Background
Methods
Participant recruitment
Statistics reference
Statistical analysis
Results
Variable | 0.5 ~ 2.99 years(n = 1166) | 3 ~ 5.99 years(n = 1680) | 6 ~ 11.99 years(n = 2265) | 12 ~ 18 years(n = 727) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
AntiHBs Expression | P | AntiHBs Expression | P | AntiHBs Expression | P | AntiHBs Expression | P | |||||
Positive (n = 913) | Negative (n = 253) | Positive (n = 1025) | Negative (n = 655) | Positive (n = 1407) | Negative (n = 828) | Positive (n = 479) | Negative (n = 248) | |||||
Gender | ||||||||||||
Female | 403 | 119 | 0.412 | 432 | 279 | 0.856 | 609 | 380 | 0.640 | 173 | 81 | 0.354 |
Male | 510 | 134 | 593 | 376 | 798 | 478 | 308 | 167 | ||||
Birth way | ||||||||||||
eutocia | 422 | 115 | 0.829 | 520 | 341 | 0.595 | 764 | 453 | 0.487 | 247 | 137 | 0.347 |
cesarean section | 491 | 138 | 505 | 314 | 643 | 405 | 232 | 111 | ||||
BMI | – | – | – | – | – | – | ||||||
thin | – | – | – | – | – | – | 116 | 66 | 0.131 | 54 | 41 | 0.133 |
normal | – | – | – | – | – | – | 1040 | 665 | 336 | 162 | ||
overweight or obese | – | – | – | – | – | – | 251 | 127 | 89 | 45 | ||
Duration of lactation period (month), | ||||||||||||
0~ | 285 | 82 | 0.150 | 328 | 208 | 0.875 | 439 | 257 | 0.311 | 160 | 86 | 0.557 |
6~ | 455 | 111 | 503 | 319 | 692 | 449 | 224 | 121 | ||||
12~ | 173 | 60 | 190 | 128 | 276 | 152 | 95 | 41 | ||||
Whether the children had a history of eczema | ||||||||||||
Yes | 318 | 93 | 0.570 | 327 | 225 | 0.297 | 443 | 220 | 0.253 | 143 | 82 | 0.375 |
No | 595 | 160 | 698 | 430 | 964 | 568 | 336 | 166 | ||||
Whether the children had a history of second-hand cigarette exposure | ||||||||||||
Yes | 259 | 66 | 0.474 | 284 | 195 | 0.361 | 431 | 233 | 0.078* | 142 | 72 | 0.864 |
No | 654 | 187 | 741 | 460 | 976 | 625 | 337 | 176 | ||||
Whether the children had a frequent cold | ||||||||||||
Yes | 214 | 67 | 0.317 | 258 | 168 | 0.828 | 349 | 203 | 0.538 | 114 | 58 | 0.901 |
No | 699 | 186 | 767 | 487 | 1058 | 655 | 365 | 190 | ||||
Anemia | ||||||||||||
Yes | 97 | 8 | < 0.001*** | 85 | 42 | 0.155 | 112 | 58 | 0.293 | 20 | 10 | 0.927 |
No | 816 | 245 | 940 | 613 | 1295 | 800 | 459 | 238 | ||||
Lead intoxication | ||||||||||||
Yes | 3 | 0 | 0.832 | 2 | 2 | 0.999 | 8 | 1 | 0.097* | 4 | 2 | 0.968 |
No | 910 | 253 | 1023 | 653 | 1399 | 857 | 475 | 248 | ||||
Cadmium intoxication | ||||||||||||
Yes | 29 | 14 | 0.078* | 17 | 12 | 0.790 | 35 | 26 | 0.439 | 11 | 7 | 0.665 |
No | 884 | 239 | 1008 | 643 | 1372 | 832 | 468 | 241 | ||||
Zinc deficiency | ||||||||||||
Yes | 673 | 174 | 0.119 | 159 | 130 | 0.022** | 988 | 632 | 0.079* | 185 | 112 | 0.089* |
No | 240 | 79 | 866 | 525 | 419 | 226 | 294 | 136 | ||||
Copper deficiency | ||||||||||||
