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14.06.2021 | Review

Comparative Analysis Between Dentinogenic Ghost Cell Tumor and Ghost Cell Odontogenic Carcinoma: A Systematic Review

verfasst von: Gustavo de Souza Vieira, Pâmella de Pinho Montovani, Rafaela Elvira Rozza-de-Menezes, Karin Soares Gonçalves Cunha, Danielle Castex Conde

Erschienen in: Head and Neck Pathology | Ausgabe 4/2021

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Abstract

Dentinogenic ghost cell tumor (DGCT) and ghost cell odontogenic carcinoma (GCOC) form a spectrum of rare benign and malignant odontogenic neoplasms, respectively. The aim of this study was to perform a comparative systematic review of the clinicopathological, genetic, therapeutic, and prognostic features of DGCT and GCOC. The electronic search was performed until December 2020 on seven electronic databases. Case reports, series, and research studies with enough histopathological criteria for diagnosis and all genomic studies were included. Both DGCT and GCOC showed a male prevalence (p = 0.043), with mandibular and maxillary predilections, respectively (p = 0.008). Peripheral DGCT (DGCTp) affected most elderly people (p < 0.001), and central DGCT (DGCTc) and GCOC occurred mainly in younger individuals. Unilateral enlargement of maxilla or mandible was the most common clinical sign associated with a radiolucent or mixed image. Ameloblastomatous epithelium was often present in both neoplasms. Basaloid and large cells with vesicular nuclei were also frequently seen in GCOC. β-catenin expression and mutations (CTNNB1 gene) were found in DGCT and GCOC. Conservative surgery was mostly used for DGCTp, while radical resection was chosen for DGCTc and GCOC. High recurrence rates were found in DGCTc and GCOC. Metastasis occurred in 16.7% of GCOC cases and the 5-year survival rate was 72.6%. DGCT and GCOC share numerous clinicopathological features and demand a careful histopathological evaluation, considering the overlap features with other odontogenic tumors and the possibility of malignant transformation of DGCT. A strict regular post-operative follow-up is mandatory due to high recurrence rates and metastatic capacity in GCOC.

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Ledesma-Montes C, Gorlin RJ, Shear M, Praetorius F, Mosqueda-Taylor A, Altini M, et al. International collaborative study on ghost cell odontogenic tumours: calcifying cystic odontogenic tumour, dentinogenic ghost cell tumour and ghost cell odontogenic carcinoma: study on ghost cell odontogenic tumours. J Oral Pathol Med. 2008;37:302–8.PubMedCrossRef

Luo H-Y, Li T-J. Odontogenic tumors: a study of 1309 cases in a Chinese population. Oral Oncol. 2009;45:706–11.PubMedCrossRef

Buchner A, Akrish SJ, Vered M. Central dentinogenic ghost cell tumor: an update on a rare aggressive odontogenic tumor. J Oral Maxillofac Surg. 2016;74:307–14.PubMedCrossRef

Jayasooriya PR, Mendis BRRN, Lombardi T. A peripheral dentinogenic ghost cell tumor with immunohistochemical investigations and a literature review-based clinicopathological comparison between peripheral and central variants. Int J Surg Pathol. 2015;23:489–94.PubMedCrossRef

Chrcanovic BR, Gomez RS. Peripheral calcifying cystic odontogenic tumour and peripheral dentinogenic ghost cell tumour: an updated systematic review of 117 cases reported in the literature. Acta Odontol Scand. 2016;74:591–7.PubMedCrossRef

Del Corso G, Tardio ML, Gissi DB, Marchetti C, Montebugnoli L, Tarsitano A. Ki-67 and p53 expression in ghost cell odontogenic carcinoma: a case report and literature review. Oral Maxillofac Surg. 2015;19:85–9.PubMedCrossRef

Sun Z-J, Zhao Y-F, Zhang L, Li Z-B, Chen X-M, Zhang W-F. Odontogenic ghost cell carcinoma in the maxilla: a case report and literature review. J Oral Maxillofac Surg. 2007;65:1820–4.PubMedCrossRef

Barnes L, Eveson JW, Reichart P, Sidransky D. Odontogenic tumors. Pathology & genetics—head and neck tumors. 3rd ed. Lyon: IARC Press; 2005.

