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2019 | OriginalPaper | Buchkapitel

9. Plasmazellneoplasien

verfasst von : Prof. Dr. Falko Fend

Erschienen in: Pathologie

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Plasmazellneoplasien zählen zu den häufigsten hämatologischen Tumoren und Indikationen einer Knochenmarkbiopsie. Die in der WHO Klassifikation gelisteten Entitäten unterscheiden sich in ihrem morphologischen, immunhistochemischen und genetischen Profil und in ihren prognostischen Parametern. Die monoklonale Gammopathie unklarer Signifikanz, die große Gruppe des multiplen Myeloms und dessen Sonderformen, das seltene solitäre Plasmozytom des Knochens, das extramedulläre solitäre Plasmozytom und das osteosklerotische Plasmozytom, werden in Diagnose und Differenzialdiagnose nach den aktuellen pathogenetischen Kriterien dargestellt.
Literatur
1.
Zurück zum Zitat International Myeloma Working Group (2003) Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol 121:749–757CrossRef International Myeloma Working Group (2003) Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol 121:749–757CrossRef
2.
Zurück zum Zitat Aguilera NS, Kapadia SB, Nalesnik MA, Swerdlow SH (1995) Extramedullary plasmacytoma of the head and neck: use of paraffin sections to assess clonality with in situ hybridization, growth fraction, and the presence of Epstein-Barr virus. Mod Pathol 8:503–508PubMed Aguilera NS, Kapadia SB, Nalesnik MA, Swerdlow SH (1995) Extramedullary plasmacytoma of the head and neck: use of paraffin sections to assess clonality with in situ hybridization, growth fraction, and the presence of Epstein-Barr virus. Mod Pathol 8:503–508PubMed
3.
Zurück zum Zitat Alexiou C, Kau RJ, Dietzfelbinger H et al (1999) Extramedullary plasmacytoma: tumor occurrence and therapeutic concepts. Cancer 85:2305–2314PubMedCrossRef Alexiou C, Kau RJ, Dietzfelbinger H et al (1999) Extramedullary plasmacytoma: tumor occurrence and therapeutic concepts. Cancer 85:2305–2314PubMedCrossRef
4.
Zurück zum Zitat Avet-Loiseau H, Daviet A, Brigaudeau C et al (2001) Cytogenetic, interphase, and multicolor fluorescence in situ hybridization analyses in primary plasma cell leukemia: a study of 40 patients at diagnosis, on behalf of the Intergroupe Francophone du Myelome and the Groupe Francais de Cytogenetique Hematologique. Blood 97:822–825PubMedCrossRef Avet-Loiseau H, Daviet A, Brigaudeau C et al (2001) Cytogenetic, interphase, and multicolor fluorescence in situ hybridization analyses in primary plasma cell leukemia: a study of 40 patients at diagnosis, on behalf of the Intergroupe Francophone du Myelome and the Groupe Francais de Cytogenetique Hematologique. Blood 97:822–825PubMedCrossRef
5.
Zurück zum Zitat Avet-Loiseau H, Garand R, Lode L, Harousseau JL, Bataille R (2003) Translocation t(11;14)(q13;q32) is the hallmark of IgM, IgE, and nonsecretory multiple myeloma variants. Blood 101:1570–1571PubMedCrossRef Avet-Loiseau H, Garand R, Lode L, Harousseau JL, Bataille R (2003) Translocation t(11;14)(q13;q32) is the hallmark of IgM, IgE, and nonsecretory multiple myeloma variants. Blood 101:1570–1571PubMedCrossRef
6.
Zurück zum Zitat Avet-Loiseau H, Gerson F, Magrangeas F et al (2001) Rearrangements of the c-myc oncogene are present in 15 % of primary human multiple myeloma tumors. Blood 98:3082–3086PubMedCrossRef Avet-Loiseau H, Gerson F, Magrangeas F et al (2001) Rearrangements of the c-myc oncogene are present in 15 % of primary human multiple myeloma tumors. Blood 98:3082–3086PubMedCrossRef
7.
Zurück zum Zitat Bakkus MH, Heirman C, Van Riet I, Van Camp B, Thielemans K (1992) Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation. Blood 80:2326–2335PubMed Bakkus MH, Heirman C, Van Riet I, Van Camp B, Thielemans K (1992) Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation. Blood 80:2326–2335PubMed
8.
Zurück zum Zitat Bannas P, Kroger N, Adam G, Derlin T (2013) Modern imaging techniques in patients with multiple myeloma. Rofo 185:26–33PubMedCrossRef Bannas P, Kroger N, Adam G, Derlin T (2013) Modern imaging techniques in patients with multiple myeloma. Rofo 185:26–33PubMedCrossRef
9.
Zurück zum Zitat Bardwick PA, Zvaifler NJ, Gill GN et al (1980) Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes: the POEMS syndrome. Report on two cases and a review of the literature. Medicine (Baltimore) 59:311–322CrossRef Bardwick PA, Zvaifler NJ, Gill GN et al (1980) Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes: the POEMS syndrome. Report on two cases and a review of the literature. Medicine (Baltimore) 59:311–322CrossRef
10.
Zurück zum Zitat Bartl R, Frisch B, Burkhardt R et al (1982) Bone marrow histology in myeloma: its importance in diagnosis, prognosis, classification and staging. Br J Haematol 51:361–375PubMedCrossRef Bartl R, Frisch B, Burkhardt R et al (1982) Bone marrow histology in myeloma: its importance in diagnosis, prognosis, classification and staging. Br J Haematol 51:361–375PubMedCrossRef
11.
Zurück zum Zitat Bartl R, Frisch B, Fateh-Moghadam A et al (1987) Histologic classification and staging of multiple myeloma. A retrospective and prospective study of 674 cases. Am J Clin Pathol 87:342–355PubMedCrossRef Bartl R, Frisch B, Fateh-Moghadam A et al (1987) Histologic classification and staging of multiple myeloma. A retrospective and prospective study of 674 cases. Am J Clin Pathol 87:342–355PubMedCrossRef
12.
Zurück zum Zitat Beck RC, Tubbs RR, Hussein M, Pettay J, Hsi ED (2003) Automated colorimetric in situ hybridization (CISH) detection of immunoglobulin (Ig) light chain mRNA expression in plasma cell (PC) dyscrasias and non-Hodgkin lymphoma. Diagn Mol Pathol 12:14–20PubMedCrossRef Beck RC, Tubbs RR, Hussein M, Pettay J, Hsi ED (2003) Automated colorimetric in situ hybridization (CISH) detection of immunoglobulin (Ig) light chain mRNA expression in plasma cell (PC) dyscrasias and non-Hodgkin lymphoma. Diagn Mol Pathol 12:14–20PubMedCrossRef
13.
