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08.05.2024 | Original Communication

History of traumatic brain injury is associated with increased grey-matter loss in patients with mild cognitive impairment

verfasst von: Marc A. Khoury, Nathan W. Churchill, Alex Di Battista, Simon J. Graham, Sean Symons, Angela K. Troyer, Angela Roberts, Sanjeev Kumar, Brian Tan, Stephen R. Arnott, Joel Ramirez, Maria C. Tartaglia, Michael Borrie, Bruce Pollock, Tarek K. Rajji, Stephen H. Pasternak, Andrew Frank, David F. Tang-Wai, Christopher J. M. Scott, Seyyed Mohammad Hassan Haddad, Nuwan Nanayakkara, Joseph B. Orange, Alicia Peltsch, Corinne E. Fischer, David G. Munoz, Tom A. Schweizer

Erschienen in: Journal of Neurology

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Abstract

Objectives

To investigate whether a history of traumatic brain injury (TBI) is associated with greater long-term grey-matter loss in patients with mild cognitive impairment (MCI).

Methods

85 patients with MCI were identified, including 26 with a previous history of traumatic brain injury (MCI[TBI-]) and 59 without (MCI[TBI+]). Cortical thickness was evaluated by segmenting T1-weighted MRI scans acquired longitudinally over a 2-year period. Bayesian multilevel modelling was used to evaluate group differences in baseline cortical thickness and longitudinal change, as well as group differences in neuropsychological measures of executive function.

Results

At baseline, the MCI[TBI+] group had less grey matter within right entorhinal, left medial orbitofrontal and inferior temporal cortex areas bilaterally. Longitudinally, the MCI[TBI+] group also exhibited greater longitudinal declines in left rostral middle frontal, the left caudal middle frontal and left lateral orbitofrontal areas sover the span of 2 years (median = 1–2%, 90%HDI [−0.01%: −0.001%], probability of direction (PD) = 90–99%). The MCI[TBI+] group also displayed greater longitudinal declines in Trail-Making-Test (TMT)-derived ratio (median: 0.737%, 90%HDI: [0.229%: 1.31%], PD = 98.8%) and differences scores (median: 20.6%, 90%HDI: [−5.17%: 43.2%], PD = 91.7%).

Conclusions

Our findings support the notion that patients with MCI and a history of TBI are at risk of accelerated neurodegeneration, displaying greatest evidence for cortical atrophy within the left middle frontal and lateral orbitofrontal frontal cortex. Importantly, these results suggest that long-term TBI-mediated atrophy is more pronounced in areas vulnerable to TBI-related mechanical injury, highlighting their potential relevance for diagnostic forms of intervention in TBI.

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Titel: History of traumatic brain injury is associated with increased grey-matter loss in patients with mild cognitive impairment
verfasst von: Marc A. Khoury
Nathan W. Churchill
Alex Di Battista
Simon J. Graham
Sean Symons
Angela K. Troyer
Angela Roberts
Sanjeev Kumar
Brian Tan
Stephen R. Arnott
Joel Ramirez
Maria C. Tartaglia
Michael Borrie
Bruce Pollock
Tarek K. Rajji
Stephen H. Pasternak
Andrew Frank
David F. Tang-Wai
Christopher J. M. Scott
Seyyed Mohammad Hassan Haddad
Nuwan Nanayakkara
Joseph B. Orange
Alicia Peltsch
Corinne E. Fischer
David G. Munoz
Tom A. Schweizer
Publikationsdatum: 08.05.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Neurology
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-024-12369-2

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