, Zhang L, Fujisawa Y, Ladanyi M et al (2019) MYOD1-mutant spindle cell and sclerosing rhabdomyosarcoma: an aggressive subtype irrespective of age. A reappraisal for molecular classification and risk stratification. Mod Pathol. 32(1):27–36. https://doi.org/10.1038/s41379-018-0120-9CrossRefPubMed

55.

Agaimy A, Dermawan JK, Leong I, Stoehr R, Swanson D, Weinreb I et al (2022) Recurrent VGLL3 fusions define a distinctive subset of spindle cell rhabdomyosarcoma with an indolent clinical course and striking predilection for the head and neck. Genes Chromosomes Cancer 61(12):701–709. https://doi.org/10.1002/gcc.23083CrossRefPubMedPubMedCentral

56.

Xu B, Suurmeijer AJH, Agaram NP, Zhang L, Antonescu CR (2021) Head and neck rhabdomyosarcoma with TFCP2 fusions and ALK overexpression: a clinicopathological and molecular analysis of 11 cases. Histopathology 79(3):347–357. https://doi.org/10.1111/his.14323CrossRefPubMedPubMedCentral

57.

Dickson BC, Antonescu CR, Argyris PP, Bilodeau EA, Bullock MJ, Freedman PD et al (2018) Ectomesenchymal chondromyxoid tumor: a neoplasm characterized by recurrent RREB1-MKL2 fusions. Am J Surg Pathol 42(10):1297–1305. https://doi.org/10.1097/pas.0000000000001096CrossRefPubMedPubMedCentral

58.

Argyris PP, Bilodeau EA, Yancoskie AE, Trochesset D, Pambuccian SE, Wetzel SL et al (2016) A subset of ectomesenchymal chondromyxoid tumours of the tongue show EWSR1 rearrangements and are genetically linked to soft tissue myoepithelial neoplasms: a study of 11 cases. Histopathology 69(4):607–613. https://doi.org/10.1111/his.12973CrossRefPubMed

59.

Dermawan JK, DiNapoli SE, Mullaney KA, Sukhadia P, Agaram NP, Dickson BC et al (2023) ALK-rearranged mesenchymal neoplasms: a report of 9 cases further expanding the clinicopathologic spectrum of emerging kinase fusion positive group of tumors. Genes Chromosomes Cancer 62(2):75–84. https://doi.org/10.1002/gcc.23097CrossRefPubMed

60.

Suurmeijer AJH, Dickson BC, Swanson D, Zhang L, Sung YS, Cotzia P et al (2018) A novel group of spindle cell tumors defined by S100 and CD34 co-expression shows recurrent fusions involving RAF1, BRAF, and NTRK1/2 genes. Genes Chromosomes Cancer 57(12):611–621. https://doi.org/10.1002/gcc.22671CrossRefPubMedPubMedCentral

61.

Antonescu CR (2020) Emerging soft tissue tumors with kinase fusions: An overview of the recent literature with an emphasis on diagnostic criteria. Genes Chromosomes Cancer 59(8):437–444. https://doi.org/10.1002/gcc.22846CrossRefPubMedPubMedCentral

62.

Xu B, Suurmeijer AJH, Agaram NP, Antonescu CR (2023) Head and neck mesenchymal tumors with kinase fusions: a report of 15 cases with emphasis on wide anatomic distribution and diverse histologic appearance. Am J Surg Pathol 47(2):248–258. https://doi.org/10.1097/pas.0000000000001982CrossRefPubMed

63.

Suurmeijer AJH, Xu B, Torrence D, Dickson BC, Antonescu CR (2023) Kinase fusion positive intra-osseous spindle cell tumors: a series of eight cases with review of the literature. Genes Chromosomes Cancer. https://doi.org/10.1002/gcc.23205CrossRefPubMed

64.

Haberecker M, Töpfer A, Melega F, Moch H, Pauli C (2023) A systematic comparison of pan-Trk immunohistochemistry assays among multiple cancer types. Histopathology 82(7):1003–1012. https://doi.org/10.1111/his.14884CrossRefPubMed

65.

Kojima N, Mori T, Motoi T, Kobayashi E, Yoshida M, Yatabe Y et al (2023) Frequent CD30 expression in an emerging group of mesenchymal tumors with NTRK, BRAF, RAF1, or RET fusions. Mod Pathol 36(4):100083. https://doi.org/10.1016/j.modpat.2022.100083CrossRefPubMed

Titel: Spindle Cell Tumors of the Sinonasal Tract: A Diagnostic Update with Focus on Ancillary Workup
verfasst von: Shahd S. Almohsen
Elizabeth G. Demicco
Publikationsdatum: 01.12.2024
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 1/2024
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-023-01605-2

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Spindle Cell Tumors of the Sinonasal Tract: A Diagnostic Update with Focus on Ancillary Workup

Abstract

Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2024

Seven Steps to Financial Health

Primary Oral Mixed Neuroendocrine–Non-neuroendocrine Neoplasm (MiNEN): A Rare Case Report and Review of the Literature

SMARCB1-Deficient Skull Base Chondrosarcoma with 12p Duplication Presenting as Somatic-Type Malignancy Arising from Metastatic Seminoma

Recurrence of Glandular Odontogenic Cysts: A Systematic Review

Melanotic Neuroectodermal Tumor of Infancy: A Case Image

Dynamic Role of miRNAs in Salivary Gland Carcinomas: From Biomarkers to Therapeutic Targets

Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren