Findings
Background and hypothesis
Methods
Study population
Phenotype
DNA extraction
SNP analysis
SNP selection
Statistics
Results
Demographics, MTX details
JIA | |
---|---|
JIA patients, n | 121 |
Girls: Boys, n | 82:39 |
Caucasian: not Caucasian, n | 117:4 |
Age at enrolment (years) | 13.3 (11.3–15.1) |
Duration of MTX treatment (days) | 340 (142–766) |
MTXo: MTXSC, n | 45:76 |
MTX dose (mg/m2/week) | 9.7 (9.0–10.9) |
Patients with completed MISS, n | 120 |
MISS total score (0–36) | 8 (3–14) |
MTXintolerant subgroup1, n | 73 |
MTXtolerant subgroup, n | 47 |
Patients with ≥ 7 completed diary entries, n | 77 |
“MTX-nausea” subgroup2, n | 56 |
SNPs in MTX transporter proteins
Gene | SNP | Ancestral Allel | Genotypes | Total, n | MTX intolerant1 | MTX tolerant | p-value | MTX Nausea2 | Controls | p-value |
---|---|---|---|---|---|---|---|---|---|---|
ABCC2 | rs2273697 | G | GG | 74 | 44 | 29 | χ2 = 0.05 | 32 | 14 | 0.81 |
GA | 32 | 20 | 12 | p = 0.98 | 16 | 5 | ||||
AA | 13 | 8 | 5 | 8 | 2 | |||||
ABCC2 | rs37400663 | G | GG | 38 | 23 | 15 | 0.74 | 19 | 7 | 1.00 |
GA | 65 | 38 | 27 | 29 | 12 | |||||
AA | 15 | 10 | 4 | 7 | 2 | |||||
ABCC2 | rs717620 | G | GG | 73 | 47 | 26 | 0.64 | 35 | 13 | 1.00 |
GA | 39 | 21 | 17 | 18 | 7 | |||||
AA | 7 | 4 | 3 | 3 | 1 | |||||
ABCB1 | rs2032582 | G | GG | 38 | 23 | 15 | 0.28 | 18 | 6 | 0.95 |
GT | 58 | 34 | 24 | 27 | 10 | |||||
GA | 2 | 0 | 2 | 1 | 1 | |||||
TA | 3 | 3 | 0 | 2 | 1 | |||||
TT | 18 | 12 | 5 | 8 | 3 | |||||
ABCB1 | rs1045642 | C | CC | 18 | 9 | 9 | χ2 = 1.34 | 8 | 4 | 0.82 |
CT | 68 | 44 | 24 | p = 0.51 | 34 | 11 | ||||
TT | 33 | 19 | 13 | 14 | 6 | |||||
SLCO1B1 | rs4149056 | T | TT | 84 | 49 | 34 | 0.86 | 39 | 15 | 1.00 |
TC | 32 | 21 | 11 | 16 | 6 | |||||
CC | 3 | 2 | 1 | 1 | 0 | |||||
SLCO1B1 | rs4149081 | G | GG | 80 | 47 | 32 | 0.86 | 38 | 14 | 1.00 |
GA | 36 | 23 | 13 | 17 | 7 | |||||
AA | 3 | 2 | 1 | 1 | 0 | |||||
SLCO1B3 | rs2117032 | C | CC | 17 | 12 | 5 | χ2 = 2.16 | 10 | 4 | 0.63 |
CT | 53 | 28 | 24 | p = 0.34 | 23 | 6 | ||||
TT | 49 | 32 | 17 | 23 | 11 | |||||
SLC19A1 | rs10512663 | G | GG | 33 | 18 | 15 | χ2 = 0.76 | 17 | 6 | 0.89 |
GA | 66 | 42 | 24 | p = 0.68 | 28 | 12 | ||||
AA | 19 | 11 | 7 | 10 | 3 | |||||
HTR3A | rs1062613 | C | CC | 80 | 52 | 28 | 0.13 | 36 | 16 | 0.58 |
CT | 37 | 20 | 16 | 19 | 5 | |||||
TT | 2 | 0 | 2 | 1 | 0 | |||||
HTR3A | rs1985242 | A | AA | 7 | 3 | 4 | 0.23 | 4 | 1 | 0.34 |
AT | 55 | 30 | 24 | 28 | 7 | |||||
TT | 57 | 39 | 18 | 24 | 13 | |||||
HTR3A | rs1176713 | C | CC | 6 | 3 | 3 | 0.68 | 3 | 1 | 0.18 |