Zurück zum Zitat Berenson JR, Anderson KC, Audell RA et al (2010) Monoclonal gammopathy of undetermined significance: a consensus statement. Br J Haematol 150:28–38PubMed Berenson JR, Anderson KC, Audell RA et al (2010) Monoclonal gammopathy of undetermined significance: a consensus statement. Br J Haematol 150:28–38PubMed
14.
Zurück zum Zitat Bergsagel PL, Chesi M, Nardini E et al (1996) Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma. Proc Natl Acad Sci Usa 93:13931–13936PubMedCrossRefPubMedCentral Bergsagel PL, Chesi M, Nardini E et al (1996) Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma. Proc Natl Acad Sci Usa 93:13931–13936PubMedCrossRefPubMedCentral
15.
Zurück zum Zitat Bergsagel PL, Kuehl WM (2005) Molecular pathogenesis and a consequent classification of multiple myeloma. J Clin Oncol 23:6333–6338PubMedCrossRef Bergsagel PL, Kuehl WM (2005) Molecular pathogenesis and a consequent classification of multiple myeloma. J Clin Oncol 23:6333–6338PubMedCrossRef
16.
Zurück zum Zitat Bergsagel PL, Kuehl WM, Zhan F et al (2005) Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Blood 106:296–303PubMedPubMedCentralCrossRef Bergsagel PL, Kuehl WM, Zhan F et al (2005) Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Blood 106:296–303PubMedPubMedCentralCrossRef
17.
Zurück zum Zitat Bink K, Haralambieva E, Kremer M et al (2008) Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics. Haematologica 93:623–626PubMedCrossRef Bink K, Haralambieva E, Kremer M et al (2008) Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics. Haematologica 93:623–626PubMedCrossRef
18.
Zurück zum Zitat Blade J, Fernandez de Larrea C, Rosinol L et al (2011) Soft-tissue plasmacytomas in multiple myeloma: incidence, mechanisms of extramedullary spread, and treatment approach. J Clin Oncol 29:3805–3812PubMedCrossRef Blade J, Fernandez de Larrea C, Rosinol L et al (2011) Soft-tissue plasmacytomas in multiple myeloma: incidence, mechanisms of extramedullary spread, and treatment approach. J Clin Oncol 29:3805–3812PubMedCrossRef
19.
Zurück zum Zitat Boll M, Parkins E, O’Connor SJ, Rawstron AC, Owen RG (2010) Extramedullary plasmacytoma are characterized by a ‘myeloma-like’ immunophenotype and genotype and occult bone marrow involvement. Br J Haematol 151:525–527PubMedCrossRef Boll M, Parkins E, O’Connor SJ, Rawstron AC, Owen RG (2010) Extramedullary plasmacytoma are characterized by a ‘myeloma-like’ immunophenotype and genotype and occult bone marrow involvement. Br J Haematol 151:525–527PubMedCrossRef
20.
Zurück zum Zitat Brouet JC, Fermand JP, Laurent G et al (1985) The association of chronic lymphocytic leukaemia and multiple myeloma: a study of eleven patients. Br J Haematol 59:55–66PubMedCrossRef Brouet JC, Fermand JP, Laurent G et al (1985) The association of chronic lymphocytic leukaemia and multiple myeloma: a study of eleven patients. Br J Haematol 59:55–66PubMedCrossRef
21.
Zurück zum Zitat Brunning RD, McKenna RW (1994) Tumors of the bone marrow. AFIP, Washington D.C. Brunning RD, McKenna RW (1994) Tumors of the bone marrow. AFIP, Washington D.C.
22.
Zurück zum Zitat Chang ST, Liao YL, Lu CL, Chuang SS, Li CY (2007) Plasmablastic cytomorphologic features in plasma cell neoplasms in immunocompetent patients are significantly associated with EBV. Am J Clin Pathol 128:339–344PubMedCrossRef Chang ST, Liao YL, Lu CL, Chuang SS, Li CY (2007) Plasmablastic cytomorphologic features in plasma cell neoplasms in immunocompetent patients are significantly associated with EBV. Am J Clin Pathol 128:339–344PubMedCrossRef
24.
Zurück zum Zitat Chesi M, Nardini E, Brents LA et al (1997) Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nat Genet 16:260–264PubMedPubMedCentralCrossRef Chesi M, Nardini E, Brents LA et al (1997) Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nat Genet 16:260–264PubMedPubMedCentralCrossRef
25.
Zurück zum Zitat Chiecchio L, Dagrada GP, White HE et al (2009) Frequent upregulation of MYC in plasma cell leukemia. Genes Chromosomes Cancer 48:624–636PubMedCrossRef Chiecchio L, Dagrada GP, White HE et al (2009) Frequent upregulation of MYC in plasma cell leukemia. Genes Chromosomes Cancer 48:624–636PubMedCrossRef
26.
Zurück zum Zitat Chng WJ, Huang GF, Chung TH et al (2011) Clinical and biological implications of MYC activation: a common difference between MGUS and newly diagnosed multiple myeloma. Leukemia 25:1026–1035PubMedPubMedCentralCrossRef Chng WJ, Huang GF, Chung TH et al (2011) Clinical and biological implications of MYC activation: a common difference between MGUS and newly diagnosed multiple myeloma. Leukemia 25:1026–1035PubMedPubMedCentralCrossRef
27.
Zurück zum Zitat Colomo L, Loong F, Rives S et al (2004) Diffuse large B-cell lymphomas with plasmablastic differentiation represent a heterogeneous group of disease entities. Am J Surg Pathol 28:736–747PubMedCrossRef Colomo L, Loong F, Rives S et al (2004) Diffuse large B-cell lymphomas with plasmablastic differentiation represent a heterogeneous group of disease entities. Am J Surg Pathol 28:736–747PubMedCrossRef
28.
Zurück zum Zitat Cook JR, Hsi ED, Worley S, Tubbs RR, Hussein M (2006) Immunohistochemical analysis identifies two cyclin D1+ subsets of plasma cell myeloma, each associated with favorable survival. Am J Clin Pathol 125:615–624PubMedCrossRef Cook JR, Hsi ED, Worley S, Tubbs RR, Hussein M (2006) Immunohistochemical analysis identifies two cyclin D1+ subsets of plasma cell myeloma, each associated with favorable survival. Am J Clin Pathol 125:615–624PubMedCrossRef
29.
Zurück zum Zitat Costes V, Magen V, Legouffe E et al (1999) The Mi15 monoclonal antibody (anti-syndecan-1) is a reliable marker for quantifying plasma cells in paraffin-embedded bone marrow biopsy specimens. Hum Pathol 30:1405–1411PubMedCrossRef Costes V, Magen V, Legouffe E et al (1999) The Mi15 monoclonal antibody (anti-syndecan-1) is a reliable marker for quantifying plasma cells in paraffin-embedded bone marrow biopsy specimens. Hum Pathol 30:1405–1411PubMedCrossRef
30.