El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. Odontogenic and maxillofacial bone tumours. WHO Classification of Head and Neck Tumours. 4th ed. Lyon: IARC Press; 2017.

10.

da Gomes Silva W, dos Ribeiro Bartholomeu Santos TC, Cabral MG, Azevedo RS, Pires FR. Clinicopathologic analysis and syndecan-1 and Ki-67 expression in calcifying cystic odontogenic tumors, dentinogenic ghost cell tumor, and ghost cell odontogenic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117:626–33.CrossRef

11.

Gong Y, Wang L, Wang H, Li T, Chen X. The expression of NF-κB, Ki-67 and MMP-9 in CCOT, DGCT and GCOC. Oral Oncol. 2009;45:515–20.PubMedCrossRef

12.

Kim S-A, Ahn S-G, Kim S-G, Park J-C, Lee S-H, Kim J, et al. Investigation of the beta-catenin gene in a case of dentinogenic ghost cell tumor. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:97–101.PubMedCrossRef

13.

Hassanein AM, Glanz SM, Kessler HP, Eskin TA, Liu C. β-catenin is expressed aberrantly in tumors expressing shadow cells: pilomatricoma, craniopharyngioma, and calcifying odontogenic cyst. Am J Clin Pathol. 2003;120:732–6.PubMedCrossRef

14.

Rumayor A, Carlos R, Kirsch HM, de Andrade BAB, Romañach MJ, de Almeida OP. Ghost cells in pilomatrixoma, craniopharyngioma, and calcifying cystic odontogenic tumor: histological, immunohistochemical, and ultrastructural study. J Oral Pathol Med. 2015;44:284–90.PubMedCrossRef

15.

Ohata Y, Kayamori K, Yukimori A, Sumikura K, Ohsako T, Harada H, et al. A lesion categorized between ghost cell odontogenic carcinoma and dentinogenic ghost cell tumor with CTNNB1 mutation. Pathol Int. 2018;68:307–12.PubMedCrossRef

16.

Ahn S-G, Kim S-A, Kim S-G, Lee S-H, Kim J, Yoon J-H. Beta-catenin gene alterations in a variety of so-called calcifying odontogenic cysts. APMIS. 2008;116:206–11.PubMedCrossRef

17.

Zhang Y, Wang X. Targeting the Wnt/β-catenin signaling pathway in cancer. J Hematol Oncol. 2020;13:165.PubMedPubMedCentralCrossRef

18.

Niu Z, Li Y, Chen W, Zhao J, Zheng H, Deng Q, et al. Study on clinical and biological characteristics of ameloblastic carcinoma. Orphanet J Rare Dis. 2020;15:1–9.CrossRef

19.

González-González R, López-Verdín S, Lavalle-Carrasco J, Molina-Frechero N, Isiordia-Espinoza M, Carreón-Burciaga RG, et al. Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: systematic review. World J Clin Oncol. 2020;11:31–42.PubMedPubMedCentralCrossRef

20.

Pereira NB, Bastos VC, de Souza JC, Diniz MG, Vitório JG, Kitten GT, et al. First insights for targeted therapies in odontogenic myxoma. Clin Oral Investig. 2020;24:2451–8.PubMedCrossRef

21.

Zhukov N, Mareeva Y, Konovalov D, Druy A, Grachev N, Litvinov D. Potentially curative targeted therapy for undifferentiated high-grade sarcoma developing after malignant transformation of a BRAF V600E–mutated ameloblastic fibroma. JCO Precis Oncol. 2019;3:1–6.

22.

de Arruda JAA, Monteiro JLGC, Abreu LG, de Oliveira Silva LV, Schuch LF, de Noronha MS, et al. Calcifying odontogenic cyst, dentinogenic ghost cell tumor, and ghost cell odontogenic carcinoma: a systematic review. J Oral Pathol Med. 2018;47:721–30.PubMedCrossRef

23.

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. PLoS Med. 2021;18:e1003583.PubMedPubMedCentralCrossRef

24.

