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Pediatric Radiology

Erschienen in:

17.08.2023 | ESPR Belgrade 2023 - Postgraduate Course and Taskforce Lectures

Lung infections in immunocompromised children

verfasst von: Alistair D. Calder, Giulia Perucca, Sarah May Johnson, Ashwin R. Pandey, Karyn Moshal, Maaike A. Kusters

Erschienen in: Pediatric Radiology | Ausgabe 4/2024

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Abstract

Pulmonary infection is the leading cause of infectious morbidity and mortality in children with immune defects. We provide a comprehensive review of lung infections in immunocompromised children, with a focus on imaging findings and imaging-based management. We include an overview of the immune defences of the respiratory tract, the aetiologies of immune defects in children, the features of specific infections and important differential diagnoses and describe diagnostic strategies using imaging and non-imaging-based techniques.

Graphical Abstract

Resnick ES, Moshier EL, Godbold JH, Cunningham-Rundles C (2012) Morbidity and mortality in common variable immune deficiency over 4 decades. Blood 119:1650–7PubMedPubMedCentralCrossRef

Jesenak M, Banovcin P, Jesenakova B, Babusikova E (2014) Pulmonary manifestations of primary immunodeficiency disorders in children. Front Pediatr 25:77

Mettelman RC, Allen EK, Thomas PG (2022) Mucosal immune responses to infection and vaccination in the respiratory tract. Immunity 55:749–780PubMedPubMedCentralCrossRef

Marshall JS, Warrington R, Watson W, Kim HL (2018) An introduction to immunology and immunopathology. Allergy Asthma Clin Immunol 14:49PubMedPubMedCentralCrossRef

Bousfiha A, Moundir A, Tangye SG et al (2022) The 2022 update of IUIS phenotypical classification for human inborn errors of immunity. J Clin Immunol 42:1508–1520PubMedCrossRef

Verhagen MV, Trevisan V, Adu J et al (2020) Chest radiographs for distinguishing ADA-SCID from other forms of SCID. J Clin Immunol 40:259–266PubMedCrossRef

Jończyk-Potoczna K, Potoczny J, Szczawińska-Popłonyk A (2022) Imaging in children with ataxia-telangiectasia-the radiologist’s approach. Front Pediatr 10:988645PubMedPubMedCentralCrossRef

Minegishi Y (2021) Hyper-IgE syndrome, 2021 update. Allergol Int 70:407–414PubMedCrossRef

Haidopoulou K, Calder A, Jones A, Jaffe A, Sonnappa S (2009) Bronchiectasis secondary to primary immunodeficiency in children: longitudinal changes in structure and function. Pediatr Pulmonol 44:669–675PubMedCrossRef

10.

Szczawinska-Popłonyk A, Ta polska-Jóźwiak K, Schwartzmann E, Popłonyk N (2022) Immune dysregulation in pediatric common variable immunodeficiency: implications for the diagnostic approach. Front Pediatr 10:855200PubMedPubMedCentralCrossRef

11.

Lehman HK (2015) Autoimmunity and immune dysregulation in primary immune deficiency disorders. Curr Allergy Asthma Rep 15:53PubMedCrossRef

12.

Marciano BE, Spalding C, Fitzgerald A et al (2015) Common severe infections in chronic granulomatous disease. Clin Infect Dis 60:1176–83PubMedCrossRef

13.

Bennett N, Maglione PJ, Wright BL, Zerbe C (2018) Infectious complications in patients with chronic granulomatous disease. J Pediatric Infect Dis Soc 7:S12–S17PubMedPubMedCentralCrossRef

14.

Yao Q, Zhou QH, Shen QL et al (2020) Imaging findings of pulmonary manifestations of chronic granulomatous disease in a large single center from Shanghai, China (1999–2018). Sci Rep 10:19349PubMedPubMedCentralCrossRef

15.

