Background
Materials and methods
Study design
Blood sampling and analysis
Statistical analysis
Results
Comparison between obese children who did or did not decrease their SDS-BMI after nine months
Children with obesity | Children with obesity | ||||
---|---|---|---|---|---|
(SDS-BMI stable) (n = 32) | (SDS-BMI decrease) (n = 31) | ||||
Relative changes (Δa) | Mean ± S.E.M | Relative changes (Δa) | Mean ± S.E.M | p | |
Age (years) | 0,88 ± 0,05 | 8.88 ± 0.17 | 0,87 ± 0,04 | 8.84 ± 0.18 | 0.8738 |
Male/Female | 15/17 | 14/17 | |||
ALT (U/L) | 0.97 ± 0.63 | 21.13 ± 0.78 | -1.23 ± 0.85 | 18.19 ± 0.63 | 0.0048 |
AST (U/L) | -0.03 ± 0.46 | 23.95 ± 0.71 | -0.97 ± 0.50 | 24.32 ± 0.67 | 0.6986 |
BChE (U/L) | 201.07 ± 126.38 | 11,027.3 ± 209.1 | -880.19 ± 128.67 | 10,555.9 ± 226.9 | 0.1314 |
BMI (Kg/m2) | 0.56 ± 0.13 | 24.19 ± 0.40 | -1.40 ± 0.12 | 21.98 ± 0.38 | 0.0002 |
SDS-BMI | -0.047 ± 0.05 | 3.29 ± 0.18 | 0.95 ± 0.07 | 2.40 ± 0.19 | 0.0014 |
Waist circumference (cm) | 4.04 ± 0.85 | 78.33 ± 1.29 | -1.15 ± 0.44 | 71.46 ± 1.19 | 0.0002 |
Glucose (mmol/L) | -0.04 ± 0.08 | 5.02 ± 0.06 | 0.02 ± 0.07 | 5.07 ± 0.06 | 0.5680 |
Insulin (µU/mL) | 0.99 ± 0.41 | 7.94 ± 0.46 | -0.35 ± 0.42 | 5.95 ± 0.32 | 0.0007 |
HOMA-IR | 0.138 ± 0.12 | 1.714 ± 0.10 | -0.056 ± 0.14 | 1.347 ± 0.08 | 0.0061 |
Total cholesterol (mmol/L) | -0.05 ± 0.06 | 4.39 ± 0.59 | -0.06 ± 0.08 | 4.55 ± 0.64 | 0.3061 |
Triglycerides (mmol/L) | 0.09 ± 0.04 | 0.87 ± 0.27 | 0.02 ± 0.05 | 0.80 ± 0.18 | 0.2322 |
HDL-cholesterol (mmol/L) | 0.01 ± 0.02 | 1.29 ± 0.14 | 0.08 ± 0.03 | 1.43 ± 0.20 | 0.0020 |
IL-6 (pg/mL) | -0,06 ± 0,15 | 1.64 ± 0.15 | 0,41 ± 0,20 | 1.25 ± 0.12 | 0.0438 |
CRP (mg/L) | 0.27 ± 0.26 | 2.77 ± 0.34 | -0.97 ± 0.24 | 1.19 ± 0.19 | 0.0001 |
NRL | 0,01 ± 0,06 | 1.299 ± 0.09 | -0,19 ± 0,06 | 1.069 ± 0.04 | 0.0286 |
PRL | 4,01 ± 3,21 | 110.47 ± 4.79 | -16,23 ± 3,64 | 97.69 ± 4.69 | 0.0524 |
Leptin (ng/mL) | 6,53 ± 1,45 | 27.0 ± 2.10 | -0,47 ± 1,42 | 16.93 ± 1.31 | 0.0002 |
sICAM-1 (ng/mL) | 4,26 ± 14,04 | 281.38 ± 8.0 | -21,94 ± 7,32 | 259.97 ± 6.77 | 0.0460 |
SBP (mm Hg) | -0,89 ± 1,41 | 101.78 ± 1.21 | -3,08 ± 1,83 | 97.48 ± 1.41 | 0.0242 |
DBP (mm Hg) | -1,14 ± 1,12 | 62.09 ± 0.71 | -4,95 ± 1,12 | 57.090 ± 1.06 | 0.0002 |
Characteristics of children with obesity stratified by alanine transaminase, divided into terciles
1er Tercile ALT | 2º Tercile ALT | 3er Tercile ALT | F | p | |
---|---|---|---|---|---|
ALT (U/L) | 15.48 ± 0.36 | 19.26 ± 0.18 | 24.18 ± 0.72 | 209.83 | < 0.001 |
Age (years) | 8.69 ± 0.24 | 9.10 ± 0.19 | 8.97 ± 0.19 | 1.18 | 0.318 |
BMI (Kg/m2) | 21.17 ± 1.19 | 22.88 ± 0.39 | 24,68 ± 0.47 | 4.91 | 0.025 |
SDS-BMI | 2.46 ± 0.31 | 2.71 ± 0.17 | 3.50 ± 0.202 | 4.90 | 0.017 |
WC | 71.95 ± 1.48 | 74.51 ± 1.37 | 78.40 ± 1.94 | 3.91 | 0.028 |
