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22.09.2023 | Research

Antineoplastic therapy in childhood cancer patients presents a negative impact in the periodontal tissues: a cohort study

verfasst von: Bruna C. Longo, Isabel B. Rohling, Pauline L. M. O. E. Silva, Maria E. F. de Morais, Hélvis E. S. Paz, Renato C. V. Casarin, Sheila A. B. Nishiyama, Maria D. B. de Souza, Cléverson O. Silva

Erschienen in: Clinical Oral Investigations | Ausgabe 11/2023

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Abstract

Objectives

To investigate the effect of antineoplastic therapy (AT) in the periodontal tissues of childhood cancer (CC) patients.

Materials and methods

Seventy-two individuals were divided into CC (n=36) and healthy individuals (control group—CG, n=36). Demographics, hygiene habits, CC type, and AT were collected. Salivary flow and the presence and concentration of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Tannerella forsythia, and Fusobacterium nucleatum were analyzed. Clinical evaluation included plaque (PI) and gingival indexes (GI), periodontal probing depth (PPD), and clinical attachment level (CAL). Patients were classified into periodontal health, gingivitis, or periodontitis. Descriptive statistics, T test, Mann-Whitney test, chi-square, Fisher’s exact test, and two-way analysis of variance were used (p<0.05).

Results

The mean age of the patients was similar (CC 12.0±3.9 years and CG 12.0±4.0 years). In the CC group, all patients underwent chemotherapy and nine radiotherapy. Color/race, income, and family education showed significant differences between groups. There was no difference between groups in salivary flow. Higher levels of Fusobacterium nucleatum were seen in CC (p=0.02). Significant difference between groups was found for PI (CC: 30.5%, CG: 22.6%), GI (CC: 28.8%, CG: 17.3%), PPD (CC: 1.77 mm, CG: 1.61 mm), and CAL (CC: 1.77 mm, CG: 1.57 mm), periodontal health (CC: 3, CG: 7), gingivitis (CC: 16, CG: 24), or periodontitis (CC: 17, CG: 5).

Conclusion

AT in CC patients presents a negative impact in the periodontal and microbiological parameters.

Clinical relevance

Childhood cancer individuals showed worse periodontal parameters and higher levels of Fusobacterium nucleatum in the saliva when compared to healthy individuals.

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Titel: Antineoplastic therapy in childhood cancer patients presents a negative impact in the periodontal tissues: a cohort study
verfasst von: Bruna C. Longo
Isabel B. Rohling
Pauline L. M. O. E. Silva
Maria E. F. de Morais
Hélvis E. S. Paz
Renato C. V. Casarin
Sheila A. B. Nishiyama
Maria D. B. de Souza
Cléverson O. Silva
Publikationsdatum: 22.09.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 11/2023
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-023-05270-1

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Antineoplastic therapy in childhood cancer patients presents a negative impact in the periodontal tissues: a cohort study