Moola S, Munn Z, Tufanaru C, Aromataris E, Sears K, Sfetc R, et al. Chapter 7: systematic reviews of etiology and risk. In: Aromataris E, Munn Z, editors. JBI Manual for Evidence Synthesis. JBI; 2020.

25.

Munn Z, Barker TH, Moola S, Tufanaru C, Stern C, McArthur A, et al. Methodological quality of case series studies: an introduction to the JBI critical appraisal tool. JBI Evid Synth. 2020;18:2127–33.PubMed

26.

Bello IO, Qannam A, Al-Zahrani A, AlDosari A. Peripheral dentinogenic ghost cell tumor: report of a case and literature review. Int J Surg Pathol. 2012;20:494–9.PubMedCrossRef

27.

Remya K, Sudha S, Nair RG, Jyothi H. An unusual presentation of ghost cell odontogenic carcinoma: a case report with review of literature. Indian J Dent Res. 2018;29:238–43.PubMedCrossRef

28.

Pinheiro TN, de Souza APF, Bacchi CE, Consolaro A. Dentinogenic ghost cell tumor: A bibliometric review of literature. J Oral Dis Markers. 2019;3:9–17.CrossRef

29.

Liu G, Li J-N, Liu F. Peripheral dentinogenic ghost cell tumor of the ethmoid sinus: a case report. Medicine. 2020;99:e18896.PubMedPubMedCentralCrossRef

30.

Lombardi T, Küffer R, Di Felice R, Samson J. Epithelial odontogenic ghost cell tumour of the mandibular gingiva. Oral Oncol. 1999;35:439–42.PubMedCrossRef

31.

Kumar U, Vij H, Vij R, Kharbanda J, Aparna I, Radhakrishnan R. Dentinogenic ghost cell tumor of the peripheral variant mimicking epulis. Int J Dent. 2010;2010:519494.PubMedPubMedCentralCrossRef

32.

Souliou X, Chrysomali E, Papadhmas X, Tzerbos F. Peripheral dentinogenic ghost cell tumor: a rare odontogenic entity hidden within the ordinary clinical features of reactive gingival lesions. Int J Dent Sci Res. 2015;3:48–51.

33.

Park H-R, Min J-H, Huh K-H, Yi W-J, Heo M-S, Lee S-S, et al. Distant metastasis of intraosseous dentinogenic ghost cell tumour to the donor site of a bone graft. Dentomaxillofac Radiol. 2013;42:20120172.PubMedPubMedCentralCrossRef

34.

Nel C, Robinson L, van Heerden WFP. Ghost cell odontogenic carcinoma arising in the background of a calcifying odontogenic cyst. Oral Radiol. 2020.

35.

Stojanov IJ, Woo S-B. Rapidly expanding mass of the maxilla and paranasal sinuses. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122:117–23.PubMedCrossRef

36.

Yoon H-J, Jayasooriya P, Hong S-D, Lee J-I, Hong S-P. Clinico-pathologic conference: case 5. Dentinogenic ghost cell tumour (DGCT). Head Neck Pathol. 2010;4:347–50.PubMedPubMedCentralCrossRef

37.

Mosqueda-Taylor A, Neville BW, Tatemoto Y, Ogawa I, Takata T. Odontogenic carcinoma with dentinoid: a new odontogenic carcinoma. Head Neck Pathol. 2014;8:421–31.PubMedPubMedCentralCrossRef

38.

Ali EAM, Karrar MA, El-Siddig AA, Gafer N, Satir AA. Ghost cell odontogenic carcinoma of the maxilla: a case report with a literature review. Pan Afr Med J. 2015;21:8.

39.

Li B-B, Gao Y. Ghost cell odontogenic carcinoma transformed from a dentinogenic ghost cell tumor of maxilla after multiple recurrences. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107:691–5.PubMedCrossRef

40.

Thompson LDR, Wenig BM, Müller S, Nelson B, editors. Ameloblastoma. Diagnostic pathology: head and neck. 2nd ed. Amsterdam: Elsevier; 2016. p. 652–7.

41.