Glucose (mmol/L) | 5.05 ± 0.08 | 4.98 ± 0.09 | 5.11 ± 0.06 | 0.72 | 0.495 |
Insulin (pmol/L) | 43.06 ± 3.43 | 47.41 ± 3.65 | 59.44 ± 3.72 | 4.17 | 0.023 |
HOMA-IR | 1.275 ± 0.11 | 1.491 ± 0.11 | 1.791 ± 0.12 | 5.07 | 0.011 |
Leptin (ng/mL) | 16.61 ± 1.74 | 21.37 ± 2.17 | 26.35 ± 2.27 | 5.29 | 0.009 |
AST (U/L) | 23.10 ± 0.90 | 23.82 ± 0.48 | 25.26 ± 0.96 | 1.99 | 0.150 |
BChE (U/L) | 9514.8 ± 314.4 | 10,026.6 ± 145.8 | 10,294.2 ± 299.4 | 2.47 | 0.098 |
SBP (mm Hg) | 98.71 ± 1.59 | 100.86 ± 1.12 | 100.38 ± 1.67 | 0.50 | 0.605 |
DBP (mm Hg) | 60.43 ± 1.46 | 58.67 ± 0.90 | 59.81 ± 1.26 | 0.55 | 0.581 |
TC (mmol/L) | 4.46 ± 0.12 | 4.44 ± 0.11 | 4.50 ± 0.17 | 0.06 | 0.943 |
TG (mmol/L) | 0.78 ± 0.04 | 0.81 ± 0.04 | 0.92 ± 0.06 | 2.01 | 0.147 |
HDL-c (mmol/L) | 1.37 ± 0.05 | 1.35 ± 0.03 | 1.36 ± 0.05 | 0.047 | 0.934 |
CRP (nmol/L) | 18.96 ± 4.48 | 16.48 ± 2.47 | 25.10 ± 3.31 | 1.58 | 0.219 |
IL-6 (pg/mL) | 1.36 ± 0.18 | 1.47 ± 0.08 | 1.52 ± 0.21 | 0.21 | 0.784 |
NLR | 1.26 ± 0.14 | 1.05 ± 0.05 | 1.19 ± 0.07 | 1.37 | 0.266 |
PLR | 97.27 ± 5.97 | 109.59 ± 6.39 | 103.27 ± 5.69 | 1.10 | 0.338 |
sICAM-1 (ng/mL) | 278.51 ± 11.61 | 266.64 ± 8.33 | 267.40 ± 7.81 | 0.53 | 0.594 |
Association between changes in alanine transaminase levels and the other variables after nine months
Δ ALT | Δ AST | Δ BChE | Δ ALT/AST | |||||
---|---|---|---|---|---|---|---|---|
r | p | r | p | r | p | r | p | |
Δ BMI | 0.3054 | 0.0149 | 0.2577 | 0.0435 | 0.5404 | < 0.0001 | 0.2705 | 0.0331 |
Δ SDS-BMI | 0.2691 | 0.0339 | 0.1669 | 0.1910 | 0.5150 | < 0.0001 | 0.2564 | 0.0456 |
Δ WC | 0.3436 | 0.0058 | 0.2869 | 0.0226 | 0.4607 | 0.0001 | 0.2638 | 0.0372 |
Δ Glucose | 0.0270 | 0.8336 | -0.1148 | 0.3703 | -0.1881 | 0.1398 | 0.0618 | 0.6306 |
Δ Insulin | 0.2602 | 0.0381 | 0.1243 | 0.3316 | 0.3036 | 0.0156 | 0.0779 | 0.5734 |
Δ HOMA-IR | 0.2710 | 0.0329 | 0.1455 | 0.2550 | 0.2762 | 0.0318 | 0.0292 | 0.8200 |
Δ SBP | -0.2256 | 0.0731 | -0.2278 | 0.0742 | 0.1192 | 0.3522 | -0.1052 | 0.4117 |
Δ DBP | -0.2326 | 0.0628 | -0.1702 | 0.1822 | 0.0543 | 0.6720 | -0.2414 | 0.0572 |
Δ Total cholesterol | -0.0119 | 0.9261 | 0.1125 | 0.3801 | 0.1682 | 0.1876 | -0.0783 | 0.5421 |
Δ Triglycerides | 0.0623 | 0.6274 | -0.0719 | 0.5755 | 0.4584 | 0.0002 | 0.0813 | 0.5266 |
Δ HDL cholesterol | -0.0290 | 0.8212 | -0.0167 | 0.8966 | -0.0116 | 0.9282 | 0.0255 | 0.8428 |
Δ CRP | 0.3424 | 0.0061 | 0.2815 | 0.0264 | 0.3181 | 0.0115 | 0.2677 | 0.0354 |
Δ IL-6 | 0.2697 | 0.0337 | 0.2839 | 0.0242 | 0.0249 | 0.8462 | 0.1718 | 0.1818 |
Δ NLR | 0.2574 | 0.0438 | 0.2348 | 0.0650 | 0.2702 | 0.0334 | 0.1540 | 0.2318 |
Δ PLR | 0.3151 | 0.0134 | 0.2684 | 0.0351 | 0.2672 | 0.0364 | 0.2679 | 0.0353 |
Δ sICAM-1 | 0.0244 | 0.8497 | 0.1150 | 0.3693 | 0.0931 | 0.4678 | -0.0135 | 0.9166 |
Δ Leptin | 0.3264 | 0.0096 | 0.3039 | 0.0167 | 0.5291 | < 0.0001 | 0.3677 | 0.0031 |