Introduction
Methods
Search strategy and selection criteria
Study selection and data extraction
Risk of bias assessment
Results
Multisensory hallucinatory and other unusual sensory experiences: case studies
References | Participant age in years and sex (and included n for case series) | Neurological and/or psychiatric comorbidity | Established aura symptomsa (including visual; complex visual hallucinations presented in next column) | Description of complex hallucinatory experiences (visual, auditory, olfactory, somatic-tactile, gustatory and other lesser-known modalities) | Other unusual sensory experiences | Associated migraine symptoms | Timeline relative to headache (if present) | |
---|---|---|---|---|---|---|---|---|
Prodromal or postdromal (sensory) symptomsb | Others | |||||||
Alstadhaug and Benjaminsen [22] | 40f | Bipolar disorder, Type II | Brief central grey scotoma; flickering or sparkling at rim of upper lateral visual field | Intense taste of lemons accompanied by salivary flow | None | Synaesthesia lasting 20–30 min | 6-year migraine history, reduced from 2 to 1 weekly episode with valproate | Before (1 h pain-free interval) |
Barros et al. [23] | 48m, 38f (2/7) | Right central facial palsy (38f) | Scintillating scotoma (4/7); zigzag lines (1/7) | Illusion of time travel, being sucked into a spiralling tunnel leading to a luminous, serene paradise and sent back after a few minutes; also sense of being followed | Photophobia; phonophobia (5/7) | None | Migraine onset at age 9–15, variable headache duration (30 min–72 h), moderate pain intensity with throbbing or tightening quality | Unknown |
Bhatia et al. [24] | 30m | No epilepsy or TBI history | Bilateral photopsia lasting 30 min; scintillating scotoma; numbness in right arm ascending to face in perioral distribution; left hemiparesis | Sensation of objects crawling over four limbs; feeling objects revolving and shimmering as if on a giant wheel | Photophobia | None | Migraine onset at age 14, > 50 lifetime episodes | Before (30 min pain-free interval); during |
Burstein et al. [25] | 42m | Unknown | Scintillating scotoma; blurred/distorted vision; numbness and tingling in arm and face, settling in lips and part of tongue contralateral to headache; tinnitus | Off-putting odours; bitter and unpleasant tastes | Photophobia; phonophobia | Osmophobia | Migraine onset at age 14, 1–2 episodes per month, lasting 2–6 h (12–24 h if untreated), unilateral headaches on either side, > 7/10 pain intensity, with throbbing quality | Before (30–60 min pain-free interval); during (gustatory) |
Chen et al. [26] | 51f | No TBI history | None | None | Photophobia | Hypoesthesia in left hand and upper limb lasting 20–30 min (resolved with menopause) | Migraine onset at age 46, monthly episodes co-occurring with menstruation, lasting 6 h, with holocranial, throbbing, outward-expanding headaches | Before (no pain-free interval) |
Donat and Donat [27] | 35f | Unknown | None | Smell of oranges or coffee, lasting several minutes | Photophobia | None | Migraine onset at age 11, lasting hours, unilateral pain on either side, with nausea | Before |
Fisher [28] | 44f | None | Fortification spectra; photopsia; scintillating scotoma; left-sided numbness spreading from head to feet causing aphasia; tingling on face and tongue lasting 2–5 min | Described built-in personal television screen showing different scenes; buzzing sounds; odour of dead cat or rotting animals at night, “resembling an awful stench-like death” or “beautiful” ammonia smells | None | Temporary loss of vision lasting days; “electric shocks” affecting arm, shoulder and head | Migraine onset at age 7, with or without headaches, > 50 lifetime unilateral episodes | Unknown |
Fuller et al. [29] | 69m | No epilepsy; recurrent psychosis | Bilateral photopsia; tingling in lips and left arm | Well-formed, colourful images in motion involving “red and squirmy” piranhas on room floor, 100 burglars in front garden, hospital bed being swallowed up by floor or threatening words written on walls (engendering refusal to enter rooms); complaints that wife and brother-in-law were morphing, with lengthening arms and a single eye, lasting 7–28 days | None | None | Migraine with aura onset at age 16, episodes every 3–6 months, right-sided throbbing headaches | Before (30 min pain-free interval) |