CT | 37 | 21 | 16 | 19 | 3 | |||||
TT | 76 | 48 | 27 | 34 | 17 | |||||
HTR3B | rs1776744 | T | TT | 50 | 30 | 20 | 0.09 | 24 | 10 | 0.58 |
TG | 58 | 32 | 25 | 27 | 8 | |||||
GG | 11 | 10 | 1 | 5 | 3 | |||||
MTHFR | rs18011313 | A | AA | 52 | 34 | 18 | χ2 = 0.93 | 24 | 9 | 0.29 |
AC | 53 | 30 | 22 | p = 0.63 | 21 | 11 | ||||
CC | 13 | 7 | 6 | 10 | 1 | |||||
MTHFR | rs1801133 | C | CC | 58 | 33 | 25 | 0.02 | 27 | 10 | 1.00 |
CT | 51 | 29 | 21 | 24 | 10 | |||||
TT | 10 | 10 | 0 | 5 | 1 |
Gene | SNP | Alleles, Major > minor | MTXintolerant1 Allel count | MTXtolerant Allel count | OR (95% CI) | p | Chr. | Genomic position | Consequence | |
---|---|---|---|---|---|---|---|---|---|---|
Hepatic | ABCC2 | rs2273697 | G > A | 36 | 22 | 1.05 (0.61–1.80) | 0.87 | 10 | 99,804,058 | Missense |
Efflux | ABCC2 | rs37400662 | G > A | 58 | 35 | 1.15 (0.64–2.07) | 0.64 | 10 | 99,844,450 | Missense |
Transporter | ABCC2 | rs717620 | G > A | 29 | 23 | 0.77 (0.42–1.41) | 0.40 | 10 | 99,782,821 | 5’UTR variant |
ABCB1 | rs2032582 | G > T | 61 | 34 | 1.28 (0.73–2.24) | 0.39 | 7 | 87,531,302 | Missense | |
G > A | 3 | 2 | 0.96 (0.15–5.96) | 0.96 | ||||||
ABCB1 | rs1045642 | T > C | 62 | 42 | 0.88 (0.49–1.57) | 0.67 | 7 | 87,509,329 | Synonymous | |
Hepatic | SLCO1B1 | rs4149056 | T > C | 25 | 13 | 1.28 (0.62–2.66) | 0.51 | 12 | 21,178,615 | Missense |
Influx | SLCO1B1 | rs4149081 | G > A | 27 | 15 | 1.19 (0.59–2.43) | 0.62 | 12 | 21,225,087 | Intron variant |
Transporter | SLCO1B3 | rs2117032 | T > C | 52 | 34 | 0.97 (0.57–1.64) | 0.90 | 12 | 20,921,188 | Down stream 3’UTR |
SLC19A1 | rs10512662 | G > A | 64 | 38 | 1.20 (0.67–2.13) | 0.54 | 21 | 45,537,880 | Missense | |
Nausea | HTR3A | rs1062613 | C > T | 20 | 20 | 0.55 (0.27–1.14) | 0.11 | 11 | 113,975,284 | 5’UTR variant |
Receptor | HTR3A | rs1985242 | T > A | 36 | 32 | 0.58 (0.31–1.09) | 0.09 | 11 | 113,977,551 | 5’UTR variant |
HTR3A | rs1176713 | T > C | 27 | 22 | 0.74 (0.40–1.39) | 0.35 | 11 | 113,989,703 | Synonymous | |
HTR3B | rs1176744 | T > G | 52 | 27 | 1.36 (0.78–2.54) | 0.26 | 11 | 113,932,306 | Missense | |
MTHFR | MTHFR | rs18011312 | A > C | 44 | 34 | 0.77 (0.44–1.33) | 0.35 | 1 | 11,794,419 | Missense |
Enzyme | MTHFR | rs1801133 | C > T | 49 | 21 | 1.77 (0.96–3.28) | 0.07 | 1 | 11,796,321 | Missense |
Gene | SNP | Alleles, Major > minor | MTX-nausea1 Allel count | Controls Allel count | OR (95% CI) | p | Chr. | Genomic Position | Consequence | |
---|---|---|---|---|---|---|---|---|---|---|
Hepatic | ABCC2 | rs2273697 | G > A | 32 | 9 | 1.35 (0.64–2.84) | 0.44 | 10 | 99,804,058 | Missense |
