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Journal of Cancer Research and Clinical Oncology

Erschienen in:

20.10.2023 | Research

In search of new stratification strategies: tissue proteomic profiling of papillary thyroid microcarcinoma in patients with localized disease and lateral neck metastases

verfasst von: Filip Matovinovic, Rudjer Novak, Stela Hrkac, Grgur Salai, Marko Mocibob, Marija Pranjic, Andro Košec, Vladimir Bedekovic, Lovorka Grgurevic

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 19/2023

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Abstract

Introduction

Papillary thyroid carcinomas (PTC) are the most common thyroid malignancies that are often diagnosed as microcarcinomas when the tumor is less than one centimetre in diameter. Currently, there are no valid stratification strategies that would reliably assess the risk of lateral neck metastases and optimize surgical treatment.

Materials and methods

Aiming to find potential tissue biomarkers of metastatic potential, we conducted a cross-sectional proteomic pilot study on formalin-fixed paraffin-embedded tissues of metastatic (N = 10) and non-metastatic (N = 10) papillary thyroid microcarcinoma patients. Samples were analysed individually using liquid chromatography/mass spectrometry, and the differentially expressed proteins (DEP) were functionally annotated.

Results

We identified five overexpressed DEPs in the metastatic group (EPB41L2, CSE1L, GLIPR2, FGA and FGG) with a known association to tumour biology. Using bioinformatic-based tools, we found markedly different profiles of significantly enriched biological processes between the two groups.

Conclusions

The identified DEPs might have a role as potential tissue biomarkers for PTC metastases. However, further prospective research is needed to confirm our findings.

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Titel: In search of new stratification strategies: tissue proteomic profiling of papillary thyroid microcarcinoma in patients with localized disease and lateral neck metastases
verfasst von: Filip Matovinovic
Rudjer Novak
Stela Hrkac
Grgur Salai
Marko Mocibob
Marija Pranjic
Andro Košec
Vladimir Bedekovic
Lovorka Grgurevic
Publikationsdatum: 20.10.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 19/2023
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-023-05452-0

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In search of new stratification strategies: tissue proteomic profiling of papillary thyroid microcarcinoma in patients with localized disease and lateral neck metastases