Hamed [30] | 20m | No significant neurological or psychiatric history | Photopsia | Lilliputian hallucinations: Feeling like he was shrinking, and other persons were similar to size of his index finger; moving objects; voices of people varying in volume and distance; not associated with distress | None | None | No details provided | Unknown |
Lindner et al. [31] | 41m | No epilepsy | Scintillating scotoma in left visual field; geometric figures and wavy lines; homonymous hemianopia | Repetitive visual hallucinations every 5–7 min, lasting ~ 3 min, seen with closed eyes (except for phosphenes) in left visual field, such as moving streets and landscapes, emergency department nurse, Garfield cartoon image, phosphenes resembling American and German flags | Photophobia | Hypoesthesia/dysesthesia in left fingertips, forearm or perioral region | No details provided | Before |
Lo et al. [32] | 22m | Brainstem lesion; psychotic illness excluded | None | Heard people talking or shouting for up to an hour, individuals were having a conversation that clearly did not involve him | Photophobia | None | Migraine episodes twice a week, lasting up to 6 h, recurrent, pulsating right frontal headaches of moderate intensity, with nausea | Unknown |
McAbee et al. [33] | 16m | Circular mass in left posterior temporal region | Occasional blurred vision; left-sided numbness | Odour of “burnt wood”, lasting seconds to minutes | Photophobia; phonophobia | None | 2-year migraine history, unilateral (primarily left temporal) severe pounding headache, lasting several hours, with nausea and vomiting | During; after |
Miller et al. [34]ş | 13–55 years old, 58% female (n = 12) | 67% diagnosed with comorbid psychiatric disorder, most commonly MDD (1 suspected SCZ) | Photopsia and other visual symptoms (50%) | Single or multiple voices (58%), some of which were known; general noises (50%), like fridge humming, bells ringing, crickets, beeping or hissing; an example included evolution of hearing muffled hissing noises inside head, which clearly sounded like the word “death” following repetition; lasting < 1 h (67%) | Phonophobia (33%) | None | Mean migraine onset at age 16 (n = 8) | During (83% visual aura; 75% auditory hallucinations) |
Partovi and Tolebeyan [35] | 53f | None | None | Onset of olfactory symptoms for several years; associated with ~ 30–50% of episodes (persisted during COVID despite loss of olfactory abilities); odour of cigarette smoke from headache commencement for 3–7 days | Photophobia; phonophobia | None | Onset in early 20 s; 12 headache days a month, with pain (rated 4–9/10) on left side of neck and occipital area at times | Unknown |
48f | Anxiety and depression | None | Occasional odour of burning for ~ 30 min prior to headache onset (followed by visual symptoms); described as cigarette smoke or trash | Photophobia; phonophobia | None | Adolescent onset and progression from mid 30 s; described as pressure or sharp pain in occipital or frontal areas lasting up to 3 days; 15 headache days a month, usually occurring towards end of day | Unknown | |
Podoll and Robinson [36] | 72f | No significant neurological or psychiatric history | None | Lilliputian hallucinations: Seeing increasing numbers of black beetles with faces running in a line across carpet and ceiling, occurring every 2–3 months, lasting 2–5 min, associated with insight and lack of distress, started at peak of severe headaches since early 30s | Photophobia; phonophobia | None | Migraine onset at age 10, with recurrent episodes diminishing from weekly to monthly with age; lasting 1–5 days, side-changing unilateral pulsating pain of moderate to severe intensity, exacerbated by stress | During |
