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27.09.2023 | Original Communication

Correlation of glymphatic system abnormalities with Parkinson’s disease progression: a clinical study based on non-invasive fMRI

verfasst von: Jing-Cai Meng, Ming-Qiang Shen, Yan-Li Lu, Hong-Xuan Feng, Xin-Yi Chen, Da-Qiang Xu, Guan-Hui Wu, Qing-Zhang Cheng, Lin-Hui Wang, Qian Gui

Erschienen in: Journal of Neurology | Ausgabe 1/2024

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Abstract

Background

The glymphatic system is reportedly involved in Parkinson’s disease (PD). Based on previous studies, we aimed to confirm the correlation between the glymphatic system and PD progression by combining two imaging parameters, diffusion tensor image analysis along the perivascular space (DTI-ALPS), and enlarged perivascular spaces (EPVS).

Methods

Fifty-one PD patients and fifty healthy control (HC) were included. Based on the Hoehn-Yahr scale, the PD group was divided into early-stage and medium-to late-stage. All PD patients were scored using the Unified PD Rating Scale (UPDRS). We assessed the DTI-ALPS indices in the bilateral hemispheres and EPVS numbers in bilateral centrum semiovale (CSO), basal ganglia (BG), and midbrain.

Results

The DTI-ALPS indices were significantly lower bilaterally in PD patients than in the HC group, and EPVS numbers in any of the bilateral CSO, BG, and midbrain were significantly higher, especially for the medium- to late-stage group and the BG region. In PD patients, the DTI-ALPS index was significantly negatively correlated with age, while the BG-EPVS numbers were significantly positively correlated with age. Furthermore, the DTI-ALPS index was negatively correlated with UPDRS II and III scores, while the BG-EPVS numbers were positively correlated with UPDRS II and III scores. Similarly, the correlation was more pronounced in the medium- to late-stage group.

Conclusion

The DTI-ALPS index and EPVS numbers (especially in the BG region) are closely related to age and PD progression and can serve as non-invasive assessments for glymphatic dysfunction and its interventions in clinical studies.

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Titel: Correlation of glymphatic system abnormalities with Parkinson’s disease progression: a clinical study based on non-invasive fMRI
verfasst von: Jing-Cai Meng
Ming-Qiang Shen
Yan-Li Lu
Hong-Xuan Feng
Xin-Yi Chen
Da-Qiang Xu
Guan-Hui Wu
Qing-Zhang Cheng
Lin-Hui Wang
Qian Gui
Publikationsdatum: 27.09.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Neurology / Ausgabe 1/2024
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-023-12004-6

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Weitere Artikel der Ausgabe 1/2024

The relationship between disease-specific psychosocial stressors and depressive symptoms in Huntington’s disease

Long-term neurological symptoms after acute COVID-19 illness requiring hospitalization in adult patients: insights from the ISARIC-COVID-19 follow-up study

Understanding the genetic mechanisms and cognitive impairments in Down syndrome: towards a holistic approach

Impairment of oculomotor functions in patients with early to advanced amyotrophic lateral sclerosis

eHealth tools to assess the neurological function for research, in absence of the neurologist – a systematic review, part I (software)