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Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery 3/2022

06.01.2022 | Original Article

Evaluation of Hearing Loss in Congenital Hypothyroid Children at a Tertiary Care Hospital in Central India

verfasst von: Praveen Kumar Thakur, Rajeev Kumar Nishad, Anil Kumar Jain

Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery | Sonderheft 3/2022

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Abstract

Hearing loss has long been associated with congenital hypothyroidism and, if not noticed and treated early, may result in delayed language acquisition and difficulties in comprehension. In light of the implications of congenital hypothyroidism and its associated hearing loss, we decided to conduct this study. The aim of this study was to identify the prevalence of hearing loss in congenital hypothyroidism and its relation to the severity of the disease and age of initiation of treatment. This study was conducted from July 2016 to June 2021 at a tertiary care hospital in Bhopal. The hearing status of congenital hypothyroid children and matched controls was assessed by pure tone audiometry or free field audiometry and, in selected cases, with brainstem evoked response audiometry. Eight children (25%) with congenital hypothyroidism had hearing loss, compared to one (3.12%) in the control group (p < 0.05). No statistically significant difference has been found in the gender, mean age of diagnosis, mean age of initiation of levothyroxine treatment, mean screening FT4 levels, and mean screening TSH levels between congenital hypothyroid children with and without hearing loss. Due to the high prevalence of hearing loss in congenital hypothyroidism and its impact on language and cognitive development, it is critical to create awareness among healthcare professionals that children diagnosed with congenital hypothyroidism must undergo audiological evaluation at the time of diagnosis and periodically thereafter. Alternatively, children with unexplained hearing loss must be screened for congenital hypothyroidism.
Literatur
1.
Zurück zum Zitat DeLong GR, Stanbury JB, Fierro-Benitez R (2008) Neurological signs in congenital iodine-deficiency disorder (endemic cretinism). Dev Med Child Neurol 27(3):317–324CrossRef DeLong GR, Stanbury JB, Fierro-Benitez R (2008) Neurological signs in congenital iodine-deficiency disorder (endemic cretinism). Dev Med Child Neurol 27(3):317–324CrossRef
2.
Zurück zum Zitat Prezioso G, Giannini C, Chiarelli F (2018) Effect of thyroid hormones on neurons and neurodevelopment. Horm Res Paediatr 90(2):73–81CrossRef Prezioso G, Giannini C, Chiarelli F (2018) Effect of thyroid hormones on neurons and neurodevelopment. Horm Res Paediatr 90(2):73–81CrossRef
3.
Zurück zum Zitat Sohmer H, Freeman S (1996) The importance of thyroid hormone for auditory development in the fetus and neonate. Audiol Neurootol 1(3):137–147CrossRef Sohmer H, Freeman S (1996) The importance of thyroid hormone for auditory development in the fetus and neonate. Audiol Neurootol 1(3):137–147CrossRef
4.
Zurück zum Zitat Andrade CLO, Machado GC, Fernandes LDC, Albuquerque JM, Casais-E-Silva LL, Ramos HE et al (2017) Mechanisms involved in hearing disorders of thyroid ontogeny: a literature review. Arch Endocrinol Metab 61(5):501–505CrossRef Andrade CLO, Machado GC, Fernandes LDC, Albuquerque JM, Casais-E-Silva LL, Ramos HE et al (2017) Mechanisms involved in hearing disorders of thyroid ontogeny: a literature review. Arch Endocrinol Metab 61(5):501–505CrossRef
5.
Zurück zum Zitat Heuer H (2011) Hear, hear! Thyroid hormone transporters in cochlear development. Endocrinology 152(12):4478–4480CrossRef Heuer H (2011) Hear, hear! Thyroid hormone transporters in cochlear development. Endocrinology 152(12):4478–4480CrossRef
6.
Zurück zum Zitat Knipper M, Zinn C, Maier H, Praetorius M, Rohbock K, Köpschall I et al (2000) Thyroid hormone deficiency before the onset of hearing causes irreversible damage to peripheral and central auditory systems. J Neurophysiol 83(5):3101–3112CrossRef Knipper M, Zinn C, Maier H, Praetorius M, Rohbock K, Köpschall I et al (2000) Thyroid hormone deficiency before the onset of hearing causes irreversible damage to peripheral and central auditory systems. J Neurophysiol 83(5):3101–3112CrossRef
