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02.05.2022 | Original Article

Laparoscopic liver resection for colorectal liver metastases: retrospective analysis of prognostic factors and oncological outcomes in a single-center cohort

verfasst von: Emily Taillieu, Celine De Meyere, Frederiek Nuytens, Glenn Vanneste, Louis Libbrecht, Herwig Alaerts, Isabelle Parmentier, Chris Verslype, Mathieu D’Hondt

Erschienen in: Langenbeck's Archives of Surgery | Ausgabe 6/2022

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Abstract

Purpose

Laparoscopic liver resection (LLR) has gained acceptance as an effective treatment for colorectal liver metastases (CRLM) in selected patients, providing similar oncologic outcomes compared to open liver resection (OLR). The aim of this study was to determine prognostic factors for survival outcomes associated with LLR for CRLM.

Methods

A single-center retrospective analysis of a prospectively maintained database was performed. The inclusion period ranged from September 2011 until mid-March 2020.

Results

Two hundred consecutive LLRs were included. The 5-year overall survival (OS) and disease-free survival (DFS) rates equalled 54.8% and 49%, respectively. A pushing (HR = 5.42, 95% CI 1.56–18.88, p = 0.008), as well as a replacement (3.87, 1.05–14.2, p = 0.04) growth pattern of the CRLM, poor differentiation of the primary colorectal cancer (CRC) (3.72, 1.72–8.07, p < 0.001) and administration of neoadjuvant chemotherapy (NAC) (2.95, 1.28–6.8, p = 0.01) were identified as independent predictors of a worse OS. Requirement of more than 6 cycles of NAC (6.17, 2.37–16.03, p < 0.001), a replacement (4.96, 1.91–12.87, p < 0.001), as well as a pushing (4.3, 1.68–11, p = 0.002) growth pattern of the CRLM and poor differentiation of the primary CRC (2.61, 1.31–5.2, p = 0.006) were identified as independent predictors of a worse DFS.

Conclusion

LLR for CRLM offers adequate long-term oncologic outcomes. OS and DFS rates are negatively affected by the administration of NAC and by pathological features, including the differentiation grade of the primary CRC and the histological growth pattern of the CRLM.

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Titel: Laparoscopic liver resection for colorectal liver metastases: retrospective analysis of prognostic factors and oncological outcomes in a single-center cohort
verfasst von: Emily Taillieu
Celine De Meyere
Frederiek Nuytens
Glenn Vanneste
Louis Libbrecht
Herwig Alaerts
Isabelle Parmentier
Chris Verslype
Mathieu D’Hondt
Publikationsdatum: 02.05.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: Langenbeck's Archives of Surgery / Ausgabe 6/2022
Print ISSN: 1435-2443
Elektronische ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-022-02534-4

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