Fonseca FP, de Almeida OP, Vargas PA, Gonçalves F, Corrêa Pontes FS, Rebelo Pontes HA. Ameloblastic carcinoma (secondary type) with extensive squamous differentiation areas and dedifferentiated regions. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;121:e154-161.PubMedCrossRef

42.

You Z, Sun L, Yan X, Zhang J, Du J, Li T, et al. Clinicopathologic study on a rare variant of ameloblastoma with basal cell features. Oral Dis. 2019;25:788–95.PubMedCrossRef

43.

McLean-Holden AC, Bishop JA, Kessler HP, Myers LL, Radwan AM, Wildey TC, et al. Spindle-cell variant of ameloblastic carcinoma: a report of 3 cases and demonstration of epithelial-mesenchymal transition in tumor progression. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019;128:e113–21.PubMedCrossRef

44.

Siriwardena BSMS, Speight PM, Franklin CD, Abdelkarim R, Khurram SA, Hunter KD. CEOT variants or entities: time for a rethink? A case series with review of the literature. Head Neck Pathol. 2021;15:186–201.

45.

Loyola AM, Cardoso SV, de Faria PR, Servato JPS, Eisenberg ALA, Dias FL, et al. Adenoid ameloblastoma: clinicopathologic description of five cases and systematic review of the current knowledge. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;120:368–77.PubMedCrossRef

46.

Adorno-Farias D, Muniz VRVM, Soares AP, Cury PR, Rabelo RG, Fernández-Ramires R, et al. Ameloblastoma with adenoid features: a series of eight cases. Acta Histochem. 2018;120:468–76.PubMedCrossRef

47.

Sonone A, Hande A, Chaudhary M, Bonde R, Sheorain A, Agni N. Adenoid ameloblastoma with dentinoid and ghost cells. A composite odontogenic tumour: a rare case report and review of the literature. Oral Surg. 2011;4:77–81.

48.

Kumar P, Jayam C, Patil S, Zingade J. Mixed odontogenic tumour with dentinoid and ghost cells. Case Rep. 2015;2015:2015211867.

49.

Rai HK, Pai SM, Dayakar A, Supriya H. Adenoid ameloblastoma with dentinoid: a rare hybrid variant. J Oral Maxillofac Pathol. 2017;21:319.PubMedPubMedCentralCrossRef

50.

Cheng Y, Long X, Li X, Bian Z, Chen X, Yang X. Clinical and radiological features of odontogenic ghost cell carcinoma: review of the literature and report of four new cases. Dentomaxillofac Radiol. 2004;33:152–7.PubMedCrossRef

51.

Siar CH, Ng KH. Aggressive (malignant?) epithelial odontogenic ghost cell tumour of the maxilla. J Laryngol Otol. 1994;108:269–71.PubMedCrossRef

52.

Sheikh J, Cohen MD, Ramer N, Payami A. Ghost cell tumors. J Oral Maxillofac Surg. 2017;75:750–8.PubMedCrossRef

53.

Ikemura K, Horie A, Tashiro H, Nandate M. Simultaneous occurrence of a calcifying odontogenic cyst and its malignant transformation. Cancer. 1985;56:2861–4.PubMedCrossRef

54.

Zhu Z-Y, Chu Z-G, Chen Y, Zhang W-P, Lv D, Geng N, et al. Ghost cell odontogenic carcinoma arising from calcifying cystic odontogenic tumor: a case report. Korean J Pathol. 2012;46:478–82.PubMedPubMedCentralCrossRef

55.

Miwako S, Hiroto I, Takahumi N, Junichi H, Tadahide N, Yoshinori J, et al. Ghost cell odontogenic carcinoma transformed from dentinogenic ghost cell tumor of the maxilla after recurrences. J Oral Maxillofacial Surg Med Pathol. 2017;29:438–42.CrossRef

56.

Saghafi S, Zare-Mahmoodabadi R, Salehinejad J, Kadeh H, Afzal-Aghaee M. Immunohistochemical analysis of p53 and PCNA expression in calcifying odontogenic cyst. J Oral Sci. 2010;52:609–13.PubMedCrossRef

57.