7.
Zurück zum Zitat Andrade CLO et al (2017) Mechanisms involved in hearing disorders of thyroid ontogeny: a literature review. Arch Endocrinol Metab 61(5):501–505CrossRef Andrade CLO et al (2017) Mechanisms involved in hearing disorders of thyroid ontogeny: a literature review. Arch Endocrinol Metab 61(5):501–505CrossRef
8.
Zurück zum Zitat Deol MS (1976) The role of thyroxine in the differentiation of the organ of Corti. Acta Otolaryngol 81(5–6):429–435CrossRef Deol MS (1976) The role of thyroxine in the differentiation of the organ of Corti. Acta Otolaryngol 81(5–6):429–435CrossRef
9.
Zurück zum Zitat Uziel A, Pujol R, Legrand C, Legrand J (1983) Cochlear synaptogenesis in the hypothyroid rat. Brain Res 283(2–3):295–301CrossRef Uziel A, Pujol R, Legrand C, Legrand J (1983) Cochlear synaptogenesis in the hypothyroid rat. Brain Res 283(2–3):295–301CrossRef
10.
Zurück zum Zitat Berbel P, Guadaño-Ferraz A, Martínez M, Quiles JA, Balboa R, Innocenti GM (1993) Organization of auditory callosal connections in hypothyroid adult rats. Eur J Neurosci 5(11):1465–1478CrossRef Berbel P, Guadaño-Ferraz A, Martínez M, Quiles JA, Balboa R, Innocenti GM (1993) Organization of auditory callosal connections in hypothyroid adult rats. Eur J Neurosci 5(11):1465–1478CrossRef
11.
Zurück zum Zitat Sharlin DS, Visser TJ, Forrest D (2011) Developmental and cell-specific expression of thyroid hormone transporters in the mouse cochlea. Endocrinology 152(12):5053–5064CrossRef Sharlin DS, Visser TJ, Forrest D (2011) Developmental and cell-specific expression of thyroid hormone transporters in the mouse cochlea. Endocrinology 152(12):5053–5064CrossRef
12.
Zurück zum Zitat Cordas EA, Ng L, Hernandez A, Kaneshige M, Cheng SY, Forrest D (2011) Thyroid hormone receptors control developmental maturation of the middle ear and the size of the ossicular bones. Endocrinology 153(3):1548–1560CrossRef Cordas EA, Ng L, Hernandez A, Kaneshige M, Cheng SY, Forrest D (2011) Thyroid hormone receptors control developmental maturation of the middle ear and the size of the ossicular bones. Endocrinology 153(3):1548–1560CrossRef
13.
Zurück zum Zitat Ng L, Goodyear RJ, Woods CA, Schneider MJ, Diamond E, Richardson GP et al (2004) Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase. Proc Natl Acad Sci U S A 101(10):3474–3479CrossRef Ng L, Goodyear RJ, Woods CA, Schneider MJ, Diamond E, Richardson GP et al (2004) Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase. Proc Natl Acad Sci U S A 101(10):3474–3479CrossRef
14.
Zurück zum Zitat Lichtenberger-Geslin L, Dos Santos S, Hassani Y, Ecosse E, Van Den Abbeele T, Léger J (2013) Factors associated with hearing impairment in patients with congenital hypothyroidism treated since the neonatal period: a national population-based study. J Clin Endocrinol Metab 98(9):3644–3652CrossRef Lichtenberger-Geslin L, Dos Santos S, Hassani Y, Ecosse E, Van Den Abbeele T, Léger J (2013) Factors associated with hearing impairment in patients with congenital hypothyroidism treated since the neonatal period: a national population-based study. J Clin Endocrinol Metab 98(9):3644–3652CrossRef
15.
Zurück zum Zitat Rovet J, Walker W, Bliss B, Buchanan L, Ehrlich R (1996) Long-term sequelae of hearing impairment in congenital hypothyroidism. J Pediatr 128(6):776–783CrossRef Rovet J, Walker W, Bliss B, Buchanan L, Ehrlich R (1996) Long-term sequelae of hearing impairment in congenital hypothyroidism. J Pediatr 128(6):776–783CrossRef
16.
Zurück zum Zitat Vanderschueren-Lodeweyckx M, Debruyne F, Dooms L, Eggermont E, Eeckels R (1983) Sensorineural hearing loss in sporadic congenital hypothyroidism. Arch Dis Child 58(6):419–422CrossRef Vanderschueren-Lodeweyckx M, Debruyne F, Dooms L, Eggermont E, Eeckels R (1983) Sensorineural hearing loss in sporadic congenital hypothyroidism. Arch Dis Child 58(6):419–422CrossRef
