All (n = 105) | Propranolol (n = 36) | Atenolol (n = 69) | p-value | |
---|---|---|---|---|
Demographics | ||||
Child age, years | ||||
Median (IQR) | 7.4 (6.7–8.5) | 8.0 (7.3–8.8) | 7.1 (6.4–8.1) | < 0.001 |
Range | 6.0–11.8 | 6.4–11.8 | 6.0–9.7 | |
Child sex, n (%) | ||||
Female | 85 (81) | 29 (81) | 56 (81) | > 0.99 |
Male | 20 (19) | 7 (19) | 13 (19) | |
Child migration backgrounda, n (%) | ||||
Yes | 10 (10) | 0 (0.0) | 10 (14) | 0.01 |
No | 94 (90) | 36 (100) | 58 (84) | |
Unknown | 1 (1.0) | 0 (0.0) | 1 (1.4) | |
Education mother, n (%) | ||||
Low | 14 (13) | 6 (17) | 8 (12) | 0.89 |
Average | 28 (27) | 8 (22) | 20 (29) | |
High | 62 (59) | 22 (61) | 40 (58) | |
Unknown | 1 (1.0) | 0 (0.0) | 1 (1.4) | |
Home language, n (%) | ||||
Dutch | 97 (92) | 35 (97) | 62 (90) | 0.37 |
Other | 2 (2.0) | 0 (0.0) | 2 (2.9) | |
Multilingual | 6 (5.7) | 1 (2.8) | 5 (7.2) | |
Confirmed diagnosis, n (%) | ||||
Attention deficit/hyperactivity disorder | 6 (5.7) | 3 (8.3) | 3 (4.3) | |
Clinical information | ||||
Location of IHb, n (%) | ||||
Head and neck | 84 (80) | 24 (67) | 60 (87) | 0.02 |
Trunk | 13 (12) | 6 (17) | 7 (10) | 0.36 |
Genital area | 13 (12) | 7 (19) | 6 (8.7) | 0.13 |
Extremities | 7 (6.7) | 3 (8.3) | 4 (5.8) | 0.69 |
Ulcerated IH, n (%) | ||||
Yes | 29 (28) | 13 (36) | 16 (23) | 0.16 |
No | 76 (72) | 23 (64) | 53 (77) | |
Treatment center, n (%) | ||||
Erasmus MC | 34 (32) | 31 (86) | 3 (4.3) | < 0.001 |
UMCU | 71 (68) | 5 (14) | 66 (96) | |
Age at treatment initiation, months | ||||
Median (IQR) | 3.5 (2.2–5.1) | 3.6 (2.2–5.3) | 3.4 (2.2–5.0) | 0.58 |
Range | 0.92–11.4 | 1.64–11.4 | 0.92–10.9 | |
Treatment duration, months | ||||
Median (IQR) | 13.8 (10.9–19.4) | 18.6 (12.5–22.7) | 13.0 (10.4–15.8) | 0.001 |
Range | 6.41–62.7 | 9.13–62.7 | 6.41–56.8 | |
Average dose, mg/kg/day | ||||
Median (IQR) | 1.2 (1.0–1.8) | 1.9 (1.8–2.0) | 1.0 (1.0–1.2) | < 0.001 |
Range | 0.8–2.5 | 1.4–2.5 | 0.8–2.0 | |
Peak dose, mg/kg/day | ||||
Median (IQR) | 1.6 (1.0–2.1) | 2.1 (2.0–2.3) | 1.0 (1.0–1.6) | < 0.001 |
Range | 1.0–14.0 | 1.9–14.0 | 1.0–3.0 | |
Cumulative dose, mg/kg | ||||
Median (IQR) | 577.4 (387.2–881.7) | 1122.7 (718.6–1282.3) | 418.7 (310.0–619.7) | < 0.001 |
Range | 186.6–3544 | 494.1–3544 | 186.6–2206 | |
Follow-up timec, years | ||||
Median (IQR) | 5.9 (5.2–6.5) | 6.2 (5.6–6.6) | 5.7 (5.1–6.2) | 0.13 |
Range | 1.6–9.7 | 1.6–9.7 | 4.5–8.4 |
Open Access 26.06.2023 | Correction
Correction to: Long-term neurocognitive functioning of children treated with propranolol or atenolol for infantile hemangioma
Erschienen in: European Journal of Pediatrics | Ausgabe 9/2023