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Erschienen in:
26.09.2023 | Correspondence
Different oxygenation targets for stable COPD and acute exacerbations in the ICU. Author’s reply
Erschienen in: Intensive Care Medicine | Ausgabe 11/2023
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We appreciate Zijlstra’s comments [1] on our retrospective study of controlled hypoxemia in patients with chronic obstructive pulmonary disease (COPD) in the intensive care unit (ICU) [2]. We agree that such retrospective data do not provide evidence for causal effects. Still, to get a better sense of whether mortality is associated with a low peripheral oxygen saturation (SpO2) range or with difficulty in maintaining a particular SpO2 range using a higher fraction of inspired oxygen (FiO2), we adjusted for FiO2 in Fig. 1 (Figure S2 from the supplementary material of our paper [2]). As demonstrated by Fig. 1, hypoxemic SpO2 levels were associated with increased mortality, with this association being independent of FiO2.
Fig. 1
Adjusted odds ratios for hospital mortality with various SpO2 ranges when also adjusting for FiO2. The dots are the adjusted odds ratios of a 10-percentage point increase in the proportion of SpO2 measurements within the specified SpO2 range. The lines are the 95% confidence intervals. Here, the logistic regression adjusted also for median FiO2
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