Zurück zum Zitat Dao LN, Hanson CA, Dispenzieri A et al (2011) Bone marrow histopathology in POEMS syndrome: a distinctive combination of plasma cell, lymphoid, and myeloid findings in 87 patients. Blood 117:6438–6444PubMedPubMedCentralCrossRef Dao LN, Hanson CA, Dispenzieri A et al (2011) Bone marrow histopathology in POEMS syndrome: a distinctive combination of plasma cell, lymphoid, and myeloid findings in 87 patients. Blood 117:6438–6444PubMedPubMedCentralCrossRef
31.
Zurück zum Zitat Delecluse HJ, Anagnostopoulos I, Dallenbach F et al (1997) Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. Blood 89:1413–1420PubMed Delecluse HJ, Anagnostopoulos I, Dallenbach F et al (1997) Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. Blood 89:1413–1420PubMed
33.
Zurück zum Zitat Dispenzieri A (2014) POEMS syndrome: 2014 update on diagnosis, risk-stratification, and management. Am J Hematol 89:214–223PubMedCrossRef Dispenzieri A (2014) POEMS syndrome: 2014 update on diagnosis, risk-stratification, and management. Am J Hematol 89:214–223PubMedCrossRef
34.
Zurück zum Zitat Durie BG, Salmon SE (1975) A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer 36:842–854PubMedCrossRef Durie BG, Salmon SE (1975) A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer 36:842–854PubMedCrossRef
35.
Zurück zum Zitat Ely SA, Knowles DM (2002) Expression of CD56/neural cell adhesion molecule correlates with the presence of lytic bone lesions in multiple myeloma and distinguishes myeloma from monoclonal gammopathy of undetermined significance and lymphomas with plasmacytoid differentiation. Am J Pathol 160:1293–1299PubMedPubMedCentralCrossRef Ely SA, Knowles DM (2002) Expression of CD56/neural cell adhesion molecule correlates with the presence of lytic bone lesions in multiple myeloma and distinguishes myeloma from monoclonal gammopathy of undetermined significance and lymphomas with plasmacytoid differentiation. Am J Pathol 160:1293–1299PubMedPubMedCentralCrossRef
36.
Zurück zum Zitat Fend F (2010) Molekulare Pathologie von Plasmazellneoplasien. Pathologe 31(Suppl 2):188–192PubMedCrossRef Fend F (2010) Molekulare Pathologie von Plasmazellneoplasien. Pathologe 31(Suppl 2):188–192PubMedCrossRef
37.
Zurück zum Zitat Fend F, Kremer M (2007) Diagnosis and classification of malignant lymphoma and related entities in the bone marrow trephine biopsy. Pathobiology 74:133–143PubMedCrossRef Fend F, Kremer M (2007) Diagnosis and classification of malignant lymphoma and related entities in the bone marrow trephine biopsy. Pathobiology 74:133–143PubMedCrossRef
38.
Zurück zum Zitat Fend F, Quintanilla-Martinez L (2013) B-Zellneoplasien mit plasmazellulärer und plasmablastischer Differenzierung. Pathologe 34:198–209PubMedCrossRef Fend F, Quintanilla-Martinez L (2013) B-Zellneoplasien mit plasmazellulärer und plasmablastischer Differenzierung. Pathologe 34:198–209PubMedCrossRef
39.
Zurück zum Zitat Feyler S, O’Connor SJ, Rawstron AC et al (2008) IgM myeloma: a rare entity characterized by a CD20-CD56-CD117- immunophenotype and the t(11;14). Br J Haematol 140:547–551PubMedCrossRef Feyler S, O’Connor SJ, Rawstron AC et al (2008) IgM myeloma: a rare entity characterized by a CD20-CD56-CD117- immunophenotype and the t(11;14). Br J Haematol 140:547–551PubMedCrossRef
40.
Zurück zum Zitat Fonseca R, Barlogie B, Bataille R et al (2004) Genetics and cytogenetics of multiple myeloma: a workshop report. Cancer Res 64:1546–1558PubMedCrossRef Fonseca R, Barlogie B, Bataille R et al (2004) Genetics and cytogenetics of multiple myeloma: a workshop report. Cancer Res 64:1546–1558PubMedCrossRef
41.
Zurück zum Zitat Fonseca R, Bergsagel PL, Drach J et al (2009) International Myeloma Working Group molecular classification of multiple myeloma: spotlight review. Leukemia 23:2210–2221PubMedPubMedCentralCrossRef Fonseca R, Bergsagel PL, Drach J et al (2009) International Myeloma Working Group molecular classification of multiple myeloma: spotlight review. Leukemia 23:2210–2221PubMedPubMedCentralCrossRef
42.
Zurück zum Zitat Fonseca R, Blood E, Rue M et al (2003) Clinical and biologic implications of recurrent genomic aberrations in myeloma. Blood 101:4569–4575PubMedCrossRef Fonseca R, Blood E, Rue M et al (2003) Clinical and biologic implications of recurrent genomic aberrations in myeloma. Blood 101:4569–4575PubMedCrossRef
43.
Zurück zum Zitat Gabrea A, Martelli ML, Qi Y et al (2008) Secondary genomic rearrangements involving immunoglobulin or MYC loci show similar prevalences in hyperdiploid and nonhyperdiploid myeloma tumors. Genes Chromosomes Cancer 47:573–590PubMedPubMedCentralCrossRef Gabrea A, Martelli ML, Qi Y et al (2008) Secondary genomic rearrangements involving immunoglobulin or MYC loci show similar prevalences in hyperdiploid and nonhyperdiploid myeloma tumors. Genes Chromosomes Cancer 47:573–590PubMedPubMedCentralCrossRef
44.
Zurück zum Zitat Galieni P, Cavo M, Pulsoni A et al (2000) Clinical outcome of extramedullary plasmacytoma. Haematologica 85:47–51PubMed Galieni P, Cavo M, Pulsoni A et al (2000) Clinical outcome of extramedullary plasmacytoma. Haematologica 85:47–51PubMed
45.
Zurück zum Zitat Garcia-Sanz R, Orfao A, Gonzalez M et al (1999) Primary plasma cell leukemia: clinical, immunophenotypic, DNA ploidy, and cytogenetic characteristics. Blood 93:1032–1037PubMed Garcia-Sanz R, Orfao A, Gonzalez M et al (1999) Primary plasma cell leukemia: clinical, immunophenotypic, DNA ploidy, and cytogenetic characteristics. Blood 93:1032–1037PubMed
46.
