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19.10.2023 | Research

Sociodemographic and clinical characterization of cases of 1,103 non-syndromic and 66 syndromic odontogenic keratocyst: a Brazilian multicenter study

verfasst von: Daiana Cristina Pereira Santana, Larissa Abbehusen Couto, Johelle de Santana Passos-Soares, Flávia Caló de Aquino Xavier, Ricardo Alves Mesquita, Fernanda Aragão Felix, Tarcília Aparecida da Silva, Cassiano Francisco Weege Nonaka, Pollianna Muniz Alves, Christany Rodrigues Ferreira, Tatiana Nayara Libório-Kimura, Lucileide Castro de Oliveira Moreira, Jeconias Câmara, Caroline Alfaia Silva, Elismauro Francisco de Mendonça, Nádia do Lago Costa, Hélder Antônio Rebelo Pontes, Lucas Lacerda de Souza, Jurema Freire de Castro Lisboa, Gustavo Pina Godoy, Laís Azevedo Lins de Holanda, Manoela Domingues Martins, Pantelis Varvaki Rados, Tuany Rafaeli Schmidt, Roseana de Almeida Freitas, Lélia Batista de Souza, Everton Freitas de Morais, Pablo Agustin Vargas, Márcio Ajudarte Lopes, Gabriella Alves Quixabeira Oliveira, Jean Nunes dos Santos, Águida Cristina Gomes Henriques

Erschienen in: Clinical Oral Investigations | Ausgabe 11/2023

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Abstract

Objectives

This multicenter study aimed to evaluate cases of non-syndrome and syndromic odontogenic keratocyst, as well as cases of recurrence within these two groups.

Methods

This descriptive, analytical, retrospective cross-sectional study evaluated the sex, age and presence of multiple lesions in 1,169 individuals seen at 10 Brazilian oral and maxillofacial pathology centers. Of these, 1,341 odontogenic keratocysts were analyzed regarding clinical diagnosis, size, site, imaging appearance, signs and symptoms, type of biopsy, treatment, and recurrence.

Results

There was a similar distribution by sex. The median age of non-syndromic and syndromic patients was 32 and 17.5 years, respectively. The posterior mandible was the site most affected by small and large lesions in both groups and in recurrent cases. Unilocular lesions were more frequent, also in recurrent cases. Mainly small lesions showed this imaging appearance. Signs and symptoms were absent in most cases. Conservative treatment was the most frequent modality in all age groups, regardless of the patient’s condition and recurrence. Recurrences were uncommon.

Conclusion

This study showed a higher frequency of non-syndromic keratocysts in the population. Clinicopathological features related to the involvement of multiple sites, age, and recurrence may differ between syndromic and non-syndromic cases. Furthermore, we found an association between lesion size and some clinical features and between the time interval to recurrence and the syndromic spectrum.

Clinical relevance

To contribute to a better understanding of the distribution and association between clinical, imaging, and sociodemographic characteristics in each spectrum of the lesion.

Philipsen HP (1956) Om keratocyster (kolesteatom) i kaeberne. Tandlaege Bladet 60:963–981

El-Naggar A et al (2017) WHO Classification of Head and Neck Tumours. World. Health Organization, 4th edition. Lyon: IARC PRESS, 347 p

Schuch LF, Arruda JAA, Mosconi C et al (2020) A Brazilian multicentre study of 2,497 isolated cases of odontogenic keratocysts. Oral Dis 26(3):711–715. https://doi.org/10.1111/odi.13278CrossRefPubMed

Boffano P, Cavarra F, Agnone AM et al (2022) The epidemiology and management of odontogenic keratocysts (OKCs): A European multicenter study. J Craniomaxillofac Surg 50(1):1–6. https://doi.org/10.1016/j.jcms.2021.09.022CrossRefPubMed

Santana DCP, Garcia JJ, Kusterer LEF et al (2021) Odontogenic keratocyst: eight-year follow-up after conservative treatment. Int J Odontostomat 15(2):520–525. https://doi.org/10.4067/S0718-381X2021000200520CrossRef

Azevedo RS, Cabral MG, dos Santos TC, de Oliveira AV, de Almeida OP, Pires FR (2012) Histopathological features of keratocystic odontogenic tumor: a descriptive study of 177 cases from a Brazilian population. Int J Surg Pathol 20(2):154–160. https://doi.org/10.1177/1066896911428072CrossRefPubMed