Efflux | ABCC2 | rs37400662 | G > A | 43 | 16 | 1.05 (0.48–2.30) | 0.90 | 10 | 99,844,450 | Missense |
Transporter | ABCC2 | rs717620 | G > A | 24 | 9 | 1.00 (0.43–2.34) | 1.00 | 10 | 99,782,821 | 5’UTR variant |
ABCB1 | rs2032582 | G > T | 45 | 17 | 0.99 (0.46–2.10) | 0.94 | 7 | 87,531,302 | Missense | |
G > A | 3 | 2 | 0.54 (0.08–3.47) | 0.51 | ||||||
ABCB1 | rs1045642 | T > C | 50 | 19 | 0.97 (0.44–2.14) | 0.94 | 7 | 87,509,329 | Synonymous | |
Hepatic | SLCO1B1 | rs4149056 | T > C | 18 | 6 | 1.16 (0.41–3.31) | 0.78 | 12 | 21,178,615 | Missense |
Influx | SLCO1B1 | rs4149081 | G > A | 19 | 7 | 1.02 (0.37–2.80) | 0.96 | 12 | 21,225,087 | Intron variant |
Transporter | SLCO1B3 | rs2117032 | T > C | 43 | 14 | 1.20 (0.61–2.39) | 0.60 | 12 | 20,921,188 | Down stream 3’UTR |
SLC19A1 | rs10512662 | G > A | 48 | 18 | 1.04 (0.49–2.18) | 0.93 | 21 | 45,537,880 | Missense | |
Nausea | HTR3A | rs1062613 | C > T | 21 | 5 | 1.82 (0.60–5.47) | 0.29 | 11 | 113,975,284 | 5’UTR variant |
Receptor | HTR3A | rs1985242 | T > A | 36 | 9 | 1.85 (0.76–4.50) | 0.17 | 11 | 113,977,551 | 5’UTR variant |
HTR3A | rs1176713 | T > C | 25 | 5 | 2.03 (0.73–5.60) | 0.17 | 11 | 113,989,703 | Synonymous | |
HTR3B | rs1176744 | T > G | 37 | 14 | 0.99 (0.46–2.12) | 0.97 | 11 | 113,932,306 | Missense | |
MTHFR | MTHFR | rs18011312 | A > C | 41 | 13 | 1.30 (0.62–2.71) | 0.49 | 1 | 11,794,419 | Missense |
Enzyme | MTHFR | rs1801133 | C > T | 34 | 12 | 1.10 (0.49–2.45) | 0.82 | 1 | 11,796,321 | Missense |
Chr | Markers | Haplotype | F cases | F controls | Score | p-value | p-sim |
---|---|---|---|---|---|---|---|
1 | rs1801131-rs1801133 | A-C | 0.348 | 0.402 | −0.916 | 0.360 | 0.329 |
1 | rs1801131-rs1801133 | A-T | 0.340 | 0.228 | 1.852 | 0.064 | 0.06 |
1 | rs1801131-rs1801133 | C-C | 0.312 | 0.370 | −0.914 | 0.361 | 0.324 |
1 | rs1801131-rs1801133 | C-T | 0.000 | 0.000 | NA | NA | NA |
7 | rs1045642-rs2032582 | C-A | 0.021 | 0.022 | −0.048 | 0.962 | 1 |
7 | rs1045642-rs2032582 | C-G | 0.401 | 0.435 | −0.530 | 0.596 | 0.557 |
7 | rs1045642-rs2032582 | C-T | 0.008 | 0.000 | NA | NA | NA |
7 | rs1045642-rs2032582 | T-G | 0.154 | 0.174 | −0.432 | 0.666 | 0.694 |
7 | rs1045642-rs2032582 | T-T | 0.415 | 0.370 | 0.758 | 0.448 | 0.422 |
10 | rs717620-rs2273697-rs3740066 | A-A-A | 0.000 | 0.000 | NA | NA | NA |
10 | rs717620-rs2273697-rs3740066 | A-G-A | 0.201 | 0.250 | −0.852 | 0.394 | 0.427 |
10 | rs717620-rs2273697-rs3740066 | A-G-G | 0.000 | NA | NA | NA | NA |
