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30.06.2023 | Original Article

Point shear-wave elastography for the diagnosis of veno-occlusive disease in children and young adults

verfasst von: Teresa Cañas, Olga Suárez, Isabel Rozas, Marta Escribano, Blanca Molina, Marta González-Vicent, Araceli Maciá

Erschienen in: Pediatric Radiology | Ausgabe 10/2023

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Abstract

Background

Hepatic veno-occlusive disease or sinusoidal obstruction syndrome is a potentially life-threatening complication of hematopoietic stem cell transplantation.

Objective

To assess the usefulness of point shear-wave elastography (pSWE) for the early diagnosis of sinusoidal obstruction syndrome (SOS) in children.

Materials and methods

A retrospective study was carried out in 43 patients with suspected SOS assessed between March 2018 and November 2021. Diagnosis of SOS was confirmed in 28 patients based on the European Society for Blood and Marrow Transplantation diagnostic criteria. Abdominal ultrasound and pSWE of the liver were performed before and after hematopoietic stem cell transplantation on first suspicion of SOS.

Results

Liver stiffness on initial suspicion was higher in patients diagnosed with SOS and these values increased compared to the pre-transplantation values. A cutoff value of 1.37 m/s was found for the diagnosis of SOS, with an area under the curve of 0.779 (95% CI 0.61–0.93).

Conclusion

Point shear wave elastography of the liver is a promising technique for the early diagnosis of pediatric SOS.

Graphical abstract

Mahadeo KM, Bajwa R, Abdel-Azim H et al (2020) Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network and the Pediatric Diseases Working Party of the European Society for Blood and Marrow Transplantation. Diagnosis, grading, and treatment recommendations for children, adolescents, and young adults with sinusoidal obstructive syndrome: an international expert position statement. Lancet Haematol 7:61–72CrossRef

Coppell JA, Richardson PG, Soiffer R et al (2010) Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome. Biol Blood Marrow Transplant 16:157–168CrossRefPubMed

Corbacioglu S, Greil J, Peters C et al (2004) Defibrotide in the treatment of children with veno-occlusive disease (VOD): a retrospective multicentre study demonstrates therapeutic efficacy upon early intervention. Bone Marrow Transplant 33:189–195CrossRefPubMed

Corbacioglu S, Carreras E, Ansari M et al (2018) Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in pediatric patients: a new classification from the European society for blood and marrow transplantation. Bone Marrow Transplant 53):138–145

Lassau N, Leclère J, Auperin A et al (1997) Hepatic veno-occlusive disease after myeloablative treatment and bone marrow transplantation: value of gray-scale and Doppler US in 100 patients. Radiology 204:545–552CrossRefPubMed

Nishida M, Kahata K, Hayase E et al (2018) Novel ultrasonographic scoring system of sinusoidal obstruction syndrome after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 24:1896–1900CrossRefPubMed

Bohte AE, Dierselhuis MP, van Noesel MM, Lequin MH (2022) Imaging features of hepatic sinusoidal obstruction syndrome or veno-occlusive disease in children. Pediatr Radiol 52:122–133CrossRefPubMed

Bamber J, Cosgrove D, Dietrich CF et al (2013) EFSUMB guidelines and recommendations on the clinical use of ultrasound elastography. Part 1: Basic principles and technology. Ultraschall Med 34:169–84

Dietrich CF, Bamber J, Berzigotti A et al (2017) EFSUMB guidelines and recommendations on the clinical use of liver ultrasound elastography, Update 2017 (Long Version) Ultraschall Med 38:e16-e47

10.

Chan SS, Colecchia A, Duarte RF et al (2020) Imaging in hepatic veno-occlusive disease/sinusoidal obstruction syndrome. Biol Blood Marrow Transplant 26:1770–1779CrossRefPubMed

11.

Reddivalla N, Robinson AL, Reid KJ et al (2020) Using liver elastography to diagnose sinusoidal obstruction syndrome in pediatric patients undergoing hematopoetic stem cell transplant. Bone Marrow Transplant 55:523–530CrossRefPubMed

12.

Colecchia A, Marasco G, Ravaioli F et al (2017) Usefulness of liver stiffness measurement in predicting hepatic veno-occlusive disease development in patients who undergo HSCT. Bone Marrow Transplant 52:494–49713CrossRefPubMed

13.

Zama D, Bossù G, Ravaioli F et al (2019) Longitudinal evaluation of liver stiffness in three pediatric patients with veno-occlusive disease. Pediatr Transplant 23:e13456CrossRefPubMed

14.

Konuş OL, Ozdemir A, Akkaya A et al (1998) Normal liver, spleen, and kidney dimensions in neonates, infants, and children: evaluation with sonography. AJR Am J Roentgenol 171:1693–1698CrossRefPubMed

15.

Ferraioli G, Wong VW, Castera L et al (2018) Liver ultrasound elastography: an Update to the World Federation for Ultrasound in Medicine and Biology Guidelines and Recommendations. Ultrasound Med Biol 44:2419–2440CrossRefPubMed

16.

Fontanilla T, Cañas T, Macia A et al (2014) Normal values of liver shear wave velocity in healthy children assessed by acoustic radiation force impulse imaging using a convex probe and a linear probe. Ultrasound Med Biol 40:470–477CrossRefPubMed

17.

Fontanilla T, Hernando CG, Claros JC et al (2011) Acoustic radiation force impulse elastography and contrast-enhanced sonography of sinusoidal obstructive syndrome (veno-occlusive disease): preliminary results. J Ultrasound Med 30:1593–1598CrossRefPubMed

Titel: Point shear-wave elastography for the diagnosis of veno-occlusive disease in children and young adults
verfasst von: Teresa Cañas
Olga Suárez
Isabel Rozas
Marta Escribano
Blanca Molina
Marta González-Vicent
Araceli Maciá
Publikationsdatum: 30.06.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Radiology / Ausgabe 10/2023
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-023-05703-9

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Point shear-wave elastography for the diagnosis of veno-occlusive disease in children and young adults