WHO Classification of Tumors Editorial Board. Head and neck tumors. Lyon (France): International Agency for Research on Cancer, 2022. (WHO classification of tumors series, 5th ed.; vol.9)

Kimonis VE, Goldstein AM, Pastakia B et al (1997) Clinical Manifestations in 105 persons with nevoid basal cell carcinoma syndrome. Am J Med Genet 69:299–308CrossRefPubMed

Kauke M, Safi AF, Kreppe M, Grandoch A, Nickenig HJ, Zöller JE, Dreiseidler T (2018) Size distribution and clinicoradiological signs of aggressiveness in odontogenic myxoma- three-dimensional analysis and systematic review. Dentomaxillofac Radiol 47(2):20170262. https://doi.org/10.1259/dmfr.20170262CrossRefPubMed

10.

Brannon RB (1976) The odontogenic keratocyst. A clinicopathologic study of 312 cases. Part I: Clinical features. Oral Surg Oral Med Oral Pathol 42(1):54–72. https://doi.org/10.1016/0030-4220(76)90031-1CrossRefPubMed

11.

Myoung H, Hong SP, Hong SD et al (2001) Odontogenic keratocyst: review of 256 cases for recurrence and clinicopathologic parameters. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91(3):328–333. https://doi.org/10.1067/moe.2001.113109CrossRefPubMed

12.

El Murtadi A, Grehan D, Toner M, McCartan BE (1996) Proliferating cell nuclear antigen staining in syndrome and nonsyndrome odontogenic keratocysts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 81(2):217–220. https://doi.org/10.1016/s1079-2104(96)80418-5CrossRefPubMed

13.

Hammannavar R, Holikatti K, Basappa S, Shinde N, Reddy M, Chidambaram YS (2014) Multiple, multifocal odontogenic keratocyst in non-syndromic patient: a case-report. J Oral Health Dent Manag 13(2):89–93

14.

Janjua OS, Tariq R, Khalid UM, Qureshi SM, Kamran A (2022) Presentation and management of syndromic and non-syndromic patients with multiple odontogenic keratocysts. Oral Maxil Surg Cases 8(2):100253. https://doi.org/10.1016/j.omsc.2022.100253CrossRef

15.

Payne TF (1972) An analysis of the clinical and histopathologic parameters of the odontogenic keratocyst. Oral Surg Oral Med Oral Pathol 33(4):538–546. https://doi.org/10.1016/0030-4220(72)90366-0CrossRefPubMed

16.

Chirapathomsakul D, Sastravaha P, Jansisyanont P (2006) A review of odontogenic keratocysts and the behavior of recurrences. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101(1):5–9. https://doi.org/10.1016/j.tripleo.2005.03.023CrossRefPubMed

17.

Borghesi A, Nardi C, Gianitto C et al (2018) Odontogenic keratocyst : imaging features of a benign lesion with an aggressive behaviour. Insights Imaging 9(2):883–897. https://doi.org/10.1007/s13244-018-0644-zCrossRefPubMedPubMedCentral

18.

Pinheiro JC, Cavalcante IL, Santos HBP, Santos PPA, de Souza LB (2020) Recurrence rate of odontogenic keratocysts: Clinical-radiographic characterization throughout a 48-year period. Rev Port Estomatol Med Dent Cir Maxilofac 61(2):52–56. https://doi.org/10.24873/j.rpemd.2020.09.705CrossRef

19.

Vallejo-Rosero KA, Camolesi GV, de Sá PLD, Bernaola-Paredes WE (2020) Conservative management of odontogenic keratocyst with long-term 5-year follow-up: case report and literature review. Int J Surg Case Rep 66:8–15. https://doi.org/10.1016/j.ijscr.2019.11.023CrossRefPubMed

20.

Donatsky O, Hjörting-Hansen E, Philipsen HP, Fejerskov O (1976) Clinical, radiologic, and histopathologic aspects of 13 cases of nevoid basal cell carcinoma syndrome. Int J Oral Surg 5(1):19–28. https://doi.org/10.1016/S0300-9785(76)80006-3CrossRefPubMed

21.

Woolgar JA, Rippin JW, Browne RM (1987) The odontogenic keratocyst and its occurrence in the nevoid basal cell carcinoma syndrome. Oral Surg Oral Med Oral Pathol 64(6):727–730. https://doi.org/10.1016/0030-4220(87)90176-9CrossRefPubMed

22.