10 | rs717620-rs2273697-rs3740066 | G-A-A | 0.023 | 0.018 | NA | NA | NA |
10 | rs717620-rs2273697-rs3740066 | G-A-G | 0.227 | 0.221 | 0.070 | 0.944 | 0.961 |
10 | rs717620-rs2273697-rs3740066 | G-G-A | 0.182 | 0.112 | 1.465 | 0.143 | 0.153 |
10 | rs717620-rs2273697-rs3740066 | G-G-G | 0.367 | 0.399 | −0.466 | 0.641 | 0.639 |
10 | rs717620-rs2273697 | A-A | 0.000 | 0.000 | NA | NA | NA |
10 | rs717620-rs2273697 | A-G | 0.201 | 0.250 | −0.852 | 0.394 | 0.36 |
10 | rs717620-rs2273697 | G-A | 0.250 | 0.239 | 0.168 | 0.867 | 0.84 |
10 | rs717620-rs2273697 | G-G | 0.549 | 0.511 | 0.537 | 0.591 | 0.572 |
10 | rs2273697-rs3740066 | A-A | 0.021 | 0.017 | NA | NA | NA |
10 | rs2273697-rs3740066 | A-G | 0.229 | 0.223 | 0.110 | 0.913 | 0.936 |
10 | rs2273697-rs3740066 | G-A | 0.386 | 0.364 | 0.376 | 0.707 | 0.732 |
10 | rs2273697-rs3740066 | G-G | 0.364 | 0.397 | −0.526 | 0.599 | 0.587 |
11 | rs1176744-rs1062613-rs1985242-rs1176713 | G-C-A-C | 0.071 | 0.043 | 0.558 | 0.577 | 0.569 |
11 | rs1176744-rs1062613-rs1985242-rs1176713 | G-C-T-T | 0.029 | 0.008 | NA | NA | NA |
11 | rs1176744-rs1062613-rs1985242-rs1176713 | G-T-A-T | 0.220 | 0.156 | 1.153 | 0.249 | 0.265 |
11 | rs1176744-rs1062613-rs1985242-rs1176713 | T-C-A-C | 0.041 | 0.035 | 0.066 | 0.948 | 0.972 |
11 | rs1176744-rs1062613-rs1985242-rs1176713 | T-C-T-T | 0.000 | 0.051 | NA | NA | NA |
11 | rs1176744-rs1062613-rs1985242-rs1176713 | T-T-A-C | 0.001 | NA | NA | NA | NA |
11 | rs1176744-rs1062613-rs1985242-rs1176713 | T-T-A-T | 0.029 | 0.063 | −1.030 | 0.303 | 0.287 |
11 | rs1176744-rs1062613-rs1985242 | G-C-A | NA | 0.016 | NA | NA | NA |
11 | rs1176744-rs1062613-rs1985242 | G-C-T | 0.513 | 0.496 | 0.406 | 0.685 | 0.693 |
11 | rs1176744-rs1062613-rs1985242 | G-T-A | 0.048 | 0.098 | −1.430 | 0.153 | 0.153 |
11 | rs1176744-rs1062613-rs1985242 | T-C-A | 0.034 | 0.034 | −1.283 | 0.199 | 0.142 |
11 | rs1176744-rs1062613-rs1985242 | T-C-T | 0.016 | NA | NA | NA | NA |
11 | rs1176744-rs1062613-rs1985242 | T-T-A | 0.097 | 0.054 | 0.822 | 0.411 | 0.397 |
11 | rs1176744-rs1062613-rs1985242 | T-T-T | 0.218 | 0.164 | 1.219 | 0.223 | 0.23 |
11 | rs1062613-rs1985242-rs1176713 | C-A-C | 0.045 | 0.075 | −1.052 | 0.293 | 0.276 |
11 | rs1062613-rs1985242-rs1176713 | C-A-T | 0.001 | NA | NA | NA | NA |
11 | rs1062613-rs1985242-rs1176713 | C-T-T | 0.030 | 0.077 | −1.331 | 0.183 | 0.186 |
11 | rs1062613-rs1985242-rs1176713 | T-A-C | 0.516 | 0.488 | 0.355 | 0.722 | 0.735 |
11 | rs1062613-rs1985242-rs1176713 | T-A-T | 0.078 | 0.142 | −1.947 | 0.052 | 0.054 |