Zurück zum Zitat Greenberg AJ, Rajkumar SV, Vachon CM (2012) Familial monoclonal gammopathy of undetermined significance and multiple myeloma: epidemiology, risk factors, and biological characteristics. Blood 119:5359–5366PubMedPubMedCentralCrossRef Greenberg AJ, Rajkumar SV, Vachon CM (2012) Familial monoclonal gammopathy of undetermined significance and multiple myeloma: epidemiology, risk factors, and biological characteristics. Blood 119:5359–5366PubMedPubMedCentralCrossRef
47.
Zurück zum Zitat Greipp PR, Leong T, Bennett JM et al (1998) Plasmablastic morphology – an independent prognostic factor with clinical and laboratory correlates: Eastern Cooperative Oncology Group (ECOG) myeloma trial E9486 report by the ECOG Myeloma Laboratory Group. Blood 91:2501–2507PubMed Greipp PR, Leong T, Bennett JM et al (1998) Plasmablastic morphology – an independent prognostic factor with clinical and laboratory correlates: Eastern Cooperative Oncology Group (ECOG) myeloma trial E9486 report by the ECOG Myeloma Laboratory Group. Blood 91:2501–2507PubMed
48.
Zurück zum Zitat Greipp PR, Raymond NM, Kyle RA, O’Fallon WM (1985) Multiple myeloma: significance of plasmablastic subtype in morphological classification. Blood 65:305–310PubMed Greipp PR, Raymond NM, Kyle RA, O’Fallon WM (1985) Multiple myeloma: significance of plasmablastic subtype in morphological classification. Blood 65:305–310PubMed
49.
Zurück zum Zitat Greipp PR, San Miguel J, Durie BG et al (2005) International staging system for multiple myeloma. J Clin Oncol 23:3412–3420PubMedCrossRef Greipp PR, San Miguel J, Durie BG et al (2005) International staging system for multiple myeloma. J Clin Oncol 23:3412–3420PubMedCrossRef
50.
Zurück zum Zitat Grogan TM (2003) Plasma cell myeloma marrow diagnosis including morphologic and phenotypic features. Semin Diagn Pathol 20:211–225PubMedCrossRef Grogan TM (2003) Plasma cell myeloma marrow diagnosis including morphologic and phenotypic features. Semin Diagn Pathol 20:211–225PubMedCrossRef
51.
Zurück zum Zitat Gualco G, Weiss LM, Bacchi CE (2010) MUM1/IRF4: A Review. Appl Immunohistochem Mol Morphol 18:301–310PubMedCrossRef Gualco G, Weiss LM, Bacchi CE (2010) MUM1/IRF4: A Review. Appl Immunohistochem Mol Morphol 18:301–310PubMedCrossRef
52.
Zurück zum Zitat Hallek M, Bergsagel PL, Anderson KC (1998) Multiple myeloma: increasing evidence for a multistep transformation process. Blood 91:3–21PubMed Hallek M, Bergsagel PL, Anderson KC (1998) Multiple myeloma: increasing evidence for a multistep transformation process. Blood 91:3–21PubMed
53.
Zurück zum Zitat Harrington AM, Hari P, Kroft SH (2009) Utility of CD56 immunohistochemical studies in follow-up of plasma cell myeloma. Am J Clin Pathol 132:60–66PubMedCrossRef Harrington AM, Hari P, Kroft SH (2009) Utility of CD56 immunohistochemical studies in follow-up of plasma cell myeloma. Am J Clin Pathol 132:60–66PubMedCrossRef
54.
Zurück zum Zitat Heerema-McKenney A, Waldron J, Hughes S et al (2010) Clinical, immunophenotypic, and genetic characterization of small lymphocyte-like plasma cell myeloma: a potential mimic of mature B-cell lymphoma. Am J Clin Pathol 133:265–270PubMedCrossRef Heerema-McKenney A, Waldron J, Hughes S et al (2010) Clinical, immunophenotypic, and genetic characterization of small lymphocyte-like plasma cell myeloma: a potential mimic of mature B-cell lymphoma. Am J Clin Pathol 133:265–270PubMedCrossRef
55.
Zurück zum Zitat Hideshima T, Bergsagel PL, Kuehl WM, Anderson KC (2004) Advances in biology of multiple myeloma: clinical applications. Blood 104:607–618PubMedCrossRef Hideshima T, Bergsagel PL, Kuehl WM, Anderson KC (2004) Advances in biology of multiple myeloma: clinical applications. Blood 104:607–618PubMedCrossRef
56.
Zurück zum Zitat Hoyer JD, Hanson CA, Fonseca R et al (2000) The (11;14)(q13;q32) translocation in multiple myeloma. A morphologic and immunohistochemical study. Am J Clin Pathol 113:831–837PubMedCrossRef Hoyer JD, Hanson CA, Fonseca R et al (2000) The (11;14)(q13;q32) translocation in multiple myeloma. A morphologic and immunohistochemical study. Am J Clin Pathol 113:831–837PubMedCrossRef
57.
Zurück zum Zitat Hsi ED, Lorsbach RB, Fend F, Dogan A (2011) Plasmablastic lymphoma and related disorders. Am J Clin Pathol 136:183–194PubMedCrossRef Hsi ED, Lorsbach RB, Fend F, Dogan A (2011) Plasmablastic lymphoma and related disorders. Am J Clin Pathol 136:183–194PubMedCrossRef
58.
Zurück zum Zitat Hussong JW, Perkins SL, Schnitzer B, Hargreaves H, Frizzera G (1999) Extramedullary plasmacytoma. A form of marginal zone cell lymphoma? Am J Clin Pathol 111:111–116PubMedCrossRef Hussong JW, Perkins SL, Schnitzer B, Hargreaves H, Frizzera G (1999) Extramedullary plasmacytoma. A form of marginal zone cell lymphoma? Am J Clin Pathol 111:111–116PubMedCrossRef
59.
Zurück zum Zitat Robert Koch Institut (2013) Krebs in Deutschland. Zentrum für Krebsregisterdaten, Berlin Robert Koch Institut (2013) Krebs in Deutschland. Zentrum für Krebsregisterdaten, Berlin
60.
Zurück zum Zitat Joshi R, Horncastle D, Elderfield K et al (2008) Bone marrow trephine combined with immunohistochemistry is superior to bone marrow aspirate in follow-up of myeloma patients. J Clin Pathol 61:213–216PubMedCrossRef Joshi R, Horncastle D, Elderfield K et al (2008) Bone marrow trephine combined with immunohistochemistry is superior to bone marrow aspirate in follow-up of myeloma patients. J Clin Pathol 61:213–216PubMedCrossRef
61.