Folpe AL, Tsue T, Rogerson L, Weymuller E, Oda D, True LD. Odontogenic ghost cell carcinoma: a case report with immunohistochemical and ultrastructural characterization. J Oral Pathol Med. 1998;27:185–9.PubMedCrossRef

58.

Motosugi U, Ogawa I, Yoda T, Abe T, Sugasawa M, Murata S, et al. Ghost cell odontogenic carcinoma arising in calcifying odontogenic cyst. Ann Diagn Pathol. 2009;13:394–7.PubMedCrossRef

59.

Lu Y, Mock D, Takata T, Jordan RCK. Odontogenic ghost cell carcinoma: report of four new cases and review of the literature. J Oral Pathol Med. 1999;28:323–9.PubMedCrossRef

60.

Crivelini MM, de Araújo VC, de Sousa SOM, de Araújo NS. Cytokeratins in epithelia of odontogenic neoplasms. Oral Dis. 2003;9:1–6.PubMedCrossRef

61.

Rosa ACG, Teixeira LN, Passador-Santos F, Furuse C, Montalli VÂM, de Araújo NS, et al. Benign odontogenic ghost cell lesions revisited and new considerations on dysplastic dentin. Clin Oral Invest. 2019;23:4335–43.CrossRef

62.

Lukinmaa PL, Leppäniemi A, Hietanen J, Allemanni G, Zardi L. Features of odontogenesis and expression of cytokeratins and tenascin-C in three cases of extraosseous and intraosseous calcifying odontogenic cyst. J Oral Pathol Med. 1997;26:265–72.PubMedCrossRef

63.

Piattelli A, Fioroni M, Di Alberti L, Rubini C. Immunohistochemical analysis of a dentinogenic ghost cell tumour. Oral Oncol. 1998;34:502–7.PubMedCrossRef

64.

Urs AB, Jot K, Kumar M. Ghost cell characterization in calcifying odontogenic cysts and dentinogenic ghost cell tumors: an immunohistochemical study. J Oral Biosci. 2020;62:336–41.PubMedCrossRef

65.

Iezzi G, Rubini C, Fioroni M, Piattelli A. Peripheral dentinogenic ghost cell tumor of the gingiva. J Periodontol. 2007;78:1635–8.PubMedCrossRef

66.

Kim J, Lee EH, Yook JI, Han JY, Yoon JH, Ellis GL. Odontogenic ghost cell carcinoma: a case report with reference to the relation between apoptosis and ghost cells. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol. 2000;90:630–5.CrossRef

67.

Fregnani ER, Pires FR, Quezada RD, Shih IM, Vargas PA, de Almeida OP. Calcifying odontogenic cyst: clinicopathological features and immunohistochemical profile of 10 cases. J Oral Pathol Med. 2003;32:163–70.PubMedCrossRef

68.

Rappaport MJ, Showell DL, Edenfield WJ. Metastatic ghost cell odontogenic carcinoma: description of a case and search for actionable targets. Rare Tumors. 2015;7:96–7.CrossRef

69.

de Sousa SF, Moreira RG, Gomez RS, Gomes CC. Interrogation of cancer hotspot mutations in 50 tumour suppressor genes and oncogenes in calcifying cystic odontogenic tumour. Oral Oncol. 2016;57:e1-3.PubMedCrossRef

70.

Yukimori A, Oikawa Y, Morita K-I, Nguyen CTK, Harada H, Yamaguchi S, et al. Genetic basis of calcifying cystic odontogenic tumors. PLoS ONE. 2017;12:e0180224.PubMedPubMedCentralCrossRef

71.

Sekine S, Sato S, Takata T, Fukuda Y, Ishida T, Kishino M, et al. Beta-catenin mutations are frequent in calcifying odontogenic cysts, but rare in ameloblastomas. Am J Pathol. 2003;163:1707–12.PubMedPubMedCentralCrossRef

72.

Zhang R, Yang Q, Qu J, Hong Y, Liu P, Li T. The BRAF p.V600E mutation is a common event in ameloblastomas but is absent in odontogenic keratocysts. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020;129:229–35.PubMedCrossRef

73.

