Erschienen in:
22.04.2016 | CORR Insights
CORR Insights
®
: What Is the Role of Allogeneic Cortical Strut Grafts in the Treatment of Fibrous Dysplasia of the Proximal Femur?
verfasst von:
Richard W. Nicholas Jr, MD
Erschienen in:
Clinical Orthopaedics and Related Research®
|
Ausgabe 3/2017
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Excerpt
Bone deformities in patients with fibrous dysplasia can be potentially disabling and difficult to treat. When involving the proximal femur, fibrous dysplasia is often progressive; resulting in pain, varus angulation of the hip (shepherd’s crook deformity) and potentially, pathological fractures [
6,
7]. The disease process is caused by a postzygotic (somatic) mutation of the
GNAS gene, manifesting in poorly functioning osteocytes, which produce an inferior quality fibro-osseous bone [
9]. The extent of the disease, as well as its extraskeletal manifestations (such as McCune–Albright Syndrome), depends upon the eventual location of the migrating, abnormal embryonic cells [
2,
10]. …