11 | rs1062613-rs1985242-rs1176713 | T-T-T | 0.015 | NA | NA | NA | NA |
11 | rs1176744-rs1062613 | G-C | 0.099 | 0.106 | −0.190 | 0.849 | 0.862 |
11 | rs1176744-rs1062613 | G-T | 0.028 | 0.025 | 0.094 | 0.925 | 0.982 |
11 | rs1176744-rs1062613 | T-C | 0.734 | 0.652 | 1.486 | 0.137 | 0.129 |
11 | rs1176744-rs1062613 | T-T | 0.088 | 0.133 | −1.048 | 0.295 | 0.302 |
11 | rs1062613-rs1985242 | C-A | 0.034 | 0.084 | −1.688 | 0.091 | 0.126 |
11 | rs1062613-rs1985242 | C-T | 0.016 | 0.000 | NA | NA | NA |
11 | rs1062613-rs1985242 | T-A | 0.323 | 0.224 | 1.489 | 0.137 | 0.137 |
11 | rs1062613-rs1985242 | T-T | 0.038 | 0.070 | −0.848 | 0.396 | 0.379 |
11 | rs1985242-rs1176713 | A-C | 0.538 | 0.559 | −0.078 | 0.937 | 0.953 |
11 | rs1985242-rs1176713 | A-T | 0.101 | 0.148 | −1.663 | 0.096 | 0.098 |
11 | rs1985242-rs1176713 | T-C | 0.128 | 0.130 | −0.136 | 0.892 | 0.868 |
11 | rs1985242-rs1176713 | T-T | 0.734 | 0.652 | 1.488 | 0.137 | 0.126 |
12 | rs2117032-rs4149056-rs4149081 | C-C-A | 0.082 | 0.045 | 0.914 | 0.361 | 0.392 |
12 | rs2117032-rs4149056-rs4149081 | C-C-G | 0.000 | 0.000 | NA | NA | NA |
12 | rs2117032-rs4149056-rs4149081 | C-T-G | 0.279 | 0.325 | −0.596 | 0.551 | 0.554 |
12 | rs2117032-rs4149056-rs4149081 | C-T-T | 0.092 | 0.097 | 0.172 | 0.864 | 0.855 |
12 | rs2117032-rs4149056-rs4149081 | T-C-A | 0.014 | 0.022 | NA | NA | NA |
12 | rs2117032-rs4149056-rs4149081 | T-C-C | 0.533 | 0.512 | 0.162 | 0.872 | 0.895 |
12 | rs2117032-rs4149056-rs4149081 | T-T-G | 0.082 | 0.046 | 0.904 | 0.366 | 0.368 |
12 | rs2117032-rs4149056 | C-C | 0.279 | 0.324 | −0.593 | 0.553 | 0.566 |
12 | rs2117032-rs4149056 | C-T | 0.091 | 0.096 | 0.177 | 0.860 | 0.828 |
12 | rs2117032-rs4149056 | T-C | 0.547 | 0.535 | 0.039 | 0.969 | 0.984 |
12 | rs2117032-rs4149056 | T-T | 0.174 | 0.141 | 0.660 | 0.509 | 0.586 |
12 | rs4149056-rs4149081 | C-A | 0.014 | 0.022 | NA | NA | NA |
12 | rs4149056-rs4149081 | C-C | 0.813 | 0.837 | −0.490 | 0.624 | 0.681 |
12 | rs4149056-rs4149081 | C-G | 0.082 | 0.045 | 0.914 | 0.361 | 0.392 |
12 | rs4149056-rs4149081 | C-T | 0.000 | 0.000 | NA | NA | NA |
12 | rs4149056-rs4149081 | T-C | 0.279 | 0.325 | −0.596 | 0.551 | 0.554 |
12 | rs4149056-rs4149081 | T-G | 0.092 | 0.097 | 0.172 | 0.864 | 0.855 |
12 | rs4149056-rs4149081 | T-T | 0.014 | 0.022 | NA | NA | NA |
Chr | Markers | Haplotype | F cases | F controls | Score | p-value | p-sim |
---|---|---|---|---|---|---|---|
1 | rs1801131-rs1801133 | A-C | 0.321 | 0.405 | −1.067 | 0.286 | 0.333 |
1 | rs1801131-rs1801133 | A-T | 0.304 | 0.286 | 0.222 | 0.825 | 0.837 |
