The choice of the best surgical approach in the treatment of temporomandibular joint (TMJ) pathologies is a much-debated topic in literature [
1]. To date, the most practiced surgical approach to TMJ is the preauricular one, which provides a wide exposure of all the articular structures [
2,
3]. However this approach is complicated by the high risk of neurovascular impairment, salivary fistulae, and facial scarring [
3]. The growing attention towards minimally invasive surgery has gradually led to new surgical approaches avoiding aesthetic and functional sequelae typical of TMJ surgeries [
4]. The intraoral approach, first reported by Sear in 1972, reduce the risks of facial nerve injury and scarring but offers limited visualization of the operating field [
1]. The endoscopic approach gives some advantages as the possibility to perform small incisions, reduced tissue’ damages, and a magnified visualization of the operating field, even in a very narrow space as the temporomandibular joint area [
5,
6]. The use of piezoelectric technology has been a great revolution in head and neck surgery due to the simplification of cutting the bone using micro-vibrations [
7]. Unlike common bone-cutting tools, piezosurgery offers the benefits of reducing tissue damage, both mechanical and thermal, and can be applied even in very restricted areas [
4,
8,
9]. The introduction on the market of piezoelectric handpieces with long tips has opened up new scenarios in the field of minimally invasive surgery [
10]. These new tools have allowed the treatment of pathologies in anatomical regions difficult to access like paranasal sinus and skull base diseases, or temporomandibular joints (TMJ) diseases like condylar benign or malign neoplasm, TMJ ankylosis, and condylectomy [
3,
6,
9]. To the best of our knowledge this I the first cadaveric study aimed to evaluate and describe the technical feasibility of the intraoral endoscopically assisted condylectomy using the long tip piezoelectric handpiece.