17.
Zurück zum Zitat Bruno R, Aversa T, Catena M, Valenzise M, Lombardo F, De Luca F et al (2015) Even in the era of congenital hypothyroidism screening mild and subclinical sensorineural hearing loss remains a relatively common complication of severe congenital hypothyroidism. Hear Res 327:43–47CrossRef Bruno R, Aversa T, Catena M, Valenzise M, Lombardo F, De Luca F et al (2015) Even in the era of congenital hypothyroidism screening mild and subclinical sensorineural hearing loss remains a relatively common complication of severe congenital hypothyroidism. Hear Res 327:43–47CrossRef
18.
Zurück zum Zitat Wasniewska M, De Luca F, Siclari S, Salzano G, Messina MF, Lombardo F et al (2002) Hearing loss in congenital hypothalamic hypothyroidism: a wide therapeutic window. Hear Res 172(1–2):87–91CrossRef Wasniewska M, De Luca F, Siclari S, Salzano G, Messina MF, Lombardo F et al (2002) Hearing loss in congenital hypothalamic hypothyroidism: a wide therapeutic window. Hear Res 172(1–2):87–91CrossRef
19.
Zurück zum Zitat Gordon N, Ward S (1995) Abnormal response to sound and central auditory processing disorder. Dev Med Child Neurol 37(7):645–652CrossRef Gordon N, Ward S (1995) Abnormal response to sound and central auditory processing disorder. Dev Med Child Neurol 37(7):645–652CrossRef
20.
Zurück zum Zitat Barett KA (1985) Hearing and immittance screening of school age children. In: Katz J (ed) Handbook of clinical audiology, 3rd edn. Williams & Wilkins, Baltimore, pp 621–641 Barett KA (1985) Hearing and immittance screening of school age children. In: Katz J (ed) Handbook of clinical audiology, 3rd edn. Williams & Wilkins, Baltimore, pp 621–641
21.
Zurück zum Zitat Léger J, Olivieri A, Donaldson M, Torresani T, Krude H, van Vliet G, Polak M, Butler G, ESPE-PES-SLEP-JSPE-APEG-APPES-ISPAE, Congenital Hypothyroidism Consensus Conference Group (2014) European Society for Paediatric Endocrinology consensus guidelines on screening, diagnosis, and management of congenital hypothyroidism. J Clin Endocrinol Metab 99(2):363–384. https://doi.org/10.1210/jc.2013-1891CrossRef Léger J, Olivieri A, Donaldson M, Torresani T, Krude H, van Vliet G, Polak M, Butler G, ESPE-PES-SLEP-JSPE-APEG-APPES-ISPAE, Congenital Hypothyroidism Consensus Conference Group (2014) European Society for Paediatric Endocrinology consensus guidelines on screening, diagnosis, and management of congenital hypothyroidism. J Clin Endocrinol Metab 99(2):363–384. https://​doi.​org/​10.​1210/​jc.​2013-1891CrossRef
22.
Zurück zum Zitat Almagor T, Rath S, Nachtigal D, Sharroni Z, Elias-Assad G, Hess O, Havazelet G, Zehavi Y, Spiegel R, Bercovich D, Almashanu S, Tenenbaum-Rakover Y (2021) High prevalence of hearing impairment in primary congenital hypothyroidism. Eur Thyroid J 10(3):215–221. https://doi.org/10.1159/000509775CrossRef Almagor T, Rath S, Nachtigal D, Sharroni Z, Elias-Assad G, Hess O, Havazelet G, Zehavi Y, Spiegel R, Bercovich D, Almashanu S, Tenenbaum-Rakover Y (2021) High prevalence of hearing impairment in primary congenital hypothyroidism. Eur Thyroid J 10(3):215–221. https://​doi.​org/​10.​1159/​000509775CrossRef
23.
Zurück zum Zitat Russ SA, White K, Dougherty D et al (2010) Preface: newborn hearing screening in the United States: historical perspective and future directions. Pediatrics 126(Suppl 1):S3-6CrossRef Russ SA, White K, Dougherty D et al (2010) Preface: newborn hearing screening in the United States: historical perspective and future directions. Pediatrics 126(Suppl 1):S3-6CrossRef
24.
Zurück zum Zitat Hull FM, Mielke PW, Willeford JA (1976) National speech and hearing survey (final report, project no. 59078). US Department of Health, Education and Welfare, Washington, DC Hull FM, Mielke PW, Willeford JA (1976) National speech and hearing survey (final report, project no. 59078). US Department of Health, Education and Welfare, Washington, DC
25.