Yes | 118 | 29 | 0.535 | 214 | 161 | 0.076* | 412 | 264 | 0.453 | 177 | 100 | 0.375 |
No | 796 | 224 | 811 | 494 | 995 | 594 | 302 | 148 | ||||
Calcium deficiency | ||||||||||||
Yes | 4 | 2 | 0.844 | 35 | 27 | 0.453 | 436 | 258 | 0.646 | 326 | 153 | 0.086* |
No | 909 | 251 | 990 | 628 | 971 | 600 | 153 | 95 | ||||
Iron deficiency | ||||||||||||
Yes | 490 | 118 | 0.095* | 388 | 236 | 0.451 | 286 | 176 | 0.915 | 28 | 16 | 0.745 |
No | 433 | 135 | 637 | 419 | 1121 | 682 | 451 | 232 |
Variable | 0.5 ~ 2.99 years(n = 1166) | 3 ~ 5.99 years(n = 1680) | 6 ~ 11.99 years(n = 2265) | 12 ~ 18 years(n = 727) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Anti-HBs Expression (\(\overline{\textrm{X}}\) ±SD) | P | Anti-HBs Expression (\(\overline{\textrm{X}}\) ±SD) | P | Anti-HBs Expression (\(\overline{\textrm{X}}\) ±SD) | P | Anti-HBs Expression (\(\overline{\textrm{X}}\) ±SD) | P | |||||
Positive (n = 913) | Negative (n = 253) | Positive (n = 1025) | Negative (n = 655) | Positive (n = 1407) | Negative(n = 828) | Positive (n = 479) | Negative(n = 248) | |||||
Age | 1.790 ± 0.663 | 2.129 ± 0.506 | < 0.001*** | 4.291 ± 0.867 | 4.398 ± 0.879 | 0.014** | 8.781 ± 1.668 | 8.697 ± 1.700 | 0.247 | 13.657 ± 1.226 | 13.608 ± 1.224 | 0.610 |
WBC(10^9/L) | 8.596 ± 2.395 | 8.236 ± 1.857 | 0.011** | 7.659 ± 2.109 | 7.571 ± 2.064 | 0.405 | 6.896 ± 1.950 | 6.870 ± 1.801 | 0.746 | 6.469 ± 1.560 | 6.487 ± 1.528 | 0.882 |
VitD(ng/ml) | 48.343 ± 18.992 | 40.810 ± 17.443 | < 0.001*** | 45.071 ± 15.604 | 43.853 ± 14.831 | 0.112 | 41.966 ± 13.144 | 41.354 ± 13.413 | 0.286 | 39.209 ± 11.843 | 36.751 ± 12.778 | 0.012** |
C3(g/L) | 1.027 ± 0.198 | 1.030 ± 0.196 | 0.814 | 1.025 ± 0.220 | 1.021 ± 0.183 | 0.670 | 1.021 ± 0.203 | 1.024 ± 0.186 | 0.758 | 1.031 ± 0.183 | 1.032 ± 0.175 | 0.954 |
C4(g/L) | 0.243 ± 0.144 | 0.255 ± 0.142 | 0.224 | 0.252 ± 0.141 | 0.246 ± 0.138 | 0.324 | 0.248 ± 0.137 | 0.252 ± 0.137 | 0.469 | 0.245 ± 0.139 | 0.241 ± 0.134 | 0.695 |
IgA(g/L) | 1.433 ± 0.720 | 1.408 ± 0.722 | 0.619 | 1.405 ± 0.739 | 1.391 ± 0.700 | 0.709 | 1.462 ± 0.719 | 1.443 ± 0.724 | 0.555 | 1.557 ± 0.750 | 1.577 ± 0.707 | 0.732 |
IgG(g/L) | 10.443 ± 2.237 | 10.436 ± 2.271 | 0.967 | 10.304 ± 2.290 | 10.165 ± 2.416 | 0.235 | 10.393 ± 2.277 | 10.417 ± 2.234 | 0.808 | 10.452 ± 2.207 | 10.650 ± 2.264 | 0.257 |
IgE(IU/mL) | 149.414 ± 86.725 | 148.166 ± 87.992 | 0.840 | 155.292 ± 130.971 | 147.866 ± 102.403 | 0.219 | 151.545 ± 134.349 | 150.814 ± 158.919 | 0.907 | 156.317 ± 139.988 | 155.264 ± 131.955 | 0.992 |
IgM(g/L) | 1.25 ± 0.71 | 1.31 ± 0.75 | 0.209 | 1.265 ± 0.709 | 1.241 ± 0.722 | 0.518 | 1.251 ± 0.725 | 1.261 ± 0.734 | 0.743 | 1.218 ± 0.719 | 1.175 ± 0.700 | 0.442 |
Variable | 0.5 ~ 2.99 years(n = 1166) | 3 ~ 5.99 years(n = 1680) | 6 ~ 11.99 years(n = 2265) | 12 ~ 18 years(n = 727) | ||||