Yao Q, Zhou QH, Shen QL et al (2022) Imaging characteristics of pulmonary BCG/TB infection in patients with chronic granulomatous disease. Sci Rep 12:11765PubMedPubMedCentralCrossRef

16.

Noma K, Mizoguchi Y, Tsumura M, Okada S (2022) Mendelian susceptibility to mycobacterial diseases: state of the art. Clin Microbiol Infect 28:1429 (Erratum in: Clin Microbiol Infect. 2022 Oct 20)

17.

Voulgaridou A, Athanasiadou KI, Athanasiadou E et al (2020) Pulmonary infectious complications in children with hematologic malignancies and chemotherapy-induced neutropenia. Diseases 8:32PubMedPubMedCentralCrossRef

18.

Bupha-Intr O, Haeusler G, Chee L et al (2021) CAR-T cell therapy and infection: a review. Expert Rev Anti Infect Ther 19:749–758PubMedCrossRef

19.

Vora SB, Waghmare A, Englund JA et al (2020) Infectious complications following CD19 chimeric antigen receptor T-cell therapy for children, adolescents, and young adults. Open Forum Infect Dis 7:ofaa121PubMedPubMedCentralCrossRef

20.

Donnelly JP, Chen SC, Kauffman CA et al (2020) Revision and update of the consensus definitions of invasive fungal disease from the european organization for research and treatment of cancer and the mycoses study group education and research consortium. Clin Infect Dis 71:1367–1376PubMedCrossRef

21.

Saxena S, Gee J, Klieger S et al (2018) Invasive fungal disease in pediatric solid organ transplant recipients. J Pediatric Infect Dis Soc 7:219–225PubMedCrossRef

22.

Toussi SS, Pan N, Walters HM, Walsh TJ (2013) Infections in children and adolescents with juvenile idiopathic arthritis and inflammatory bowel disease treated with tumor necrosis factor-α inhibitors: systematic review of the literature. Clin Infect Dis 57:1318–30PubMedPubMedCentralCrossRef

23.

Vonasek BJ, Rabie H, Hesseling AC, Garcia-Prats AJ (2022) Tuberculosis in children living with HIV: ongoing progress and challenges. J Pediatric Infect Dis Soc 11:S72–S78PubMedCrossRef

24.

Horger M, Hebart H, Einsele H et al (2005) Initial CT manifestations of invasive pulmonary aspergillosis in 45 non-HIV immunocompromised patients: association with patient outcome? Eur J Radiol 55:437–444PubMedCrossRef

25.

Burgos A, Zaoutis TE, Dvorak CC et al (2008) Pediatric invasive aspergillosis: a multicenter retrospective analysis of 139 contemporary cases. Pediatrics 121:e1286–e1294PubMedCrossRef

26.

Taccone A, Occhi M, Garaventa A et al (1993) CT of invasive pulmonary aspergillosis in children with cancer. Pediatr Radiol 23:177–180PubMedCrossRef

27.

Thomas KE, Owens CM, Veys PA et al (2003) The radiological spectrum of invasive aspergillosis in children: a 10-year review. Pediatr Radiol 33:453–460PubMedCrossRef

28.

Katragkou A, Fisher BT, Groll AH et al (2017) Diagnostic imaging and invasive fungal diseases in children. J Pediatric Infect Dis Soc 6:S22–S31PubMedCrossRef

29.

Bain V, Barrientos ACMGA, Suzuki L et al (2022) Radiological patterns of pulmonary fungal infection in pediatric hematology and oncology patients. Radiol Bras 55:78–83PubMedPubMedCentralCrossRef

30.

Han SB, Kim SK, Bae EY et al (2015) Clinical features and prognosis of invasive pulmonary aspergillosis in Korean children with hematologic/oncologic diseases. J Korean Med Sci 30:1121–8PubMedPubMedCentralCrossRef

31.