Zurück zum Zitat Kaufmann H, Ackermann J, Baldia C et al (2004) Both IGH translocations and chromosome 13q deletions are early events in monoclonal gammopathy of undetermined significance and do not evolve during transition to multiple myeloma. Leukemia 18:1879–1882PubMedCrossRef Kaufmann H, Ackermann J, Baldia C et al (2004) Both IGH translocations and chromosome 13q deletions are early events in monoclonal gammopathy of undetermined significance and do not evolve during transition to multiple myeloma. Leukemia 18:1879–1882PubMedCrossRef
62.
Zurück zum Zitat Kremer M, Ott G, Nathrath M et al (2005) Primary extramedullary plasmacytoma and multiple myeloma: phenotypic differences revealed by immunohistochemical analysis. J Pathol 205:92–101PubMedCrossRef Kremer M, Ott G, Nathrath M et al (2005) Primary extramedullary plasmacytoma and multiple myeloma: phenotypic differences revealed by immunohistochemical analysis. J Pathol 205:92–101PubMedCrossRef
63.
Zurück zum Zitat Kremer M, Quintanilla-Martinez L, Nahrig J, von Schilling C, Fend F (2005) Immunohistochemistry in bone marrow pathology: a useful adjunct for morphologic diagnosis. Virchows Arch 447:920–937PubMedCrossRef Kremer M, Quintanilla-Martinez L, Nahrig J, von Schilling C, Fend F (2005) Immunohistochemistry in bone marrow pathology: a useful adjunct for morphologic diagnosis. Virchows Arch 447:920–937PubMedCrossRef
64.
65.
Zurück zum Zitat Kyle RA, Durie BG, Rajkumar SV et al (2010) Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management. Leukemia 24:1121–1127PubMedCrossRefPubMedCentral Kyle RA, Durie BG, Rajkumar SV et al (2010) Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management. Leukemia 24:1121–1127PubMedCrossRefPubMedCentral
66.
Zurück zum Zitat Kyle RA, Maldonado JE, Bayrd ED (1974) Plasma cell leukemia. Report on 17 cases. Arch Intern Med 133:813–818PubMedCrossRef Kyle RA, Maldonado JE, Bayrd ED (1974) Plasma cell leukemia. Report on 17 cases. Arch Intern Med 133:813–818PubMedCrossRef
67.
Zurück zum Zitat Kyle RA, Rajkumar SV (2006) Monoclonal gammopathy of undetermined significance. Br J Haematol 134:573–589PubMedCrossRef Kyle RA, Rajkumar SV (2006) Monoclonal gammopathy of undetermined significance. Br J Haematol 134:573–589PubMedCrossRef
68.
Zurück zum Zitat Kyle RA, Rajkumar SV (2014) An overview of the progress in the treatment of multiple myeloma. Expert Rev Hematol 7:5–7PubMedCrossRef Kyle RA, Rajkumar SV (2014) An overview of the progress in the treatment of multiple myeloma. Expert Rev Hematol 7:5–7PubMedCrossRef
69.
Zurück zum Zitat Kyle RA, Therneau TM, Rajkumar SV et al (2004) Incidence of multiple myeloma in Olmsted County, Minnesota: trend over 6 decades. Cancer 101:2667–2674PubMedCrossRef Kyle RA, Therneau TM, Rajkumar SV et al (2004) Incidence of multiple myeloma in Olmsted County, Minnesota: trend over 6 decades. Cancer 101:2667–2674PubMedCrossRef
70.
Zurück zum Zitat Kyle RA, Therneau TM, Rajkumar SV et al (2006) Prevalence of monoclonal gammopathy of undetermined significance. N Engl J Med 354:1362–1369PubMedCrossRef Kyle RA, Therneau TM, Rajkumar SV et al (2006) Prevalence of monoclonal gammopathy of undetermined significance. N Engl J Med 354:1362–1369PubMedCrossRef
71.
Zurück zum Zitat Landgren O, Gridley G, Turesson I et al (2006) Risk of monoclonal gammopathy of undetermined significance (MGUS) and subsequent multiple myeloma among African American and white veterans in the United States. Blood 107:904–906PubMedPubMedCentralCrossRef Landgren O, Gridley G, Turesson I et al (2006) Risk of monoclonal gammopathy of undetermined significance (MGUS) and subsequent multiple myeloma among African American and white veterans in the United States. Blood 107:904–906PubMedPubMedCentralCrossRef
72.
Zurück zum Zitat Landgren O, Kyle RA, Pfeiffer RM, et al (2009) Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study. Blood 113:5412–7PubMedPubMedCentralCrossRef Landgren O, Kyle RA, Pfeiffer RM, et al (2009) Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study. Blood 113:5412–7PubMedPubMedCentralCrossRef
73.
Zurück zum Zitat Larson RS, Sukpanichnant S, Greer JP, Cousar JB, Collins RD (1997) The spectrum of multiple myeloma: diagnostic and biological implications. Hum Pathol 28:1336–1347PubMedCrossRef Larson RS, Sukpanichnant S, Greer JP, Cousar JB, Collins RD (1997) The spectrum of multiple myeloma: diagnostic and biological implications. Hum Pathol 28:1336–1347PubMedCrossRef
74.
75.
Zurück zum Zitat Lin P, Mahdavy M, Zhan F et al (2004) Expression of PAX5 in CD20-positive multiple myeloma assessed by immunohistochemistry and oligonucleotide microarray. Mod Pathol 17:1217–1222PubMedCrossRef Lin P, Mahdavy M, Zhan F et al (2004) Expression of PAX5 in CD20-positive multiple myeloma assessed by immunohistochemistry and oligonucleotide microarray. Mod Pathol 17:1217–1222PubMedCrossRef
76.
Zurück zum Zitat Lohr JG, Stojanov P, Carter SL et al (2014) Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy. Cancer Cell 25:91–101PubMedPubMedCentralCrossRef Lohr JG, Stojanov P, Carter SL et al (2014) Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy. Cancer Cell 25:91–101PubMedPubMedCentralCrossRef
77.
Zurück zum Zitat Lorsbach RB, Hsi ED, Dogan A, Fend F (2011) Plasma cell myeloma and related neoplasms. Am J Clin Pathol 136:168–182PubMedCrossRef Lorsbach RB, Hsi ED, Dogan A, Fend F (2011) Plasma cell myeloma and related neoplasms. Am J Clin Pathol 136:168–182PubMedCrossRef
78.
Zurück zum Zitat Lugli A, Went P, Khanlari B, Nikolova Z, Dirnhofer S (2004) Rare KIT (CD117) expression in multiple myeloma abrogates the usefulness of imatinib mesylate treatment. Virchows Arch 444:264–268PubMedCrossRef Lugli A, Went P, Khanlari B, Nikolova Z, Dirnhofer S (2004) Rare KIT (CD117) expression in multiple myeloma abrogates the usefulness of imatinib mesylate treatment. Virchows Arch 444:264–268PubMedCrossRef
79.
