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16.11.2023 | RESEARCH

SLAMF7 Promotes Foam Cell Formation of Macrophage by Suppressing NR4A1 Expression During Carotid Atherosclerosis

verfasst von: Fengjiao Yuan, Jianmei Wei, Yan Cheng, Feifei Wang, Mingliang Gu, Yanhui Li, Xin Zhao, Hao Sun, Ru Ban, Jing Zhou, Zhangyong Xia

Erschienen in: Inflammation | Ausgabe 2/2024

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Abstract

Macrophage-derived lipid-laden foam cells from the subendothelium play a crucial role in the initiation and progression of atherosclerosis. However, the molecule mechanism that regulates the formation of foam cells is not completely understood. Here, we found that SLAMF7 was upregulated in mice bone marrow–derived macrophages and RAW264.7 cells stimulated with oxidized low-density lipoprotein (ox-LDL). SLAMF7 promoted ox-LDL-mediated macrophage lipid accumulation and M1-type polarization. SLAMF7 deficiency reduced serum lipid levels and improved the lesions area of carotid plaque and aortic arch in high-fat diet-fed ApoE^−/− mice. In response to ox-LDL, SLAMF7 downregulated NR4A1 and upregulated RUNX3 through transcriptome sequencing analysis. Overexpression NR4A1 reversed SLAMF7-induced lipid uptake and M1 polarization via inhibiting RUNX3 expression. Furthermore, RUNX3 enhanced foam cell formation and M1-type polarization. Taken together, the study suggested that SLAMF7 play contributing roles in the pro-atherogenic effects by regulating NR4A1-RUNX3.

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Titel: SLAMF7 Promotes Foam Cell Formation of Macrophage by Suppressing NR4A1 Expression During Carotid Atherosclerosis
verfasst von: Fengjiao Yuan
Jianmei Wei
Yan Cheng
Feifei Wang
Mingliang Gu
Yanhui Li
Xin Zhao
Hao Sun
Ru Ban
Jing Zhou
Zhangyong Xia
Publikationsdatum: 16.11.2023
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 2/2024
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-023-01926-y

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SLAMF7 Promotes Foam Cell Formation of Macrophage by Suppressing NR4A1 Expression During Carotid Atherosclerosis

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