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Journal of Cancer Research and Clinical Oncology

Erschienen in:

03.11.2023 | Review

Melittin: a possible regulator of cancer proliferation in preclinical cell culture and animal models

verfasst von: Shafiul Haque, Arif Hussain, Hemant Joshi, Ujjawal Sharma, Bunty Sharma, Diwakar Aggarwal, Isha Rani, Seema Ramniwas, Madhu Gupta, Hardeep Singh Tuli

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 19/2023

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Abstract

Background

Melittin is a water-soluble cationic peptide derived from bee venom that has been thoroughly studied for the cure of different cancers. However, the unwanted interactions of melittin produce hemolytic and cytotoxic effects that hinder their therapeutic applications. To overcome the shortcomings, numerous research groups have adopted different approaches, including conjugation with tumor-targeting proteins, gene therapy, and encapsulation in nanoparticles, to reduce the non-specific cytotoxic effects and potentiate their anti-cancerous activity.

Purpose

This article aims to provide mechanistic insights into the chemopreventive activity of melittin and its nanoversion in combination with standard anti-cancer drugs for the treatment of cancer.

Methods

We looked over the pertinent research on melittin's chemopreventive properties in online databases such as PubMed and Scopus.

Conclusion

In the present article, the anti-cancerous effects of melittin on different cancers have been discussed very nicely, as have their possible mechanisms of action to act against different tumors. Besides, it interacts with different signal molecules that regulate the diverse pathways of cancerous cells, such as cell cycle arrest, apoptosis, metastasis, angiogenesis, and inflammation. We also discussed the recent progress in the synergistic combination of melittin with standard anti-cancer drugs and a nano-formulated version of melittin for targeted delivery to improve its anticancer potential.

Graphical abstract

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Titel: Melittin: a possible regulator of cancer proliferation in preclinical cell culture and animal models
verfasst von: Shafiul Haque
Arif Hussain
Hemant Joshi
Ujjawal Sharma
Bunty Sharma
Diwakar Aggarwal
Isha Rani
Seema Ramniwas
Madhu Gupta
Hardeep Singh Tuli
Publikationsdatum: 03.11.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 19/2023
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-023-05458-8

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