Zurück zum Zitat Majumdar G, Grace RJ, Singh AK, Slater NG (1992) The value of the bone marrow plasma cell cytoplasmic light chain ratio in differentiating between multiple myeloma and monoclonal gammopathy of undetermined significance. Leuk Lymphoma 8:491–493PubMedCrossRef Majumdar G, Grace RJ, Singh AK, Slater NG (1992) The value of the bone marrow plasma cell cytoplasmic light chain ratio in differentiating between multiple myeloma and monoclonal gammopathy of undetermined significance. Leuk Lymphoma 8:491–493PubMedCrossRef
80.
Zurück zum Zitat McKenna RW, Kyle RA, Kuehl WM et al (2017) Plasma cell neoplasms. In: Swerdlow SH, Campo E, Harris NL, al (Hrsg) WHO classification of tumours of haematopoietic and lymphoid tissues. IARC, Lyon McKenna RW, Kyle RA, Kuehl WM et al (2017) Plasma cell neoplasms. In: Swerdlow SH, Campo E, Harris NL, al (Hrsg) WHO classification of tumours of haematopoietic and lymphoid tissues. IARC, Lyon
81.
Zurück zum Zitat Menke DM, Horny HP, Griesser H et al (2001) Primary lymph node plasmacytomas (plasmacytic lymphomas). Am J Clin Pathol 115:119–126PubMedCrossRef Menke DM, Horny HP, Griesser H et al (2001) Primary lymph node plasmacytomas (plasmacytic lymphomas). Am J Clin Pathol 115:119–126PubMedCrossRef
82.
Zurück zum Zitat Morgan GJ, Johnson DC (2014) Inherited genetic susceptibility to multiple myeloma. Leukemia 28:518–524PubMedCrossRef Morgan GJ, Johnson DC (2014) Inherited genetic susceptibility to multiple myeloma. Leukemia 28:518–524PubMedCrossRef
83.
Zurück zum Zitat Morgan GJ, Walker BA, Davies FE (2012) The genetic architecture of multiple myeloma. Nat Rev Cancer 12:335–348PubMedCrossRef Morgan GJ, Walker BA, Davies FE (2012) The genetic architecture of multiple myeloma. Nat Rev Cancer 12:335–348PubMedCrossRef
84.
Zurück zum Zitat Ng AP, Wei A, Bhurani D et al (2006) The sensitivity of CD138 immunostaining of bone marrow trephine specimens for quantifying marrow involvement in MGUS and myeloma, including samples with a low percentage of plasma cells. Haematologica 91:972–975PubMed Ng AP, Wei A, Bhurani D et al (2006) The sensitivity of CD138 immunostaining of bone marrow trephine specimens for quantifying marrow involvement in MGUS and myeloma, including samples with a low percentage of plasma cells. Haematologica 91:972–975PubMed
85.
Zurück zum Zitat Oracki SA, Walker JA, Hibbs ML, Corcoran LM, Tarlinton DM (2010) Plasma cell development and survival. Immunol Rev 237:140–159PubMedCrossRef Oracki SA, Walker JA, Hibbs ML, Corcoran LM, Tarlinton DM (2010) Plasma cell development and survival. Immunol Rev 237:140–159PubMedCrossRef
86.
Zurück zum Zitat Paiva B, Almeida J, Perez-Andres M et al (2010) Utility of flow cytometry immunophenotyping in multiple myeloma and other clonal plasma cell-related disorders. Cytom B Clin Cytom 78:239–252 Paiva B, Almeida J, Perez-Andres M et al (2010) Utility of flow cytometry immunophenotyping in multiple myeloma and other clonal plasma cell-related disorders. Cytom B Clin Cytom 78:239–252
87.
Zurück zum Zitat Pantic M, Schroettner P, Pfeifer D et al (2010) Biclonal origin prevails in concomitant chronic lymphocytic leukemia and multiple myeloma. Leukemia 24:885–890PubMedCrossRef Pantic M, Schroettner P, Pfeifer D et al (2010) Biclonal origin prevails in concomitant chronic lymphocytic leukemia and multiple myeloma. Leukemia 24:885–890PubMedCrossRef
88.
Zurück zum Zitat Pellat-Deceunynck C, Barille S, Jego G et al (1998) The absence of CD56 (NCAM) on malignant plasma cells is a hallmark of plasma cell leukemia and of a special subset of multiple myeloma. Leukemia 12:1977–1982PubMedCrossRef Pellat-Deceunynck C, Barille S, Jego G et al (1998) The absence of CD56 (NCAM) on malignant plasma cells is a hallmark of plasma cell leukemia and of a special subset of multiple myeloma. Leukemia 12:1977–1982PubMedCrossRef
89.
Zurück zum Zitat Perez-Persona E, Mateo G, Garcia-Sanz R et al (2010) Risk of progression in smouldering myeloma and monoclonal gammopathies of unknown significance: comparative analysis of the evolution of monoclonal component and multiparameter flow cytometry of bone marrow plasma cells. Br J Haematol 148:110–114PubMedCrossRef Perez-Persona E, Mateo G, Garcia-Sanz R et al (2010) Risk of progression in smouldering myeloma and monoclonal gammopathies of unknown significance: comparative analysis of the evolution of monoclonal component and multiparameter flow cytometry of bone marrow plasma cells. Br J Haematol 148:110–114PubMedCrossRef
90.
Zurück zum Zitat Peterson LC, Brown BA, Crosson JT, Mladenovic J (1986) Application of the immunoperoxidase technic to bone marrow trephine biopsies in the classification of patients with monoclonal gammopathies. Am J Clin Pathol 85:688–693PubMedCrossRef Peterson LC, Brown BA, Crosson JT, Mladenovic J (1986) Application of the immunoperoxidase technic to bone marrow trephine biopsies in the classification of patients with monoclonal gammopathies. Am J Clin Pathol 85:688–693PubMedCrossRef
91.
Zurück zum Zitat Petruzziello F, Zeppa P, Catalano L et al (2010) Amyloid in bone marrow smears of patients affected by multiple myeloma. Ann Hematol 89:469–474PubMedCrossRef Petruzziello F, Zeppa P, Catalano L et al (2010) Amyloid in bone marrow smears of patients affected by multiple myeloma. Ann Hematol 89:469–474PubMedCrossRef
92.
Zurück zum Zitat Pileri S, Poggi S, Baglioni P et al (1989) Histology and immunohistology of bone marrow biopsy in multiple myeloma. Eur J Haematol 51(Suppl):52–59 Pileri S, Poggi S, Baglioni P et al (1989) Histology and immunohistology of bone marrow biopsy in multiple myeloma. Eur J Haematol 51(Suppl):52–59
93.