Diniz MG, Gomes CC, Guimarães BVA, Castro WH, Lacerda JCT, Cardoso SV, et al. Assessment of BRAFV600E and SMOF412E mutations in epithelial odontogenic tumours. Tumor Biol. 2015;36:5649–53.CrossRef

74.

Han N, Zheng Y, Li R, Li X, Zhou M, Niu Y, et al. β-catenin enhances odontoblastic differentiation of dental pulp cells through activation of runx2. PLoS ONE. 2014;9:e88890.PubMedPubMedCentralCrossRef

75.

Siar CH, Kawakami T, Buery RR, Nakano K, Tomida M, Tsujigiwa H, et al. Notch signaling and ghost cell fate in the calcifying cystig odontogenic tumor. Eur J Med Res. 2011;16:501.PubMedPubMedCentralCrossRef

76.

Zhang L, Chen X-M, Sun Z-J, Bian Z, Fan M-W, Chen Z. Epithelial expression of SHH signaling pathway in odontogenic tumors. Oral Oncol. 2006;42:398–408.PubMedCrossRef

77.

Bose P, Pleasance ED, Jones M, Shen Y, Ch’ng C, Reisle C, et al. Integrative genomic analysis of ghost cell odontogenic carcinoma. Oral Oncol. 2015;51:e71–5.PubMedCrossRef

78.

Sun G, Huang X, Hu Q, Yang X, Tang E. The diagnosis and treatment of dentinogenic ghost cell tumor. Int J Oral Maxillofac Surg. 2009;38:1179–83.PubMedCrossRef

79.

Garcia Garcia B, Ruiz Masera JJ, Zafra Camacho FM, Centella GC. Intraosseous dentinogenic ghost cell tumor: case report and treatment review. Revista Española de Cirugía Oral y Maxilofacial. 2015;37:243–6.CrossRef

80.

Martos-Fernández M, Alberola-Ferranti M, Hueto-Madrid JA, Bescós-Atín C. Ghost cell odontogenic carcinoma: a rare case report and review of literature. J Clin Exp Dent. 2014;6:e602-606.PubMedPubMedCentralCrossRef

81.

Grodjesk JE, Dolinsky HB, Schneider LC, Dolinsky EH, Doyle JL. Odontogenic ghost cell carcinoma. Oral Surg Oral Med Oral Pathol. 1987;63:576–81.PubMedCrossRef

82.

Namana M, Majumdar S, Uppala D, Avv A, Rao AK. Ghost cell odontogenic carcinoma arising denovo with distant metastasis: a case report and review of literature. J Clin Diagn Res. 2017;11:ZD01.PubMedPubMedCentral

83.

Sukumaran R, Somanathan T, Kattoor J. Odontogenic ghost cell carcinoma with pulmonary metastasis. J Oral Maxillofac Pathol. 2015;19:371–4.PubMedPubMedCentralCrossRef

84.

Ahmed SK, Watanabe M, deMello DE, Daniels TB. Pediatric metastatic odontogenic ghost cell carcinoma: a multimodal treatment approach. Rare Tumors. 2015;7:5855.

85.

Kao SY, Pong BY, Li WY, Gallagher GT, Chang RC. Maxillary odontogenic carcinoma with distant metastasis to axillary skin, brain, and lung: case report. Int J Oral Maxillofac Surg. 1995;24:229–32.PubMedCrossRef

86.

Urs AB, Augustine J, Singh H, Kureel K, Mohanty S, Gupta S. Calcifying ghost cell odontogenic tumor (CGCOT) with predominance of clear cells: a case report with important diagnostic considerations. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;121:e32-37.PubMedCrossRef

87.

Inoue K, Shigematsu H, Fukuda M, Hoshino M, Kikuchi K, Sakashita H. A case of a dentinogenic ghost cell tumor of the maxilla. Jpn J Oral Maxillofac Surg. 2019;65:661–6.CrossRef

88.

Soares CD, Carlos R, de Lima Morais TM, de Almeida OP. Giant dentinogenic ghost cell tumor: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;126:e215–9.PubMedCrossRef

89.