---|---|---|---|---|---|---|---|---|
OR(95%CI) | P value | OR(95%CI) | P value | OR(95%CI) | P value | OR(95%CI) | P value | |
Whether the children had a history of second-hand cigarette exposure | ||||||||
No | 0.891(0.650–1.221) | 0.474 | 1.106(0.891–1.347) | 0.361 | 0.844(0.699–1.019) | 0.078* | 0.971(0.693–1.361) | 0.864 |
Yesa | ||||||||
Anemia | ||||||||
No | 0.275(0.132–0.573) | < 0.001*** | 0.758(0.516–1.112) | 0.156 | 0.838(0.603–1.166) | 0.293 | 0.964(0.444–2.092) | 0.927 |
Yesa | ||||||||
Lead intoxication | ||||||||
No | 1.567(0.22–11.111) | 0.645 | 0.204(0.025–1.634) | 0.134 | 0.965(0.176–5.319) | 0.968 | ||
Yesa | ||||||||
Cadmium intoxication | ||||||||
No | 1.786(0.929–3.436) | 0.082* | 1.106(0.525–2.331) | 0.79 | 1.225(0.732–2.409) | 0.44 | 1.236(0.473–3.226) | 0.666 |
Yesa | ||||||||
Zinc deficiency | ||||||||
No | 0.786(0.580–1.065) | 0.119 | 0.741(0.574–0.958) | 0.022** | 1.186(0.980–1.435) | 0.079* | 1.309(0.96–1.786) | 0.089* |
Yesa | ||||||||
Copper deficiency | ||||||||
No | 0.873.(0.566–1.344) | 0.536 | 1.235(0.978–1.56) | 0.076* | 1.073(0.892–1.292) | 0.453 | 1.153(0.842–1.580) | 0.375 |
Yesa | ||||||||
Calcium deficiency | ||||||||
No | 1.812(0.330–9.901) | 0.494 | 1.217(0.729–2.028) | 0.454 | 0.958(0.796–1.152) | 0.646 | 0.756(0.549–1.041) | 0.087* |
Yesa | ||||||||
Iron deficiency | ||||||||
No | 0.789(0.596–1.043) | 0.095* | 0.925(0.755–1.134) | 0.451 | 1.011(0.82–1.248) | 0.915 | 1.111(0.589–2.096) | 0.745 |
Yesa | ||||||||
Age | 2.476(1.932–3.172) | < 0.001*** | 1.151(1.028–1.288) | 0.014** | 0.971(0.923–1.021) | 0.247 | 0.968(0.853–1.098) | 0.609 |
WBC(10^9/L) | 0.93(0.872–0.992) | 0.028** | 0.98(0.935–1.028) | 0.405 | 0.993(0.949–1.038) | 0.746 | 1.008(0.913–1.112) | 0.882 |
VitD(ng/ml) | 0.978(0.971–0.986) | < 0.001*** | 0.995(0.988–1.001) | 0.112 | 0.997(0.99–1.003) | 0.286 | 0.984(0.972–0.996) | 0.010** |
Variable | OR(95%CI) | P value |
---|---|---|
0.5 ~ 2.99 years(n = 1166) | ||
Anemia | ||
No | 0.392(0.185–0.835) | 0.015* |
Yesa | ||
Cadmium intoxication | ||
No | 1.88(0.93–3.802) | 0.079 |
Yesa | ||
Age | 2.542(1.961–3.295) | < 0.001*** |
VitD(ng/ml) | 0.977(0.969–0.984) | < 0.001*** |
3 ~ 5.99 years(n = 1680) | ||
Zinc deficiency | ||
No | 0.713(0.551–0.923) | 0.01* |
Yesa | ||
Copper deficiency | ||
No | 1.264(0.998–1.6) | 0.052 |
Yesa | ||
Age | 1.151(1.028–1.289) | 0.015* |
6 ~ 11.99 years(n = 2265) | ||
Whether the children had a history of second-hand cigarette exposure | ||
No | 0.841(0.697–1.015) | 0.072 |
Yesa | ||
Zinc deficiency | ||
No | 0.84(0.695–1.016) | 0.073 |
Yesa | ||
12 ~ 17.99 years(n = 727) | ||
Zinc deficiency | ||
No | 1.355(0.991–1.855) | 0.057 |
Yesa | ||
VitD(ng/ml) | 0.983(0.971–0.995) | 0.007** |