Browne RM (1975) The pathogenesis of odontogenic cysts: a review. J Oral Pathol 4(1):31–46. https://doi.org/10.1111/j.1600-0714.1975.tb01738.xCrossRefPubMed

23.

Johnson NR, Batstone MD, Savage NW (2013) Management and recurrence of keratocystic odontogenic tumor: a systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol 116(4):271–276. https://doi.org/10.1016/j.oooo.2011.12.028CrossRef

24.

Mendonça JCG, Jardim ECG, da Silva JCL, Valente FRF, dos Santos MES (2022) Surgical treatment of odontogenic keratocyst associated with cryotherapy with refrigerant gas: 10- year follow-up. Res Soc Develop 11(3):e40511326784. https://doi.org/10.33448/rsd-v11i3.26784CrossRef

25.

Yilmaz O, Sagnak Yilmaz Z, Balaban E, Candirli C (2020) Management of recurrence of ameloblastoma and odontogenic keratocyst: a cross-sectional study. Odovtos-Int J Dent Sci 22(3):174–186. https://doi.org/10.15517/ijds.2020.41564CrossRef

26.

Forssell K (1980) The primordial cyst. Clinical and radiographic study. Proc Finn Dent Soc 77(5):129–174

27.

Mesquita PMV (2001) Queratocisto Odontogênico. Uma Entidade Clínico- Radiográfica de Diagnóstico Histológico. Dissertation, University of Porto

28.

Habibi A, Saghravanian N, Habibi M, Mellati E, Habibi M (2007) Keratocystic odontogenic tumor: a 10-year retrospective study of 83 cases in an Iranian population. J Oral Sci 49(3):229–235. https://doi.org/10.2334/josnusd.49.229CrossRefPubMed

29.

Ianculovici C, Blinder D, Peleg O (2016) Trends in recurrence of keratocystic odontogenic tumor. Int J Oral Dent Health 2:031. https://doi.org/10.23937/2469-5734/1510031CrossRef

30.

Warburton G, Shihabi A, Ord RA (2015) Keratocystic odontogenic tumor (KCOT/OKC)— clinical guidelines for resection. J Maxillofac Oral Surg 14(3):558–564. https://doi.org/10.1007/s12663-014-0732-7CrossRefPubMedPubMedCentral

31.

Baik WK, Baik HS, Choi SH (2020) Comprehensive orthodontic treatment of a young girl with an odontogenic keratocyst and impacted teeth in the mandible. Korean J Orthod 50(1):63–71. https://doi.org/10.4041/kjod.2020.50.1.63CrossRefPubMedPubMedCentral

Titel: Sociodemographic and clinical characterization of cases of 1,103 non-syndromic and 66 syndromic odontogenic keratocyst: a Brazilian multicenter study
verfasst von: Daiana Cristina Pereira Santana
Larissa Abbehusen Couto
Johelle de Santana Passos-Soares
Flávia Caló de Aquino Xavier
Ricardo Alves Mesquita
Fernanda Aragão Felix
Tarcília Aparecida da Silva
Cassiano Francisco Weege Nonaka
Pollianna Muniz Alves
Christany Rodrigues Ferreira
Tatiana Nayara Libório-Kimura
Lucileide Castro de Oliveira Moreira
Jeconias Câmara
Caroline Alfaia Silva
Elismauro Francisco de Mendonça
Nádia do Lago Costa
Hélder Antônio Rebelo Pontes
Lucas Lacerda de Souza
Jurema Freire de Castro Lisboa
Gustavo Pina Godoy
Laís Azevedo Lins de Holanda
Manoela Domingues Martins
Pantelis Varvaki Rados
Tuany Rafaeli Schmidt
Roseana de Almeida Freitas
Lélia Batista de Souza
Everton Freitas de Morais
Pablo Agustin Vargas
Márcio Ajudarte Lopes
Gabriella Alves Quixabeira Oliveira
Jean Nunes dos Santos
Águida Cristina Gomes Henriques
Publikationsdatum: 19.10.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 11/2023
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-023-05313-7

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Sociodemographic and clinical characterization of cases of 1,103 non-syndromic and 66 syndromic odontogenic keratocyst: a Brazilian multicenter study