Zurück zum Zitat Pruneri G, Fabris S, Balsini L et al (2000) Immunohistochemical analysis of cyclin D1 shows deregulated expression in multiple myeloma with the t(11;14). Am J Pathol 156:1505–1513PubMedPubMedCentralCrossRef Pruneri G, Fabris S, Balsini L et al (2000) Immunohistochemical analysis of cyclin D1 shows deregulated expression in multiple myeloma with the t(11;14). Am J Pathol 156:1505–1513PubMedPubMedCentralCrossRef
94.
Zurück zum Zitat Pruneri G, Ponzoni M, Ferreri AJ et al (2006) The prevalence and clinical implications of c-kit expression in plasma cell myeloma. Histopathology 48:529–535PubMedCrossRef Pruneri G, Ponzoni M, Ferreri AJ et al (2006) The prevalence and clinical implications of c-kit expression in plasma cell myeloma. Histopathology 48:529–535PubMedCrossRef
95.
Zurück zum Zitat Rajkumar SV, Dimopoulos MA, Palumbo A et al (2014) International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol 15:e538–548PubMedCrossRef Rajkumar SV, Dimopoulos MA, Palumbo A et al (2014) International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol 15:e538–548PubMedCrossRef
96.
Zurück zum Zitat Rajkumar SV, Dispenzieri A, Kyle RA (2006) Monoclonal gammopathy of undetermined significance, Waldenstrom macroglobulinemia, AL amyloidosis, and related plasma cell disorders: diagnosis and treatment. Mayo Clin Proc 81:693–703PubMedCrossRef Rajkumar SV, Dispenzieri A, Kyle RA (2006) Monoclonal gammopathy of undetermined significance, Waldenstrom macroglobulinemia, AL amyloidosis, and related plasma cell disorders: diagnosis and treatment. Mayo Clin Proc 81:693–703PubMedCrossRef
97.
Zurück zum Zitat Rajkumar SV, Fonseca R, Lacy MQ et al (1999) Plasmablastic morphology is an independent predictor of poor survival after autologous stem-cell transplantation for multiple myeloma. J Clin Oncol 17:1551–1557PubMedCrossRef Rajkumar SV, Fonseca R, Lacy MQ et al (1999) Plasmablastic morphology is an independent predictor of poor survival after autologous stem-cell transplantation for multiple myeloma. J Clin Oncol 17:1551–1557PubMedCrossRef
98.
Zurück zum Zitat Rajkumar SV, Kyle RA, Buadi FK (2010) Advances in the diagnosis, classification, risk stratification, and management of monoclonal gammopathy of undetermined significance: implications for recategorizing disease entities in the presence of evolving scientific evidence. Mayo Clin Proc 85:945–948PubMedPubMedCentralCrossRef Rajkumar SV, Kyle RA, Buadi FK (2010) Advances in the diagnosis, classification, risk stratification, and management of monoclonal gammopathy of undetermined significance: implications for recategorizing disease entities in the presence of evolving scientific evidence. Mayo Clin Proc 85:945–948PubMedPubMedCentralCrossRef
99.
Zurück zum Zitat Rasche L, Bernard C, Topp MS et al (2012) Features of extramedullary myeloma relapse: high proliferation, minimal marrow involvement, adverse cytogenetics: a retrospective single-center study of 24 cases. Ann Hematol 91:1031–1037PubMedCrossRef Rasche L, Bernard C, Topp MS et al (2012) Features of extramedullary myeloma relapse: high proliferation, minimal marrow involvement, adverse cytogenetics: a retrospective single-center study of 24 cases. Ann Hematol 91:1031–1037PubMedCrossRef
100.
Zurück zum Zitat Reichard K (2010) Plasma cell myeloma and other immunosecretory disorders. In: Foucar K, Reichart K, Czuchlewski D (Hrsg) Bone marrow pathology. ASCP Press, Chicago, S 524–553 Reichard K (2010) Plasma cell myeloma and other immunosecretory disorders. In: Foucar K, Reichart K, Czuchlewski D (Hrsg) Bone marrow pathology. ASCP Press, Chicago, S 524–553
101.
Zurück zum Zitat Robillard N, Avet-Loiseau H, Garand R et al (2003) CD20 is associated with a small mature plasma cell morphology and t(11;14) in multiple myeloma. Blood 102:1070–1071PubMedCrossRef Robillard N, Avet-Loiseau H, Garand R et al (2003) CD20 is associated with a small mature plasma cell morphology and t(11;14) in multiple myeloma. Blood 102:1070–1071PubMedCrossRef
103.
Zurück zum Zitat Schmidt J, Federmann B, Schindler N et al (2015) MYD88 L265P and CXCR4 mutations in lymphoplasmacytic lymphoma identify cases with high disease activity. Br J Haematol 169:795–803PubMedCrossRef Schmidt J, Federmann B, Schindler N et al (2015) MYD88 L265P and CXCR4 mutations in lymphoplasmacytic lymphoma identify cases with high disease activity. Br J Haematol 169:795–803PubMedCrossRef
104.
Zurück zum Zitat Seegmiller AC, Xu Y, McKenna RW, Karandikar NJ (2007) Immunophenotypic differentiation between neoplastic plasma cells in mature B-cell lymphoma vs plasma cell myeloma. Am J Clin Pathol 127:176–181PubMedCrossRef Seegmiller AC, Xu Y, McKenna RW, Karandikar NJ (2007) Immunophenotypic differentiation between neoplastic plasma cells in mature B-cell lymphoma vs plasma cell myeloma. Am J Clin Pathol 127:176–181PubMedCrossRef
105.
Zurück zum Zitat Shao H, Xi L, Raffeld M et al (2010) Nodal and extranodal plasmacytomas expressing immunoglobulin a: an indolent lymphoproliferative disorder with a low risk of clinical progression. Am J Surg Pathol 34:1425–1435PubMedPubMedCentralCrossRef Shao H, Xi L, Raffeld M et al (2010) Nodal and extranodal plasmacytomas expressing immunoglobulin a: an indolent lymphoproliferative disorder with a low risk of clinical progression. Am J Surg Pathol 34:1425–1435PubMedPubMedCentralCrossRef
106.
Zurück zum Zitat Short KD, Rajkumar SV, Larson D et al (2011) Incidence of extramedullary disease in patients with multiple myeloma in the era of novel therapy, and the activity of pomalidomide on extramedullary myeloma. Leukemia 25:906–908PubMedPubMedCentralCrossRef Short KD, Rajkumar SV, Larson D et al (2011) Incidence of extramedullary disease in patients with multiple myeloma in the era of novel therapy, and the activity of pomalidomide on extramedullary myeloma. Leukemia 25:906–908PubMedPubMedCentralCrossRef
107.
