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2022 | OriginalPaper | Buchkapitel

34. Allergische bronchopulmonale Aspergillose

verfasst von : J. Christian Virchow

Erschienen in: Seltene Lungenerkrankungen

Verlag: Springer Berlin Heidelberg

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Zusammenfassung

Die allergische bronchopulmonale Aspergillose ist eine seltene, oft erst spät diagnostizierte Atemwegs- und Lungenerkrankung, die auf dem Boden eines allergischen Asthma bronchiale entsteht. Die klinischen Zeichen purulentes Sputum, rezidivierende pulmonale Infiltrate wechselnder Ausprägung bei einer kutan und serologisch nachweisbaren IgE-abhängigen Sensibilisierung gegen A. fumigatus und rekombinante A.-fumigatus-Antigene (oder seltener anderen Schimmelpilzen), gepaart mit einer labortechnisch nachweisbaren, ausgeprägten Eosinophilie und hohen, polyklonalen gesamt-IgE-Titern und dem Nachweis von Bronchiektasen, Mucoid Impaction und fibrotischen Veränderungen sollten die Diagnose einer ABPA nahelegen. Die Therapie umfasst immunsuppressive Behandlung mit systemischen und topischen Kortikosteroiden, Antimykotika und in Zukunft möglicherweise die Immuntherapie mit Anti-IgE- und/oder Anti-Zytokin-Antikörpern. Gesamt-IgE-Spiegel sind zur Therapiesteuerung geeignet.

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Titel: Allergische bronchopulmonale Aspergillose
verfasst von: J. Christian Virchow
Verlag: Springer Berlin Heidelberg
Buch: Seltene Lungenerkrankungen
Print ISBN: 978-3-662-63650-3

Electronic ISBN: 978-3-662-63651-0

Copyright-Jahr: 2022
DOI: https://doi.org/10.1007/978-3-662-63651-0_34

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