Roussos and Hirsch [37] | 32f | No significant neurological history | Fortification spectra; perioral paresthesia extending from philtrum to chin | Odours of foods or cleaning products, of 5/10 intensity, occurring once per month, lasting ~ 1 min | Photophobia; phonophobia | Burning sensation in eyes and nose; generalised pruritus; tongue and neck pain; pallinosmia and smell distortions; metallic pallinugeusia | 5-year history of migraine triggered by allium aromas; biparietal, crushing headaches, 10/10 pain intensity | Before (visual aura); during (burning sensation); after (paresthesia and other unusual sensory experiences) |
Spranger et al. [38] | 46m, 42m, 12m | Cerebellar atrophy (in two adults) | Distorted double vision; contralateral hemiparesis | Fully formed, colourful visual hallucinations in motion, alongside persecutory delusions, provoking intense anxiety; auditory hallucinations (in two adults) | None | Hemi-hypoesthesia | Unilateral severe throbbing headache, 2–3 episodes per year, lasting 3–14 days | After (within 24 h) |
van der Feltz-Cornelis et al. [39] | 40m | No epilepsy or narcolepsy; Psychotic disorder excluded | Photopsia; blurred vision | Voices suggesting to kill son, provoking anxiety and depressive symptoms, and sleep problems | None | None | Nocturnal migraine, several times per week, unilateral throbbing pain localised at temple | Before |
Vreeburg et al. [40] | 29m | Tonic–clonic seizures with LOC; no significant psychiatric history | None | Heard “plopping” sounds, followed by voices at times, involving several known individuals, of negative emotional valence, for example commands to jump in front of a train, occurring once a week, lasting several minutes | None | None | Occurs with or without headache, latter involves throbbing pain lasting up to two days | Before |
Multisensory hallucinatory and other unusual sensory experiences: group design studies
References | N, participant characteristics, age (M ± SD in yrs) and sex (% male) | Established aura symptoms (including visual; complex visual hallucinations presented in next column) | *Description of complex hallucinatory experiences (visual, auditory, olfactory, tactile, gustatory and other lesser-known modalities) | Unusual sensory experiences (prodromal or postdromal symptoms) | *Unusual sensory experiences (other) |
---|---|---|---|---|---|
Albanese et al. [41] | Mi+: n = 50, 36 ± 10, 30% HC: n = 58; 35 ± 8, 34% | n = 15 MA +; n = 35 MA− MA + had VA only | N/A | N/A | 22% Mi + had ear fullness |
Alstadhaug et al. [42] | n = 245; 55 ± 13, 62%; MA+: n = 95, 62% | 98% of MA + had VA; ~ 8% of MA + had sensory auras; 14% of n = 245 had VA without headache; n = 10 had migrainous vertigo at least once | N/A | N/A | 8% of n = 254 had UA + including distorted perception of time (n = 3), out-of-body sensation (n = 2), deja vu (n = 1), jamais vu (n = 1), microsomatognosia (n = 1) |
Ashkenazi et al. [43] | n = 38; MA + n = 12; MA − n = 26, median = 26 (range 18–51); 21% | N/A | N/A | 90% of AL + & 75% AL- had phonophobia; 97% AL + and 88% of AL- had photophobia; 53% of AL + rated phonophobia during Mi as moderately worse than phonophobia between Mi; 75% of AL- rated phonophobia during Mi minimally worse than phonophobia between Mi | 35% of AL + and 25% of AL- had osmophobia during attacks |
Baldacci et al. [17] | n = 100 Mi +; 39 ± 11; 33% | N/A | N/A | N/A | 58% of n = 100 had osmophobia |
Beh et al. [11] | n = 17 Mi +; Median = 49 (range = 17–63); 41% | 47% had MA + (visual distortion): illusory splitting, teleopsia ("furniture seems far away, floor fells like a canyon"), underwater vision, xanthopsia ("yellow tint washing into visual field like a tide"), visual dolly zoom effect, frosted glass vision, enhanced stereoscopic vision ("seeing everything in extreme detail or extra 3D vision"), closed-eye visual hallucinations ("flashing images of unfamiliar people, trees, mountains, or buildings and phosphenes when eyes closed"). ~ 50% had visual distortion occurring during vestibular Mi, lasting for duration of Mi episodes (1–3 days); the distortion occurring between attacks usually lasted for mins to hours | 100% Alice in Wonderland syndrome. Auditory distortion (“unable to hear own voice”) occurred during and lasted whole duration of Mi episodes (2–4 h). 