Kanda N, Oikawa M, Hirotani H, Kawai T, Kumamoto H, Takahashi T. A case of peripheral dentinogenic ghost cell tumor in the mandible. Jpn J Oral Maxillofac Surg. 2017;63:251–5.CrossRef

90.

Walia C, Kashyap B, Roy S. Disorganized histomorphology: dentinogenic ghost cell tumor. J Oral Maxillofac Pathol. 2017;21:154–7.PubMedPubMedCentralCrossRef

91.

Soluk Tekkesin M, Erdem MA, Ozer N, Olgac V. Intraosseous and extraosseous variants of dentinogenic ghost cell tumor: two case reports. J Istanb Univ Fac Dent. 2015;49:56–60.PubMedPubMedCentralCrossRef

92.

de Pulino BFB, Siqueira CS, Duarte CME, de Sousa SCOM. Expression of PCNA, p53 and Ki-67 in dentinogenic ghost cell tumors and calcifying cystic odontogenic tumors. Clin Lab Res Dent. 2014;20:16.CrossRef

93.

Li B-H, Cho Y-A, Kim S-M, Kim M-J, Hong S-P, Lee J-H. Recurrent odontogenic ghost cell carcinoma (OGCC) at a reconstructed fibular flap: a case report with immunohistochemical findings. Med Oral Patol Oral Cir Bucal. 2011;16:e651-656.PubMedCrossRef

94.

Candido GA, Viana KA, Watanabe S, Vencio EF. Peripheral dentinogenic ghost cell tumor: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108:e86-90.PubMedCrossRef

95.

Yun KI, Lee JA, Lee YS, Kim TJ, Park JU. Dentinogenic ghost cell tumors. J Oral Maxillofac Surg. 2007;65:1816–9.PubMedCrossRef

96.

Yoon JH, Ahn SG, Kim SG, Kim J. Odontogenic ghost cell tumour with clear cell components: clear cell odontogenic ghost cell tumour?: odontogenic ghost cell tumour with clear cell components. J Oral Pathol Med. 2003;33:376–9.CrossRef

97.

Mori M, Kasai T, Nakai M, Sato K, Takeuchi H, Takai Y, et al. Dentinogenic ghost cell tumor: histologic aspects, immunohistochemistry, lectin binding profiles, and biophysical studies. Oral Oncol. 2000;36:134–43.PubMedCrossRef

98.

Araki D, Yoshida S, Koyama K, Ishii S, Hasegawa T, Ooyama S. A case of large ghost cell odontogenic carcinoma arising in the mandible. Jpn J Oral Maxillofac Surg. 2018;64:708–14.CrossRef

99.

Park SY, Park J, Kwon DH, Jeon J, Kim SM, Myoung H, et al. Ghost cell odontogenic carcinoma on right mandible and its respective surgical reconstruction: a case report. J Korean Assoc Oral Maxillofac Surg. 2017;43:415–22.PubMedPubMedCentralCrossRef

100.

Kawai S, Ito E, Yamaguchi A, Eishi Y, Okada N. Immunohistochemical characteristics of odontogenic carcinomas: their use in diagnosing and elucidating histogenesis. Oral Med Pathol. 2009;13:55–63.CrossRef

101.

Takata T, Lu Y, Ogawa I, Zhao M, Zhou ZY, Mock D, et al. Proliferative activity of calcifying odontogenic cysts as evaluated by proliferating cell nuclear antigen labeling index. Pathol Int. 1998;48:877–81.PubMedCrossRef

Titel: Comparative Analysis Between Dentinogenic Ghost Cell Tumor and Ghost Cell Odontogenic Carcinoma: A Systematic Review
verfasst von: Gustavo de Souza Vieira
Pâmella de Pinho Montovani
Rafaela Elvira Rozza-de-Menezes
Karin Soares Gonçalves Cunha
Danielle Castex Conde
Publikationsdatum: 14.06.2021
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 4/2021
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-021-01347-z

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Comparative Analysis Between Dentinogenic Ghost Cell Tumor and Ghost Cell Odontogenic Carcinoma: A Systematic Review

Abstract

Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

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