1 | rs1801131-rs1801133 | C-C | 0.376 | 0.310 | 0.730 | 0.465 | 0.523 |
1 | rs1801131-rs1801133 | C-T | 0.000 | 0.000 | NA | NA | NA |
7 | rs1045642-rs2032582 | C-A | 0.027 | 0.048 | NA | NA | NA |
7 | rs1045642-rs2032582 | C-G | 0.420 | 0.405 | 0.184 | 0.854 | 0.929 |
7 | rs1045642-rs2032582 | C-T | 0.000 | 0.000 | NA | NA | NA |
7 | rs1045642-rs2032582 | T-G | 0.152 | 0.143 | 0.144 | 0.886 | 0.917 |
7 | rs1045642-rs2032582 | T-T | 0.402 | 0.405 | −0.035 | 0.972 | 0.931 |
10 | rs717620-rs2273697-rs3740066 | A-A-A | 0.000 | NA | NA | NA | NA |
10 | rs717620-rs2273697-rs3740066 | A-A-G | 0.214 | 0.214 | 0.000 | 1.000 | 0.964 |
10 | rs717620-rs2273697-rs3740066 | A-G-A | 0.000 | NA | NA | NA | NA |
10 | rs717620-rs2273697-rs3740066 | G-A-A | 0.014 | 0.000 | NA | NA | NA |
10 | rs717620-rs2273697-rs3740066 | G-A-G | 0.272 | 0.214 | 0.735 | 0.463 | 0.478 |
10 | rs717620-rs2273697-rs3740066 | G-G-A | 0.159 | 0.167 | −0.011 | 0.991 | 0.977 |
10 | rs717620-rs2273697-rs3740066 | G-G-G | 0.341 | 0.405 | −0.802 | 0.423 | 0.385 |
10 | rs717620-rs2273697 | A-A | 0.000 | 0.000 | NA | NA | NA |
10 | rs717620-rs2273697 | A-G | 0.214 | 0.214 | 0.000 | 1.000 | 0.94 |
10 | rs717620-rs2273697 | G-A | 0.286 | 0.214 | 0.783 | 0.434 | 0.44 |
10 | rs717620-rs2273697 | G-G | 0.500 | 0.571 | −0.748 | 0.454 | 0.469 |
10 | rs2273697-rs3740066 | A-A | 0.013 | 0.000 | NA | NA | NA |
10 | rs2273697-rs3740066 | A-G | 0.273 | 0.214 | 0.706 | 0.480 | 0.534 |
10 | rs2273697-rs3740066 | G-A | 0.376 | 0.381 | −0.014 | 0.989 | 0.966 |
10 | rs2273697-rs3740066 | G-G | 0.338 | 0.405 | −0.791 | 0.429 | 0.397 |
11 | rs1176744-rs1062613-rs1985242-rs1176713 | G-C-A-C | 0.070 | 0.035 | 0.589 | 0.556 | 0.552 |
11 | rs1176744-rs1062613-rs1985242-rs1176713 | G-C-T-T | 0.030 | NA | NA | NA | NA |
11 | rs1176744-rs1062613-rs1985242-rs1176713 | G-T-A-T | 0.144 | 0.288 | −1.331 | 0.183 | 0.171 |
11 | rs1176744-rs1062613-rs1985242-rs1176713 | T-C-A-C | 0.060 | NA | 1.641 | 0.101 | 0.076 |
11 | rs1176744-rs1062613-rs1985242-rs1176713 | T-C-T-T | 0.026 | 0.010 | NA | NA | NA |
11 | rs1176744-rs1062613-rs1985242-rs1176713 | T-T-A-C | 0.035 | 0.064 | −0.373 | 0.709 | 0.78 |
11 | rs1176744-rs1062613-rs1985242-rs1176713 | T-T-A-T | 0.000 | 0.024 | NA | NA | NA |
11 | rs1176744-rs1062613-rs1985242 | G-C-A | NA | 0.000 | NA | NA | NA |
11 | rs1176744-rs1062613-rs1985242 | G-C-T | 0.534 | 0.470 | 0.151 | 0.880 | 0.87 |
11 | rs1176744-rs1062613-rs1985242 | G-T-A | 0.059 | 0.020 | 0.943 | 0.346 | 0.38 |
11 | rs1176744-rs1062613-rs1985242 | T-C-A | 0.042 | 0.060 | 0.086 | 0.931 | 0.917 |