41% had extrapersonal misperceptions: derealisation or out-of-body experience; most extrapersonal misperceptions occurred during and lasted whole duration of Mi. 29% had somesthetic distortion: aschematia “feeling as though [they] have no eyes but knows [they are] able to see”; partial macrosomatognosia – “brain becoming too big”; total body macrosomatognosia – “feels like [they are] growing so big [their] head would push through the roof”; microsomatognosia – “feels [they are] shrinking and becoming so small [they] would disappear behind the steering wheel”; most somesthetic symptoms occur during and lasted whole duration of Mi, except total body macrosomatognosia and microsomatognosia for n = 1 occurred between Mi episodes. 6% of Mi + experienced time distortion: "everything suddenly slowing down and moving very slowly even if [they were] driving at 80 mph on a highway"; occurred 1 day after Mi and lasted 5 min | ||
MA + found these experiences more fascinating than worrisome | |||||
Celebisoy et al. [44] | Vestibular M: n = 415, 42 ± 12 (17–74), 15% | 10% of N reported hearing loss in audiometry; 41% of N reported tinnitus; 69% of N reported vertigo attacks lasting 60 min–24 h; 62% of N reported vertigo attacks associated with headache in > 50% of the attacks; median vertigo attack severity = 7a | N/A | 42% of N reported photophobia or phonophobia | 32% of N reported aural fullness; 20% of N reported osmophobia; 12% of N reported AL |
Demarquay et al. [45] | n = 74 Mi + (n = 48 non-olfactory hypersensitive (OH-), n = 26 olfactory hypersensitive (OH +)), n = 30 HC; Mi + 42 ± 12; OH- 41 ± 13, OH + 44 ± 10, HC: 38 ± 12; Mi + 18%, OH- 15%, OH + 23%, HC 27% | 23% of OH- had non-olfactory established aura; 15% of OH + had non-olfactory established aura | N/A | N/A | 35% of Mi + had interictal olfactory hypersensitivity. OH + judged odours as less pleasant than OH- (p = 0.002) and controls (p = 0.006) |
Dispenza et al. [19] | n = 30 Mi + with vertigo; 45 (range 18–64 yrs), 20% | n = 12 VA; all had vertigo; n = 10 had episodic tinnitus | N/A | n = 20 patients reported dizziness and unsteadiness. All had photophobia, n = 26 patients reported phonophobia | n = 20 had transitory ear fullness sensation, of which n = 9 had both symptoms after first pure tone audiometry testing |
Gossrau et al. [46] | Mi: n = 113, 46 ± 14, 12% | 44% of N reported Mi with aura | N/A | N/A | 38%, 62% and 32% of n = 113 reported preictal, ictal and interictal hypersensitivity to odours respectively; common feared odours: perfumes, food odours and smoke (~ 35%, 22% and 12% of Mi + with osmophobia respectively) |
Hansen et al. [47] | n = 267; MA +, 39 ± 11; 20% | Most common auras were dots or flashing lights (70%), wavy or jagged lines (47%), blind spots (42%) and tunnel vision (27%) | Visual hallucinations (n = 22). 19% of MA + experienced changes in smell | 88% of Mi attacks were associated with photophobia and 73% with phonophobia | 14% of MA + had changes in taste or touch |
Blurry vision (n = 22), photopsia (n = 14), halos (n = 7), obscuration (n = 4) and micropsia (n = 1). Most reported > one VA symptom (median = 2, range 1–5). 30% had numbness or pins and tingling | |||||
Jürgens et al. [14] | n = 149 MA −, n = 70 MA +; n = 161 HC; MA− = 40; MA + = 39; HC = 42; MA− = 15%; MA + = 11%; HC = 20% | 91% MA + reported VA symptoms. visual illusions: autokinesis, corona phenomenon, cinematographic vision, double vision, macropsia, micropsia, pelopsia, teleopsia, metamorphopsia, visual splitting, inverted vision, inversion of 2D/3D vision, dyschromatopsia and illusionary visual spread. 23% MA + had sensory aura symptoms | 5% Mi + had complex visual hallucination. Mi + reported distorted perception: altered perception of body size, altered perception of body weight, altered perception of body position in space. Others: out-of-body experience, doppelganger phenomenon, synesthesia | N/A | N/A |