Yeoh DK, McMullan BJ, Clark JE et al (2023) The challenge of diagnosing invasive pulmonary aspergillosis in children: a review of existing and emerging tools. Mycopathologia. https://doi.org/10.1007/s11046-023-00714-4CrossRefPubMedPubMedCentral

32.

Pasqualotto AC (2009) Candida and the paediatric lung. Paediatr Respir Rev 10:186–191PubMedCrossRef

33.

Toma P, Bertaina A, Castagnola E et al (2016) Fungal infections of the lung in children. Pediatr Radiol 46:1856–1865PubMedCrossRef

34.

Guo S, Liu H, Tang X, Yang H (2019) Clinical characteristics and prognoses of pulmonary mucormycosis in four children. Pediatr Investig 3:223–227PubMedPubMedCentralCrossRef

35.

Lehrnbecher T, Schöning S, Poyer F et al (2019) Incidence and outcome of invasive fungal diseases in children with hematological malignancies and/or allogeneic hematopoietic stem cell transplantation: results of a prospective multicenter study. Front Microbiol 16:681CrossRef

36.

Caselli D, Petris MG, Rondelli R et al (2014) Single-day trimethoprim/sulfamethoxazole prophylaxis for pneumocystis pneumonia in children with cancer. J Pediatr 164:389–392PubMedCrossRef

37.

Mantadakis E (2020) Pneumocystis jirovecii pneumonia in children with hematological malignancies: diagnosis and approaches to management. J Fungi (Basel) 6:331PubMedCrossRef

38.

Restrepo-Gualteros SM, Gutierrez MJ, Villamil-Osorio M et al (2019) Challenges and clinical implications of the diagnosis of cytomegalovirus lung infection in children. Curr Infect Dis Rep 21:24PubMedPubMedCentralCrossRef

39.

Yeh TJ, Yang CI, Huang CT et al (2022) Revisit of the association between cytomegalovirus infection and invasive fungal infection after allogeneic hematopoietic stem cell transplantation: a real-world analysis from a high CMV seroprevalence area. J Fungi (Basel) 8:408PubMedCrossRef

40.

SeyedAlinaghi S, Karimi A, Barzegary A et al (2022) COVID-19 mortality in patients with immunodeficiency and its predictors: a systematic review. Eur J Med Res 27:195PubMedPubMedCentralCrossRef

41.

Zhang Q, Bastard P, Liu Z et al (2020) Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science 370:4570CrossRef

42.

Shields AM, Anantharachagan A, Arumugakani G et al (2022) Outcomes following SARS-CoV-2 infection in patients with primary and secondary immunodeficiency in the UK. Clin Exp Immunol 209:247–258PubMedPubMedCentralCrossRef

43.

Chappell H, Patel R, Driessens C et al (2022) Immunocompromised children and young people are at no increased risk of severe COVID-19. J Infect. 84(1):31–39.PubMedCrossRef

44.

Shrot S, Barkai G, Ben-Shlush A, Soudack M (2016) BCGitis and BCGosis in children with primary immunodeficiency - imaging characteristics. Pediatr Radiol 46:237–245PubMedCrossRef

45.

Naidoo J, Mahomed N, Moodley H (2017) A systemic review of tuberculosis with HIV coinfection in children. Pediatr Radiol 47:1269–1276PubMedCrossRef

46.

Boisson-Dupuis S, Bustamante J (2021) Mycobacterial diseases in patients with inborn errors of immunity. Curr Opin Immunol 72:262–271PubMedPubMedCentralCrossRef

47.

Boisson-Dupuis S, Bustamante J, El-Baghdadi J et al (2015) Inherited and acquired immunodeficiencies underlying tuberculosis in childhood. Immunol Rev 264:103–120PubMedPubMedCentralCrossRef

48.

Tamburro RF, Cooke KR, Davies SM et al (2021) Pulmonary complications of pediatric hematopoietic stem cell transplantation workshop participants. pulmonary complications of pediatric hematopoietic cell transplantation. A National Institutes of Health Workshop Summary. Ann Am Thorac Soc 18:381–394PubMedPubMedCentralCrossRef

49.