11 | rs1176744-rs1062613-rs1985242 | T-C-T | NA | 0.0282 | NA | NA | NA |
11 | rs1176744-rs1062613-rs1985242 | T-T-A | 0.098 | 0.034 | 1.044 | 0.297 | 0.281 |
11 | rs1176744-rs1062613-rs1985242 | T-T-T | 0.144 | 0.299 | −1.300 | 0.194 | 0.197 |
11 | rs1062613-rs1985242-rs1176713 | C-A-C | 0.089 | 0.000 | 1.273 | 0.203 | 0.234 |
11 | rs1062613-rs1985242-rs1176713 | C-T-C | 0.036 | 0.089 | −0.798 | 0.425 | 0.455 |
11 | rs1062613-rs1985242-rs1176713 | C-T-T | 0.535 | 0.459 | 0.128 | 0.898 | 0.898 |
11 | rs1062613-rs1985242-rs1176713 | T-A-C | 0.099 | 0.091 | 0.893 | 0.372 | 0.4 |
11 | rs1062613-rs1985242-rs1176713 | T-A-T | NA | 0.028 | NA | NA | NA |
11 | rs1062613-rs1985242-rs1176713 | T-T-T | 0.104 | 0.099 | 0.184 | 0.854 | 0.864 |
11 | rs1176744-rs1062613 | G-C | 0.030 | 0.025 | NA | NA | NA |
11 | rs1176744-rs1062613 | G-T | NA | 0.000 | NA | NA | NA |
11 | rs1176744-rs1062613 | T-C | 0.679 | 0.757 | −1.075 | 0.282 | 0.255 |
11 | rs1176744-rs1062613 | T-T | 0.119 | 0.020 | 1.760 | 0.078 | 0.09 |
11 | rs1062613-rs1985242 | C-A | 0.068 | 0.070 | −0.053 | 0.958 | 0.997 |
11 | rs1062613-rs1985242 | C-T | 0.000 | 0.028 | NA | NA | NA |
11 | rs1062613-rs1985242 | T-A | 0.252 | 0.333 | −0.579 | 0.563 | 0.564 |
11 | rs1062613-rs1985242 | T-T | 0.078 | 0.000 | 1.293 | 0.196 | 0.162 |
11 | rs1985242-rs1176713 | A-C | 0.560 | 0.548 | −0.264 | 0.792 | 0.802 |
11 | rs1985242-rs1176713 | A-T | 0.109 | 0.119 | 0.494 | 0.621 | 0.592 |
11 | rs1985242-rs1176713 | T-C | 0.134 | 0.124 | 0.256 | 0.798 | 0.826 |
11 | rs1985242-rs1176713 | T-T | 0.679 | 0.757 | −1.072 | 0.284 | 0.241 |
12 | rs2117032-rs4149056-rs4149081 | C-C-A | 0.105 | 0.000 | 1.143 | 0.253 | 0.26 |
12 | rs2117032-rs4149056-rs4149081 | C-C-G | 0.279 | 0.333 | 0.009 | 0.993 | 0.978 |
12 | rs2117032-rs4149056-rs4149081 | C-T-G | 0.056 | 0.143 | −0.827 | 0.408 | 0.419 |
12 | rs2117032-rs4149056-rs4149081 | T-C-A | 0.009 | 0.024 | NA | NA | NA |
12 | rs2117032-rs4149056-rs4149081 | T-T-G | 0.551 | 0.500 | −0.041 | 0.968 | 0.968 |
12 | rs2117032-rs4149056 | C-C | 0.105 | 0.000 | 1.135 | 0.256 | 0.257 |
12 | rs2117032-rs4149056 | C-T | 0.279 | 0.333 | 0.011 | 0.991 | 0.96 |
12 | rs2117032-rs4149056 | T-C | 0.056 | 0.143 | −0.824 | 0.410 | 0.5 |
12 | rs2117032-rs4149056 | T-T | 0.560 | 0.524 | −0.200 | 0.841 | 0.843 |
12 | rs4149056-rs4149081 | C-A | 0.161 | 0.143 | 0.285 | 0.776 | 0.617 |
12 | rs4149056-rs4149081 | C-G | 0.009 | 0.024 | NA | NA | NA |
12 | rs4149056-rs4149081 | T-G | 0.830 | 0.833 | −0.047 | 0.963 | 0.869 |