Kandemir et al. [48] | MA+: n = 30, 34 ± 8, 13%; MA−: n = 30, 32 ± 8, 27%; HC: n = 30, 32 ± 7, 20% | N/A | N/A | N/A | 77% MA + and 60% MA − reported osmophobia; perfume and cleaning products were the most common offensive odours during or between Mi attacks |
Karli et al. [15] | n = 96 (n = 23 MA +, n = 33 MA −, n = 31 episodic tension-type headache (ETTH); n = 9 Aura without headache (A + H-)); MA + = 40 ± 11, MA− = 37 ± 10, ETTH = 35 ± 10, A + H− = 35 ± 10; MA + = 9%, MA− = 3%, ETTH = 23%, A + H− = 0% | 44% of MA + had photopsia as VA; 33% of MA − also experienced photopsia before or during headache, but the symptom lasted < 5 min. 47% of MA + had fortification spectra. 39% of MA + had scotoma. 48% of MA + had paraesthesia, 12% MA − had paraesthesia within 1 h before or during headache, but the symptom lasted < 5 min | 22% of MA + had olfactory hallucinations, 6% of MA − had olfactory hallucinations | Photophobia before headaches: 91% of MA +, 85% of MA −. Phonophobia before headaches: 87% of MA +, 91% MA − | 13% of MA + had micropsia/macropsia; ↑ % of MA + felt cold before headache than MA − |
Kayabaşoglu et al. [18] | n = 30 HC, n = 60 Mi +; HC range = 20–56 yrs, Mi + range = 20–54 yrs; HC = 40%; Mi + = 39% | N/A | N/A | N/A | Mi + detected odorant at ↓ odour concentration level than HC (threshold scores: 8 ± 2 Mi + with osmophobia; 8 ± 2 Mi + without osmophobia; 11 ± 1 HC, p < 0.001). Mi + with osmophobia had ↑difficulty discriminating odours. (discrimination scores: 6 + 1 Mi + with osmophobia; 9 + 1 Mi + without osmophobia; 12 ± 1 HC, p < 0.001). Mi + with osmophobia rated perfume (80%), smoke (70%), stale food (63%), fish (47%), coffee or spices (40%) and leather (40%) as a disturbing smell |
Kelman [49] | n = 952 Mi +; 38 ± 12; 15% | 92% of MA + had VA. VA was often the only aura symptom. 67% of MA + rated VA as very frequent. Out of total episodes of sensory aura (numbness and tingling), only 9% of sensory aura occurred in absence of VA. Those w/more frequent VAs were ↑likely to experience more frequent non-VA symptoms. 26% of MA + had frequent numbness or tingling sensation. n = 1 participant had hearing loss. n = 2 had tinnitus | N/A | When asked about “other aura symptoms before Mi”: n = 4 had photophobia | When asked about “other aura symptoms before Mi”: n = 1 patient reported vision jumping, “things go black. n = 1 had smell intolerance, strange smells. n = 1 had strange taste, metallic taste and acid taste. n = 1 had facial pain, flushing of face, chest tightness, body cold, neck tightness, head tightness, neck burning, stiff neck and shoulder burning |
Leveque et al. [50] | MA−: n = 46, 29 ± 9, 22%; HC: n = 46, 27 ± 11, 28% | N/A | N/A | Mi + experienced ↑ sensory hypersensitivity than HC in the visual (p < 0.001) and auditory modalities (p = 0.002); visual hypersensitivity correlated with auditory in Mi + in interictal periods (r = 0.3, p = 0.0043) and ictal period (r = 0.432, p = 0.003) | Mi + experienced ↑ sensory hypersensitivity than HC in olfactory modality (p = 0.032); olfactory hypersensitivity correlated with auditory hypersensitivity (r = 0.315, p = 0.033) in ictal period |
Mahmud and Sina [51] | MA+: n = 18; 30 (24–36), 17%; Patient with occipital epilepsy: n = 10, 22 (15–47), 20% age presented as median and IQR | Scotomas, white or golden dots, or light flashes lasting for minutes before the headache; median duration of the visual phenomenon = 460 s, IQR: 225–1800; vertigo (56% MA +) and tinnitus (6% MA +) | Photophobia (94% MA +), phonophobia (89% MA +) | Osmophobia (39% MA +); 2 MA + reported transient loss of consciousness as aura symptoms | |
Mainardi et al. [4] | Mi + with olfactory hallucinations: n = 11 (10MA −, 1MA +), 40 (25–36), 18% | N/A | Reported olfactory hallucinations included smell of burnt wood, vanilla, gas, jasmine, coffee, smoke, rotten meat, banana, bitter almonds, chemical, melon, metallic, sulphur. The smells were always the same for most participant. Average age of onset of olfactory hallucinations = 32 yrs (5–54); ~ 50% of n = 11 had sudden onset and stop of olfactory hallucinations; ~ 70% of n = 11 reported olfactory hallucinations lasted 3–10 min; all Mi + reported changing intensity of olfactory hallucinations during the attack (mild or extremely intense); ~ 70% of n = 11 considered the smell consistently unlikeable | Phonophobia and photophobia constantly accompanied the pain phase in all patients | 50% of n = 11 reported osmophobia |
