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18.03.2024 | Original Article

Associations of pyrethroid exposure with bone mineral density and osteopenia in adults

verfasst von: Zhubin Shen, Fengyi Zhang, Xiaoqing Guan, Zhiming Liu, Yuan Zong, Ding Zhang, Rui Wang, Qian Xue, Wenxuan Ma, Ruijian Zhuge, Li Guo, Fei Yin

Erschienen in: Journal of Bone and Mineral Metabolism | Ausgabe 2/2024

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Abstract

Introduction

This study was to investigate the correlations between pyrethroid exposure and bone mineral density (BMD) and osteopenia.

Materials and methods

This cross-sectional study included 1389 participants over 50 years of age drawn from the 2007–2010 and 2013–2014 National Health and Nutrition Examination Survey (NHANES). Three pyrethroid metabolites, 3-phenoxybenzoic acid (3-PBA), trans-3-(2,2-dichlorovinyl)-2,2-dimethyl-cyclopropane-1-carboxylic acid (trans-DCCA), and 4-fluoro-3-phenoxybenzoic acid (4-F-3PBA) were used as indicators of pyrethroid exposure. Low BMD was defined as T-score < − 1.0, including osteopenia. Weighted multivariable linear regression analysis or logistic regression analysis was utilized to evaluate the correlation between pyrethroid exposure and BMD and low BMD. Bayesian kernel machine regression (BKMR) model was utilized to analyze the correlation between pyrethroids mixed exposure and low BMD.

Results

There were 648 (48.41%) patients with low BMD. In individual pyrethroid metabolite analysis, both tertile 2 and tertile 3 of trans-DCCA were negatively related to total femur, femur neck, and total spine BMD [coefficient (β) = − 0.041 to − 0.028; all P < 0.05]. Both tertile 2 and tertile 3 of 4-F-3PBA were negatively related to total femur BMD (P < 0.05). Only tertile 2 [odds ratio (OR) = 1.63; 95% CI = 1.07, 2.48] and tertile 3 (OR = 1.65; 95% CI = 1.10, 2.50) of trans-DCCA was correlated with an increased risk of low BMD. The BKMR analysis indicated that there was a positive tendency between mixed pyrethroids exposure and low BMD.

Conclusion

In conclusion, pyrethroids exposure was negatively correlated with BMD levels, and the associations of pyrethroids with BMD and low BMD varied by specific pyrethroids, pyrethroid concentrations, and bone sites.

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Titel: Associations of pyrethroid exposure with bone mineral density and osteopenia in adults
verfasst von: Zhubin Shen
Fengyi Zhang
Xiaoqing Guan
Zhiming Liu
Yuan Zong
Ding Zhang
Rui Wang
Qian Xue
Wenxuan Ma
Ruijian Zhuge
Li Guo
Fei Yin
Publikationsdatum: 18.03.2024
Verlag: Springer Nature Singapore
Erschienen in: Journal of Bone and Mineral Metabolism / Ausgabe 2/2024
Print ISSN: 0914-8779
Elektronische ISSN: 1435-5604
DOI: https://doi.org/10.1007/s00774-024-01499-2

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Associations of pyrethroid exposure with bone mineral density and osteopenia in adults