Zurück zum Zitat Siragusa S, Morice W, Gertz MA et al (2011) Asymptomatic immunoglobulin light chain amyloidosis (AL) at the time of diagnostic bone marrow biopsy in newly diagnosed patients with multiple myeloma and smoldering myeloma. A series of 144 cases and a review of the literature. Ann Hematol 90:101–106PubMedCrossRef Siragusa S, Morice W, Gertz MA et al (2011) Asymptomatic immunoglobulin light chain amyloidosis (AL) at the time of diagnostic bone marrow biopsy in newly diagnosed patients with multiple myeloma and smoldering myeloma. A series of 144 cases and a review of the literature. Ann Hematol 90:101–106PubMedCrossRef
108.
Zurück zum Zitat Solly S (1844) Remarks on the pathology of mollities ossium with cases. Med Chir Trans Lond 27:435–461CrossRef Solly S (1844) Remarks on the pathology of mollities ossium with cases. Med Chir Trans Lond 27:435–461CrossRef
109.
Zurück zum Zitat Specht K, Haralambieva E, Bink K et al (2004) Different mechanisms of cyclin D1 overexpression in multiple myeloma revealed by fluorescence in situ hybridization and quantitative analysis of mRNA levels. Blood 104:1120–1126PubMedCrossRef Specht K, Haralambieva E, Bink K et al (2004) Different mechanisms of cyclin D1 overexpression in multiple myeloma revealed by fluorescence in situ hybridization and quantitative analysis of mRNA levels. Blood 104:1120–1126PubMedCrossRef
110.
Zurück zum Zitat Susnerwala SS, Shanks JH, Banerjee SS et al (1997) Extramedullary plasmacytoma of the head and neck region: clinicopathological correlation in 25 cases. Br J Cancer 75:921–927PubMedPubMedCentralCrossRef Susnerwala SS, Shanks JH, Banerjee SS et al (1997) Extramedullary plasmacytoma of the head and neck region: clinicopathological correlation in 25 cases. Br J Cancer 75:921–927PubMedPubMedCentralCrossRef
111.
Zurück zum Zitat Takatsuki K, Sanada I (1983) Plasma cell dyscrasia with polyneuropathy and endocrine disorder: clinical and laboratory features of 109 reported cases. Jpn J Clin Oncol 13:543–555PubMed Takatsuki K, Sanada I (1983) Plasma cell dyscrasia with polyneuropathy and endocrine disorder: clinical and laboratory features of 109 reported cases. Jpn J Clin Oncol 13:543–555PubMed
112.
Zurück zum Zitat Terpstra WE, Lokhorst HM, Blomjous F, Meuwissen OJ, Dekker AW (1992) Comparison of plasma cell infiltration in bone marrow biopsies and aspirates in patients with multiple myeloma. Br J Haematol 82:46–49PubMedCrossRef Terpstra WE, Lokhorst HM, Blomjous F, Meuwissen OJ, Dekker AW (1992) Comparison of plasma cell infiltration in bone marrow biopsies and aspirates in patients with multiple myeloma. Br J Haematol 82:46–49PubMedCrossRef
113.
Zurück zum Zitat Treon SP, Xu L, Yang G et al (2012) MYD88 L265P somatic mutation in Waldenstrom’s macroglobulinemia. N Engl J Med 367:826–833PubMedCrossRef Treon SP, Xu L, Yang G et al (2012) MYD88 L265P somatic mutation in Waldenstrom’s macroglobulinemia. N Engl J Med 367:826–833PubMedCrossRef
114.
Zurück zum Zitat Van Camp B, Durie BG, Spier C et al (1990) Plasma cells in multiple myeloma express a natural killer cell-associated antigen: CD56 (NKH-1; Leu-19). Blood 76:377–382PubMed Van Camp B, Durie BG, Spier C et al (1990) Plasma cells in multiple myeloma express a natural killer cell-associated antigen: CD56 (NKH-1; Leu-19). Blood 76:377–382PubMed
115.
Zurück zum Zitat Varettoni M, Zibellini S, Arcaini L et al (2013) MYD88 (L265P) mutation is an independent risk factor for progression in patients with IgM monoclonal gammopathy of undetermined significance. Blood 122:2284–2285PubMedCrossRef Varettoni M, Zibellini S, Arcaini L et al (2013) MYD88 (L265P) mutation is an independent risk factor for progression in patients with IgM monoclonal gammopathy of undetermined significance. Blood 122:2284–2285PubMedCrossRef
116.
Zurück zum Zitat Vasef MA, Medeiros LJ, Yospur LS et al (1997) Cyclin D1 protein in multiple myeloma and plasmacytoma: an immunohistochemical study using fixed, paraffin-embedded tissue sections. Mod Pathol 10:927–932PubMed Vasef MA, Medeiros LJ, Yospur LS et al (1997) Cyclin D1 protein in multiple myeloma and plasmacytoma: an immunohistochemical study using fixed, paraffin-embedded tissue sections. Mod Pathol 10:927–932PubMed
117.
Zurück zum Zitat Vega F, Chang CC, Medeiros LJ et al (2005) Plasmablastic lymphomas and plasmablastic plasma cell myelomas have nearly identical immunophenotypic profiles. Mod Pathol 18:806–815PubMedCrossRef Vega F, Chang CC, Medeiros LJ et al (2005) Plasmablastic lymphomas and plasmablastic plasma cell myelomas have nearly identical immunophenotypic profiles. Mod Pathol 18:806–815PubMedCrossRef
118.
Zurück zum Zitat Walker BA, Wardell CP, Johnson DC et al (2013) Characterization of IGH locus breakpoints in multiple myeloma indicates a subset of translocations appear to occur in pregerminal center B cells. Blood 121:3413–3419PubMedCrossRef Walker BA, Wardell CP, Johnson DC et al (2013) Characterization of IGH locus breakpoints in multiple myeloma indicates a subset of translocations appear to occur in pregerminal center B cells. Blood 121:3413–3419PubMedCrossRef
119.
Zurück zum Zitat Weiss BM, Abadie J, Verma P, Howard RS, Kuehl WM (2009) A monoclonal gammopathy precedes multiple myeloma in most patients. Blood 113:5418–5422PubMedPubMedCentralCrossRef Weiss BM, Abadie J, Verma P, Howard RS, Kuehl WM (2009) A monoclonal gammopathy precedes multiple myeloma in most patients. Blood 113:5418–5422PubMedPubMedCentralCrossRef
Metadaten
Titel
Plasmazellneoplasien
verfasst von
Prof. Dr. Falko Fend
Copyright-Jahr
2019
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-540-85184-4_9

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