Pekdemir and Tanik [52] | n = 145; Mi with osmophobia: n = 98, 36 ± 11, 14%; Mi with osmophobia: n = 47, 36 ± 9.26% | N/A | N/A | N/A | 68% of Mi + reported osmophobia; median scores of ASC-12 (allodynia symptom checklist): Mi + with osmophobia = 5 (mild AL) and Mi + without osmophobia = 2 (no AL) |
Petrusic et al. [53] | MA+: n = 40, 16 ± 2 (13–19), 50% | 38% of MA + had VA only; 20% of MA + had visual and somatosensory auras; common VA included scintillating scotoma (67.5% of MA +), blurry vision (60%), tunnel vision (40%) and zigzag lines (25%); Feature of scintillating scotoma: onset time 21 ± 16 (25–60) mins in regard to the beginning of headache; duration 19 ± 17 (2–75) mins; 60% of MA + had somatosensory symptoms, including numbness in the left hand or both hands (53% of MA +), numbness in lips and/or face (30%), tongue (28%) and legs (15%) | N/A | N/A | 23% MA + experienced deja vu phenomenon during the aura; 5% of MA + experienced neglecting hand syndrome (duration: 1 ± 18 (5–30) mins) |
Price et al. [54] | Mi + with probable Mi: n = 117, 48 ± 14, 15%; HC: n = 827, 54 ± 17, 35% | N/A | N/A | Mi + have a ↑ level of sensory sensitivity in visual and auditory modalities than HC (p < 0.001) | Mi + have a ↑ level of sensory sensitivity in touch and taste modalities than HC (p < 0.001); sensory sensitivities in the different sensory modalities (visual, touch, taste and auditory) are correlated with each other (p < 0.01) |
Saisu et al. [16] | n = 110, MA+: n = 31, 34 ± 10, 29%; MA−: n = 49, 35 ± 11, 23%; HC: n = 30, 35 ± 11.25% | N/A | No differences in gustatory sensation (hypogeusia or hypergeusia) found between Mi + and HC or between the MA + and MA − | 66% Mi + reported photophobia and 74% Mi + reported phonophobia; ↑ MA + had photophobia and phonophobia than MA − (p < 0.05) | 63% Mi + reported osmophobia: 45% MA + and 29% MA − found perfume offensive; 29% MA + and 5% MA − found cigarette smoke offensive; ~ 50% Mi + with osmophobia experienced osmophobia since the initial onset of Mi, before Mi attacks or within 30 min after attack onset; 71% Mi + with osmophobia had osmophobia stopped when the Mi ended; Mi + showed ↑ dislike towards odours of Japanese cypress, rose and perfume than HC (p < 0.05); MA + showed ↑ dislike towards clothes smelling of perspiration, rose scents and odours of cooking gas and curry than MA − (p < 0.05); 10% Mi + had dysgeusia |
Shepherd and Patterson [5] | n = 151, MA+: n = 33, 39 ± 12, 27%; MA−: n = 44, 36 ± 11, 23%; HC: n = 74, 32 ± 8, 59% | 3 MA + experienced tinnitus (buzzing in the ears); n = 9 MA + experienced dizziness or vertigo; 32 MA + experienced VA (included wavy lines, zigzags, squiggles, radiating lines, a sparkly big wheel, black and silver lines, flashes of dots, a scintillating scotoma, moving bright blue and black swirls like a lava lamp); most VA included motion, started small and centrally and then grow out to the periphery, superimposed on objects, obscuring them; 12 MA + experienced pins and needles or numbness, most commonly on one side of the face or on the nose, lips and mouth, less frequently on a hand or the fingertips, down one arm, leg or foot; Higher proportion of MA + experienced distorted or non-shared sensory experiences in visual modality (e.g. see shapes, lights, or colours when there is nothing there) than MA − and lastly than HC | ↑ proportion of MA + experienced distorted or non-shared sensory experiences in auditory modality (e.g. hear noise and sounds that people near you do not; find sounds are distorted in a strange way), in olfactory modality (e.g. detect smells which do not seem to come from your surroundings), in tactile modality (feel someone is touching you but when you look nobody is there; burning sensation on your body), in gustatory modality (e.g. food or drink seems to have an unusual taste; unexplained tastes in your mouth) than MA − and lastly than HC | ↑ proportion of MA + experienced visual and auditory sensitivity than MA − and lastly than HC | 2 MA + experienced double vision; ↑ proportion of MA + experienced olfactory and tactile sensitivity (e.g. notice skin is more sensitive to touch, heat or cold than usual) than MA − and lastly HC |
