Background
Methods
Enrolment procedures
Follow up period
Data analysis
Results
Participants’ enrollment and demographic characteristics
Characteristics | HIV-infected Number: (%): or Median [IQR] N = 49 | HIV-uninfected Number: (%): or Median [IQR] N = 476 | P- Value |
---|---|---|---|
Male gender | 30 (61.2%) | 286 (60.1%) | 0.877 |
Age (in months) | 23 [9–27] | 29 [15–60] | <0.001 |
Residence | |||
Mwanza region | 41 (83.7%) | 363 (76.3%) | 0.241 |
Out of Mwanza region | 8(16.3%) | 113 (23.7%) | |
Caregiver's level of education | |||
≤ 7 years in school | 7 (14.3%) | 82 (17.2%) | 0.601 |
> 7 years in school | 42 (85.7%) | 394 (82.8%) | |
Vital status of parents | |||
Parents alive | 40 (81.6%) | 447 (93.9%) | 0.002 |
One or both parents deceased | 9 (18.4%) | 29 (6.1%) | |
Mother's HIV status during pregnancy or delivery | |||
HIV negative | 8 (16.3%) | 307 (64.5%) | < 0.001 |
HIV positive | 14 (28.6%) | 16 (3.4%) | |
Unknown HIV status | 27 (55.1%) | 153 (32.1%) | |
HIV-infected mothers who received HAART during pregnancy | 6/14 (42.9%) | 14/16 (87.5%) | 0.01 |
Breastfeeding status | |||
Never breastfed | 1 (2%) | 5 (1.1%) | 0.609 |
Still breastfeeding | 16 (32.7%) | 124 (26.0%) | |
Stopped breastfeeding < 3 months ago | 5 (10.2%) | 41 (8.6%) | |
Stopped breastfeeding > 3 months ago | 27 (55.1%) | 306 (64.3%) | |
Previous admissions | 31 (63.3%) | 226 (47.5%) | 0.035 |
Number of previous admissions | 2 [2–4] | 2 [1–3] | 0.05 |
History of HIV testing | 23 (46.9%) | 93 (19.5%) | < 0.001 |
Patient HIV status before enrollment | |||
Confirmed HIV positive | 16 (32.6%) | 0 (0.0%) | < 0.001 |
HIV exposed not confirmed | 9 (18.4%) | 8 (1.7%) | |
Unknown | 24 (49.0%) | 468 (98.3%) |
Prevalence and characteristics of participants with and without HIV infection
Characteristics | HIV-infected Number (%) or Median [IQR] N = 49 | HIV-uninfected Number: (%): or Median [IQR] N = 476 | P-Value |
---|---|---|---|
Presenting symptoms and signs | |||
Fever | 36 (73.5%) | 333 (70.0%) | 0.609 |
Cough | 26 (53.1%) | 173 (36.3%) | 0.022 |
Difficulty in breathing | 14 (28.6%) | 110 (23.1%) | 0.391 |
Weight loss | 25 (51.0%) | 119 (25.0%) | < 0.001 |
Lethargy | 3 (6.1%) | 28 (5.9%) | 0.946 |
Diarrhea | 17 (34.7%) | 127 (26.7%) | 0.231 |
Oral thrush | 30 (61.2%) | 17 (3.6%) | < 0.001 |
Lymphadenopathy | 8 (16.3%) | 13 (2.7%) | < 0.001 |
Hepatomegaly | 8 (16.3%) | 42 (8.8%) | 0.088 |
Splenomegaly | 5 (10.2%) | 35 (7.4%) | 0.474 |
Vital signs | |||
Temperature (OC) | 37 [36.7–37.8] | 37 [36.5–38.0] | 0.98 |
Pulse rate | 120 [102–149] | 119 [102–134] | 0.282 |
Respiratory rate | 36 [30–56] | 34[26–44] | 0.028 |
Acute Malnutrition | |||
None | 6 (12.2%) | 219 (46%) | < 0.001 |
Mild | 0 (0.0%) | 79 (16.6%) | |
Moderate | 7 (14.3%) | 74 (15.6%) | |
Severe | 36 (73.5%) | 104 (21.8%) | |
Stunting | |||
None | 7 (15.6%) | 170 (45.6%) | < 0.001 |
Mild | 7 (15.6%) | 119 (31.9%) | |
Moderate | 9 (20.0%) | 53 (14.2%) | |
Severe | 22 (48.9%) | 31 (8.3%) |
Variable | Number (%) |
---|---|
HIV diagnostic test results | |
Positive HIV determine test (N = 509) | 43 (8.4%) |
Positive HIV Unigold test (N = 43) | 16 (37.2%) |
Positive HIV DNA PCR (N = 43) | 17 (39.5%) |