Broglie L, Fretham C, Al-Seraihy A et al (2019) Pulmonary complications in pediatric and adolescent patients following allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 25:2024–2030PubMedPubMedCentralCrossRef

50.

Yoshihara S, Yanik G, Cooke KR, Mineishi S (2007) Bronchiolitis obliterans syndrome (BOS), bronchiolitis obliterans organizing pneumonia (BOOP), and other late-onset noninfectious pulmonary complications following allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 13:749–759PubMedCrossRef

51.

Leonard JT, Newell LF, Meyers G et al (2015) Chronic GvHD-associated serositis and pericarditis. Bone Marrow Transplant 50:1098–1104PubMedCrossRef

52.

Rodina Y, Deripapa E, Shvets O et al (2021) Rituximab and abatacept are effective in differential treatment of interstitial lymphocytic lung disease in children with primary immunodeficiencies. Front Immunol 12:704261PubMedPubMedCentralCrossRef

53.

Grunebaum E, Cutz E, Roifman CM (2012) Pulmonary alveolar proteinosis in patients with adenosine deaminase deficiency. J Allergy Clin Immunol 129:1588–1593PubMedCrossRef

54.

Gao X, Michel K, Griese M (2022) Interstitial lung disease in immunocompromised children. Diagnostics (Basel) 13:64PubMedCrossRef

55.

Hsu AJ, Tamma PD, Zhang SX (2021) Challenges with utilizing the 1,3-beta-d-glucan and galactomannan assays to diagnose invasive mold infections in immunocompromised children. J Clin Microbiol. 59(9):e0327620PubMedCrossRef

56.

Onishi A, Sugiyama D, Kogata Y et al (2012) Diagnostic accuracy of serum 1,3-β-D-glucan for Pneumocystis jirovecii pneumonia, invasive candidiasis, and invasive aspergillosis: systematic review and meta-analysis. J Clin Microbiol 50:7–15PubMedPubMedCentralCrossRef

57.

Leeflang MM, Debets-Ossenkopp YJ et al (2015) Galactomannan detection for invasive aspergillosis in immunocompromised patients. Cochrane Database Syst Rev 2015:007394

58.

Esposito S, Mencacci A et al (2019) Multiplex platforms for the identification of respiratory pathogens: are they useful in pediatric clinical practice? Front Cell Infect Microbiol 4:196CrossRef

59.

Naureckas Li C, Nakamura MM (2022) Utility of broad-range PCR sequencing for infectious diseases clinical decision making: a pediatric center experience. J Clin Microbiol 60:e0243721PubMedCrossRef

60.

Tschiedel E, Goralski A, Steinmann J et al (2019) Multiplex PCR of bronchoalveolar lavage fluid in children enhances the rate of pathogen detection. BMC Pulm Med 19:132.PubMedPubMedCentralCrossRef

61.

Stefanutti D, Morais L, Fournet JC et al (2000) Value of open lung biopsy in immunocompromised children. J Pediatr 137:165–171PubMedCrossRef

62.

Naiditch JA, Barsness KA, Rothstein DH (2013) The utility of surgical lung biopsy in immunocompromised children. J Pediatr 162:133–6.e1PubMedCrossRef

63.

Ozcan HN, Gormez A, Ozsurekci Y et al (2017) Magnetic resonance imaging of pulmonary infection in immunocompromised children: comparison with multidetector computed tomography. Pediatr Radiol 47:146–153PubMedCrossRef

Titel: Lung infections in immunocompromised children
verfasst von: Alistair D. Calder
Giulia Perucca
Sarah May Johnson
Ashwin R. Pandey
Karyn Moshal
Maaike A. Kusters
Publikationsdatum: 17.08.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Radiology / Ausgabe 4/2024
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-023-05735-1

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