Shi et al. [55] | Vestibular Mi: n = 166, 43 ± 15 (6–76), 21% | 52% of N had tinnitus; 21% of N had hearing loss- majority had mild and easily reversible low-frequency hearing loss; ↑ Mi + with hearing loss experience tinnitus versus those without (tinnitus = 80% of Mi + with hearing loss vs. 44% of Mi + without hearing loss); 14% of N had visual aura; most Mi + reported vestibular symptoms (incl. vertigo, dizziness and lightheadedness) monthly or yearly and lasted 5 min–72 h | N/A | 32% of N had phonophobia; 24% of N had photophobia | 8% of N had otalgia (majority one sided); 41% of N had aural fullness (majority one sided); ↑ Mi + with hearing loss experience aural fullness than those without (p < 0. 05) (aura fullness: 89% of Mi + with hearing loss vs. 29% of Mi + without hearing loss) |
Silva et al. [12] | Sightless Mi+: n = 8, 40 ± 13 yrs (range 25–56), 33% | Short VA (< 5 min), with colour blue, silver or fire like and usually in round shapes, | Uncharacteristic noise | Photophobia reported by all Mi + whom the headache preceded the blindness in time (n = 6) disappeared after visual impairment | N/A |
Sjaastad et al. [13] | n = 1838, mean = 43, 49% | 10% of n = 1838 had visual disturbances: scintillating scotoma (62% of N with visual disturbances), obscuration (33%), photopsia (unformed flashes of light/star-shaped figures) (16%); photopsia coexisted with scintillating scotomas and/or obscuration occasionally; anopsia (dimness of vision) (5%), autokinesis (movement of stationary objects), tunnel vision and micropsia (< 5%); most of the rare visual disturbances (< 5% of N with visual disturbances) appeared before pain and appeared with other visual disturbances at the same time; 67% of those with visual experienced reported the experience lasted from > 15 to ≤ 35 min | One participant had red and hot ears bilaterally during Mi | N/A | N/A |
Paraesthesias usually occurred at face or upper extremity and occurred at multiple locations during Mi | |||||
Teggi et al. [56] | Definite vestibular Mi+: n = 252, 46 ± 14 (range = 19–76), 15% | 11% Mi + had tinnitus; 73% Mi + had internal vertigo – a false sensation of self-motion when no self-motion is occurring; ~ 50% Mi + with internal vertigo had spinning sensation; the age at the first vertigo attack = 38 ± 13 yrs (range 16–60 yrs.); vertigo usually lasted < 5 min (23% Mi +) or 6–60 min (22% Mi +) | N/A | Photophobia (44% Mi +), phonophobia (39% Mi +) | Fullness of the ear (9% Mi +) |
Wang et al. [6] | MA−: n = 52, 24 ± 10; MA+: n = 28, 24 ± 10.00 (F), 19 ± 2 (M), 50% | MA + were ↑ likely to experience vision blurred and seeing black spot during Mi versus MA − (p < 0.01); | MA + were ↑ likely to experience the sensations that "head being hooped by a ribbon", "head being pressed by a big stone", "feeling like I was wearing hat" during Mi versus MA − (p = 0.01) | Blurred vision, light hypersensitivity (sensitivity to strong light when headache attacked), sound hypersensitivity | N/A |
Zanchin et al. [57] | n = 1005, 37 ± 11, 23% MA−: n = 677, 38 ± 11, 20% MA+: n = 130, 36 ± 11, 27% Tension-type headache: n = 198, 36 ± 12, 31% | N/A | N/A | N/A | 44% MA − and 39% MA + had osmophobia during Mi; For Mi + with osmophobia: 91% had osmophobia since first headache; 53% had osmophobia in 10/10 attacks; 73% had osmophobia during Mi; 98% had osmophobia stop with the pain phase; 43% had sensitivity towards two types of odours; most frequently reported offending odours: scents (e.g. feminine scents, deodorants, fresh flowers) (64% Mi +), food (e.g. coffee, fried foods, onion, etc.) (55% Mi +) and cigarette smoke (55% Mi +) |