WHO HIV/AIDS clinical stage (N = 49) | |
Stage III | 10 (20.4%) |
Stage IV | 39 (79.6%) |
Low CD4 count (N = 49) | 41 (83.7%) |
Factors associated with HIV infection
Variable Number: (%): or Median [IQR] | HIV- infected (n = 49) | HIV- uninfected (n = 476) | OR [95% CI] (Univariable) | p-value | OR[95% CI] (Multivariable) | p-value | |
---|---|---|---|---|---|---|---|
Male gender | 30 (61.2%) | 286 | (60.1%) | 1.05 [0.57–1.92] | 0.88 | ||
Age in categories | |||||||
1–24 months | 32 (65.3%) | 186 (39.1%) | 2.93 [1.58–5.44] | 0.001 | 1.66 [0.64–4.27] | 0.294 | |
25–59 months | 12 (24.5%) | 170 (35.7%) | 0.58 [0.30–1.15] | 0.119 | |||
> 60 months | 5 (10.2%) | 120 (25.2%) | 0.34 [0.13–0.87] | 0.025 | 0.75 [0.19–2.97] | 0.683 | |
Place of residence | |||||||
Other than Mwanza | 8 (16.3%) | 113 (23.7%) | 1 | 1 | |||
Mwanza | 41 (83.7%) | 363 (76.3%) | 1.60 [0.73–3.50] | 0.24 | |||
Caregiver's level of education | |||||||
> 7 years in school | 7 (14.3%) | 82 (17.2%) | 1 | 1 | |||
≤ 7 years in school | 42 (85.7%) | 394 (82.8%) | 1.25 [0.54–2.88] | 0.602 | |||
Vital status of parents | |||||||
Parents are alive | 40(81.6%) | 447 (93.9%) | 1 | 1 | |||
One or both parents are deceased | 9 (18.4%) | 29 (6.1%) | 3.47 [1.54–7.83] | 0.003 | 3.62 [1.10–11.87] | 0.034 | |
HIV-infected mothers who received HAARTduring pregnancy | 6/14 (42.9%) | 14 /16(87.5%) | 0.11 [0.02–0.66] | 0.016* | |||
Previous admission | 31 (63.3%) | 226 (47.5%) | 1.91 [1.04–3.50] | 0.038 | 1.38 [0.60–3.13] | 0.446 | |
Number of previous Admissions | 2 [2–4] | 2 [1–3] | 1.15 [0.93–1.42] | 0.19 | |||
Breastfeeding (in last 3 months) | 21 (42.9%) | 165 (34.7%) | 1.41 [0.78–2.57] | 0.26 | |||
Presenting symptoms and signs | |||||||
Fever | 36 (73.5%) | 333 (70.0%) | 1.194 [0.61–2.31] | 0.609 | |||
Cough | 26 (53.1%) | 173 (36.3%) | 1.98 [1.10–3.58] | 0.024 | 2.40 [1.08–5.31] | 0.031 | |
Difficulty in breathing | 14 (28.6%) | 110 (23.1%) | 1.33 [0.69–2.56] | 0.39 | |||
Weight loss | 25 (51.0%) | 119 (25.0%) | 3.13 [1.72–5.68] | < 0.001 | 0.65 [0.26–1.60] | 0.346 | |
Lethargy | 3 (6.1%) | 28 (5.9%) | 1.04 [0.31–3.57] | 0.95 | |||
Diarrhea | 17 (34.7%) | 127 (26.7%) | 1.46 [0.78–2.72] | 0.23 | |||
Oral thrush | 30 (61.2%) | 17 (3.6%) | 42.6 [20.1–90.4] | < 0.001 | 20.06[8.29–48.52] | < 0.001 | |
Lymphadenopathy | 8 (16.3%) | 13 (2.7%) | 6.95 [2.72–17.73] | < 0.001 | 5.61 [1.06–29.56] | 0.042 | |
Hepatomegaly | 8 (16.3%) | 42 (8.8%) | 2.02 [0.89–4.58] | 0.09 | |||
Splenomegaly | 5 (10.2%) | 35 (7.4%) | 1.43 [0.53–3.84] | 0.48 | |||
Acute Malnutrition | |||||||
None | 6 (12.2%) | 219 (46%) | 1 | 1 | |||
Milda | 0 (0.0%) | 79 (16.6%) | (-) | (-) | |||
Moderate | 7 (14.3%) | 74 (15.6%) | 3.45 [1.12–10.60] | 0.03 | 2.97 [0.80–10.99] | 0.102 | |
Severe | 36 (73.5%) | 104 (21.8%) | 12.6 [5.16–30.93] | < 0.001 | 6.78 [2.28–20.12] | 0.001 | |
Stunting | |||||||
None | 7 (15.6%) | 170 (45.6%) | 1 | 1 | |||
Mild | 7 (15.6%) | 119 (31.9%) | 1.43 [0.49–4.18] | 0.56 | |||
Moderate | 9 (20.0%) | 53 (14.2%) | 4.12 [1.47–11.61] | 0.007 | 2.90 [0.82–10.17] | 0.097 | |
Severe | 22 (48.9%) | 31 (8.3%) | 17.24 [6.78–43.80] | < 0.001 | 9.09 [2.80–29.53] | < 0.001 |