Zurück zum Zitat Brookhouser PE (1993) NIH consensus development conference, early identification of hearing impairment in infants and young children. Incidence/prevalence. National Institutes of Health, Bethesda Brookhouser PE (1993) NIH consensus development conference, early identification of hearing impairment in infants and young children. Incidence/prevalence. National Institutes of Health, Bethesda
27.
Zurück zum Zitat Joint Committee on Infant Hearing 1994 position statement. ASHA 36(12):38–41 (1994) Joint Committee on Infant Hearing 1994 position statement. ASHA 36(12):38–41 (1994)
28.
Zurück zum Zitat Conway CM, Pisoni DB, Kronenberger WG (2009) The importance of sound for cognitive sequencing abilities: the auditory scaffolding hypothesis. Curr Dir Psychol Sci 18(5):275–279CrossRef Conway CM, Pisoni DB, Kronenberger WG (2009) The importance of sound for cognitive sequencing abilities: the auditory scaffolding hypothesis. Curr Dir Psychol Sci 18(5):275–279CrossRef
29.
Zurück zum Zitat Davis JM, Elfenbein J, Schum R, Bentler RA (1986) Effects of mild and moderate hearing impairments on language, educational, and psychosocial behavior of children. J Speech Hear Disord 51(1):53–62CrossRef Davis JM, Elfenbein J, Schum R, Bentler RA (1986) Effects of mild and moderate hearing impairments on language, educational, and psychosocial behavior of children. J Speech Hear Disord 51(1):53–62CrossRef
30.
Zurück zum Zitat Karolyi IJ, Dootz GA, Halsey K, Beyer L, Probst FJ, Johnson KR et al (2007) Dietary thyroid hormone replacement ameliorates hearing deficits in hypothyroid mice. Mamm Genome 18(8):596–608CrossRef Karolyi IJ, Dootz GA, Halsey K, Beyer L, Probst FJ, Johnson KR et al (2007) Dietary thyroid hormone replacement ameliorates hearing deficits in hypothyroid mice. Mamm Genome 18(8):596–608CrossRef
31.
Zurück zum Zitat Forrest D, Erway LC, Ng L, Altschuler R, Curran T (1996) Thyroid hormone receptor beta is essential for development of auditory function. Nat Genet 13(3):354–357CrossRef Forrest D, Erway LC, Ng L, Altschuler R, Curran T (1996) Thyroid hormone receptor beta is essential for development of auditory function. Nat Genet 13(3):354–357CrossRef
32.
Zurück zum Zitat Thornton AR, Jarvis SJ (2008) Auditory brainstem response findings in hypothyroid and hyperthyroid disease. Clin Neurophysiol 119(4):786–790CrossRef Thornton AR, Jarvis SJ (2008) Auditory brainstem response findings in hypothyroid and hyperthyroid disease. Clin Neurophysiol 119(4):786–790CrossRef
33.
Zurück zum Zitat Brucker-Davis F, Skarulis MC, Pikus A, Ishizawar D, Mastroianni MA, Koby M et al (1996) Prevalence and mechanisms of hearing loss in patients with resistance to thyroid hormone. J Clin Endocrinol Metab 81(8):2768–2772 Brucker-Davis F, Skarulis MC, Pikus A, Ishizawar D, Mastroianni MA, Koby M et al (1996) Prevalence and mechanisms of hearing loss in patients with resistance to thyroid hormone. J Clin Endocrinol Metab 81(8):2768–2772
34.
Zurück zum Zitat Brucker-Davis F, Skarulis MC, Grace MB, Benichou J, Hauser P, Wiggs E et al (1995) Genetic and clinical features of 42 kindreds with resistance to thyroid hormone: The National Institutes of Health Prospective Study. Ann Intern Med 123(8):572–583CrossRef Brucker-Davis F, Skarulis MC, Grace MB, Benichou J, Hauser P, Wiggs E et al (1995) Genetic and clinical features of 42 kindreds with resistance to thyroid hormone: The National Institutes of Health Prospective Study. Ann Intern Med 123(8):572–583CrossRef
35.
Zurück zum Zitat Vikas M, Shukla G, Naresh B (2002) Hearing profile in hypothyroidism. Indian J Otolaryngol Head Neck Surg 54:285–290CrossRef Vikas M, Shukla G, Naresh B (2002) Hearing profile in hypothyroidism. Indian J Otolaryngol Head Neck Surg 54:285–290CrossRef
Metadaten
Titel
Evaluation of Hearing Loss in Congenital Hypothyroid Children at a Tertiary Care Hospital in Central India
verfasst von
Praveen Kumar Thakur
Rajeev Kumar Nishad
Anil Kumar Jain
Publikationsdatum
06.01.2022
Verlag
Springer India
Erschienen in
Indian Journal of Otolaryngology and Head & Neck Surgery / Ausgabe Sonderheft 3/2022
Print ISSN: 2231-3796
Elektronische ISSN: 0973-7707
DOI
https://doi.org/10.1007/s12070-021-03063-0

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